Many infectious and inflammatory processes in the body can not do without the use of antibiotics. A group of these drugs kills harmful microorganisms and pathogens. One of the known antibacterial drugs is Gentamicin Sulfate. It is considered a broad-spectrum antibiotic and is used to treat humans and animals.
Form and composition of the drug
The product is available in the form of a 4% solution for injection and eye drops. The main substance in the composition of the drug is gentamicin sulfate at a dose of 4 mg in one milliliter. It belongs to the group of aminoglycosides and is considered a broad-spectrum antibiotic.
The medicine has anti-inflammatory and bactericidal effects. Has high activity against anaerobic gram-negative bacteria and gram-positive cocci. After administration intramuscularly, the drug is rapidly absorbed. The maximum effect is achieved within an hour after the injection. Almost does not bind to blood proteins. The antibiotic in the extracellular fluid is distributed to all organs and systems. The drug is not metabolized and is mainly excreted by the kidneys, slightly with bile. The drug "Gentamicin sulfate" has the property of passing through the placental barrier. Application, side effects - all this should be studied before planning therapy.
Indications
The drug is prescribed for infectious and inflammatory processes in the body that are caused by antibiotic-sensitive microorganisms. For parenteral administration :
- cystitis;
- acute cholecystitis;
- purulent lesions of the skin;
- burns of various degrees;
- pyelonephritis;
- cystitis;
- diseases of the joints and bones of an infectious nature;
- sepsis;
- peritonitis;
- pneumonia.
When applied externally:
- furunculosis;
- folliculitis;
- seborrheic dermatitis;
- infected burns;
- wound surfaces of various etiologies;
- sycosis.
For topical application:
- blepharitis;
- blepharoconjunctivitis;
- dacryocystitis;
- conjunctivitis;
- keratitis.
With such pathologies, "Gentamicin sulfate" is used. Instructions for use are in the middle of the pharmacy packaging with the medicine.
Contraindications:
- hypersensitivity to antibiotics;
- severe pathology of the kidneys and liver;
- violation of the auditory nerve;
- gestation;
- breast-feeding.
Also, the antibiotic Gentamicin Sulfate is not prescribed in ampoules for uremia.
Dosage
The drug is prescribed individually for each patient. Dosage depends on the severity of the process and hypersensitivity to the drug. From 1 to 1.7 mg per kg of body weight is administered at one time. The drug is injected into a vein or intramuscularly. The medicine is used two to four times a day. The maximum dosage per day cannot be more than 5 mg. The course of therapy is 1.5 weeks.
For children after two years, the medicine is administered several times a day in the amount of 1 mg per kilogram of weight. For babies under the age of a month, the daily dosage cannot be more than 2-5 mg per kilogram of body weight. The antibiotic is administered several times a day.
For topical use, eye drops drip 1 drop every two hours. For external use, the substance is prescribed up to three times a day. People with impaired renal function, depending on the clinical picture, are corrected with the drug "Gentamicin Sulfate". Eye drops are instilled directly into the conjunctiva sac of the diseased eye.
Interaction with other means
Co-administration with the following medicines is not recommended:
- Vancomycin
- "Cephalosporin";
- "Ethacrylic acid";
- "Indomethacin";
- drugs for anesthesia;
- analgesics;
- loop diuretics.
Before planning therapy, it is necessary to carefully study the interaction of other drugs and the antibiotic Gentamicin Sulfate.
Neglect of recommendations can lead to the development of the following side effects:
- nausea;
- vomiting
- increased bilirubin in the blood;
- anemia;
- thrombocytopenia;
- leukemia;
- migraine;
- dizziness;
- proteinuria;
- disorders of the vestibular apparatus.
It can also cause allergic reactions "Gentamicin sulfate." Drops and solution in rare cases can lead to Quincke's edema or anaphylactic shock, which is fraught with serious complications. When using an antibiotic, it is necessary to control the functions of the kidneys, auditory and vestibular apparatus.
"Gentamicin sulfate" - an antibiotic for animals
Pets may also be susceptible to bacterial infections. For the treatment of a sick animal, special groups of antibiotics are used. These drugs include Gentamicin Sulfate. It belongs to the group of aminoglycosides and is a mixture of gentamicins C1, C2 and C1a. The composition of the drug includes gentamicin in a dose of 40 and 50 mg in one milliliter of solution. The product is stored at a temperature of no more than 25 degrees, in a dry place inaccessible to children. Two years - the shelf life of the drug "Gentamicin sulfate." Instructions for use for animals will tell you in detail about the indications and dosage of the drug.
Act
The medicine has a wide spectrum of effects and has activity against gram-positive and gram-negative microorganisms. After administration of the drug, it penetrates into all organs and systems in a short time. After one hour, its maximum activity is observed and lasts for 8 hours. It is excreted mainly in urine and in a small concentration with animal feces.
The medicine is prescribed in the treatment of pathologies of the stomach, intestines, peritonitis, meningitis, pyelonephritis and other diseases in pets. The drug is administered twice a day with an interval of 10 hours. Gentamicin sulfate for animals is also prescribed orally.
Dosage
For the treatment of horses, an antibiotic is administered intramuscularly at a dose of 2.5 mg per kilogram of body weight. The duration of therapy is from 3 to 5 days. For cattle, the dose is administered at the rate of 3 mg per kilogram of body weight for 5 days. Also, the medicine can be used orally at a dosage of 8 mg per kilogram of weight.
The solution is administered to pigs intramuscularly at the rate of 4 mg per 1 kilogram of weight. The duration of therapy should not exceed three days. The drug is administered orally at a dose of 4 mg per kilogram of body weight for 5 days. Dogs and cats are given intramuscularly 2.5 mg of solution per kilogram of weight. Treatment takes up to seven days.
When used internally, the drug is not absorbed in the stomach, but only after 12 hours in the intestine. Only the veterinarian can administer the antibiotic Gentamicin Sulfate intramuscularly. The instructions for animals describe how to administer the drug.
special instructions
It is forbidden to use an antibiotic with other groups of nephrotic drugs, especially with kidney pathology and hearing impairment. Slaughter of the animal is allowed only three weeks after the last dose of the drug. The tool does not affect the simplest fungi, viruses and anaerobic bacteria. Only a professional veterinarian can correctly calculate the dose of the drug "Gentamicin Sulfate 4%" and cure the pet.
The drug "Gentamicin"
The drug belongs to antibiotics from the group of aminoglycosides, which are widely used to treat many diseases. The tool has the following effects on the body:
- bactericidal;
- anti-inflammatory;
- has a high activity against gram-positive and gram-negative bacteria.
The drug is available in the form of a solution. After intramuscular administration, the drug is rapidly absorbed into the tissues of the whole body. The highest bioavailability is observed after half an hour. Half of the drug after 3 hours is excreted in the urine. Penetrates through the placenta, therefore, it is not recommended to prescribe the drug "Gentamicin" and its analogue "Gentamicin sulfate" during pregnancy. Instructions for use of these funds contain useful information and a description of antibiotics.
Indications and contraindications
Therapy of infectious and inflammatory diseases, which are caused by microorganisms sensitive to the active component, can be carried out using the Gentamicin agent. The drug is used for parenteral, external and local use.
Contraindications:
- hypersensitivity to the aminoglycoside group;
- gestation;
- lactation;
- severe renal failure;
Before starting the treatment process, it is worthwhile to carefully study all contraindications to the use of the antibiotics Gentamicin and Gentamicin Sulfate.
Dosage
The medicine is prescribed individually, the dose depends on the severity of the disease. For intramuscular and intravenous administration, the drug is calculated at a dose of 1 to 1.7 mg per kilogram of body weight at a time. The drug is administered two or three times a day. The maximum daily allowance for an adult should not exceed 5 mg / kg, and for children - 3 mg per kilogram of weight. The medicine is administered for 7 days. Eye drops are used three times a day and are instilled one drop directly into the affected eye. Outwardly, an antibiotic is applied four times a day. In severe renal pathology, the medicine is prescribed according to the clinical picture, and the dosage can be adjusted. For children, the daily norm depends on the age and condition of the body.
Drug interaction
Gentamicin is not recommended for use in combination with the following drugs:
- Vancomycin
- "Cephalosporin";
- "Ethacrylic acid";
- "Indomethacin";
- analgesics;
- medicines for anesthesia;
- diuretics.
The medicine "Gentamicin" and the solution "Gentamicin sulfate 4%" have the same composition and indications for use. Both drugs have an increased bacterial and anti-inflammatory property.
The drug "Gentamicin-Ferein"
The drug belongs to the group of aminoglycosides and is widely used to treat many organs and systems. It has increased activity to gram-positive and gram-negative anaerobic bacteria. It has a bactericidal effect. After administration, the antibiotic is absorbed intramuscularly and intravenously into all organs and tissues of the body.
40 minutes after the injection, the medicine reaches maximum activity, which lasts for 12 hours. The drug is not metabolized and excreted in the urine. It has the ability to penetrate the placental barrier.
Indications and contraindications
The medicine is used for parenteral, local and external use in the treatment of diseases of an infectious and inflammatory nature.
Contraindications:
- pregnancy;
- breast-feeding;
- pathology of the kidneys and liver;
- hypersensitivity;
- neuritis of the auditory nerve.
Dosage of the drug "Gentamicin-Ferein"
For adults, the drug is administered in an amount of not more than 5 mg per kilogram of body weight per day. At one dose, the dose is from 1 to 1.7 mg per 1 kilogram of patient weight. The course of treatment depends on the severity of the process and ranges from 7 to 10 days. The drug is found two or three times a day
For children, the dosage is 3 mg per kilogram of body weight per administration. The medicine is injected twice a day. In patients with renal failure, the dosage of the antibiotic is constantly adjusted and depends on the clinical indications.
Eye drops are used every 4 hours and are instilled into the affected eye one drop at a time. Outwardly, the drug is prescribed three or four times a day.
Possible side effects:
- nausea;
- vomiting
- increased bilirubin;
- anemia;
- leukopenia;
- drowsiness;
- migraine;
- disorders of the vestibular apparatus;
- deafness;
- allergic reactions, up to Quincke's edema.
Similar side effects may have a solution of "Gentamicin Sulfate 4%" during treatment of infectious and inflammatory processes in the body.
Product reviews based on gentamicin sulfate
Medicines do not belong to new-generation antibiotics, but they are quite well used in our time to treat microbial diseases. Therefore, the pharmaceutical market has many products that include gentamicin. This is not only a solution for injection, but also creams, ointments, eye drops. The medicine affects the genetic information that is embedded in the cells of the pathogen. The active component is absorbed into the body tissues in a short time and begins its antibacterial effect.
In most cases, the medicine is well tolerated, but may cause an allergic reaction. Also, an antibiotic can be taken from birth. There is a special dosage calculation scheme for this. This antibiotic is very widely used in veterinary medicine. It helps animals get rid of the infection and normalize the work of the stomach and intestines.
Sometimes the medicine "Gentamicin" can lead to hearing loss, and this is its main drawback. Studying all the reviews, especially doctors, you can understand how powerful this antibiotic is. It has a high activity against gram-positive and gram-negative anaerobic organisms. Also in the complex is prescribed for the treatment of pneumonia and meningitis. It is necessary to strictly observe the dosage of the drug to avoid side effects. According to many experts, the drug "Gentamicin sulfate" is toxic. Its constant use can affect the work of all body systems. Antibacterial agents should not be used without consulting a specialist.