"Amoxicillin" refers to penicillins and has an extensive spectrum of effects. It inhibits the functioning of pathogens, affecting the walls of their cells. But the medication itself is destroyed in the body by the action of the beta-lactamase enzyme. The drug is available in tablets that have an oval or oblong biconvex shape, from milky to slightly yellowish in color.
Structure
According to the instructions, "Amoxicillin Sandoz" contains the following substances:
- amoxicillin trihydrate;
- sodium carboxymethyl starch;
- polyvinylpyrrolidone;
- magnesium salt of stearic acid;
- talc;
- titanium dioxide;
- hypromellose.
Pharmacological properties
The effect of this drug is based on its ability to reduce the rate of chemical reactions of enzymes of bacterial cell membranes, which leads to the death of the pathogen. Amoxicillin is active in eliminating:
- Staphylococcus.
- Streptococcus.
- Listeria.
- Enterococcus feces.
- Corynebacterium.
- Anthrax Bacilli.
- Escherichia coli.
- Helicobacter pylori.
- Borrelia
- Salmonella.
- Shigella.
- Campylobacter.
- Hemophilic infection.
- Proteus mirabilis.
- Neisseria.
- Chlamydia.
- Clostridium.
- Peptostreptococcus.
- Fusobacteria.
"Amoxicillin" is not destroyed by the influence of gastric juice and is completely absorbed from the digestive system. The maximum blood content reaches after two hours. When doubling the dosage, the concentration of the active substance also increases.
When is the drug prescribed?
According to the instructions and reviews, Amoxicillin Sandoz (1g) is recommended for use in the presence of the following conditions and ailments:
- Bacterial diarrhea.
- Dysentery.
- Middle and external otitis media.
- Endocarditis.
- Inflammation of the mucous membrane of one or more sinuses.
- Acute pharyngitis.
- Diffuse inflammation of the mucous membrane of the bronchi, capturing the deep layers of the wall of the bronchus with the development of peribronchitis.
- Pneumonia.
- Inflammation in the bladder.
Dosage
When eliminating infections, treatment should be continued for another 2-3 days after the disappearance of signs of the disease. In infections provoked by beta-hemolytic streptococcus, the complete elimination of the pathogen requires the implementation of therapy within ten days.
Injections are prescribed if oral therapy is not possible and when severe infections are eliminated, according to the instructions and reviews. Methods of using "Amoxicillin Sandoz" (adult doses):
- The usual dose of the active substance varies from 750 milligrams to 3 grams per day, which must be taken in several stages. In rare situations, you should limit yourself to a dosage of 1500 mg per day in several doses.
- In uncomplicated urinary tract infections, a two-dose dose of 3 grams is prescribed with a time interval between procedures of ten to twelve hours.
Children's doses of the drug:
- Daily dosage for children varies from 25 to 50 milligrams per kilogram per day for several uses (maximum 60 mg / kg / day), depending on the purpose and severity of the disease.
- Young patients weighing over forty kilograms should receive an adult dose of the medicine.
How to take the drug for kidney diseases:
- In people with severe lesions, dosing may be reduced.
- In renal failure, short courses of 3 grams are prohibited.
What is the difference between Amoxicillin Sandoz and Amoxicillin? According to reviews, drugs have different maximum dosages of the active substance. In the first case - 1 gram, in the second - 500 milligrams. "Amoxicillin Sandoz" has an age limit - children under three years of age, when the usual "Amoxicillin" is allowed for use even by children younger (in the form of a powder for suspension).
Adverse reactions
A medication with improper use can provoke certain negative manifestations:
- Hives.
- Runny nose.
- Inflammation of the mucous membrane of the eye.
- Angioneurotic edema.
- Increased UV sensitivity.
- Anaphylaxis.
- Severe variant of bullous allergic dermatitis.
- Depression.
- Dizziness.
- Impaired brain signaling due to damage to one nerve.
- Cardiopalmus.
- Inflammation of the vein wall.
- Lowering blood pressure.
- Decreased white blood cell count.
- Reducing platelets in the blood.
- The pathology of red blood cells, the hallmark of which is the accelerated destruction of red blood cells.
- A type of hemorrhagic diathesis characterized by a deficiency of red blood plates.
- Nausea.
- Violations of the stool.
- Taste changes.
- Inflammation of the tongue resulting from injury.
What other negative effects does the drug provoke?
According to the instructions and reviews for "Amoxicillin Sandoz" it is known that the drug can cause the following undesirable manifestations:
- Damage to the oral mucosa.
- Increased liver enzymes.
- Dyspepsia.
- Hepatitis.
- Pain in the epigastric region.
- Diarrhea with blood.
- Acute liver disease.
- Inflammatory bowel disease.
- Dyspnea.
- A pathological condition that occurs when the smooth muscles of the bronchi are contracted and their lumen is reduced.
- An affliction that affects the tissues of the kidneys.
- Migraine.
- Drowsiness.
- Nervousness.
- Dizziness.
- Anxiety.
- Impaired brain signaling due to damage to one nerve.
- Behavior change.
- Violations of tactile sensitivity.
- Muscle pain.
- A pathological condition, which is characterized by the appearance of a pronounced pain syndrome both in one joint and in several at once.
- Muscle weakness.
- Inflammation and degeneration of tendon tissue.
- The destruction of muscle cells.
- Thrush.
- Hard breath.
Interaction
With the combination of Amoxicillin with glucosamines, as well as aminoglycosides, laxatives and antacids, delayed absorption is noted, when consumed with vitamin C, the metabolism is enhanced.
Medicines that block tubular secretion are the cause of increased exposure to Amoxicillin, with the combined use of Methotrexate it increases the toxicity of the latter.
When combined with "Metronidazole", as a rule, nausea, vomiting, diarrhea, pain in the epigastric region occur.
It is strictly forbidden to use simultaneously with "Disulfiram". Special care must be taken when combining Amoxicillin with anticoagulants.
Simultaneous use with Probenecid enhances the serum concentration of an antimicrobial substance and reduces its excretion from the body. Amoxicillin, like other antibiotics, reduces the effectiveness of oral contraceptives.
Limitations
The drug "Amoxicillin" is contraindicated in the following conditions:
- Infectious mononucleosis.
- Increased sensitivity to drug substances.
- Excessive sensitivity to penicillin.
- Severe digestive diseases.
- Acute lymphoblastic leukemia.
- Age to three years.
- Bronchial asthma.
- Hay fever.
- Viral infections.
- Allergic diathesis.
Features
"Amoxicillin" with extreme caution must be used with a tendency to allergies. People under the age of eighteen and patients who suffer from liver diseases should not use the medicine in combination with Metronidazole.
In case of impaired renal function, the concentration of the drug should be reduced, and the time intervals between doses increased. During therapy, you need to regularly monitor the work of the liver, as well as the kidneys and hematopoiesis.
To reduce the likelihood of complications from the gastrointestinal tract (nausea, vomiting, diarrhea, bloating), Amoxicillin should be consumed during meals. There is no information about the harmful effects of the drug on the ability to drive a car.
How to store medicine?
Keep the medication away from the light and children, at a temperature of no more than twenty-five degrees. Amoxicillin is suitable for use for three years. To use the drug after this period indicated on the package is contraindicated.
Opinions
Reviews about "Amoxicillin Sandoz" from people and medical professionals, as a rule, are positive. They confirm the effectiveness of the drug in eliminating most infectious diseases using a wide spectrum of antimicrobial drugs. People also note the rapid onset of a positive pharmacological effect, as well as good tolerance, the absence of severe negative manifestations, low cost.
In the reviews it is noted that after the start of the intake, a positive effect instantly occurs, "Amoxicillin" is conveniently used for both adult patients and children. Also, as an advantage, it is mentioned that the drug can be used during pregnancy, with the permission of the doctor.