Myasthenia gravis is a fairly common disease. It is manifested by asthenic bulbar paralysis. It is characterized by severe weakness and rapid muscle fatigue. During the disease, any part of the body can be affected, but lips, tongue, pharynx and neck are considered more vulnerable. Such a pathology requires professional treatment. One of the popular and high-quality drugs for the treatment of myasthenia gravis is the medicine Kalimin. Instructions for use are in the package with tablets.
The composition of the drug
Means "Kalimin" is considered a cholinesterase inhibitor. White tablets, slightly convex. They have an oblong shape with slight roughness. In the middle of the tablet is divided by a strip. The main substance in the composition is pyridostigmine bromide in a dosage of 60 mg. Auxiliary components of the drug are microcrystalline cellulose, corn starch, silicon dioxide, polyvidone, glutamic acid hydrochloride, purified water, magnesium stearate.
The drug is available in dark bottles, 100 tablets each. Despite the fact that Kalimin tablets are dispensed without a prescription, the instructions for use must be studied before starting therapy.
The action of tablets "Kalimin"
The drug improves nervous and muscle transmission, increases the motility of the gastrointestinal tract, increases the tone of the bladder, bronchi, and secretion of the endocrine glands. Causes bradycardia, mild myosis, spasm of accommodation. Achieving the greatest effect in the body can be expected in 2 hours. The bioavailability of the drug is 20%.
Taking the medicine with food does not reduce bioavailability, but it lengthens the time to reach the effect by 1.5 hours. The product does not cross the blood-brain barrier. The drug generally does not bind to plasma. It is metabolized in a certain amount in the liver and forms inactive metabolites after cleavage. The kidney drug "Kalimin" is excreted unchanged by the kidneys. Reviews, indications, the correct dosage - all this should be read before treatment.
Indications and contraindications
Indications for the use of the drug are myasthenia gravis. You can not prescribe a drug for bronchial asthma and chronic obstructive bronchitis. Obstructive disease of the biliary and urinary tract is also a contraindication. You can not drink tablets during mechanical intestinal obstruction, myotonia. Contraindications to the use of the drug are pregnancy and lactation, the age of 18 years. With increased sensitivity to the components of the tablets, they are not recommended.
With caution, it is worth using the remedy for people who are prone to allergic reactions. You need to know that with reduced pressure, renal and heart failure, the drug is prescribed under the close supervision of a doctor. During therapy, it is necessary to monitor blood pressure indicators. Tablets are used with caution in diabetes mellitus, gastric and duodenal ulcers, with hyperthyroidism, after
surgery on the stomach.Before starting treatment, it is worth carefully familiarizing yourself with the contraindications to the use of Kalimin. Instructions for use, reviews - all this is important information for patients.
Drug dosage
The tablet is taken orally. It is recommended to drink plenty of fluids. To achieve a quick effect, it is worth using the drug on an empty stomach. At the beginning of the disease, you need to drink half or a whole tablet once or twice a day. In more severe cases of myasthenia gravis, it is prescribed to take one to three tablets two or four times a day. The maximum allowable dose for admission per day is 12 tablets. The daily rate and duration of treatment are determined by the doctor individually. The characteristics of the body and the progression of the disease are taken into account.
Patients suffering from kidney pathologies should take a medication in a reduced dosage. It is worth considering that the Kalimin agent can lead to the development of side effects. Instructions for use contain information on concomitant therapy of negative reactions.
Overdose
With an overdose of the drug, salivary, sweat, and lacrimal glands increase. The patient turns red, weakness appears, and vision is impaired. Spontaneous urination and bowel movements may occur. The patient complains of nausea, vomiting, blood pressure decreases, bronchospasm builds up. In severe cases of overdose, cardiac arrest may occur, which will lead to death. This condition requires immediate help. The antipode for Kalimin tablets is Atropine. It must be administered intravenously at a dose of 2 ml.
Further, depending on the condition of the patient, you can repeat the introduction of the drug after three hours. It is recommended to wash the stomach and give an adsorbent drink. The patient should be supervised by medical personnel so that respiratory arrest does not occur. According to indications, resuscitation measures should be taken. Such severe consequences of an overdose may have the drug "Kalimin". Reviews show that bad consequences can be expected only if the medication is used incorrectly.
Interaction with other groups of drugs
"Atropine" reduces the effect of the drug "Kalimin", but does not affect skeletal muscle. Pyridostigmine bromide, which is part of the tablets, enhances the action of "Morphine" and barbiturates. The drug is completely incompatible with ethanol. Reduce the pronounced effect of the drug "Quinidine", ganglion blockers, antidepressants, antiepileptic and antiparkinsonian drugs.
During pregnancy and lactation, it is not recommended to prescribe the drug. In the last months of pregnancy, it can cause an early birth. When feeding, the substance enters the milk, which can cause poisoning in the newborn with the drug "Kalimin". Instructions for use must be studied in order to avoid the unpleasant consequences of therapy.
Reviews about the drug
Patients who suffer from myasthenia respond positively to the drug Kalimin. Instructions for use will familiarize the patient with contraindications and indications in an accessible form. Pills in a short time give a positive therapeutic effect, patients note. The drug has an affordable price and good quality.
The tool is not addictive and most often tolerated quite well. However, cases of the development of severe side effects are known.