In the article, we consider the instructions for use, reviews and analogues to the Lozap preparation.
It is the most popular and safe drug, the action of which is aimed at the treatment of arterial hypertension. The main active substance in its composition has a pronounced vasodilating effect, can inhibit the development of serious pathological changes in the cardiovascular system. The drug has a number of contraindications, therefore, the treatment regimen and dosage of the drug should be previously discussed with a therapist or cardiologist. Reviews about the "Lozap" are in large numbers.
Pharmacological forms
The manufacturer produces the drug in a single pharmacological form - tablet. The tablets have an oval and oblong shape, white, have a dividing risk on both sides. The top of the tablet is film-coated.
Regardless of dosage, tablets are packaged in blisters of 10 pieces. One box made of cardboard can accommodate 3, 6, 9 blisters.
Feedback on the use of Lozap is mostly positive.
Composition, description
The main active ingredient in the composition is potassium losartan. One tablet may have a dosage of 12.5, 50, 100 mg.
As additional components are used: croscarmellose sodium, talc, mannitol, dimethicone, povidone, macrogol, microcrystalline cellulose, magnesium stearate.
The price, reviews, analogues of "Lozap" are of interest to many.
Pharmacological group
Potassium losartan, which is the active component of Lozap, is included in the group of specific substances that block the angiotensin receptors of the second type of ATI subtype. The substance is capable of exerting a hypotensive effect without suppressing the kinase II enzyme. As a result, a constant and normal level of bradykinin is maintained. Thanks to this property, it is possible to minimize the likely negative effects. Against the background of the use of the drug, there is a decrease in blood pressure, total peripheral vascular resistance, afterload, pressure in the small circle of blood flow. Under the influence of Lozap, the concentration of adrenaline and aldosterone in the blood decreases, the urea content returns to normal, pathological myocardial growth is prevented, and the ability of patients suffering from various forms of heart failure to tolerate physical loads is improved. Along with this, “Lozap” has a moderate diuretic effect.
The bioavailability of the active component is at the level of 33%, the ability to bind to plasma proteins is at the level of 99%.
3 hours after oral administration of the drug, the highest concentration of losartran potassium in the blood is noted, 4 weeks after the start of therapy, the best therapeutic effect develops. “Lozap” is metabolized in the tissues of the liver, resulting in the formation of a metabolite with activity. Half the entire dose taken is excreted after 5 hours (on average). The metabolites of the drug are evacuated partially together with feces and urine.
This is confirmed by the instructions for use with the Lozap. According to reviews, the price of the drug is quite acceptable.
Indications for use
The most common indications justifying the use of Lozap are CVD pathologies accompanied by elevated blood pressure. Before starting therapy using this medication, you should consult a cardiologist and undergo various examinations in order to identify existing contraindications.
Adult patients "Lozap" is prescribed for such pathological conditions as:
- Arterial hypertension.
- Diabetic nephropathy, accompanied by hypercreatinemia and proteinuria, is the second type of diabetes mellitus, a complication of which is an increase in blood pressure.
- Chronic heart failure.
- Reducing the risk of developing some pathologies of CVS against the background of hypertrophic changes in the left ventricle.
- Immunity to ACE inhibitors.
The use of "Lozap" for the treatment of patients under 18 years of age is unacceptable. This is due to the lack of information about the safety of the drug in patients of this age category.
Against the background of the use of losartan potassium, fetal development may be impaired. Also, the development of irreversible consequences is not excluded. In this regard, the use of "Lozap" during pregnancy is contraindicated. Do not use the medication in the lactation period. If there is an urgent need, a specialist can recommend taking therapeutic doses of Lozap, but only after the woman completely stops breastfeeding.
Contraindications
The current component of Lozapa is highly active, and therefore there are a number of contraindications that prevent its use. The main ones are the following restrictions:
- Age to 18 years.
- Individual hypersensitivity to losartan potassium or any auxiliary component that is part of the drug.
- Lack of liver or kidney activity.
- The lactation period.
- Pregnancy.
- Arterial hypotension.
It is necessary to take the drug with caution if the patient has the following disorders:
- Water-electrolyte imbalance.
- Renal artery stenosis on both sides.
- Diabetes.
- Insufficient circulating blood volume.
- Narrowing the arterial lumen of a single kidney.
It is better to familiarize yourself with the reviews about Lozap in advance.
Drug use
Reception must be carried out once a day at any time. Tablets should be washed down with water in large quantities. If necessary, the doctor can adjust the dosage of the drug and the scheme of its use, taking into account the patient's condition and the nature of the course of the disease.
Adult patients with the goal of hypertension therapy are shown to take 50 mg of losartan potassium once a day. If the necessary therapeutic effect is absent, the dosage after consultation with the doctor may be increased. Per day, it is allowed to take no more than 100 mg of the drug.
If the patient takes diuretic medicines at the same time, then the average daily dosage of losartran potassium should be reduced to 25 mg.
In order to treat chronic heart failure in a chronic form, it is indicated to take 12.5 mg of the drug once a day, while the dosage should be gradually increased every two weeks until it reaches 50 mg.
Individual dose adjustment for elderly patients is not required.
For pediatric patients, both prophylactic and therapeutic use of "Lozap" is contraindicated.
For the treatment of pregnant women, the medicine is not used, but can be prescribed in the lactation period in standard dosages. However, before starting the use of the drug, it is important to immediately stop breastfeeding.
Negative impact
Compared with other antihypertensive drugs, it has a limited number of negative effects. According to the instructions for use and reviews of “Lozap”, against the background of its use, some undesirable reactions may develop, among which:
- Nasal congestion.
- Redness of the skin, itching.
- Fatigue.
- Weakness.
- Peripheral puffiness.
- Diarrhea.
- Dry mucous membranes in the oral cavity.
- Cough.
- Sleep disturbance.
- A sharp drop in blood pressure.
- Bradycardia
- Cramps.
- Pain in the limbs, back, chest, gastrointestinal tract.
- Calls for vomiting, nausea.
- Headache.
- Tachycardia.
- Dizziness.
If any of the adverse reactions described occurs, it is important to consult with your healthcare cardiologist.
So it is said in the instruction to "Lozap". Reviews and price will be presented at the end of the article.
Interaction with other medicines
Potassium losartan is able to enhance the therapeutic effect of other drugs that lower blood pressure. The simultaneous use of the drug with drugs having a diuretic effect can provoke the occurrence of an additive effect. When used concomitantly with rifampicin and fluconazole, the concentration of losartan metabolite in the blood decreases. Complex use with potassium-sparing diuretic drugs increases the likelihood of hyperkalemia. Joint use with NSAIDs can reduce the therapeutic effectiveness of the drug. When used with lithium preparations, the occurrence of acute intoxication is not excluded.
This is confirmed by the instructions and reviews to "Lozap".
Overdose
With the development of intoxication, the following symptoms appear:
- Bradycardia
- Tachycardia.
- A sharp drop in blood pressure.
The consequences of an overdose are most often eliminated by means of forced diuresis. Then the patient should be prescribed symptomatic treatment. Hemodialysis with intoxication with losartan potassium does not give effectiveness.
Analogs
If necessary, "Lozap" can be replaced with the following medications:
- "Vazotens". The active component in its composition is losartan. The manufacturer produces in tablet form, is used in the treatment of heart failure and arterial hypertension in patients from 18 years of age. Its use in the lactation period and pregnant women is not allowed.
- Gizaar. It is a combination agent, incorporating not only losartan, but also hydrochlorothiazide, which has a diuretic effect. Produced by the manufacturer in tablet form, can be used exclusively by adult patients. The use of the drug is incompatible with breastfeeding, its use during pregnancy is strictly prohibited, since there is a possibility of fetal death.
- "Simartan-N". It is a combined drug that has a diuretic and atihypertensive effect. The active substances in its composition are hydrochlorothiazide and losartan. It can be used by adult patients who require combination therapy of arterial hypertension. The drug is not allowed for use in the treatment of children, pregnant women, in the lactation period.
It is important to remember that each of these drugs has specific contraindications and can provoke the occurrence of various negative reactions, in connection with which any replacement of the drug should be made only after consultation with the doctor.
In the instructions to "Lozap" price, reviews and analogues are not indicated.
Cost
The average cost of packing “Lozapa” in Russian pharmacies is about 520 rubles. However, the price may vary depending on the region of distribution, the number of tablets in the package, the pricing policy of the drugstore distributing the drug.
Reviews about "Lozapa"
The responses of patients who used “Lozap” indicate that the drug effectively reduces blood pressure and improves the well-being of patients suffering from CVS diseases. It is separately noted that against the background of the use of the drug, negative reactions rarely develop. An undoubted advantage is that the drug should be taken only once a day.
In rare cases, patients in reviews of Lozap report the development of such adverse reactions as coughing, hearing impairment. However, you can minimize the risk of unpleasant symptoms by strictly adhering to the dosage recommended by the doctor and the treatment regimen.
It must be remembered that self-medication is fraught with complications, therefore, drug therapy should be prescribed by a doctor.
The article was presented to the medication "Lozap" instructions for use, price, reviews and analogues.