The basis of the drug "Creon" is pancreatin, which, being a substance of natural origin, is a pancreatic juice . For the manufacture of medications that regulate digestion, the cause of which was caused by enzyme deficiency, we use medical pancreatin obtained from fragments of the pancreas of animals, in this case pigs. This drug is indicated for overeating, as well as in the presence of some digestive system dysfunctions.
What helps “Creon” is interesting to many.
The drug is an enzyme preparation that helps to improve the digestion process. It consists of pancreatic enzymes, which facilitate the breakdown of the main types of proteins, fats and carbohydrates, which contributes to their complete absorption in the small intestine. The drug is available in capsules that contain mini-microspheres coated with a special enteric coating. They quickly dissolve in the stomach cavity, whereby hundreds of mini-microspheres are released.
Release form "Creon"
The pharmacological form of the drug is enteric-soluble capsules: size No. 2, gelatinous, hard, with a brown opaque cap and a colorless transparent body. Content - light brown minimicrospheres (20, 50 and 100 pcs each in polyethylene bottles with a screw cap and control of the first opening, 1 bottle in a cardboard bundle).
According to the instructions, "Creon" contains pancreatin of porcine origin in the form of gelatin capsules, which are coated with an enteric coating that is resistant to acidic conditions. Minimicrospheres are released according to the multidose principle, which allows for better mixing of substances with the contents of the stomach, as well as transportation from it and distribution of enzymes. After minimicrospheres enter the small intestine, the capsule shell begins to dissolve quickly, after which enzymes with proteolytic, lipolytic and amylolytic activity are released, and this, in turn, ensures the complete breakdown of fats, proteins and carbohydrates, which are then absorbed either immediately or after further hydrolysis by intestinal enzymes. Instructions for "Creon" will be given below.
Clinical efficacy of a drug
In total, about fifty different studies of the effectiveness of this drug were carried out, and patients with diagnosed exocrine pancreatic insufficiency (ENPI) took part in the study of its effectiveness in the treatment of digestive diseases. Some of them were placebo-controlled or they used a comparison with the initial indicators. Such studies involved people with diagnoses of “cystic fibrosis”, “chronic pancreatitis” and patients after surgical procedures.
In all placebo-controlled studies of the action of "Creon" and its effectiveness in the treatment of various diseases, a predetermined goal was to prove the effectiveness of the drug compared to placebo, namely, the absorption coefficient of fat.
This indicator determines the percentage of fat that is absorbed into the body, and here was taken into account the initial consumption of fat and its excretion with feces. In placebo-controlled trials, the average value of this indicator was higher in those patients who took the drug "Creon". This was 85%, compared with the placebo group, where the rate was - 64.6%. Thus, in the course of all studies, the average value of this value at the end of the Creon therapy period was equal to the average value of the LEL for this medication, which was used during placebo-controlled trials.
During all studies, regardless of the type of disease, there was also an improvement in certain symptoms, for example, stool and its consistency became more frequent, flatulence was reduced.
The effectiveness of the drug in the treatment of children
This fact was demonstrated in 279 children from infancy to adolescence suffering from cystic fibrosis. In the course of all the studies, the average values of life expectancy at the end of the period of treatment with the drug were established, and such indicators significantly exceeded 85% in children of different age groups.
Let’s figure out how “Creon” helps?
Pharmacological properties of the drug
Scientific studies that were conducted on animals have not established signs of absorption of specific enzymes in unchanged forms, therefore, classical pharmacological studies have not been conducted. Pancreatic enzymes do not require absorption to achieve a therapeutic effect. On the contrary, their most effective effect is observed in the lumen of the gastrointestinal. Even more, as a certain type of protein, they undergo the so-called “proteolytic” digestion, during passage through the digestive tract, before being absorbed in the form of amino acids and peptides.
The data of the studies do not indicate a specific acute, chronic or subchronic toxicity of these enzymes. Studies on carcinogenicity, genotoxicity, or on toxic effects on human reproductive functions have not been conducted.
Indications "Creon 10000"
The treatment of exocrine disorders and pancreatic insufficiency of people of different age groups, which are caused by the presence of various diseases, involves the appointment of a medication in the diagnosis of the following diseases:
- Cystic fibrosis.
- Pancreatectomy
- Chronic pancreatitis.
- Oncological neoplasms in the pancreas.
- Gastrectomy
- Surgical interventions using the gastrointestinal anastomosis (Billroth gastroenterostomy 2).
- Schwachmann-Diamond syndrome.
- Obstruction of pancreatic or common bile ducts.
- Conditions after attacks of acute pancreatitis during the restoration of oral or enteral nutrition.
Application methods
According to the instructions for "Creon", the dosage of this drug is usually based on the individual needs of the patient and may depend on the severity of a particular pathological process, as well as on the composition of the food used. It is recommended to take the “Creon” medicine immediately after eating or during meals.
Capsules and minimicrospherical granules must be swallowed whole without chewing them and without breaking the containment. They should be washed down with a sufficient amount of water or other liquid. If the patient has difficulty swallowing the capsule as a whole, which is often observed in childhood and old age, you can carefully open it and mix the minimicrospherical granules with soft food that does not require chewing, for example, fruit puree, or a liquid having an acidic environment, for example, orange or apple juice, kefir, or drinking yogurt. This is confirmed by the "Creon" instruction. This is especially important for children.
This mixture is not to be stored. The breaking or grinding of minimicrospherical granules or their addition to food sometimes contributes to the destruction of their protective intestinal membranes, which leads to the premature release of the enzymes contained in their mouth, and this, in turn, provokes a decrease in the effectiveness of the drug and can irritate the mucous membrane of the oral cavity. After taking the drug in this form, you must carefully rinse your mouth to remove particles of the drug.
During treatment with the “Creon” medication, which is available in various dosages in the pharmacy network, it is very important to use a sufficient amount of fluid, especially in cases where there is a period of increased loss, for example, with chronic or symptomatic diarrhea, since there is a water deficiency in the body may aggravate constipation and lead to other serious complications.
Dosage for cystic fibrosis
How long should I take Creon?
The duration of the courses is determined by the doctor. This is influenced by the cause and speed of achieving the result. Sometimes it is difficult to limit course assignment and supportive therapy is required, but only if the abnormalities of the cavity digestion are secondary (not pathology of the pancreas). Enzymes are used for symptomatic purposes until clinical and laboratory signs disappear. Long-term use can cause addiction (the development of lazy pancreas syndrome).
Based on the main recommendations of the Coordinating Conference on the study and treatment of this disease, as well as on the basis of placebo-controlled studies, the following methods of dosing this drug in cases of replacement treatment with pancreatic enzymes were determined:
- The initial dose in childhood (up to 5 years) is usually 1000 units. lipases per kilogram of body weight of the child during all meals, and in the treatment of diseases in children aged 5 years and over, the dose of the drug is 500 units. lipases per kilogram of total body weight.
- The dosage of "Creon" for adults must be selected strictly individually, which should correspond to the severity of the disease and control of steatorrhea.
- The prophylactic dose for the bulk of patients should not exceed 10,000 units. lipases per kilogram of total body weight per day or 5000 units. lipases per kilogram of edible fat.
Dosages for other types of exocrine disorders and pancreatic insufficiency are also individual and depend on the degree of diseases of the digestive system, as well as the fat composition of the consumed products. During meals, the necessary dose is considered to be 30,000-70000 units. lipase, or half a similar dose in the implementation of a light snack.
Consider the main contraindications of "Creon".
Contraindications to the use of the medication
The main contraindication in this case is the increased sensitivity of the patient's body to the active substances of the drug or to substances that perform auxiliary functions in it.
Side effects
In the course of scientific trials, the influence of the “Creon” medical preparation was observed using more than 900 patients undergoing treatment with this agent as an example. The most frequent negative manifestation from its intake was a certain disorder of the digestive system, which ranged from mild to moderate.
This is confirmed by the instruction. For children, “Creon” most often works well, but there are exceptions.
Adverse reactions identified in the course of clinical trials, as well as their frequency:
- From the digestive tract: abdominal pain, nausea, vomiting, constipation, flatulence symptoms, diarrhea; narrowing of the ileocecal sections of the intestine, especially the colon - the so-called "fibrosing colonopathy." However, similar symptoms could be associated with a history of diseases.
- From the skin, as well as subcutaneous tissue, various rashes, itching, urticaria.
- On the part of the immune system - hypersensitivity, anaphylactic reactions.
- There are also some reports of narrowing of the ileocecal sections of the intestine, in particular the colon in patients with a diagnosis of cystic fibrosis who took the drug in high doses.
Side effects in children
Specific adverse reactions in children when studying the clinical picture while taking a medication have not been established. The frequency and severity of adverse events occurring in such cases in childhood were the same as in adult patients.
special instructions
As a precaution to avoid the occurrence of undesirable side effects, it is recommended to seek the advice of a specialist, especially in order to exclude the development of fibrosing colonopathy, in cases where a sick patient takes more than 20,000 units. drug per day.
Analogues of "Creon" should be selected by a doctor.
Analogues of the drug
Today on the pharmacological market there is a huge variety of therapeutic drugs that have an effect similar to the “Creon” remedy. These medicines include:
- "Panzinorm forte";
- Mezim Forte;
- "Pangrol";
- "Pankrelipaza";
- Gastenorm forte;
- Pancreasim
- Enzistal-P;
- "Pancytrate";
- "Pancreatin LekT";
- "PanziKam";
- Pancreatin forte;
- Penzital;
- Panzim Forte;
- Gastenorm forte;
- "Festal N";
- Mikrazim;
- The Hermitage.
Analogues of “Creon” are absolutely not inferior in terms of effectiveness to the means described by us.
Other drug information
Like all the main medicines of pig origin, which are provided on the market of medicines, the drug "Creon" is made from the tissues of the pancreas of pigs, which are intended for food purposes. The risks that a causative agent of any dangerous infection will enter the human body along with a medical device are minimized by testing and corresponding deactivation of specific viruses and bacteria during the manufacturing process. However, there is some theoretical risk of transmission of such infections, including those caused by new, still unstudied, viruses. The appearance of swine viruses and other infections that can affect the human body is absolutely inexpedient to rule out.
However, to date, no such cases of transmission of infectious diseases as a result of the use of drugs derived from porcine pancreatin have been recorded, especially given that they have been used for a very long period of time.
The drug must be taken with extreme caution in the treatment of patients who have kidney failure, hyperuricemia, as well as the occurrence of allergic reactions to the presence of proteins of porcine origin.
Patient reviews of "Creon" consider below.
The use of the drug during pregnancy and lactation
Due to the fact that there are no clinical studies regarding the effects of the enzymes that make up the drug on the body of pregnant women, this medicine should be used with caution in these cases. Animal tests showed that signs of enzyme absorption were also absent. Therefore, the possibility of toxic effects on fetal development and reproductive function is not expected. The same applies to women in lactation. What else does the instruction for Creon tell us?
The effect of the drug on the psychomotor functions of the body
The drug, as shown by numerous chemical studies of its main active substance, is not able to affect the speed of psychomotor reactions in humans. In connection with this fact, driving a vehicle or other mechanism at the stage of taking this medication is not contraindicated.
Overdose and able to eliminate it
There are some reports that during treatment with large doses of the drug "Creon" there were cases of hyperuricosuria and hyperuricemia.
Reviews
Reviews on this drug are mostly positive. It is effective, the result of therapy becomes quickly noticeable, lasts a long time. His body most often normally tolerates it, rarely there are adverse reactions.
It suits even small children, which especially pleases mothers.