What is Cloveit? Instructions for use, reviews, analogues and types of this medication will be discussed later. We will also talk about the side effects of this drug, its composition and therapeutic properties.
Release forms and composition
In what form is the medicine “Cloveit” made? Instructions for use, a description of this drug say that you can buy it in two different forms:
- 0.05% cream for external application in the form of a uniform and white mass. The main ingredient of this tool is clobetasol propionate. It also includes the following additional substances: polysorbate 40, propylene glycol, sodium citrate, citric acid, disodium edetate, colloidal silicon dioxide, chlorocresol, cetostearyl alcohol, liquid paraffin, purified water, white petrolatum, triglycerides octanoic and decanoic acid, glyceryl monster hemoderm 841 (flavoring). Cloveit external cream, the instructions for use of which is enclosed in a pack of cardboard, are sold in 25 g tubes of aluminum.
- 0.05% ointment for external application in the form of a translucent, white, soft and oily homogeneous mass. Clobetasol propionate also acts as its active element. In addition, propylene glycol, white petrolatum and sorbitan sesquioleate are part of this preparation. Cloite ointment can be purchased in 25 g tubes (aluminum), packed in packs of cardboard.
Therapeutic properties of the drug
What features are inherent in such drug as "Cloveit"? Instructions for use, reviews of experts report that it is a glucocorticosteroid, which is intended for external application.
The use of the ointment or cream in question helps to prevent marginal accumulation of neutrophils, reduce inflammatory exudation and production of lymphokines, as well as slow down the migration of macrophages, reduce the intensity of granulation and infiltration.
It should also be noted that the Cloveit medication exhibits local antipruritic, anti-inflammatory, antiexudative and anti-allergic properties.
Pharmacokinetic characteristics of the drug
Is Clovec glucocorticosteroid absorbed? The instruction for use states that the average concentration of its active substance in the blood of people with healthy skin is approximately 0.635 ng / ml. This value is achieved 13 hours after the first application and approximately 8.2 hours after the reuse of 0.05% ointment in an amount of 30 g.
As for the cream, after its second application at a dose of 30 g (after 10 hours), the average plasma concentration of clobetasol propionate exceeds that of the ointment.
After a single application of a 0.05% ointment in an amount of 25 g, its main component reaches a peak in blood plasma in patients with eczema and psoriasis after 3 hours. The average concentration of clobetasol propionate is 4.65 ng / ml and 2.35 ng / ml, respectively.
It cannot be said that after applying the drug in question to large areas of the skin, its absorption into the systemic bloodstream is possible (inflammation of the skin and damage to its integrity enhances the absorption of the drug). As a result of this, the patient may manifest general adverse reactions.
Where does Clovec glucocorticosteroid metabolism occur? Instructions for use states that this drug is metabolized mainly in the liver, as well as in a small amount - in the kidneys. The absorbed drug is excreted along with urine.
Indications for applying cream and ointment
What diseases does the Cloveit external preparation treat? Instructions for use indicate the following indications for use of the drug in question:
- eczema (including its various forms);
- psoriasis (except extensive plaque and pustular);
- discoid lupus erythematosus;
- lichen planus red;
- skin diseases that show high resistance to treatment with less active local glucocorticosteroids.
Bans for applying cream and ointment
What contraindications should the patient be warned before using Cloveit local medicine? Instructions for use (the composition of the ointment and cream was described in detail above) indicates the following conditions that prohibit applying the drug in question to the skin:
- Hyde nodule pruritus;
- rosacea;
- breastfeeding time;
- acne vulgaris;
- pustular and plaque psoriasis (common);
- skin manifestations of syphilis;
- perioral dermatitis;
- diaper rash;
- skin cancer;
- pregnancy period;
- genital and perianal itching;
- age up to one year;
- diseases of the skin of fungal, viral and bacterial origin, including herpes simplex, tuberculosis of the skin, chickenpox, actinomycosis;
- hypersensitivity to the elements of a local medicine.
Local drug "Cloveit": instructions for use, dosage
The medication in question should be used only externally. An ointment or cream is applied to the affected skin in a small layer twice a day. The duration of a continuous course of treatment with this drug is limited to four weeks.
In resistant cases, including in the presence of hyperkeratosis, the anti-inflammatory effect of the external drug Cloveit should be enhanced with a plastic film dressing applied to the area of application of the cream or ointment all night. Such therapeutic measures almost always give a positive result. It should be noted that when changing the occlusive dressing, the skin must be cleaned. Subsequently, the achieved therapeutic effect must be maintained without the use of dressings.
Side effects
Does the local drug Clovev cause negative reactions? Instructions for use (analogues will be listed below) states that in some cases, the medication in question contributes to the development of the following effects:
- itchy skin, burning, dry skin, steroid acne;
- weakening of skin protection (with prolonged use);
- atrophic changes on the skin, including its thinning, expansion of blood vessels located on the surface, the appearance of striae, hypertrichosis;
- skin pigmentation, pustular psoriasis;
- ulceration of the gastrointestinal tract mucosa, gastritis, increased pressure inside the eye, symptoms of hypercorticism;
- hypercorticism (with prolonged use of corticosteroids), suppression of the adrenal gland and pituitary gland;
- exacerbation of the symptoms of the underlying disease.
Overdose of local drug and its drug interaction
Due to the insignificant local absorption of ointment and cream, the development of acute overdose during their use is unlikely. With a chronic overdose of such drugs, as well as with their improper use, patients may experience symptoms of hypercorticism. The development of such a side effect requires the gradual abolition of a local remedy, but only under the close supervision of a doctor.
As for drug interactions, there are currently no data on this.
The period of feeding and bearing the fetus
Now you know why such a local remedy as Cloveit is needed. Instructions for use, side effects of this drug have also been described above.
Can the medication in question be used during pregnancy? Specialists argue that glucocorticosteroids intended for external use should not be used during gestation in large doses and for a long time.
It should also be noted that the safety of the drug in question during breastfeeding has not been established.
Special information
What you need to know before using Cloveit ointment (cream)? Instructions for use reports that the drug in question is not recommended for hyperkeratosis, skin lesions, as well as its dryness and thickening.
Cloveit cream should be used only for the treatment of inflammatory skin diseases of an acute nature, including those associated with the development of weeping. Also, the mentioned medication can be used for inflammation of the skin on the scalp.
Ointment and cream are intended for short-term use. It is necessary to avoid the appointment of an external glucocorticosteroid for an extended period of time, especially to young children (due to the possible suppression of the adrenal glands).
It is forbidden to apply the drug “Cloveit” in the eye area, otherwise it can cause the development of glaucoma. The same goes for the face. Atrophic changes may appear on it.
When attaching a secondary infection, the patient must undergo antibiotic therapy.
Warm and humid conditions that were created with an occlusive dressing can lead to a bacterial infection. In this regard, before the direct application of a new dressing, the skin should be cleaned.
Similar means
What drugs can replace Cloveit ointment or cream? Experts say that this medicine has few analogues. The following are allowed to be used as them: "Clobetasol", "Powercourt", "Etrivex", "Dermoveyt" and others.
Consumer Reviews
Cloveit is a fairly popular glucocorticosteroid. Therefore, there are a lot of reviews about it. Most of them are positive. Patients claim that this remedy treats skin diseases such as eczema, psoriasis, lichen planus red, lupus erythematosus and others quite well and quickly enough. However, he has many contraindications, as well as side effects.
It cannot be said that so many consumers complain that the drug in question is contraindicated in children under one year of age. In addition, its use in children older than this age requires regular monitoring by a pediatrician (at least once a week).