The drug "Nurofen" on sale is presented in various forms of release: suppositories and tablets, syrups and capsules. Options for adults and children are produced. The drug is truly indispensable and is in the medicine cabinet of almost any of our compatriots, since it quickly and effectively relieves pain attacks of a different nature. To use the medication safely, you must study the instructions for Nurofen before use. The manufacturer indicates the need for consultation with a doctor before using the drug - this will help minimize the risk of negative reactions.
Tablets and features of their use
Among all release forms, reinforced tablets (the manufacturer completes the packaging with instructions) “Nurofen” are especially popular. 400 mg - dosage of the active compound in one capsule of the drug. The cost of one package varies from 80 to 120 rubles.
The main substances on which the drug is created are the products of propionic acid processing; the active ingredient is called ibuprofen.
The instructions to "Nurofen" indicate that the drug:
- relieves pain;
- relieves inflammation;
- knocks down the heat.
The active compound is able to inhibit the activity of two cyclooxygenase isoenzymes at once.
Kinetics Features
Studies have shown that ibuprofen in the highest concentration in the body is observed already half an hour after the drug is ingested. In some cases, the time period reaches one hour. The instructions to "Nurofen" indicate the accumulation of active compounds in the synovial cavities - in these elements of the human body, the concentration of ibuprofen is much higher than in the circulatory system.
Once in the body, the active compound undergoes biological and chemical reactions. The instructions for "Nurofen" indicate the elimination pathway - the kidneys.
Under the influence of the active compound, the permeability of the vascular walls becomes lower, blood circulation is activated at the level of the capillaries, which leads to an improvement in the condition of a person suffering from an inflammatory disease. In the instructions for Nurofen, the manufacturer indicates the inhibition of the processes of the emission of inflammatory mediators by the cells. At the same time, the inflammatory process cannot receive the necessary energy volumes, since ibuprofen blocks the transmission of energy to the diseased area.
Instructions for use "Nurofen" is recommended as an anesthetic. Its effectiveness in this capacity is explained by inhibition of the intensity of inflammatory processes. Under the influence of the compound, smaller volumes of bradykinin are generated, while its ability to provoke pain is reduced.
The manufacturer in the instructions for use of "Nurofen" draws attention to the correction by the active components of the drug the work of the brain centers responsible for regulating the heat of the human body. This leads to a decrease in temperature in people with fever.
A single use of the enhanced release option (400 mg of the active compound) allows you to achieve a pronounced eight-hour effect (in some cases, the duration may vary). Nurofen has an antipyretic effect, the strength of which depends on the dosage of the drug and the initial condition of the patient. The active compound of the drug is able to inhibit platelet aggregation. All changes are reversible.
Negative consequences
As can be seen from the reviews (this is also noted in the instructions for use), Nurofen can cause negative consequences, a negative response of the body. Most often, adverse reactions are observed from the digestive tract. Patients taking the composition noted weight loss, nausea and vomiting. Some were tormented by heartburn, others noted that there were discomfort, discomfort and even pain in the stomach area. Perhaps a violation of the stool and increased gas formation, there is a risk of constipation.
In the instructions for use of Nurofen, the manufacturer indicates among the possible side effects:
- erosion, gastrointestinal ulcers;
- signs of bleeding in the digestive tract;
- noise in ears;
- sleep disturbances;
- excitement;
- vision problems;
- swelling.
Some patients complained that they were sick and dizzy while using the pills. Tests have shown that there is a risk of fluid retention in body tissues. While taking the pills, blood pressure may increase. In the instructions for use of "Nurofen" it is mentioned that tablets can provoke granulo-, thrombocytopenia and allergic reactions, as well as some types of anemia.
Reinforced version: when recommended?
The manufacturer indicates the wisdom of using the drug with:
- arthritis;
- synovitis;
- gout
- arthrosis;
- spondylosis;
- sciatica;
- lumbalgia;
- Barre-Lieu syndrome;
- bursitis;
- myalgia;
- neuralgia;
- Tondovaginitis;
- amyotrophy;
- injuries
- pain against the background of surgery;
- Toothache
- bronchitis;
- pneumonia.
The following situations are mentioned in the instructions for use of Nurofen:
- stretching;
- hematomas;
- ENT diseases;
- inflammation in the pelvic area;
- cold;
- nephrotic syndrome;
- low blood pressure due to the use of hypertension medications;
- fever;
- ARVI.
Strongly impossible!
Containing 400 mg of the active component of the Nurofen capsule (the instruction pays special attention to this) cannot be used if the patient is hypersensitive to any compound used by the manufacturer in the manufacture of the drug. In addition, Nurofen is contraindicated in:
- gastrointestinal ulcers, exacerbated at the moment;
- ulcerative colitis;
- thrombocyte and leukopenia;
- aspirin asthma;
- diathesis;
- hypertension in portal form or arterial;
- scotoma;
- amblyopia.
You can not use the drug if severe violations of the functionality of the liver, kidneys, insufficiency of the heart muscle are detected. "Nurofen" is contraindicated in diseases that affect the optic nerve, as well as in violation of the perception of colors by the organs of vision.
It is additionally indicated in the instructions for "Nurofen": adult women who have a baby or breast-feeding, the drug can not be used. If you need to choose an antipyretic or analgesic, you need to contact the doctor for the selection of a more suitable option for an "interesting" position.
Features of use
In the instructions for the Nurofen tablets, the manufacturer indicates that the preparation containing 400 mg of the active compound in each capsule is intended for persons over the age of twelve. The tablets are taken orally. For an adult patient, the maximum dose per day is 1200 mg, and for children from twelve years of age until adulthood - 1000 mg.
If you use the medication in too much volume, there is a risk of overdose. The instructions for the use of Nurofen tablets containing 400 mg of the active ingredient indicate that an overdose manifests itself:
- soreness in the abdomen, head;
- craving for sleep;
- depressive states;
- retardation;
- vomiting and nausea;
- tinnitus;
- acidosis;
- coma;
- impaired breathing function;
- pressure reduction;
- violation of the rhythm and heart rate.
There are known cases of acute renal failure due to the intake of excess Nurofen. In rare cases, atrial fibrillation has been diagnosed.
The instructions for the use of Nurofen capsules contain instructions on how to bring the patient to life. If an overdose is detected, it is necessary to rinse the stomach, if it was possible to detect an event within the first hour from the moment the agent enters the body. To slightly reduce absorption, the patient is given activated charcoal. In case of overdose are shown:
Additionally, the doctor prescribes the means and measures to eliminate the symptoms characteristic of a particular case. These can be drugs to normalize blood pressure and drugs that stop bleeding in the stomach, as well as other specific compounds.
Interaction with other drugs
According to the instructions for use, Nurofen (adults and children from 12 years old are allowed to use the strongest form - 400 mg) can interact with certain drugs. In particular, if the patient uses IPAF, Nurofen can reduce their effect on pressure indicators. Also, the analgesic reduces the activity of hypothiazide, furosemide relative to the concentration of sodium in the body. Against the background of the use of lithium preparations, methotrexate and Nurofen, the poisoning ability of these groups of drugs is growing.
The simultaneous use of funds that affect blood coagulation (coumarin series), alcohol and Nurofen is more likely to provoke hemorrhagic complications. The instructions for the use of adult tablets "Nurofen" also mention the possibility of a negative effect with a combination of pain medication and drugs from the class of corticosteroids, if they are used orally, this combination can provoke bleeding in the digestive tract.
The manufacturer recommends avoiding simultaneous use with Nurofen:
- acetylsalicylic acid;
- drugs from the group of anti-inflammatory non-steroidal;
- diabetes medications;
- hormonal contraceptives;
- phenytoin.
Under the influence of ibuprofen, an increase in the concentration of digoxin in the blood plasma is possible. The analgesic effectiveness of the drug can increase caffeine.
A special case
The use of anti-inflammatory non-steroidal drugs can cause gastropathy, so at an advanced age Nurofen can only be used under medical supervision. Particularly attentive should be persons who have suffered from peptic ulcer of the intestine and stomach in the past, as well as other pathologies that affect the gastrointestinal tract.
Care requires taking a painkiller while taking GCS, NSAIDs. Persons who use Nurofen for a long time should be cautious.
If there is a suspicion of gastropathy, you should immediately undergo esophagogastroduodenoscopy, check the blood for hemoglobin indicators, analyze the discharge from the intestines for the presence of hidden blood inclusions.
To prevent gastropathy, therapy is supplemented with agents containing misoprostol.
According to the instructions to Nurofen, children's age (before reaching 12 years of age) is not an absolute contraindication for using the medication, but taking tablets containing 400 mg of the active ingredient is not recommended for children. If the need arises for such treatment, it is important to monitor the patient's condition.
Particular caution requires taking the drug against a background of diseases, impaired liver and kidney function - you will have to take tests from time to time to identify vital signs. The insufficiency of the heart in a chronic form, high blood pressure also oblige to monitor the patient's condition. We'll have to track the change in weight, pressure, every day to monitor diuresis.
If the use of "Nurofen" is accompanied by a negative response from the visual system, the drug is canceled or reduced dosage. During the course, alcohol-containing products should be avoided.
Tender age: Nurofen suspension
Instruction, this form is recommended for the treatment of children. 5 ml account for 100 mg of the active compound. The manufacturer used additional components:
- aromatic additives;
- polysobrat;
- maltitol;
- saccharinate;
- sodium chloride, citrate;
- water;
- gum;
- lemon acid.
The drug is available in the form of a suspension of a white shade or close to white. The consistency resembles syrup. The instructions for Nurofen indicate that the product has a light aroma and a touch of orange.
Technical points
As in the case of tablets, the instructions for use of the children's "Nurofen" (suspension) indicate that the product belongs to the category of non-steroidal compounds that stop inflammatory processes. The active substance is ibuprofen, obtained by processing propionic acid.
In the instructions for the use of Nurofen Children's Syrup, the manufacturer indicates a high level of absorption of the active component. Ibuprofen is able to interact with plasma proteins by 90%. The drug penetrates relatively slowly into the articular cavities, can accumulate in the synovial areas, and the content indicators here are greater than characteristic of the circulatory system. Relatively small amounts are observed in the fluid of the spinal cord.
Soon after absorption, about 60% of inactive compounds enter into reactions, being converted to form S. Localization of the chemical reaction - the gastrointestinal tract, liver. Metabolic processes occur in the liver. The instructions for use of Nurofen syrup say that the highest levels of concentration in the blood plasma are achieved in a period of one to two hours. The elimination half-life takes about two hours.
Elimination is mainly done through the kidneys (70-90% of the total drug taken). The drug is excreted both in its original form (ibuprofen), and in the form of its metabolites. About one hundredth of the total volume of the drug received leaves the body unchanged. About 2% of the drug is excreted in the bile.
Features of the reception
As many assure, among non-steroidal formulations for stopping inflammatory processes, if necessary, to alleviate the condition of a minor patient, perhaps the best option is Nurofen baby syrup. The instruction says that the drug not only inhibits inflammatory foci, but also reduces fever, relieves pain. Ibuprofen, on which the drug is based, inhibits cyclooxygenase enzymes, which means that prostaglandins are generated in smaller quantities.
The effect lasts up to eight hours.
Syrup is allowed for children from the age of three months. It is recommended to choose this form for children under the age of twelve, and older ones are better to use tablets and other forms.
For kids, Nurofen is an indispensable composition for relieving pain and lowering temperature. It is prescribed for acute respiratory viral infections, influenza and infectious diseases, as well as for:
- vaccine reactions;
- infectious inflammatory processes that provoke fever;
- migraine;
- neuralgia;
- sprains.
"Nurofen" will help if it hurts and is dizzy, teeth, throat or ears hurt.
Terms of use
Express instruction "Nurofen" for children:
- Shake the bottle thoroughly.
- Use a measuring syringe.
- Submit dosage to manufacturer's recommendations.
Rules for using a syringe:
- the item is tightly placed in the neck;
- the suspension is thoroughly mixed;
- the bottle is turned upside down, the piston is pulled out, gaining the necessary volume of the drug;
- flip the bottle;
- remove the syringe;
- smoothly pour the contents of the syringe into the child's mouth;
- thoroughly wash the device, dry in a place inaccessible to children.
Dosage Features
Choose the amount of medication, focusing on age, weight, condition of the baby. For once recommended no more than 10 mg per kilogram of weight. Frequency - up to 4 times a day. At most, 30 mg / kg can be used per day. Between applications, it is necessary to withstand time periods of at least six hours.
Crumbs from three months to six months old syrup "Nurofen" is shown in the amount of 2.5 ml three times a day. The maximum daily volume is 150 mg. For older children, but until the age of one year, the drug is used 2.5 ml up to four times daily, given that a maximum of one day is 200 mg.
From one to three years, the drug is allowed in the amount of 5 ml three times a day. The daily limit is 300 ml. Until the age of six, a single dose is increased to 7.5 ml, while maintaining the same frequency of use. The maximum daily volume is 450 mg.
At the age of 7-9 years, children are allowed to use the composition three times a day in 10 ml. Parents should control that more than 600 mg of the drug is not used per day. Finally, for older children (up to twelve), syrup is shown in the amount of 15 ml three times a day. The maximum possible volume for 24 hours is 900 mg.
Post-vaccine fever
In this condition, for a day, the product can be used in an amount of up to 5 ml, but no more. Before reaching the age of one year, half as much is laid per day. The entire volume is taken at a time. If necessary, children older than one year of age can be given another 2.5 ml of Nurofen six hours after the initial intake.
To reduce the temperature, syrup is used for up to three days. As a drug for the relief of pain - no more than a five-day course. If the symptoms of fever continue to bother after this time, you should show the child to the doctor.
Negative effects: what to prepare for?
"Nurofen" can provoke a violation of the stool and soreness in the abdomen in the child, causing nausea. Allergic reactions are possible, most often manifested by skin rashes, itching. There is a risk of urticaria.
In rare cases, the use of Nurofen syrup provoked:
- increased gas formation;
- vomiting
- constipation;
- loose stools.
Very rarely, hypersensitivity reactions were recorded. More often, these are expressed by swelling of the throat, face, respiratory and rhythm disturbance, heart rate. Perhaps a sharp decrease in pressure, Quincke's edema, shock and strangulation. In extremely rare cases, Nurofen provoked:
- asthma
- an ulcer;
- bronchospasm;
- bleeding in the digestive tract;
- stomatitis;
- gastritis;
- colitis;
- Crohn's disease;
- headache;
- papillonecrosis;
- renal failure in acute form;
- inhibition of the hematopoietic function of the body;
- impaired hepatic function;
- severe skin reactions (bullous, erythema, necrolysis).
It is extremely rare, but there are risks!
There is information that in some cases, Nurofen syrup caused aseptic meningitis. This is possible if the patient has autoimmune diseases, disorders. At the same time, the child complains that his head hurts, he cannot navigate in space. The patient is in fever, nausea and vomiting, examination allows to establish stiff neck muscles.
Features and dangers of use
It is known that the use of non-steroidal drugs for the relief of inflammatory processes can be the cause of swelling, persistently low blood pressure and insufficient functioning of the heart muscle.
Based on medical statistics, clinical observations, the risks are associated to a large extent with ibuprofen treatment in a high dosage, when the patient uses up to 2.4 g of compound per day. Doctors suggest that this can cause the formation of blood clots in the arteries and provoke a stroke, heart attack.
If the use of the composition is accompanied by side effects, the medication is canceled and consult a doctor for choosing a more suitable option.
No way!
"Nurofen" is not used if hypersensitivity to any compound used by the manufacturer of the composition in the work on the drug is known. You can not use syrup (like other forms of release) if the patient is sensitive to ibuprofen, NSAIDs, including acetylsalicylic acid.
Nurofen is not used in combination with other non-steroidal anti-inflammatory drugs, including all substances that have a narrow spectrum of activity and inhibit only the second cyclooxygenase.
Contraindications for use are:
- asthma, urticaria, runny nose on the background of salicylates, other NSAIDs;
- an ulcer of the stomach, intestines;
- GI bleeding
- perforation, bleeding in the digestive tract when using non-steroidal anti-inflammatory drugs;
- vasculitis;
- hemophilia and other blood diseases;
- insufficient functioning of the kidneys, liver, and heart (in severe form);
- weak hearing
- glucose-6-phosphate dehydrogenase deficiency.
Syrup "Nurofen" can not be used until the age of three months.
Mutual influence with other means
The combination of drugs that inhibit the ability of blood to coagulate, and "Nurofen" leads to increased action of drugs. Concentrations in the circulatory system of medicines (if combined with Nurofen) may increase, containing:
- digoxin;
- methotrexate;
- lithium;
- phenytoin.
A decrease in the effectiveness of the drug program is possible if the described pain medication is used simultaneously with diuretics and drugs to reduce blood pressure.
The simultaneous use of ibuprofen, corticosteroids and mineralocorticosteroids can cause activation of toxic effects of drugs.
Application Nuances
If the drug is supposed to be used before reaching the age of six months, first you need to carefully weigh all the advantages of such a drug program, as well as the dangers associated with it. Parents should be aware of the possible negative consequences of the course. In addition, a special analysis requires a situation when the baby is prescribed other painkillers.
"Nurofen" is taken very carefully if there is any mention in the medical history of gastritis, ulcer, colitis, bleeding in the digestive tract. Pain medication is allowed only under medical supervision if liver and kidney diseases are established, and medications are prescribed that indirectly affect blood coagulation. This requires pressure-lowering compounds, diuretics, lithium medicines, drugs containing methotrexate, as well as all glucocorticosteroids.
Certain risks are associated with taking the suspension in children who are diagnosed with asthma, urticaria. Before starting the course, you need to visit a doctor to clarify the possibility of using the medication.
Too much!
Note that the child has taken too much “Nurofen”, according to the following phenomena:
- sore stomach;
- nausea and vomiting;
- headache;
- rustling in the ears.
Overdose can cause:
- acidosis;
- coma
- disturbances in the rhythm and heart rate;
- pressure reduction;
- kidney failure in acute form.
If an overdose was detected within the first hour from the moment the medication was ingested, gastric lavage is indicated. The patient is prescribed activated charcoal and alkaline liquid, therapy to eliminate the symptoms. The manufacturer recommends diuresis.
What's on sale?
On drugstore shelves, the Nurofen option, intended for children, is a cardboard package in which the manufacturer places instructions for use and a dark glass bottle containing the drug. Additionally, the tool is equipped with a syringe for accurate dose measurement. The bottle is made of plastic, darkened to prevent destruction under the influence of light. The cork is made of polyethylene. A hole is provided in the center through which a syringe is inserted.
Syrup and tablets are not the only forms of the drug. You can buy, for example, Nurofen candles. The instructions indicate at what age this form of release can be used (usually from three months, but with a weight of 6 kg or more).
When choosing the optimal format of the drug, it is reasonable to consult a doctor first. This will allow you to choose the most convenient option for a particular case, to take into account the characteristics of the patient's condition, his age and weight, as well as the specifics of the drugs used in parallel. It is important to follow both the manufacturer's recommendations and all the advice of a doctor. Only careful observance of these restrictions will allow you to get a reliable result of therapy without harming the patient.
Note!
You can use Nurofen strictly in the period until the expiration date has expired. The date of manufacture and shelf life, the conditions in which the drug should be, must be indicated on the packaging. The manufacturer duplicates the information in the instructions. Neglect of these rules can provoke an unpredictable reaction of the body, cause poisoning.