Sulfamethoxazole and trimethoprim are included as active substances in the composition of the drug under the name "Co-trimoxazole", which is a combined antibacterial drug with a wide spectrum of action. Used in medicine to kill bacteria that cause infections such as pneumonia, infections of the ears or urinary tract. This medicine may sometimes be prescribed for other purposes. It is known as Biseptolum. The antibiotic, however, has many other trade names: Bactrim, Bi-sept-Farmak, Berlotsid, Bi-Septin, Bisutrim, Biseptrim, Bikotrim, Groseptol, “ Gene-Ultrazole ”,“ Disepton ”,“ Duo-Septol ”,“ Cotrimol ”,“ Kotrim-Rivofarm ”,“ Novo-Trimel ”,“ Cotrifarm, “Oribact”, “Rankotrim”, “Oprim,“ Septrin ”,“ Sulotrim ”,“ Sinersul ”,“ Sumerolim ”,“ Trimezol ”,“ Trim ”,“ Trimosul ”,“ Expozol ”,“ Tsiplin ”,“ Intrim ”.
A wide range of bactericidal action is characterized by the drug "Biseptolum". The antibiotic is available in tablet form. The chemotherapeutic effect is due to two active substances. Sulfamethoxazole inhibits the process of PABA utilization and disrupts the synthesis of dihydrofolic acid in bacterial cells, exerting a bacteriostatic effect. Trimethoprim is able to inhibit the enzyme involved in folic acid metabolism and convert dihydrofolate to tetrahydrofolate. As a result of the blocking of two successive stages of the biosynthesis of purines and nucleic acids , the conditions for the reproduction and growth of bacteria are violated. High concentrations of the drug are created in the tissues of the kidneys, lungs, prostate gland, bile, cerebrospinal fluid, and bones.
Only as prescribed by the doctor should take "Biseptolum." The antibiotic should not be taken along with other drugs, such as Phenytoin (Dilantin), Warfarin (Coumadin) and others. You should also inform your doctor if you are allergic to co-trimoxazole, diuretics, or diabetes medications. The patient should tell the doctor the history of his illness and report on kidney diseases, asthma. After all, only a doctor can evaluate the appropriateness of using the Biseptol drug in this case. Indications for its use should repeatedly outweigh the risk of possible negative consequences. Taking "Biseptolum", you need to analyze any changes in the physical and moral condition. If adverse reactions are detected, such as vomiting, loss of appetite, sore throat, fever, pallor, you should immediately consult a doctor.
The patient should remember that immediate medical advice is required in case of any questions that arose during the treatment with Biseptol. An antibiotic is characterized by the most common side effects - these are gastrointestinal upsets. Sulfamethoxazole may cause nausea, heaviness in the stomach, or abdominal pain. An allergy to sulfa drugs usually causes a rash on the skin, hives, trouble breathing or swallowing. In this case, you must immediately stop taking the medicine and contact your doctor. Sometimes when taking this medication, muscle pain occurs . If symptoms persist, contact a physician. If breathing problems or swelling of the face, mouth, tongue are noticed, then you need to stop treatment and get emergency medical care, as these reactions are often symptoms of a severe allergy.
"Biseptol" is an antibiotic whose main substances are sulfamethoxazole in combination with trimethoprim. They can cause megaloblastic anemia in some patients (they are caused by a deficiency of B12 or folic acid), because they are antagonists of this acid. The clinical manifestations of this condition are associated with impaired functions of the nervous system and the entire blood system, as well as the gastrointestinal tract due to damage to the epithelium. Problems in the blood system are accompanied by anemic syndrome (weakness, fatigue, tachycardia, dyspnea with physical exertion, pallor of the mucous membranes and skin).