How many times a day can I drink Nimesil? We will understand in this article. It is an anti-inflammatory non-steroidal drug that belongs to the class of sulfonamides. It is able to have anti-inflammatory, analgesic and antipyretic effects. Often used when toothaches and pains appear on the background of injuries.
Structure
In the composition of the drug, nimesulide is used as the main active component. In one sachet of the drug contains 100 mg of active substance. As additional components, maltodextrin, citric acid, sucrose and orange flavoring are present. How to drink "Nimesil"? The instructions contain such information.
Drug release form
Nimesil is produced by the manufacturer in the form of granules, which are intended for the preparation of an oral suspension. The granules are light yellow in color and have an orange aroma. The granules of the drug are packed in paper bags of two grams. Each cardboard packaging can contain 9, 15 or 30 sachets. How many times a day you can drink Nimesil is interesting to many.
Pharmacodynamics and pharmacokinetics
"Nimesil" refers to the group of sulfonamides, is a non-steroidal anti-inflammatory drug. It has analgesic, antipyretic, anti-inflammatory effects. Nimesulide in the composition of the drug is able to block the second type cyclooxygenase, which is responsible for the synthesis of prostaglandins.
After oral administration, the drug is well absorbed in the intestine. The highest concentration in the blood is observed after 3 hours. 97.5% bound to plasma proteins. The average half-life of the main substance is up to 5 hours. Nimesulide is able to quickly penetrate histohematological barriers.
Biotransformation under the influence of cytochrome P450 occurs in the liver. The result is the formation of an active metabolite, hydroxy-nimesulide, which in glucuronidated form is excreted together with bile. About half of the dose taken is excreted from the body by the kidneys. It is important to find out in advance how to drink Nimesil according to the instructions.
Indications for taking the drug
"Nimesil" is intended for symptomatic therapy, relief of pain and inflammation at the time of administration. The use of Nimesil is shown in the following cases:
- Symptomatic treatment of a pain syndrome arising against the background of osteoarthrosis.
- Algodismenorea.
- Relief of acute painful sensations, including toothache, back and lower back pain arising from bursitis, dislocation, sprain, tendonitis, trauma.
Many people wonder how many times a day you can drink Nimesil. About it further.
Contraindications to taking the medication
Nimesil is contraindicated in the following cases:
- With hypersensitivity to any component that is part of the drug.
- Under the age of 12 years.
- During pregnancy.
- During lactation.
- With drug addiction or alcoholism.
- With renal failure.
- If there are diagnosed liver diseases.
- With hyperkalemia, decompensated renal failure.
- With severe coagulation disorders.
- If decompensated heart failure is observed.
- With bleeding that has cerebrovascular or other localization, with diseases that are accompanied by pathological bleeding.
- If the patient has nasal polyposis and bronchial asthma in combination with intolerance to non-steroidal drugs against inflammation.
- With peptic ulcer during exacerbation, with perforation or bleeding in the digestive tract.
- If the temperature increase is caused by diseases that have an infectious-inflammatory etymology.
- With inflammatory bowel pathologies, for example, with Crohn's disease or ulcerative colitis.
- After a coronary artery bypass grafting.
- When conducting complex therapy using medicines that have hepatotoxicity.
- With rhinitis, urticaria, bronchospasm, which are associated with the use of acetylsalicylic acid or other non-steroidal drugs against inflammation.
- If there is a history of data on hepatotoxic reactions that were caused by nimesulide.
The instructions for use also contain information about how many days to drink Nimesil and that it should be prescribed with caution to patients suffering from decompensated somatic diseases, severe forms of type II diabetes, coronary artery disease, hypertension, heart failure cerebrovascular diseases, dyslipidemia, peripheral artery disease. Also, the drug should be administered under the supervision of a doctor if the patient is old, has an infection associated with helicobacterpylori, has been using non-steroidal anti-inflammatory drugs for a long time, smokes, takes anticoagulants, oral glucocorticosteroids, antiplatelet agents, selective serotonin reuptake blockers.
Next, it will be considered how many days you can drink Nimesil so that there are no side effects.
Side effects from the use of the drug
"Nimesil" is often used in case of toothache and headache, during colds, with painful menstruation in women. In this case, some negative effects of nimesulide may occur:
- Allergic reactions. It is not excluded the development of Lyell syndrome, Stevens-Johnson syndrome. Angioedema, polymorphic erythema, urticaria, dermatitis, erythema, pruritus, rash, sweating, anaphylactoid reactions may occur.
- Hematopoiesis. The appearance of thrombocytopenic purpura, hemorrhagic syndrome, thrombocytopenia, anemia, pacitopenia, eosinophilia is not ruled out.
- Visual impairment. Sometimes patients note blurred vision.
- Circulatory disorders. Sudden changes in blood pressure, arterial hypertension, tachycardia, hot flashes can occur.
- Disorders on the part of the National Assembly in the form of encephalopathy, nervousness, drowsiness, nightmare nightmares, headache, dizziness, feelings of fear.
- From the gastrointestinal tract: jaundice, cholestasis, elevated liver enzymes, hepatitis, ulcer or perforation of the duodenum, gastric ulcer or perforation, gastrointestinal bleeding, stomatitis, stool disorders, dyspepsia, gastritis, abdominal pain, constipation, flatulence, diarrhea, vomiting and nausea.
- Respiratory organs can respond by shortness of breath, asthma attacks.
- Genitourinary system: interstitial nephritis, oliguria, dysuria, urinary retention, hematuria, renal failure.
In addition, the patient may experience hypothermia, general malaise, asthenia, hyperkalemia.
So, let's figure out how many times a day you can drink "Nimesil."
Dosage and route of administration of the drug
Granules must be placed in a glass and diluted with water in an amount of 100 ml. It is impossible to store the prepared solution, it should be taken in the very near future. Dissolve the drug granules in plain, warm, boiled water. This is indicated in the instructions for use.
How to drink "Nimesil"? The suspension prepared from the powder should be taken orally twice a day after meals, one sachet. The maximum duration of treatment can be two weeks. To reduce the likelihood of cork effects, you should use the smallest dosage, which has the desired effect, for a minimum period of time.
How many times can I drink Nimesil? 1 sachet every 12 hours is the usual dosage. Use this medicine, as well as any drugs based on nimesulide, can be children from 12 years old. The dosage is standard. Dose adjustment when taking Nimesil in patients with renal failure is not required. When using the medication in elderly patients, the doctor needs to adjust the dose of the drug taking into account the likelihood of interaction of nimesulide with other drugs taken.
It is important to find out how many days you can drink Nimesil so that there is no overdose.
Drug overdose
The first signs of an overdose of the drug are epigastric pain, nausea, apathy, drowsiness, and vomiting. Bleeding in the digestive tract is not excluded. In rare cases, there may be an increase in blood pressure, acute renal failure, anaphylactoid reactions, respiratory depression, coma.
In case of an overdose of nimesulide, symptomatic therapy is indicated. There is currently no selective antidote. Within 4 hours from the moment of an overdose, the patient should undergo gastric lavage, ensure that drugs of the enterosorbent group are taken (this can be either activated carbon or osmotic laxative). In the near future after an overdose, monitoring of liver and kidney functions is necessary.
Interaction of Nimesil with other medicines
The concomitant use of Nimesil and glucocorticosteroids can increase the likelihood of developing an ulcer or the appearance of gastric or intestinal bleeding.
The concurrent use of nimesulide and selective serotonin reuptake inhibitors, as well as antiplatelet agents, increases the risk of intestinal and stomach bleeding.
The effect of anticoagulants when taken with anti-inflammatory non-steroid drugs is enhanced. Therefore, in patients with severe coagulation disorders, such combinations are not recommended. In the case when such a combination is necessary, carefully monitor the indicators of blood coagulation.
The effect of diuretics when taken with anti-inflammatory non-steroidal agents weakens.
Why else do you need to know how to drink Nimesil? Drugs based on nimesulide are able to temporarily reduce the evacuation of potassium and sodium under the action of "Furosemide." As a result, the diuretic effect of the latter weakens. It must be remembered that such combinations of drugs for use in persons with impaired heart and kidney function should be prescribed with caution.
Non-steroidal anti-inflammatory drugs can also worsen the therapeutic effect of antihypertensive drugs. If nimesulide is taken by people with compensated impaired renal function simultaneously with ACE blockers, type II angiotensin receptor antagonists, and cyclooxygenase suppressants, the development of acute renal failure and impaired renal function are possible.
Nonsteroidal anti-inflammatory drugs can reduce lithium clearance. As a result, there is an increase in its level in the blood. How many times to drink "Nimesil" per day, you can also check with your doctor.
Caution should be taken during the day before and after taking Methotrexate. This is due to the fact that the toxic effect of the latter is greatly increased.
Special instructions for taking the medication
The risk of side effects while taking Nimesil can be minimized by using it at the minimum therapeutic dosages for a minimum short period.
Drugs based on nimesulide should be taken with caution to persons with a history of gastrointestinal disease, since an exacerbation of these pathologies may occur.
Due to the fact that the drug is partially excreted by the kidneys, it is necessary to reduce the dosage of the medication depending on the volume of urine excreted in people suffering from impaired renal function.
You should immediately stop taking the medicine and seek the advice of a specialist if the primary symptoms of liver damage appear, for example, urine darkens, abdominal pains, nausea and vomiting appear, and the skin turns yellow.
In case of any visual impairment during administration, an examination should be carried out by an ophthalmologist. How many times a day you can drink Nimesil, we found out.
Nimesulide is able to retain fluid in the body, therefore, people with heart disease and high blood pressure should take it with caution.
If signs of infection with an acute respiratory infection appear during treatment with the drug, discontinue use of the drug immediately.
The simultaneous administration of the drug with other non-steroidal anti-inflammatory drugs should be excluded.
Nimesil and other nimesulide-based medicines can affect platelet characteristics. This necessitates the careful use of the drug in patients with hemorrhagic diathesis. It must be remembered that a medication cannot replace the preventive action of acetylsalicylic acid in pathologies of the circulatory system.
How much can Nimesil drink for pregnant and lactating women? Use of the drug is prohibited for pregnant women and during lactation. This is due to the ability of the drug to adversely affect the course of pregnancy, the process of development of the child.
Drug Analogs
The following medicines belong to Nimesil's analogs: Taro-Sanovel, Sulidin, Remesulid, Pansulid, Nimuspaz, Nimulid, Nimujet, Nimid, Nimesulide, Nimegesic , "Nigan", "Nise", "Mesulide", "Affida Fort", "Aponil", "Ameolin", "Sigan", "Chondroitin sulfate", "Diacerein".
As a rule, the analogues of "Nimesil" have a lower cost than the described tool. However, it is important to remember that any replacement of one drug with another should be done only after consulting with your doctor.
The cost of "Nimesil"
Packaging "Nimesil", containing 9 bags of powder for the preparation of the suspension, costs an average of 620 rubles. Thus, the price of one sachet fluctuates at the level of 25-30 rubles. How much to drink "Nimesil" in conjunction with alcohol? About it below.
Drug Compatibility with Alcohol
Drugs that include nimesulide and alcohol are incompatible. This is due to the high hepatotoxicity of both substances. With the simultaneous administration of Nimesil and alcohol, severe liver function disorders and irreversible consequences can occur, especially if the patient already has diseases of the hepatobiliary system.
Now we know how much you can drink "Nimesil" per day. Consider the reviews about this tool.
Drug Reviews
Nimesil powder is widely used in case of toothache or other pain (with injuries or algodismenorea). Patients report that the drug in this case is very effective, and undesirable consequences are very rare.
Doctors also respond positively to Nimesil, as nimesulide effectively relieves traumatic pains and pains localized in the musculoskeletal system. Nevertheless, it is important to remember that nimesulide has increased hepatotoxicity, and therefore its use is prohibited in several countries. Anyway, when choosing an anti-inflammatory drug, one should not rely on reviews, but on the recommendations of the attending physician. Only a competent doctor is able to choose a medicine, taking into account the characteristics of the health and body of a patient.
We examined how many times to drink "Nimesil" per day. The main thing is to do it correctly and strictly adhere to the instructions.