In the article, we consider the instructions for use, price and analogues of Sitagliptin.
It is produced in the form of phosphate monohydrate. Its release form is film-coated tablets.
The drug has significant differences in pharmacological action and chemical structure from analogues, as well as derivatives of alpha-glycosidase inhibitors, biguanides and sulfonylureas.
Inhibition of DPP 4 by means of "Sitagliptin" causes an increase in the concentration of the hormones HIP and GLP-1. These hormones are among incretins. Their secretion is made in the intestines.
As a result of eating, the concentration of such hormones increases. The incretins are part of the physiological system that regulates sugar homeostasis in the human body. Analogues of "Sitagliptin" should be selected by a doctor.
Features of pharmacokinetics
The drug is absorbed at a high rate after its use by the patient. This tool has a perfect bioavailability of 87%. The intake of fatty foods does not have a significant effect on the pharmacological kinetics of the drug.
The drug is excreted as part of urine unchanged. After administration is stopped, it is excreted in the week with urine (87%) and feces (13%).
This is confirmed by the instructions for use with Sitagliptin. Analogues of the drug are of interest to many.
Indications for use of the drug
The drug is used in the implementation of monotherapy, if the patient is diagnosed with type 2 diabetes mellitus. This drug is approved for use regardless of food intake. The combination of Sitagliptin and Metformin can be used as a complex treatment for patients with type 2 diabetes.
In combination with Metformin, the recommended dosage of the drug is 100 mg once a day.
If you missed the time of its administration, you should drink Sitagliptin as soon as possible. This is due to the fact that the use of a double dosage of the drug is not allowed.
Drinking a drug more often than recommended in the instructions is prohibited.
The drug makes it possible to control the level of sugars in the body, however, this drug does not treat diabetes.
The use of the drug must be carried out when the patient is well, stop treatment only after the recommendation and consultation of the attending physician.
Does Sitagliptin have any analogues? About it below.
Instructions for use of the drug
"Sitagliptin" is a medicine that is tolerated fairly well when taken by a patient, not only as monotherapy, but as part of a comprehensive treatment with other agents with hypoglycemic properties.
The main dose of the drug is excreted through the kidneys. This method of removing the active component from the human body requires a specialist to monitor the performance of this body if the patient had kidney failure before using the drug. If necessary, the dose taken is adjusted. If there is a mild form of kidney failure, the dose adjustment of the drug is not performed.
If a patient has moderate renal failure, the dosage of the medication should not be more than 50 milligrams per day. The drug can be used at any time, regardless of the procedure, such as dialysis.
When this drug is used as part of a complex treatment, to prevent the occurrence of sulfon-induced hypoglycemia in the patient's body, the amount of sulfonylurea derivatives to be taken must be reduced.
The dosage of the drugs used is determined by the attending physician as soon as a complete examination of the patient’s body suffering from the second type of diabetes is performed.
If there is a suspicion of the development of pancreatitis in the patient’s body, it is necessary to stop the use of “Sitagliptin” and other medicines that could potentially cause an exacerbation of the pathology.
Before using the drug, a specialist should inform the patient about the first specific signs of pancreatitis.
So it is said in the instructions for use to "Sitagliptin." Price, reviews and analogues will be presented below.
Contraindications
The use of this drug can cause a life-threatening, serious inflammation of the pancreas in the human body.
If the medicine is not used correctly, it can cause many side effects in the body. If the first symptoms of violations occur, you should immediately consult a specialist.
Use the drug in strict accordance with the instructions and in the correct amount prescribed by the attending physician.
When a drug is used, it must be taken into account that there is a whole range of various contraindications:
- the presence of the first type of diabetes;
- hypersensitivity;
- baby bearing time;
- diabetic ketoacidosis;
- breast-feeding;
- the patient's age is less than eighteen years.
Price and analogues are not indicated in the instructions for use with Sitagliptin.
Feasible side effects
During the use of the drug in humans, quite a few side effects can occur. Among them are noted:
- angioedema;
- itching
- anaphylaxis;
- pain in the limbs;
- rash;
- backache;
- skin vasculitis;
- arthralgia;
- hives;
- myalgia;
- exfoliative skin diseases, Stevens-Johnson syndrome;
- headache;
- acute pancreatitis;
- deterioration of kidney activity, insufficiency of this organ in acute form, which needs dialysis;
- constipation;
- nasopharyngitis;
- vomiting
- infections of the respiratory system.
When using the drug, it is necessary to strictly follow the recommendations in the instructions, you can not take it if you have at least one of the contraindications. If poisoning or an overdose occurs as a result of the use of the drug, you should immediately call an ambulance, since these negative phenomena can cause significant health problems that can even lead to death.
Possibility of complex application
Sitagliptin does not inhibit the activity of Rosiglitazone, Simvastatin, Metformin and Warfarin. It can be used by women who regularly use oral contraceptives. If it is prescribed in parallel with Dioxin, then the possibilities of the latter are slightly enhanced, however, such changes do not require dosage adjustment.
"Sitagliptin" is allowed to be used simultaneously with inhibitors (for example, with "Ketoconazole") and with cyclosporine. The effect of the drug in such situations is not critical and does not change the conditions of their use.
Since in the treatment of type 2 diabetes, a double load is made on the kidneys, choosing a complex of drugs, it is necessary to take into account their capabilities and condition.
Analogs
"Sitagliptin" is the international name of the drug, its trade synonym is "Januvia."
During clinical trials, medications based on sitagliptin did not have a significant and significant effect on the pharmacological kinetics of Rosiglitazon, Simvastatin, Metformin, oral contraceptives, Warfarin and Glibenclamide.
When using preparations based on sitagliptin, inhibition of CYP2C9, CYP3A4 and CYP2C8 isoenzymes does not occur. In addition, these drugs do not inhibit the following enzymes: CYP2C19, CYP1A2, CYP2B6 and CYP2D6. ”
The simultaneous use of Metformin and Sitagliptin does not bring significant changes in the pharmacokinetics of the active substance of the latter in diabetes mellitus.
Yanumet
The combined Yanumet can be considered an analog of Sitagliptinum Sitagliptin, it includes metformin and sitagliptin.
There is a drug with the same active substances - metformin and sitagliptin - this is Velmetia. Other analogues of "Yanumet" have a similar effect and ATC code:
- "Avandamet";
- Glibomet;
- Douglimax
- Tripride.
In accordance with the reviews of patients using these drugs for treatment, they significantly affect the sugar level in the human body, however, they require strict control of the condition due to the possible appearance of many side effects.
Price
The cost of the medicine depends on the packaging and region of the country. Varies between 1596-1724 rubles. The price of the analogue of Sitagliptin Yanumet is from 1680 rubles.
Reviews
According to reports on various forums, the drug is most often prescribed to diabetics at an early stage of pathology. The reviews of specialists and patients show that there are a large number of subtleties in using incretinomimetic.
"Sitagliptin" is a new generation drug, not all doctors have much experience in its use. Until recently, Metformin was widely used, but now Januvia is prescribed as monotherapy. With a sufficient number of possibilities, it is inappropriate to supplement it with such drugs as Metformin.
The analogue of "Sitagliptin" "Yanumet" is shown as an addition to the regime of physical activity and diet, contributing to a better control of glycemia in type 2 diabetes. Reviews about him are mostly positive. However, diabetics say that the drug and its analogues do not always meet all the requirements, its effectiveness decreases over time. The point here is not addiction, but in the characteristics of the disease: the second type of diabetes is a chronic pathology that is progressing.
We reviewed the drug “Sitagliptin” price, reviews and analogues.