In the article, we will consider how to breed "Bicillin."
This antibacterial drug belongs to the category of natural penicillins. It can produce a bactericidal effect, while possessing a very wide spectrum of effects. Gram-positive and negative bacteria, along with some protozoa, are usually fatal. The product is released exclusively in bottles containing white powder for dilution. Method of use: intramuscular injection.
Not everyone knows how to breed Bicillin for injection.
The composition of the drug
The presented remedy has several generations, which include various combinations of penicillin salts:
- The drug "Bicillin-1" is attributed to the first generation. The composition of which includes only benzathine salts of benzylpenicillin. In pharmacies, you can find two dosages: 600,000 units and 1,200,000 units (units of action).
- The medicine "Bicillin-3" is attributed to the second generation. It has in its composition just three salts: benzathine benzylpenicillin, benzylpenicillin sodium and novocaine benzylpenicillin. Dosing also has two gradations at once: for 400,000 and 200,000 units. How to breed "Bicillin-3" according to the instructions, many are interested.
- Means "Bitsillin-5" belong to the last generation, its composition is adjusted. Now the powder includes benzylpenicillin benzathine and novocaine salt. The medicine is released in only one dosage. What to breed "Bicillin 5", it is important to find out in advance.
Characteristic of this drug
Any type of this medicine is released in identical bottles with a capacity of 10 milliliters. The package contains fifty bottles. Inside there is a homogeneous powder, characterized by white color. The powder has virtually no odor. It tastes bitter. Immediately after contact with water, as a rule, it assumes a homogeneous structure and forms a stable suspension. In the event that the resulting solution was not administered within one hour, its properties change. The solution is loose, with many different small lumps, which makes subsequent administration impossible.
"Bicillin" bred novocaine? We will talk about this below.
The cost of this antibiotic is quite low. Currently, “Bicillin-1” is almost out of circulation, and almost the same “Bicillin-5” has come to replace it. But if you can find it, then the average price for 1 bottle of this salt will be ten rubles. "Bicillin-3" and "Bicillin-5" slightly differ in the price category, the cost ranges from thirty to fifty rubles per bottle.
How to dilute Bicillin with water is not indicated in the instructions.
Shelf life must be indicated on each bottle. The duration of possible use is three years. It is advisable to store the medicine at a temperature of eight to fifteen degrees in a protected and dark place. If these conditions are violated, the active component may lose its properties.
Patients are often asked how to chop and breed “Bicillin”. Let's figure it out.
The mechanism of action of this drug
The pharmacodynamics of this drug is the same, and does not depend on the generation used. The drug has a bactericidal effect on many strains due to beta-lactams. These particles act as inhibitors of the synthesis of peptidoglycans. In the case of the action of the drug "Bicillin" beta-lactams can be embedded in the synthesized genetic chain and block further production.
Peptidoglycan is a complex protein that is part of the protective membrane of many bacteria. Without this protein, the cell is not able to defend and function normally. Therefore, macrophages of the human body quickly detect it, and the pathogenic agent immediately lends itself to lysis, that is, cleavage by enzymes.
The drug in question can have a great effect on gram-positive flora (i.e., staphylococcus, streptococcus, diphtheria bacillus, anthrax pathogen and so on), inhibiting the growth of anaerobic organisms. And in some situations it is sensitive to gram-negative organisms (meningococci, pale treponema and the causative agent of gonorrhea).
Pharmacokinetics also acts as an important link. Since it is the slow withdrawal of the drug that makes it indispensable in the process of preventing streptococcal complications.
The therapeutic concentration in the blood is detected already in the first hours immediately after the injection. The maximum numbers can be fixed after twelve hours. It is important that the drug "Bicillin-3" remains in the therapeutic dose in the blood for at least seven days after administration, and "Bicillin-5" can last for twenty-eight days. This is due to the slow biotransformation of the drug and its gradual release. This antibiotic is excreted by the kidneys as inactivated forms.
How to breed "Bitsillin-3", they find out very often.
Indications for the use of a medication
Bacterial microflora over the period of the long existence of antibiotics has repeatedly managed to mutate and develop resistance to their effects. In the case of this drug, bacteria learned to produce beta-lactamases, which are able to break down beta-lactams. To protect against inactivation, penicillins add sulbactam with tazobactam and clavulanic acid to penicillins. Since the tool in question does not have any protection, most often it is used to combat the effects of the life of beta-hemolytic streptococci and pale treponema.
Indications for use are syphilis along with gonorrhea, erysipelas, severe scarlet fever, prevention of rheumatism after a severe sore throat, tonsillitis and leishmaniasis. Often this drug is used to treat glomerulonephritis and streptococcal carditis. The advantage in the treatment of the above pathologies is given to “Bicillin” due to its long cumulative ability.
So, how to breed "Bitsillin"?
Rules for the use of this drug
Instructions for use indicate the desired dosage and the principle of input. But she does not specify how to properly breed “Bicillin”, and how to inject medicine. Given that injections are often done at home, it is necessary to stipulate some details that are missing in the annotation. So, for starters, we’ll clarify how to breed “Bitsillin”.
The preparations "Bicillin-1" and "-3" are diluted exclusively with physiological saline or water for injection.
At the same time, they often ask the question of how to breed “Bicillin-3” with novocaine.
Dilution of the powder with novocaine is contraindicated. The medicine "Bicillin-5" is the only representative of these drugs that can be diluted with an anesthetic. But until the patient is eight years old, this is also not allowed.
Let us turn to the question of how to breed and chop Bitsillin-5. To do this, 5 milliliters of solvent are drawn into a syringe, a rubber cap is punctured with a needle, and the drug is injected under pressure. After shaking the medicine for twenty seconds until the homogenization of the suspension. Pour the prepared solution back into the syringe.
What to breed "Bitsillin" better, the doctor will tell.
Make an injection right after that. The injection is performed intramuscularly in the region of the upper outer quadrant, deep into the buttock. After inserting the needle, make sure that it does not enter the vessel. To do this, pull the piston. In the event that blood does not enter the syringe, a solution is slowly introduced.
You can "Bicillin" dilute lidocaine to 10 ml.
The instructions for using the drug indicate the average dosage of the drug. It must be remembered that the doctor will select the optimal dose of the drug, taking into account the characteristics of the patient and his disease, which must be dealt with. On average, the following dosages are used:
- In the treatment with Bicillin-1, 600,000 IU is used only once a week.
- The drug "Bicillin-3" is used at 300,000 IU on the first day, on the fourth day this dosage is doubled.
- The medicine "Bicillin-5" is used in an amount of 1.5 million IU once a month.
Contraindications to the use of a medication
The main contraindication to the use of this medication is the presence of individual intolerance to the components of the patient. Attention should be paid to the history of an allergy to cephalosporins and sulfonamides. They have a similar structure and principle of influence.
Do not use this medicine for sick people with bronchial asthma and those who have hay fever. Particular attention should be paid to patients who suffer from other allergic pathologies (hay fever, food and contact allergies). With caution, this medicine is prescribed for pregnant women, and in addition, for sick people with chronic kidney failure and pseudomembranous colitis.
Alcohol is also prohibited. If acetaldehyde enters the body, the effect of the drug is usually minimized, or can be completely distorted. This will certainly slow down the achievement of the desired results and increase the risks of developing resistance.
Now we find out what side effects are possible when using this remedy.
Side effects from the use of this drug
As indicated by the instructions for the use of the drug "Bicillin", the main side effect is the development of an allergic reaction, which can manifest itself in the form of itching, urticaria, Quincke's edema, anaphylactic shock and bronchial spasms. Rarely, a reaction from the functioning of the hematopoietic system can be observed. In this case, patients note coagulopathy along with anemic syndrome, thrombocytopenic purpura and leukopenia.
Common symptoms inherent in taking antibiotics are the appearance of a headache, unmotivated weakness, diarrhea, dysbiosis, glossitis and stomatitis, joint pain and fever of unknown origin. Prolonged use of an antibiotic with non-compliance with the indicated dosage and frequency of use can lead to the development of superinfection, due to the development of resistance of pathogenic bacteria to antibacterial drugs from the beta-lactam category.
Features of the use of this drug in different population groups
Children, pregnant women, and in addition, elderly people have their own physiological individual characteristics. Penicillins are not included in the list of teratogenic factors. But their use is extremely undesirable. Therefore, during pregnancy there are strict instructions. This drug is prescribed only if the benefit to the mother far exceeds the risks to the developing fetus. Dosage is selected individually by the doctor, taking into account all the features.
The lactation period is a contraindication, since a low concentration of the drug passes into breast milk. This can cause allergic reactions or the development of resistance to the bacterial flora.
Such a contingent as children is recommended to prescribe only Bitsillin-5. The difference in dosage depends on age. Children from three to eight years old are recommended to enter 600,000 IU just once every three weeks. After the child reaches the age of eight, the dosage is doubled. It is recommended that 1.2 million IU be administered every four weeks. It is allowed to increase the dose to 1.5 million units.
People who are over sixty years old are recommended to reduce adult dosage by half, since during this period the elimination half-life slows down, due to which the pharmacodynamics are enhanced.
Analogues of the drug
In pharmacies, there are many analogues for each drug, and this tool, of course, is no exception. Depending on the constituent ingredients, a number of the following similar drugs are distinguished: “Benzicillin” along with “Retarpen”, “Moldamine”, “Extentsillin”, “Ditsillin” and so on.
Now we will consider the reviews of patients and doctors, and, in addition, we will find out what they write about the effectiveness of this medical product.
Testimonials of doctors and patients about Bicillin
Since this drug has long existed in the pharmaceutical market, on the Internet you can read a lot of reviews about its effectiveness. It is worth noting that every doctor managed to try this drug in action.
Based on expert reviews, the drug in question is very effective in the treatment of chronic diseases that are caused by flora sensitive to beta-lactams, because they require long-term treatment. Doctors report that if at first “Bicillin” had pronounced adverse reactions, the new generation is able to cure a particular disease already with rare negative manifestations.
This is also confirmed directly by the patients themselves, who report that during the treatment with this medication they easily enough suffered all adverse reactions, which were mainly expressed in headaches and slight weakness.
Next, we consider in more detail the drug "Bicillin 3".
"Bicillin-3": indications for use
The drug "Bicillin-3" is usually prescribed to treat various kinds of infectious diseases provoked by organisms sensitive to the effects of the antibiotic. This antibacterial drug is usually prescribed by doctors in a number of the following situations:
- In the presence of acute or chronic tonsillitis.
- Against the background of infection of wound surfaces.
- If a person has scarlet fever.
- Against the background of rheumatoid arthritis and arthrosis.
- In the presence of a sore throat.
- As part of the prevention of rheumatism.
- Against the background of erysipelas.
- In the presence of syphilis, as well as frambesia.
The drug in question can be used to treat infectious pathologies in poultry (for example, chickens), and in addition, in cattle.
The composition of "Bicillin-3"
This antibiotic is made in powder form. The medicine contains the active ingredient benzathine benzylpenicillin. In addition, sodium benzylpenicillin along with novocaine salt are additional ingredients of this drug.
Healing properties
The mechanism of action of Bitsillin-3 is based on inhibition of growth and numerical reproduction of pathogenic organisms. Thus, this tool effectively copes with gram-positive, gram-negative and anaerobic organisms. The activity of the drug in question against pathogens of fungal pathologies, poliomyelitis, smallpox and influenza has not been identified.
As part of the intake of "Bicillin 3" in the body, hydrolysis is observed with the gradual release of the main active ingredient. With a single administration of this antibiotic, it is possible to maintain its therapeutic concentration for seven days. The highest concentration is observed after twenty-four hours from the injection. Penetration of benzathine benzylpenicillin into physiological fluid is significantly higher than into tissue. The drug can penetrate the placenta and is detected in breast milk. The medicine, as a rule, is partially transformed, after which it is excreted by the genitourinary system.
The use of "Bicillin-3" in veterinary medicine
How to breed "Bitsillin" dog? We will clarify this below.
This antibiotic is very successfully used in veterinary medicine in order to treat infectious pathologies. They treat pets (including chickens and cattle). The drug in question is already acting directly in the first hours after the injection.
How to breed "Bitsillin-3" for animals, not everyone knows. It is recommended to dilute the powder in water for injection, you need to inject the drug quickly into the gluteal muscle.
Depending on the doses used, the drug is retained in the animal’s body for five to ten days, therefore, the drug is indicated exclusively for intramuscular administration once every ten days. Dilute the powder with physiological saline or with purified water. The dosage of Bicillin-3 for intramuscular administration is calculated taking into account the weight of the sick animal:
- For the treatment of horses, for example, 12 thousand units are used.
- For the treatment of cattle up to 20 thousand units.
- In order to cure chickens, 100 thousand units are used.
- And for the treatment of sheep and pigs they use 20 thousand units of medicine.
It is worth noting that the drug in question can be used to prevent infectious diseases of chickens and turkeys.
We examined how to breed "Bitsillin."