Frequent rhinitis of various etiologies cause a person a lot of trouble. They interfere with normal breathing, provoke shortness of breath, affect mood and performance. That is why, to improve their well-being, doctors prescribe Avamis nasal spray to their patients. Instructions and analogues of this drug are of interest to many patients. It is about this tool that will be discussed in this article.
What are Avamis nose drops? The instructions for using this product after purchase are recommended to be carefully studied first. How to use the drug and in what dosage? Can it be used for adenoids in children? The instruction to Avamis gives detailed answers to these and many other questions.
Drug release form
What are Avamis drops? Instructions for use indicate that this pharmacological drug is available as a nasal spray. That is, it must be used intranasally.
The preparation itself is a homogeneous white suspension, placed in a plastic or glass bottle, equipped with a dispensing cap and a pressure valve.
What active substances are included in this medication?
Active ingredients of the drug
According to the instructions, the Avamys nasal spray has one active component - micronized fluconazole furoate. One dose of the spray includes 27.5 micrograms of this component.
Excipients are dextrose, dispersible cellulose, polysorbate, a solution of benzalkonium chloride, disodium ediate and purified water.
How is the pharmacological action of these components achieved?
Effects on the body
According to the annotation to the drug, the active substance of the drug is a synthetic fluorinated corticosteroid. Is it considered hormonal? According to the instructions for Avamis, the nasal spray is indeed a hormonal anti-inflammatory drug, but it acts locally.
That is, getting on the mucous membranes of the nose, the drug is not completely absorbed. Its binding to plasma proteins exceeds 99 percent, thereby the concentration of the active substance in the blood is so small that it does not have any systemic effect on the body.
The medication reduces the concentration of biologically active substances such as cytokines and immunoglobulins. This process leads to a narrowing of blood vessels and a decrease in swelling of the sinuses.
Pharmacokinetic properties
The active component of the drug is excreted through the metabolic process in the liver through the intestines. Only one to two percent of the drug is excreted through the kidneys. It is noteworthy that the splitting of the substance to fluticasone does not occur.
In what cases is the use of this hormonal drug justified?
When a remedy is prescribed
Most often, doctors recommend a nasal spray for rhinitis of an allergic etiology of a seasonal or chronic nature.
It is noteworthy that this medication can be taken both by adults and small patients. This information is confirmed by the instruction to Avamis and reviews. Children well tolerate the injection of the solution. Doctors recommend the use of a spray for babies from two years.
In addition, the drug is actively prescribed to older people and patients with impaired liver and kidney function. According to various studies, the concentration of the drug in such vital organs is not so significant as to harm them.
How should this drug be used to achieve the necessary therapeutic effect?
Algorithm for the use of the drug
Before determining the dosage and treatment regimen, it is necessary to familiarize yourself with the rules for using the dispensing bottle. According to the instructions, before injecting the solution into the nose, it is necessary to prepare it. To do this, shake the product thoroughly before use (at least ten seconds), then carefully remove the cap and press the tip several times with force. It is necessary to press until a cloud of drug solution appears from the nebulizer. In this case, the bottle must be kept upright. It is advisable to carry out this procedure for the first time after buying a spray, as well as if the drug was without a cap.
Before each injection, it is also important to shake the bottle well. This must be done because the drug suspension is quite thick. Therefore, in order for the drug to disperse well, the solution must be made more liquid by carefully shaking the bottle.
Before the procedure itself, the nose must be cleaned, and the head tilted slightly forward. Then the tip from the bottle should be inserted into the nostril, trying to direct it not to the nasal septum, but to the outside of the nose. The bottle should be in an upright position.
When you press the nebulizer, it is recommended to inhale through the nose. Thus, the solution will go deeper. After injection, the tip is pulled out of the nostrils and exhaled. Next, they manipulate the other nostril. After the procedure, the bottle is closed with a cap.
Be careful! Try to keep the solution out of your eyes. If this happens, eyes should be rinsed under running water.
It is noteworthy that the manufacturer made sure that there was a viewing window on the bottle that would help determine how much suspension was inside. In order to check the level of the drug solution, it is necessary to turn the bottle into the light. The amount of liquid will be viewed in the viewing window.
How to care for your spray gun
This is a very important question, as the tip may become clogged and the spray may stop spraying due to improper care. Many well-meaning people try to rinse the spray bottle with water or clean it with a needle. However, this is categorically impossible.
After each use, the tip and cap should be blotted with a clean, dry cloth. The bottle must be tightly closed and put in a darkened place inaccessible to children.
It is recommended to preserve the drug at a temperature not exceeding thirty degrees. In no case should you freeze the solution.
Dosage and dosage regimen
How should I apply the spray to achieve the best result? According to the instructions, “Avamis” for children from two to eleven years is prescribed one injection in each nasal passage once a day. If there is no improvement in the child’s condition, the dosage can be increased to two injections in each nasal passage once a day.
Adult patients (over twelve years of age) must be injected twice in each nostril once a day. As maintenance therapy, if no worsening is observed, the dose can be reduced to one spray once a day. In some cases, the doctor may consider it appropriate to increase the frequency of taking the medication.
These recommendations apply to patients with allergic rhinitis. Is Avamis prescribed for adenoids? According to the instructions, the drug can be used for such purposes, however, it should be remembered that it does not treat adenoids, but only eliminates the symptoms. That is, after spraying the solution it will become easier for the child to breathe, however, this improvement will be temporary, so Avamis should be prescribed for adenoids in combination with other medical devices aimed at eliminating the pathology.
Can this drug cause side effects? Of course, we will talk about them below.
Adverse reactions
In some cases, the patient's body may react negatively to the administration of a corticosteroid. The most common adverse effects of the drug are nosebleeds and ulceration or dryness of the nasal mucosa. In most cases, this situation is observed with prolonged use of the spray.
Some studies show that the drug may increase the risk of such an unpleasant phenomenon as growth retardation in children. However, fluticasone furoate, administered orally or parenterally, can most often provoke this phenomenon.
Other side effects include skin rashes, hives, anaphylactic shock, and even Quincke's edema. Quite often, treatment with Avamis is accompanied by a headache. Very rarely, various visual impairments are possible.
Sometimes this corticosteroid, even with intranasal use, can cause mental abnormalities (depression, insomnia, aggression, hyperactivity, groundless anxiety).
Contraindications briefly
The drug should not be taken with hypersensitivity or individual intolerance by the patient of certain components of the medication. It is also undesirable to use it by people suffering from severe disorders of the liver.
Pregnancy and breastfeeding are relative contraindications for taking the drug. The active substance of the drug can cause various fetal malformations. However, with intranasal administration, this probability is practically reduced to zero. And yet, the appointment of the drug to a pregnant woman carries a certain risk and is carried out when the expected benefit for the expectant mother exceeds the possible risk for the development of the fetus. The same principle applies when using “Avamisa” by breast-feeding women. Very often in such situations, doctors recommend transferring the child to artificial feeding while taking the drug.
Under two years of age is also considered a contraindication to the use of spray.
Other directions
Since, according to studies, fuluticasone furoate can provoke growth retardation in infants, with prolonged use of the drug, this indicator must be carefully monitored using medical examinations. In any case, the dosage of the medication for children should be minimal.
As already mentioned above, this tool can provoke visual impairment. If a person has a history of such pathologies (glaucoma, intraocular pressure, cataracts), then the use of the spray should be carried out under the close supervision of an oculist.
The use of fuluticasone furoate intranasally does not affect the ability to control vehicles and vehicles.
Cases of overdose of the active substance
It must immediately be said that in practice such cases have not been recorded. According to the instructions for use, increasing the dosage by 24 times over three days is not able to have any significant disturbances in the human body.
Interaction with other drugs
According to the instructions for use, no clinical studies have been conducted regarding the integrated use of fluticasone furoate, administered intranasally, and other pharmacological substances. However, it was noted that when taking the medication of interest to us with ketoconazole-based drugs, there were cases of increased concentration of fluticasone in the blood plasma. And yet, this phenomenon does not have a significant effect on the human body.
Also, doctors do not recommend the combined use of Avamis and ritonavir, as this can also provoke a high concentration of fluticasone in the blood.
Drug cost
According to reviews, the price of the medicine is quite high. For example, a spray of 120 doses can be purchased for six hundred to seven hundred rubles. Price varies by pharmacy and manufacturer.
What patients say about the drug
In their reviews of Avamis, people often express gratitude to the manufacturers and manufacturers of the medicine. After all, it helps not only with allergic rhinitis, but also facilitates the condition of young children with adenoids. Many mothers say that if it weren’t for “Avamis”, their beloved baby would have continued to breathe through her mouth and suffocate. The effect of the spray is also noted by adult patients suffering from allergic rhinitis.
And yet, many people are scared by the composition of the medication. In their reviews, patients note that they are afraid of the adverse effects of the hormonal drug on their body. Especially people worry when it comes to prolonged use of the medication. After all, it is no secret to anyone that an artificial effect on the hormonal background can provoke many problems in the future. On the other hand, even with prolonged use, such a small percentage of the active substance enters the bloodstream that you should not worry.
Among the negative reviews, one can single out the dissatisfaction of patients regarding the price of the drug. It is estimated that a 120-dose vial lasts as long as two months. And if you consider that usually the drug is prescribed in combination with other medicines, then treatment for allergies is quite expensive for the patient.
In their reviews of Avamis, people also note other negative factors. For example, for some, the medication was completely useless. In other cases, the medication not only did not eliminate nasal congestion, but even provoked the development of some unpleasant symptoms.
Moreover, people note that recently, more and more often, doctors began to prescribe this nasal spray for adenoids in children. Therefore, many mothers warn that “Avamis” alone does not cure the disease. It simply eliminates nasal congestion, but does not affect the development of adenoiditis. For a complete cure, you must use other drugs.
Also, many patients warn that you should not expect an instant result from the spray. This drug has an accumulating effect, so the result will be noticed after a few days, or even a week.
What about substitutes
For some reason, the patient may ask the attending physician to cancel the use of Avamis and prescribe an analogue of the drug. In this case, the specialist may recommend substitutes for the spray of interest to us.
What drugs can be prescribed?
First of all, the doctor can ascribe “Nazofan.” This tool is a metered spray, the active substance of which is fluticasone propionate. Additional components are anhydrous glucose, dispersed cellulose, phenylethyl alcohol, water, benzalkonium chloride and polysorbate. The drug is considered a decongestant and anti-allergic medicine for allergic rhinitis. Contraindications to the use of the spray are children under four years of age and individual sensitivity to the components. The daily dose of the drug is one injection into each nostril. In some cases, the dosage may be increased. Adults are allowed to inject up to four times a day in each nasal passage, children - up to two times in knocking.
Another analogue of Avamis is Benarin. The drug is presented not only in the form of a spray, but is also available in the form of drops. The active substance of this medication is budesonide, additional components include thiourea, succinic and benzoic acids, propylene glycol, Trilon B, purified water, nipazole and others. This glucocorticosteroid is prescribed for allergic rhinitis. Inflammatory processes of the nasal cavity of a non-infectious nature, vasomotor rhinitis, and prevention of polyps are also considered indications for the use of Benarin. In the form of a spray, the drug is used for two injections into each nostril twice a day. In the form of drops, the medication is used two or three drops no more than three times a day. Among the main contraindications of the medication, pulmonary tuberculosis, inflammatory processes of the nasopharynx of a viral, fungal or bacterial nature, fresh nose injuries, the period of pregnancy and breastfeeding, and others are distinguished.
Another glucocorticosteroid, considered to be an analogue of Avamis, is Bekonase spray. Its active substance is beclomethasone. This drug is prescribed not only for allergic rhinitis, but also for nasal polyposis, inflammation of the nasal cavity of a non-infectious nature. The doctor may prescribe the use of a spray of two injections twice a day. With special care, medication is used during pregnancy and breastfeeding, pulmonary tuberculosis, myocardial infarction, glaucoma, hypothyroidism and so on.
In some cases, the analogue of “Avamis” is the drug “Polydex with phenylephrine”. The composition of this medication includes substances such as neomycin sulfate, polymyxin B sulfate, phenylephrine hydrochloride and sodium dexamethasone metasulfobenzoate. The drug is available in the form of a spray and drops in the nose and is prescribed for purulent rhinitis, sinusitis, adenoiditis and so on.
Before choosing an analogue of “Avamis”, it is necessary to consult with your doctor.