Dexketoprofen trometamol - what is it? We will understand in this article.
It is a non-narcotic analgesic belonging to the NSAID group. The substance is obtained from propionic acid. This is the main active ingredient in the composition of the drug "Dexketoprofen." The manufacturer produces the drug in tablet, ointment, injectable form (the solution can be used for intravenous, intramuscular, parenteral administration).
Pharmacological effects
Dexketoprofen trometamol has an antipyretic, anti-inflammatory, analgesic effect.
The mechanism of action of the substance is based on the suppression of the activity of enzymes involved in the synthesis of prostaglandins. The analgesic effect of the use of the drug develops within half an hour after its use, persists for 5 hours. The concentration of the active component in the blood when administered intravenously and intramuscularly reaches 99%.
Indications for use
The use of dexketoprofen trometamol is justified in the following cases:
- Pain of any etiology: neuralgic, renal, gynecological, postoperative, traumatic.
- Bone pain resulting from metastasis.
- Toothache, sciatica, sciatica.
- Therapy of diseases in a chronic, acute form.
- Diseases of the musculoskeletal system of an inflammatory nature: osteochondrosis, osteoarthrosis, arthrosis, various arthritis.
Contraindications
According to the instructions for dexketoprofen trometamol, its use is unacceptable if the following physiological or pathological conditions in the patient are noted:
- The lactation period.
- Pregnancy.
- Bleeding of any etiology.
- Intolerance to Aspirin.
- Asthma.
- Polyps in the nose.
Against the background of application, some negative effects may develop, for example, gastric ulcer, exacerbation of gastritis, nausea. When there is a feeling of heaviness in the hypochondrium on the right side, we can talk about negative processes in the liver.
Using
The instructions for use of dexketoprofen trometamol contain clear instructions on how to use the drug. A tablet medication should be taken with food. If the patient has abnormalities in the activity of the liver and kidneys, it is important to start therapy with the lowest doses of the drug. Tablets should be taken every 8 hours, and the duration of therapy should be about 5 days.
For severe pain, the use of an injectable drug is recommended. The introduction should be carried out every 8-12 hours. The solution can be used for no more than two days, then it is necessary to switch to the tablet form of the drug.
It should be noted that it is necessary to type dexketoprofen trometamol into the syringe immediately before injection. In this case, the needle should be inserted as deeply as possible, and the solution should be released slowly.
The solution is infused intravenously for up to 30 minutes. Previously, it is diluted with Ringer's solution with lactate, glucose, sodium chloride.
The ointment form of dexketoprofen trometamol is available in pharmacies under the trade name "Dextanol". Apply the gel externally, treating it with inflamed areas. External forms of the drug can be used several times during the day, however, its use is prohibited for longer than a week.
Before starting therapy with dexketoprofen trometamol, it is necessary to carefully study the instructions, since the medication has contraindications.
Careful use
It is important to exercise caution when prescribing the drug to patients suffering from disorders in the activity of the heart. During therapy, glucose, cholesterol, blood pressure should be monitored. With their increase, the use of the drug should be discontinued, since there is a risk of myocardial infarction, stroke.
Against the background of prolonged use of the drug in the blood, the content of creatinine and nitrogen increases, which negatively affects the functionality of the kidneys and can provoke the development of renal failure, nephritis.
This is confirmed by the instructions for use of dexketoprofen trometamol.
Interaction with other medicines, alcohol
The effect of the drug with parallel use with other drugs of the NSAID group is greatly increased.
When prescribing a medication, a doctor should take into account such features of the active substance as:
- It is undesirable to combine the drug with anticoagulants that promote blood thinning, since in this case the likelihood of the manifestation of the negative effects of both drugs will increase.
- It is forbidden to take dexketoprofen trometamol in parallel with lithium preparations, as this leads to an increase in the amount of lithium in the blood and subsequent poisoning of the body.
- Parallel use with hormonal agents can provoke internal bleeding in the digestive tract.
- With simultaneous use with sulfonamides and hydantoin, the toxicity of dexketoprofen trometamol increases.
- There is a risk of developing anemia when combined with the antiviral Zidovudine.
- When combined with Methotrexate, hemolytic toxicity may occur.
- You can take dexketoprofen trometamol only 12 hours after the use of Mifepristone.
- In parallel with Pentoxifylline, the likelihood of bleeding increases.
- Combination with Cyclosporin, Tacrolimus is toxic to the kidneys.
- Concurrent use with cardiac glycosides leads to an increase in the concentration of the latter in the blood.
- With simultaneous use with quinolone drugs, there is a risk of seizures.
It is forbidden to mix trometamol with promethazine, petidine, pentazocine, hydroxyzine, dopamine in the same syringe of dexketoprofen.
During the course of therapy using the drug, alcohol is prohibited, since the consequences of such a combination can be unpredictable.
It is important to remember that only a doctor should prescribe the drug.
The article provided information on what it is - dexketoprofen trometamol.