Not all married couples manage to conceive naturally. Women who decide on artificial insemination will need serious medical support, because the process is quite time-consuming. The use of the Proginova drug in IVF helps to preserve pregnancy, because it supports the hormonal background of a woman in good condition. The active component of the drug is estradil. In the natural processes of fertilization, the substance plays an important role at the time of conception. When this hormone is produced in small quantities or completely absent, then natural pregnancy is excluded.
Drug review
Sometimes women cannot become pregnant on their own and resort to an IVF procedure. The use of Proginova in this case is justified, because the medication replaces the female sex hormone, which normally should be in the body of a healthy patient.
The medicine is available in the form of small tablets. Pills are prescribed for natural pregnancy, when there are risks of its interruption. In this case, one tablet is prescribed. They must be taken strictly at a specific time, every 24 hours. In the IVF protocol, there are no uniform requirements. The treatment regimen is selected only individually.
Features of the drug
The medication "Proginova" is an artificially grown hormones that are in no way inferior to physiological hormones. Used in IVF as hormone replacement therapy.
However, not only with artificial conception this drug is required, at different age stages a woman may need hormonal support. Among the main appointments, it is worth noting:
- early menopause;
- artificial provocation of cessation of menstruation;
- difficulty in conception.
However, the main purpose of "Proginov" - with IVF to stimulate the ovaries.
When reception is shown
The drug, unlike other similar ones, acts effectively, but more gently. When using the medication, not only the pregnancy that has arisen is supported, but also the normal development of the embryo at all stages of its growth is maintained. Indications for use may be as follows:
- When a woman had several pregnancies that ended in miscarriages.
- If ovulation does not occur. After the start of administration, the process occurs naturally.
- The egg does not leave the follicle due to a lack of hormones in the body.
- When the endometrium is insufficiently sized. Normally, for successful conception, the thickness of the endometrial layer should be in the range of 7-10 mm. With smaller sizes, the egg does not get the opportunity to fully attach to the uterine cavity and leaves it.
- The appointment of Proginova in IVF is necessary so that the body does not perceive the embryo as a foreign body. Then the pregnancy will continue.
The dosage of the drug in artificial insemination can only be determined by the attending physician. In this case, a full examination of the woman is carried out.
What gives a welcome?
Many expectant mothers are concerned about the question of why “Proginova” is appointed during IVF. The medication brings tremendous benefits to the body, because:
- stabilizes the hormonal background, which is disturbed in preparation for the procedure and replanting the embryo;
- reduces the risks of natural abortion and late miscarriage;
- supports normal functioning, growth and development of the fetus;
- reduces the likelihood of placental abruption;
- improves placental blood flow.
Doctors often use the drug if pregnancy after IVF has occurred, but there is a decrease in the amount of estrogen. Usually this situation can be observed until the eighth week. Also, the medication is justified in case of weak labor or prolongation of pregnancy.
Medication in IVF protocol
Estrogen hormones play a crucial role in conception and maintaining pregnancy. Normally, in a healthy woman, after successful fertilization and attachment of the egg to the uterus, estrogen levels increase hundreds of times. If they are not enough, then it is possible:
- miscarriage;
- frozen pregnancy;
- delay in fetal development;
- incorrect embryo formation.
With artificial insemination, the body lacks its own hormones, and they must be taken in the form of drugs. Therefore, the attending physician will definitely prescribe Proginova during the preparation for conception and within 7-8 weeks, when the pregnancy has already begun.
It should be remembered that the information indicated in the instructions for the medication about the termination of admission with the onset of pregnancy refers only to the natural process. With IVF, the reception must necessarily continue, because the fact of conception does not mean successful birth of the baby. This is due to the fact that during natural pregnancy, a healthy body independently produces the necessary hormones and does not need additional administration from the outside. With IVF, they are clearly not enough.
When to take
After visiting the reproductive clinic, a woman can get a recommendation on taking Proginova. What is prescribed for IVF medication, can tell in detail a doctor who specializes in artificial conception and bearing such a pregnancy.
There are two schemes of admission:
- With simultaneous stimulation of the ovaries. However, the started course does not end after replanting and engraftment of the embryo. There are situations when the fetus does not attach and a natural abortion occurs. In this case, the reception may be continued or suspended.
- When a long-awaited pregnancy occurs, the course must be continued until a period of 8-10 weeks. Until this age of the embryo, he just needs hormonal support, which the woman’s ovaries are unable to give during IVF. Further, the fetus begins to develop on its own, and the need for medication disappears.
It should be remembered that only a reproductologist can prescribe a remedy.
Preparation for the artificial insemination procedure
Only the full course prescribed by your doctor can guarantee a positive result. You can not take a break in treatment for more than 24 hours if the drug "Proginova" is prescribed. The instruction for IVF prescribes the total dosage only at the initial stages of preparation for the procedure.
To stimulate the endometrium, the doctor usually recommends a three-week course. The amount of dragees is determined strictly individually, depending on the condition of the ovaries, the production of their own hormones and the presence of side effects. The doctor can adjust the Proginova dosage when planning pregnancy with IVF, because the growth and condition of the endometrium are constantly monitored by ultrasound.
Therapy after embryo transfer
After embryo transfer, it is important to maintain the hormonal background of the woman. For this, "Urozhestan" is often prescribed. But along with this quite popular tool is Proginova. It must be used so that the body does not reject the fetus that has fallen into the uterus.
"Proginova" with IVF is necessary so that the endometrial layer grows to the required 7-10 mm. Only in this case, the successful implantation of the embryo into the walls of the uterus is possible. Too thin a layer of the endometrium is the main cause of infertility and the inability to conceive independently and with the help of artificial insemination. In this case, the fertilized egg simply cannot catch on for further development and leaves with the next menstrual cycle.
Only an individual dosage is possible with Proginova treatment. The instruction for IVF is intended for informational purposes only. In particular, it says that the standard regimen involves the use of half a dragee per day to 5-6 pills per day.
Pregnancy support
"Proginova" with IVF is necessary in the case of successful implantation of embryos and a successful pregnancy. In order to hold it, appropriate hormones must be produced in the body, which are not enough with artificial insemination. That is why the doctor prescribes them in the form of medications.
A hormonal drug is necessary up to 5-10 weeks of pregnancy in order to maintain a natural level of estradiol. Further, based on the analysis of a woman, the medicine is canceled.
"Proginova" - instructions for use in IVF
It is strictly forbidden to use the drug on your own. If a woman undergoes an IVF procedure, then treatment adjustment can be made only by the attending physician. If the appointment is "Proginova", then the patient should not violate the time of admission or the recommended dosage.
In the IVF protocol, medication is usually prescribed during the preparation period and before the 10th week of pregnancy. Therapy is necessary:
- to maintain a constant level of hormones;
- to prevent sharp fluctuations in the level of estrogen in the body;
- to equalize the general hormonal background, if during preparation for IVF or after a long-awaited pregnancy a woman is very nervous, has an infectious disease or has chronic diseases.
Possible risks
Reproductologists know that the IVF protocol does not always end with a successful pregnancy. The use of Proginova is justified, because in the first weeks after transplantation, more than half of pregnancies are lost due to a lack of their own hormones.
In the early stages, signs of miscarriage may occur. In this case, it is important not to stop taking it and urgently contact your doctor. The drug itself can not provoke bleeding, because it is designed specifically for fixing the embryo in the uterine cavity.
Sometimes a doctor may even recommend substantially increasing the standard dosage. However, this cannot be done without the permission of a specialist.
When cancellation of "Proginov" with IVF
Pregnancy after artificial insemination may well proceed normally, after 10 weeks the embryo can function independently. From this moment, after a full examination of the patient, the doctor usually cancels the drug. The IVF protocol contains clear instructions that a complete rejection of this medication should occur no later than 15 weeks of pregnancy. However, it is important not to abruptly throw dragees. The dosage is reduced gradually, every day you should drink 1/4 of the pill less. Only in this case can unwanted consequences be avoided.
Contraindications
"Proginova", like any hormonal drug, has a number of strict contraindications. Therefore, before his appointment, the doctor will fully examine the patient and collect an anamnesis. If there are contraindications, then even such a sparing drug as Proginova will not benefit. The instructions for use in IVF and expert reviews have clear instructions when using the pills will only harm:
- with endometriosis;
- if diabetes is detected;
- when a woman has obvious obesity;
- if the tests show hanging blood clotting;
- when there is a tumor process in the liver;
- with internal bleeding;
- if a woman is breastfeeding.
If there is at least one of these conditions, therapy will cause a deterioration in the patient's health.
Reviews of women about treatment
"Proginova" with IVF reviews is quite positive. As hormone replacement therapy for in vitro fertilization, such treatment has proven to be the best. Women claim that the teratogenic effect does not occur during treatment. If you strictly follow all the recommendations of a doctor, then the reception does not cause undesirable consequences. Usually women do not feel any changes in health.
They note that the chance of becoming pregnant during the first transfer increases if the doctor prescribes Proginova. In this case, the embryo is successfully implanted in the uterus and develops correctly, according to accepted standards.
Side effects
Sometimes patients complain of side effects while taking the medicine. However, it is strictly forbidden to independently interrupt the prescribed course so as not to provoke serious health disorders. If negative effects occur, it is important to immediately contact your doctor. Only a specialist is able to assess the degree of manifestation of adverse reactions and their effect on the body. If a decision is made to discontinue treatment, then the dosage is reduced gradually.
During therapy, each patient should carefully monitor their well-being in order to notice the problem in time. Sometimes the following unpleasant symptoms may disturb:
- swelling and swelling of the mammary glands;
- proliferation of the endometrium and increased manifestation of endometriosis;
- visual impairment;
- hearing problems;
- headache;
- the appearance of age spots on the face and other parts of the body;
- the appearance of extra pounds.
It must be understood that the Proginova drug does not have a negative effect on a developing child. Therefore, abdominal pain does not serve as a reason for drug withdrawal, but can serve as an indicator for changing the dosage. Sometimes the drug provokes a rise in temperature. If the indicators do not exceed 37.4 degrees, then this is considered the norm.
Conclusion
The drug "Proginova" refers to hormonal drugs along with other similar drugs, often used in the IVF protocol. The medicine is necessary to prepare the woman’s body for conception and create the most optimal conditions for the preservation and development of the embryo. The reviews of specialists and their patients show that therapy brings a positive result in most cases.