In the article, we consider the instructions for use for the Nystatin preparation. It is an antifungal drug that is often prescribed to eliminate candidiasis, the appearance of which is provoked by candida fungi or aspergillus. It can be used for the treatment of candidiasis both on the skin and in the oral cavity, and in the vagina and intestines. This is possible due to the various forms of release of the drug and its local effect on the fungus.
Structure
As indicated by the instructions for "Nystatin", it is produced in the form of suppositories containing the same active substance of 250 thousand and 500 thousand units, ointments of 100 thousand units, and tablets for oral administration of 500 thousand units. When taken orally, the drug is practically not absorbed into the systemic circulation, which excludes its effect on the body. Also, the tool does not have the property to accumulate with prolonged use. Residual substances are excreted through the intestines with feces. When using the drug externally, the drug is also not absorbed through the vaginal mucosa and skin.
Indications for use
In accordance with the instructions, suppositories "Nystatin" for intravaginal administration are used in the following cases:
- Candidiasis localized in the vulvovaginal region.
- During antibiotic therapy for the prevention of pathologies caused by fungus.
According to the instructions for Nystatin tablets, they are prescribed to solve the following problems:
- In the period after the operation on the organs of the gastrointestinal tract, the drug is taken as a prophylactic for fungal infections.
- Candidiasis that occurs on the mucous membranes and skin of internal organs.
- When conducting antibiotic therapy as a preventive measure.
Ointment is used for candidiasis that develops on the skin and mucous membranes.
Contraindications
What else does the instruction for Nystatin tell us?
A common contraindication for all dosage forms is hypersensitivity to the components of the drug, as well as the period of gestation.
There are also separate limitations for each form of the drug. So, tablets can not be taken with liver failure, against a background of gastric ulcer, as well as with pancreatitis.
Suppositories are prohibited for use by patients under the age of 18, and the ointment should not be used for children under one year of age.
Adverse reactions
Adverse reactions are also possible during treatment with Nystatin. Tablets can lead to the following complications:
- Nausea and vomiting.
- Diarrhea.
- Bitterness in the mouth.
- Soreness in the abdomen.
- Chills.
- Allergy.
When treating with suppositories, the following undesirable effects are observed:
- Itching and burning.
- Allergic reactions of a local nature.
According to the instructions, Nystatin ointment can cause such side effects:
- Rash.
- Irritation of mucous membranes and skin.
- Hives.
Instruction "Nystatin"
Since the medication has several forms of release, its use for each of them has its own characteristics.
The tablets are intended for oral use, regardless of the time of meal. The drug is swallowed whole, you can not chew the tablet. Adults for the treatment of candidiasis in the internal organs are prescribed 500 thousand units up to eight times a day. Treatment should be at least two weeks. The daily dosage on average ranges from 1.5 million to 3 million units. If candidiasis is generalized, the daily dosage is increased to 6 million units, and a second course is carried out after a two-week break.
This is confirmed by the instructions for use with the Nystatin tablets.
The children's dosage is 125 thousand units, if the child is under the age of one year, and 250 thousand units from the age of one to five years. Children over 13 years of age are advised to take 500 thousand units up to four times a day. Treatment should not exceed a period of two weeks.
The ointment is used exclusively externally. The drug is applied to the affected skin or mucous membranes with a thin layer in the morning and evening. The duration of treatment is 10 days. Quite often, the use of ointment is combined with taking a tablet form.
During the treatment of stomatitis, lesions are lubricated with the drug three times a day after meals. Such treatment should be carried out for at least seven days. If skin irritation, a rash or hives occur during the use of the ointment, the drug is canceled.
As indicated by the instructions for the use of suppositories "Nystatin" must be entered deep into the vagina. Dosage is selected individually. One suppository is most often prescribed in the morning and evening. Treatment should occur for at least two weeks. It should not be interrupted if menstruation has begun. Sexual contact during treatment should be avoided. In addition, the sexual partner should also be treated with antifungal drugs.
The instruction to "Nystatin" should be strictly observed.
Thrush treatment
Candidiasis, which is localized in the genital area or the oral cavity, is called thrush in common people. If we are talking about damage to the oral cavity in moderate or mild severity, local therapy is carried out, which consists in rinsing the mouth, as well as treating the affected areas with Nystatin solution.
Women most often suffer from pathologies such as vulvovaginitis or candidal vulvitis. "Nystatin" in the form of ointment is used for vulvitis, and suppositories and tablets are used for vaginitis. If the course of vulvovaginitis is mild, local treatment consisting in the use of suppositories is sufficient.
Recently, nystatin suppositories are prescribed for the treatment of candidiasis quite rarely. This is due to the fact that many strains of Candida fungus become insensitive to the drug. Candles in this case bring only temporary relief, not eliminating the problem itself and provoking a relapse.
Analogs
The following drugs are considered the most effective and common analogues of Nystatin:
- "Natamycin."
- "Ketoconazole."
- "Clotrimazole."
- "Miconazole."
- Intraconazole
- "Fluconazole."
Candidiasis is a fungal disease that can affect the skin, nails, internal organs and mucous membranes. The most common form of candidiasis is the so-called thrush, localized in the oral cavity and in the vagina.
Reviews
On the Internet you can find quite a lot of reviews about Nystatin, all of them are often contradictory. Negative reviews about the action of suppositories are associated with the development of side effects. Women quite often complain of frequent urination, burning and irritation in the vagina. Many believe that Nystatin is outdated and at the moment the pharmaceutical market is ready to offer much more effective drugs with a minimum of adverse reactions.
Tablets are most often prescribed for the prevention of intestinal dysbiosis during antibiotic therapy. In this case, the drug is really effective and does its job well. However, with this use, undesirable reactions in the form of nausea and diarrhea are not excluded. Often, "Nystatin" is prescribed for simultaneous administration with tetracycline-based drugs.
Thus, if you focus on reviews, it is not advisable to use Nystatin for the treatment of thrush, since the absence of any effect is most likely. However, as a prophylaxis of intestinal dysbiosis, the drug is still effective.