The drug "Sanpraz" - is a medication that is used in the treatment of gastric ulcers and is an inhibitor.
According to the instructions for use with Sanpraz, the main substances of this medication are able to block the final stage of the production of hydrochloric (hydrochloric) acid, reduce the level of stimulated (regardless of the type of irritant) and basal secretion of the substance in the stomach cavity.
How does the drug work?
In case of duodenal ulcer, which is provoked by such an infectious agent as Helicobacter pylori, a decrease in the level of gastric secretion increases the threshold of sensitivity of the pathological microorganism to antibacterial drugs.
The tool affects the motility of the digestive tract. Secretory activity stabilizes approximately three to four days after cessation of its use. The instructions for Sanprozra are very detailed, consider the main points that will help to use the drug correctly.
Forms of release and constituent substances
The drug is available in two main dosage forms:
- In the form of a lyophilisate for the preparation of solutions for intravenous use: the powder is almost or completely white. The solvent is a clear, colorless solution. The medicine is available in 10 ml 40 mg glass vials. The instruction to Sanprozra indicates that the carton packs contain one such bottle in a kit with a solvent ampoule.
- The tablets, coated with a special enteric-soluble coating, have a round biconvex shape and yellow color (packaged in 10 pieces in aluminum strips, and in cardboard packages one or three strips).
Instructions for use with Sanprozu informs that the lyophilisate contains the main active element pantoprazole (in the form of pantoprazole sodium sesquihydrate) and an additional component (solvent): isotonic sodium chloride solution. The composition of one tablet contains the main active substance and auxiliary elements: calcium stearate, magnesium oxide, colloidal silicon dioxide, sodium lauryl sulfate, calcium carbonate, crospovidone. The enteric coating contains a methacrylic acid ethyl acrylate copolymer and copovidone, macrogol 6000, titanium dioxide, triethyl citrate, yellow iron oxide, talc.
Indications for the appointment of the drug
In accordance with the instructions for use with Sanpraz, the main pathological conditions in which this medication is prescribed are:
- gastrinoma (Ellison-Zollinger syndrome);
- elimination of Helicobacter pylori bacteria (as part of combination treatment with antibacterial drugs);
- peptic ulcer of the stomach and duodenum during exacerbation;
- hemorrhagic (erosive) gastritis provoked by the Helicobacter pylori bacterium;
- ulcerative erosive lesions of the above organs, due to the use of anti-inflammatory non-steroidal medications;
- therapy for reflux gastroesophageal disease;
- therapy and prevention of ulcers that have arisen on the nervous system due to stress, as well as their consequences (bleeding, penetration of ulcers, perforation).
Contraindications
According to the instructions for use, Sanpraz is contraindicated for use in the following cases:
- dyspeptic disorder of neurotic origin;
- malignant neoplasm in the digestive organs;
- children and adolescents under the age of 18 years (since there is no data on the use of the drug in pediatric clinical practice);
- lactation period;
- hypersensitivity or individual intolerance to any of the medicinal elements of the medication.
The medicine "Sanpraz" is prescribed with some caution during pregnancy and liver failure.
Dosage and route of administration
Sanpraz tablets are intended for oral use. A medicine is taken, usually in the morning, one hour before a meal. When prescribing a dosage twice a day, the second dose is taken before an evening meal (also, one hour). The tablet is recommended to be swallowed whole and washed down with the necessary volume of liquid. Adult patients "Sanpraz" is prescribed in the following dosages: the destruction of bacteria Helicobacter pylori - one tablet twice a day. The therapeutic course is 7-14 days. Treatment can be combined with certain antimicrobial medications. With hemorrhagic gastritis, ulcerative lesions of the stomach and duodenum, patients are prescribed 1-2 tablets per day. The course of therapy is selected, as a rule, individually, taking into account the stage of the disease and the progression of ulcers.
With prolonged use of anti-inflammatory non-steroidal drugs, Sanpraz is used prophylactically for half a tablet per day.
In cases of impaired hepatic function, a dosage adjustment is severely required. A drug is taken in 1 piece every other day. At the same time, biochemical blood counts are regularly monitored. With an increase in the functionality of hepatic enzymes, Sanpraz medicine must be canceled. If oral medication is not possible, patients are prescribed intravenous administration of medicinal solutions. As soon as it becomes possible to take the drug inside, the patient is immediately transferred to the tablet form of the drug. This is confirmed by the instructions for the use of "Sanpraza". Analogs will be considered below.
Solution preparation
To prepare the solutions, you need to restore the bottle with the lyophilisate contained in it using the solvent that is supplied with the kit. The finished medicine is administered intravenously in a jet or in the form of infusions, lasting from 3 to 15 minutes.
To prepare the solution for infusion, the reconstituted lyophilisate should be mixed with 100 ml of physiological or glucose solution, while it should have a pH of 9-10. The shelf life of the finished product is three hours from the date of manufacture. With the intravenous form of the drug, the recommended dosage per day is 40 mg.
Instructions for use with Sanprozra informs that the duration of the therapeutic course is about seven to ten days, and if necessary, it can be extended for another few days.
In Ellison-Zollinger syndrome, this drug is used for a very long period of time, while the initial daily dosage can be up to 80 mg, and then reduce it.
It is necessary to strictly observe the instructions for use with Sanpraz tablets. Exceeding the recommended dosages can adversely affect the body.
When prescribing a medication in a dose of more than 80 mg, it is divided into two stages of administration. In certain cases, a temporary increase in doses to 160 mg is required. In order to eradicate bacteria Helicobacter, the drug is used in a daily dosage of 80 mg in two applications. In this case, systematic monitoring of the biochemical properties of blood is required.
For elderly patients and people with impaired renal function, the drug is prescribed in the doses recommended by the instructions for use, and correction of such a regimen is usually not required.
Adverse reactions
According to the instructions for use and reviews, Sanpraz can cause a number of negative adverse reactions, which include:
- Digestive system: dry mouth, pain in the upper abdomen, dyspepsia, stool disorders, functional failure of liver cells, accompanied by jaundice, increased production of liver enzymes flatulence.
- Nervous system: headaches, impaired vision and disorientation, dizziness, confusion, depression, hallucinations, weakness.
- Hematopoietic system: a decrease in the number of platelets and white blood cells.
- Musculoskeletal system: arthralgia, myalgia.
- Allergic and dermatological and reactions: itching and rash on the skin, anaphylactic shock, urticaria, sensitivity to light, Lyell syndrome, angioedema, erythema multiforme, Johnson-Stevens syndrome.
- Local reactions at injection sites: phlebitis and thrombophlebitis.
- Other reactions: peripheral edema, tension and pain in the tissues of the mammary glands, hyperthermia, interstitial nephritis, increased triglycerides.
When using this medication, according to the indications and in the recommended dosages, undesirable reactions occur extremely rarely. This is confirmed by the instruction and reviews to "Sanpraz".
Special recommendations
Therapy with Sanpraz medicine can mask the symptoms of malignant neoplasms in the stomach or esophagus, therefore, patients are advised to conduct an endoscopic examination before using pantoprazole and after the end of therapeutic procedures.
When dyspeptic disorders of neurogenic etiology occur, the drug is ineffective.
In addition, this medicine does not affect the ability to drive a car and engage in other potentially dangerous activities that are associated with a high risk of harm to health.
The instructions for use with the Sanpraz medicine do not end there.
Drug interaction
With the parallel use of the drug with ketoconazole, ritonavir and iron salts, their absorption rate is significantly reduced; with warfarin - the prothrombin time is lengthened and there is a risk of bleeding, sometimes with a fatal outcome; with atazanavir - its effectiveness decreases.
No clinically significant therapeutic interaction was found with the following medicinal substances: ethinylestradiol, nifedipine, amoxicillin, ethanol, caffeine, digoxin, diclofenac, metronidazole, cisapride, glibenclamide, naproxen, cyclosporine, levothyroxine sodium, diazepam, phenimonazin pirifenazin pirinazin pirinazin piferintin midazolam, theophylline, metoprolol, clarithromycin.
The instructions do not indicate analogues of "Sanpraza". We will consider them below.
Analogs
Similar in effect or composition of medications in this case are:
- "De nol";
- Drotaverinum;
- Gaviscon;
- Kvamatel;
- "Ectis";
- "Abisib";
- "Metrogil";
- Beta Clatinol;
- "Famotidine";
- "Vis-nol";
- Taltsid;
- Pantasan
- "Proxy";
- "Limzer";
- Gastrofitol;
- "Vicair";
- "Alumag";
- "Almagel";
- "Renorm";
- "Diaprazole";
- "Yazbin";
- "Soars."
Reviews about the drug
The drug “Sanpraz” is currently widely used and prescribed by specialists in the treatment of certain gastric pathologies. Patient reviews are mixed. One category of patients is of the opinion that the medication is very effective and helps to cope with gastritis and ulcers in the stomach, without causing significant inconvenience associated with the development of negative side reactions.
Other patients prefer other medicines to Sanpraz, because they did not notice a special clinical effect, and some of them experienced severe side effects, for example, severe dry mouth, dyspepsia, pain, which had to be treated with analgesics . Also often the occurrence of dizziness, sleep disturbances and disturbances in the psychological state.
What do the experts say?
Experts do not recommend using this medication on their own, as it can cause a number of complications. Assign it only by detecting conditions included in the list of indications for use and in strictly controlled dosages. Otherwise, doctors warn that with the development of acute negative symptoms, it is urgent to stop taking this drug.
We reviewed the instructions for use for Sanprozu and reviews, this information will be useful to those who suffer from gastrointestinal diseases.