The article will present instructions and analogues of the drug "Reopoliglyukin."
It is a plasma-replacing antishock drug with hemodynamic effects. The drug quickly and for a long period increases pressure, improving microcirculation in tissues and preventing platelet aggregation along with their adhesion to the walls of blood vessels.
A detailed description of the drug "Reopoliglyukin" is indicated in the annotation.
This tool eliminates the formation of blood clots and increases thrombolysis, stimulating diuresis, that is, it helps to accelerate the detoxification of the body. Next, we consider the instructions for use of this drug, find out what its composition is, and in addition, get acquainted with the reviews of doctors and patients.
Composition and form of release
According to the instructions for use with Reopoliglyukin, a ten percent solution for infusion is its dosage form. The drug is produced in 100, 500, and in addition, 1000 milliliters in polymer containers. In 1000 milliliters of the solution contains 100 grams of the active substance, which is dextran. Auxiliary components are sodium chloride and water for injection.
So, we proceed directly to the testimony and find out in which cases "Reopoliglyukin" is suitable for use.
Indications
As indicated by the instructions for use, Reopoliglyukin is taken in a number of the following cases:
- Against the background of traumatic, surgical and burn shock for prevention and treatment.
- In violation of arterial, capillary or venous circulation. In this case, the medicine is used for the prevention and treatment of thrombosis, thrombophlebitis, endarteritis and so on.
- As part of the surgical intervention on the heart, which is carried out using a cardiopulmonary bypass. In this case, Reopoliglyukin is added to the perfusion fluid.
- During vascular and plastic surgery to improve local circulation.
- Against the background of burns, peritonitis and pancreatitis to accelerate detoxification.
- With eye diseases. The drug is used to treat inflammation of the cornea and choroid.
Indications (Reopoliglyukin is used as prescribed by the doctor) must be strictly observed.
The drug has many different contraindications, we will find out in which cases this drug is not suitable for patients to treat.
Contraindications
In accordance with the instructions for use, Reopoliglyukin has the following absolute contraindications:
- The patient has pulmonary edema.
- The development of decompensated heart failure.
- The presence of thrombocytopenia.
- The development of severe renal failure, accompanied by anuria.
- The patient has ongoing internal bleeding.
- The presence of hypocoagulation or hemorrhagic stroke.
- Getting traumatic brain injury, accompanied by an increase in intracranial pressure.
- The appearance of hyperhydration, hypervolemia, as well as other situations in which the introduction of fluids in a large volume is contraindicated.
- The patient has hypersensitivity to any of the components of the drug solution.
The relative contraindications of Reopoliglukin with glucose include the following diseases or conditions:
- Violation of the blood coagulation system.
- The presence of dehydration.
- The appearance of diabetes with severe hyperglycemia.
- The development of hyperosmolarity.
- The presence of disturbances in water and electrolyte balance.
During pregnancy, the presented drug is administered with extreme caution and only when the expected benefit exceeds the possible risks to the fetus. During lactation during the treatment period, breastfeeding should be discontinued, as there is insufficient clinical data on the effects of dextran on the health of the child.
This is confirmed by the instructions for use with Reopoliglyukin.
Method of use and dosage
The solution is administered intravenously. The rate of administration and dosage of the drug are selected individually based on the patient's condition, which depends on the magnitude of the pressure and heart rate. Hematocrit values are also taken into account.
One day before the use of the medicine, a skin test is required. 0.05 milliliters of solution is injected intradermally on the inner surface of the forearm until the effect of the so-called lemon peel appears. The reaction is evaluated by the doctor at the end of one day from the date of the test.
In the case of the formation of redness at the injection site or the appearance of symptoms of general allergic reactions in the form of dizziness, nausea, and other effects fifteen minutes after the solution enters the body, it can be concluded that the patient is highly sensitive to this drug and that it cannot be used further during treatment.
In the event that there are no reactions, the patient can be administered a dose of Reopoliglukin according to the instructions for use. You need to use a solution of the series that was taken for the test. The results of the performed test should be included in the medical history. But a skin test does not guarantee absolute results in determining the patient's sensitization to dextran. In this regard, with intravenous administration of the drug in the first ten minutes, carefully monitor the patient's condition in absolutely every case.
We continue to consider the description and instructions for use with Reopoliglyukin.
As part of the use of the drug for the treatment of emergency conditions, a test is mandatory, for which the first five drops of the solution are injected slowly, and then the procedure stops for three minutes. Then thirty more drops are introduced, and again a three-minute pause is maintained. In the event that the patient has no reaction to the drug, then the infusion continues at the recommended rate. At the end of the procedure, the results of the sample should be recorded in the patient's general medical history. Consider further the dosage regimen depending on the disease:
- Against the background of various forms of shock with impaired capillary blood flow, adults are injected up to 1000 milliliters once a day. The maximum dose is 1,500 milliliters. As for children, for them the dosage is calculated at the rate of 10 milliliters per kilogram of weight. The maximum infant dose is 15 milliliters per kilogram of weight. The infusion period is usually sixty minutes.
- In plastic and cardiac surgery, immediately before the start of surgery, the drug is administered at a dosage of 10 milliliters per kilogram of weight. During surgery, adults are given 500 milliliters each. Children are given 15 milliliters per kilogram of weight.
- During surgery using a cardiopulmonary bypass, the solution is added to the blood at a dosage of 20 milliliters per kilogram of weight to fill the oxygenator pump. In this case, the concentration of dextran in the perfusion solution cannot be more than three percent. Immediately after the operation, Reopoliglukin is used in dosages recommended for the treatment of capillary blood flow disorders.
- Drip detoxification for adults is 1000 milliliters. If necessary, increase the dose on the first day by 500 milliliters.
- In ophthalmic practice, 10 milliliters are used. The course of therapy is ten procedures.
Reopoliglyukin and side effects
Against the background of the use of this drug in patients, undesirable effects may occur in the form of hypersensitivity reactions, skin rashes, skin hyperemia and itching. Pseudo-allergic reactions in the form of a decrease in pressure, oliguria and collapse up to the occurrence of anaphylactic shock are not excluded. Nausea and fever are also possible. "Reopoliglyukin" is able to provoke an increase in bleeding along with the development of acute renal dysfunction.
In case of excessive excess of the infusion rate or administration of the drug in large volumes, the symptoms of an overdose are likely to occur, and arrhythmia, left ventricular heart failure , pulmonary hypertension and an allergic reaction may occur. To treat all these conditions in most situations, it is enough to simply stop the infusion, but in more difficult cases, urgent symptomatic treatment may be needed.
In the event of an anaphylactic reaction in the form of itching or redness of the skin during infusion, stop the administration of dextran immediately, and then, without removing the needle from the vein, proceed to the implementation of therapeutic measures, which are provided for by the relevant instructions. In order to eliminate transfusion reactions, antihistamines and cardiac drugs are taken along with corticosteroids, calcium preparations, respiratory analeptics, etc. In addition, if necessary, resuscitation should begin. It is possible that the plasmapheresis procedure is performed. It is worth saying that hemodialysis in this situation is ineffective.
So it is said in the instructions for the drug "Reopoliglyukin."
special instructions
During transportation of the presented drug in glass containers, it is allowed to freeze. In this case, due to the temperature difference in the solution, a white film or flakes may form, which are particles of dextran. In this case, it will be necessary to dissolve the formation using autoclaving. The temperature should be 120 degrees. Dissolution itself lasts twenty minutes. The drug can be dissolved in a water bath with regular shaking for one hour. Next, the solution is cooled to body temperature and used strictly for its intended purpose.
It is worth noting that the introduction of the drug into the peripheral vessels can cause a feeling of pain, and in addition, a burning sensation in the limb area along the vein. In parallel with Reopoliglyukin, it is advisable to inject crystalloid solutions, such as, for example, five percent dextrose or sodium chloride. Substances are introduced in an amount that is sufficient to replenish and maintain water and electrolyte balance. Extreme caution should be exercised in the presence of risks of circulatory overload, especially in the case of a clinically obvious or latent form of heart failure.
Against the background of hemodilution caused by dextran, a decrease in plasma levels of blood coagulation is possible, which may cause bleeding. Simultaneous administration of Reopoliglukin infusion solution with anticoagulants requires a reduction in their dosage.
The main substance (dextran) is able to increase diuresis. In the event that during the treatment, doctors observe a decrease in urine output with the release of viscous syrupy urine, this may be a sign of dehydration. In such a case, intravenous administration of crystalloid solutions should be performed without delay in order to replenish, and at the same time, maintain the water and electrolyte balance. Against the background of the occurrence of oliguria, it will be necessary to intensify the ongoing therapy and take Furosemide.
Considering the ability of Reopoliglukin to envelop red blood cells, which impedes the possibility of determining the blood group, it is better to use washed elements for this analysis.
Drug Interactions "Reopoliglyukina"
As we are informed by the instructions for use with Reopoliglyukin in solution, its combined use with other transfusion traditional solutions is usually allowed. All drugs that are planned to be introduced into the infusion solution are pre-tested for compatibility. Dosages of anticoagulants and antiplatelet agents should be reduced when combined with Reopoliglyukin, since dextran can significantly potentiate their effect.
Indications for use of Reopoliglyukin should be taken into account without fail.
Analogs
Analogues include drugs in the form of Neorodex, Dextran, Hemostabil, Polyglukin, and Polydextran.
There is no information about this in the instructions for use with Reopoliglyukin. The price of the product will be presented below.
Terms and conditions of storage of the drug
The drug must be stored exclusively in a place that is inaccessible to children. The medication is stored at a temperature of ten to twenty-five degrees. In case of non-compliance with temperature conditions during transportation or storage, the appearance of a white film or flakes is allowed (the main substance of the drug dextran may take this form). The shelf life of the product is up to four years.
Drug cost
In Russian pharmacies, the average cost per 100 milliliters is about one hundred rubles. Further, it may increase depending on the volume of medicinal contents. According to reviews, the price of Reopoliglyukin is quite reasonable.
Reviews of doctors and patients about the drug
Most patients and doctors in their comments respond positively about this drug. Its rapid therapeutic effect is noted along with a small frequency of adverse reactions.
People write that this drug helps to cope with health problems. For example, those who used it to treat multiple sclerosis report that Reopoliglyukin perfectly restores blood flow in the capillaries, relieving intoxication of the body. In particular, patients recommend it to relieve exacerbations, to prevent the formation of blood clots and report that you can not be afraid of any adverse reactions.
In addition, people praise this drug for its low cost, against which the achievement of the expected result from treatment is noted.
Doctors are also happy with this drug and often prescribe it for treatment to their patients. Experts say that this plasma-replacing agent can perfectly increase the suspension resistance of blood, reducing its viscosity, and in addition, restoring blood flow in small capillaries. Doctors report that this remedy can effectively normalize arterial and, at the same time, venous circulation, preventing or at least reducing the aggregation of shaped blood elements. Also, experts note that "Reopoliglyukin" has a detoxifying effect on the body.
In addition, doctors write that, according to the osmotic mechanism, Reopoliglyukin stimulates diuresis, thereby accelerating the elimination of poisons and, in addition, degraded metabolic products and toxins. The pronounced volemic effect of the drug positively affects the processes of hemodynamics and at the same time can be accompanied by leaching of metabolic products from the tissues, which, together with the growth of urine output, provides acceleration of detoxification of the body.
We reviewed the preparation "Reopoliglyukin" instructions for use and analogues.