The Tulip medication includes the atorvastatin component. This substance is a competitive selective inhibitor of the enzyme that is involved in the conversion of 3-hydroxy-3-methylglutaryl coenzyme A. to mevalonate (a precursor of cholesterol and other steroids). Atorvastatin helps to reduce the synthesis and concentration of LDL and total cholesterol, apolipoprotein B in patients with mixed hyperlipidemia hypercholisterinemia (primary, heterozygous and homozygous familial). When ingested, a high absorption of the component is noted. Atorvastatin concentration reaches a maximum after an hour or two. When eating food, absorption is somewhat reduced. The degree of absorption is dose dependent. Metabolism occurs in liver cells.
The drug "Tulip." Instructions for use
Before starting therapy, the patient should be prescribed a diet with low cholesterol. The drug is taken orally, regardless of food. Dosage - from 10 to 80 mg once a day. In primary hypercholesterolemia and mixed hyperlipidemia, ten milligrams is prescribed once a day. Subsequently, the amount of the drug increases in accordance with the target cholesterol content and the response of the patient. After 2-4 weeks from the start of therapy, lipid concentration is determined. In accordance with the result of the verification, the further reception scheme is adjusted. The maximum amount of medication per day is 80 milligrams. For patients with kidney failure, dose adjustment is not required.
The drug "Tulip." Instruction Contraindications
Do not prescribe medication for the active stages of liver pathologies: chronic hepatitis, including alcohol , liver failure, increased activity of AST and ALT (more than three times in comparison with the upper level of the norm). Not recommended for women of reproductive age who do not use adequate contraceptives. Contraindications include intolerance to the components of the drug, pregnancy. The drug "Tulip" instruction for use does not recommend during feeding. Caution is exercised with patients who abuse alcohol, have disorders in the electrolyte balance, metabolic and endocrine disorders, and arterial hypertension. Dose adjustment may be required against the background of pathologies in skeletal muscle, with uncontrolled epilepsy, with acute severe infections (sepsis, for example). Efficacy and safety have not been established when children take the medicine.
The drug "Tulip." Instructions for use. Adverse reactions
During treatment, constipation, pancreatitis, glossitis, dysphagia, and vomiting may occur. Negative manifestations include: nosebleeds, dry mouth, anorexia, changes in appetite, tenesmus. When taking the medication, ataxia, headache, insomnia, cholestatic jaundice, peptic ulcer, belching, lesions in the oral cavity of an erosive ulcerous character are sometimes observed.
The drug "Tulip." Instructions for use. Price
The cost of the medicine is from 200 rubles in pharmacies.