The drug “Minirin” refers the instruction to funds with a vasopressin-like effect. The active substance is desmopressin, a structural analogue of arginine-vasopressin, the human pituitary hormone .
Medication Minirin (the instruction contains such information) increases the permeability in the epithelium of the distal sections of the convoluted tubules, enhances the reabsorption of water. This provokes a decrease in the volume of urine excreted, an increase in its osmolarity, while a decrease in osmolarity in the plasma. As a result, the frequency of urination decreases. During the first 30-120 minutes after administration, an increase in concentration to a maximum is noted. The content of the drug in the body is directly proportional to the dosage. The ability of the drug to pass the BBB is not noted. Excretion occurs through the kidneys.
Means "Minirin". Instruction Appointment
The drug is recommended for primary enuresis (nocturnal) in children from six years old, diabetes insipidus. With symptomatic therapy, the drug is used for nocturnal polyuria.
Contraindications
The medicine “Minirin” is not prescribed (the instruction confirms this) in case of psychogenic or habitual polydipsia (with a urine production volume of 40 ml / kg / day), hypersensitivity, heart failure and other conditions in which diuretic medication may be required. Contraindications include age up to 6 years, the syndrome of inadequate production of antidiuretic hormone. Caution during treatment should be shown to patients with renal failure, disorders of water-electrolyte metabolism, fibrosis in the bladder. Dose adjustment is required if there is a potential likelihood of increased intracranial pressure in old age. Despite the absence of a negative effect on the condition of the mother and the fetus, during the bearing of the child, the medicine “Minirin” the instruction allows for appointment according to vital indications. During treatment during these periods, a dose adjustment may be required, and therefore, the doctor should monitor the treatment.
Means "Minirin". Instruction Adverse reactions
As a rule, undesirable consequences of treatment are noted in cases of uncontrolled intake of fluid by the patient. In these cases, water retention in the body, hyponatremia are likely. These phenomena can be asymptomatic or manifest as dry mouth, nausea, weight gain, dizziness, peripheral swelling, headache. In some cases, convulsions are noted.
Medication Minirin. Instructions for use
The medicine is prescribed sublingually (for resorption). The required dosage is selected individually. The drug is taken after a meal. In diabetes insipidus, the recommended initial dosage is 60 micrograms three times a day. In accordance with the onset of effect, the amount of medication can be adjusted. The optimal therapeutic dose per day is 120-720 mcg, prophylactic - 60-120 mcg / 3 r. / Day. With primary enuresis, 120 mcg is prescribed. The drug is given at night. In the absence of a result of therapy, the dose may be doubled (up to 240 mcg). During therapy, fluid intake should be limited.
Means "Minirin". Instruction Price
The cost of the medication is from 1300 rubles.