The most common disease among the adult population is hypertension. The causes of high blood pressure are very diverse. At such moments, a person feels headaches, a feeling of tiredness, may be nausea or vomiting. Fighting such a condition is vital. After all, the consequences of high blood pressure are a stroke, a heart attack. Therefore, along with the elimination of the causes, it is necessary to use drugs that lower blood pressure. One of these drugs is Lisinopril. What are these pills from? How they are used, how they work, and also what analogues of this drug exist, we will consider further.
In what form is Lisinopril produced?
In what form is Lisinopril produced? Release form - tablets. They are flat shaped, round, with a risk on one side. Depending on how much active substance is contained in lisinopril dihydrate, tablets have a different color:
- Dark orange color - active substance 2.5 mg.
- Orange - 5 mg.
- Pink color - 10 mg.
- White - 20 mg.
The auxiliary components are as follows:
- lactose monohydrate;
- corn starch;
- methylene chloride;
- povidone;
- magnesium stearate;
- dye.
How does lisinopril act on the body?
The drug "Lisinopril" has the following effects:
- Lowers blood pressure.
- Able to narrow blood vessels.
- Prevents heart remodeling processes.
- Prevents the development of ischemia.
- Increases the excretion of sodium ions from the body.
The active substance lisinopril dihydrate inhibits the transition of angiotensin 1 to angiotensin 2, this helps to reduce the formation of the hormone aldosterone. The process of biosynthesis of prostaglandins is also stimulated.
The drug begins to act after administration after 1 hour. After 6-7 hours, the drug is maximized. With regular use of the drug "Lisinopril" therapeutic effect will be visible after a few days. A lasting positive effect will be achieved if you take it for at least two months.
For the drug "Lisinopril" (tablets), the instructions for use indicate that no more than 60% of the drug substance is absorbed in the digestive tract. The bioavailability of the active substance is 25%. The elimination half-life averages 12 hours.
Who is prescribed Lisinopril?
Tablets "Lisinopril" indications for use are as follows:
- High blood pressure.
- Problems in the work of the heart.
- An early stage of myocardial infarction.
- Diabetic nephropathy.
Pills for pressure "Lisinopril" are more effective in combination therapy and preventive measures. In combination with antihypertensive agents, they achieve good and stable results
We found out the composition of the drug "Lisinopril", from which these tablets and to whom they are prescribed. Of course, the drug of this action has contraindications for use.
Who should not use Lisinopril?
Who should not take Lisinopril (tablets)? Instructions for use indicate the following diagnosed diseases:
- Special sensitivity, intolerance to the components of the drug.
- Lactose intolerance.
- Angioneurotic or idiopathic edema.
- Intolerance to ACE inhibitors.
Also, you can not use the drug "Lisinopril" in patients whose age is less than 18 years.
Especially careful tablets from pressure increased "Lisinopril" should be taken:
- To old people;
- patients with diabetes;
- with coronary heart disease;
- in the presence of systemic diseases;
- if there are kidney diseases;
- with insufficient cerebral circulation;
- in the presence of chronic heart failure.
How to take Lisinopril tablets?
Take "Lisinopril" is necessary 1 time per day. It is recommended to do this at the beginning of the day. Drink plenty of fluids.
If you take Lisinopril tablets (indications for use are described above), then the recommended regimen is as follows:
- For the treatment of diabetic nephropathy, the initial dosage should be the minimum of that which is "Lisinopril" (tablets). 10 mg per day is the best option. Further, it is possible to increase the dose to 20 mg.
- With essential hypertension, the initial dose is 10 mg. For maintenance therapy, 20 mg, and the maximum is 40 mg. It should be borne in mind that a persistent effect will be observed after 1-2 months. If the patient takes diuretics, they will have to be canceled 2-3 days before the start of the course with Lisinopril.
- In case of chronic heart failure, “Lisinopril” tablets are used. Use begins with a dose of 2.5 mg and is gradually increased over 3-5 days to a maintenance dose of 5-10 mg per day. In this case, the dosage of the diuretic must be reduced.
- Renovascular hypertension is treated with an initial dose of 2.5-5 mg per day. In this case, it is necessary to control blood pressure and kidney function. Given these indicators, it is necessary to choose a maintenance dose of the drug.
Possible side effects
In any case, it is worth taking the Lisinopril tablets carefully. The instruction indicates the occurrence of possible side effects:
- headaches, dizziness;
- nausea, diarrhea;
- fast fatiguability;
- dry cough.
Very rarely observed such side effects of the drug:
- Drowsiness, confusion.
- Chest pain, shortness of breath, bronchospasm.
- Bradycardia
- A sudden drop in blood pressure.
- Increased sweating.
- Muscle pain, tremors, cramps.
- Excessive hair loss.
- Hypersensitivity to ultraviolet radiation.
- Allergic reactions.
- Change in blood counts.
Before using the drug, consult your doctor. He will choose the right dosage for you. This will help reduce the risk of side effects.
The use of "Lisinopril" for children and pregnant women
Pressure pills "Lisinopril" is not used to treat children and adolescents who have not reached 18 years of age. Because their effect on the children's body is not fully understood.
Pregnant women and during lactation "Lisinopril" is not prescribed. Since the drug can affect the development of the fetus, its death is possible. During lactation, it is assumed that the drug can pass into breast milk.
Lisinopril and alcohol
It should be noted that if you take Lisinopril, you should completely eliminate the use of drinks that contain ethyl alcohol. "Lisinopril" enhances the toxic effect of alcohol.
Special instructions for the use of "Lisinopril"
There are some features when taking the drug "Lisinopril."
During therapy, it is necessary to regularly monitor the functioning of the kidneys. It is necessary to make up for the loss of fluid and salts before taking the drug.
Excessive moisture loss after taking diuretics, a salt-free diet, or vomiting can cause arterial hypotension. Particular attention should be paid to patients who have impaired renal function, as well as renal artery stenosis, severe congestive heart failure.
You can not take "Lisinopril" with cardiogenic shock and acute myocardial infarction.
If angioedema occurs during treatment with Lisinopril, treatment should be discontinued and patient monitoring should be established.
Care must be taken in the treatment of elderly patients, as very often they have intolerance to "Lisinopril."
When taking the drug, it is not necessary to engage in intense physical activity in hot weather, this can contribute to a sharp drop in blood pressure.
If side effects occur in the form of dizziness, lethargy, or a deterioration in the concentration of attention, then you should refuse to drive transport and work that requires increased attention.
Lizinopril-ratiopharm tablets are absorbed in their own way. The instruction notes that the active substance is not biotransformed in the liver, therefore, it can be prescribed to patients with impaired liver function.
How does lisinopril interact with other drugs?
Consider how "Lisinopril" simultaneously works with some drugs:
- Joint use with oral hypoglycemic and insulin can contribute to the development of hypoglycemia.
- With the simultaneous use of the drug with lithium carbonate, intoxication of the body with lithium increases.
- The therapeutic effect of "Lisinopril" is reduced when taken with adrenergic agonists and non-steroidal anti-inflammatory drugs.
- Salicylic acid enhances its neurotoxic effect.
- Birth control pills are becoming less effective.
- Diuretic potassium-sparing drugs together with "Lisinopril" can cause the development of hyperkalemia.
- The simultaneous use of ACE inhibitors and NSAIDs increases the risk of impaired renal function.
- "Lisinopril" in combination with cardiac glycosides can enhance the side effects of these drugs.
Gold preparations in combination with Lisinopril can lead to the development of facial hyperemia, decreased blood pressure, vomiting and nausea.
Symptoms of an overdose of "Lisinopril"
If you are taking the drug "Lisinopril", from which these tablets must be known and the recommended dosage should be observed.
In case of an overdose, the following symptoms are observed:
- severe tiredness;
- drowsiness;
- dry mouth
- blood pressure drops significantly;
- violation of urination;
- tachycardia, bradycardia;
- anxiety.
In such cases, symptomatic therapy is used. Perhaps the appointment of intravenous saline, the use of hemodialysis. When angioneurotic edema appears, antihistamines are used. With persistent bradycardia, electrical stimulation is performed.
In the case of using the drug "Lisinopril", it is necessary to control the performance of vital organs, as well as the concentration of serum electrolytes and keratin.
Analogues of the drug "Lisinopril"
If you cannot find Lisinopril tablets in the pharmacy, the drug’s analogues will help you replace it. These drugs have a practically similar composition with the same active substance.
These are drugs such as:
- Dapril;
- "Equator";
- Diroton
- Lizitar
- Diropress;
- Lysacard
- Lisinopril Huxl;
- "Lizonorm";
- "Liten."
Before you buy an analogue of the drug, consult your doctor. And also specify what dosage of analog you need to use.
Reviews on the drug "Lisinopril"
Pills for pressure "Lisinopril" reviews are very different. Patients note that a decrease in blood pressure occurs gradually, without sharp jumps. Many are satisfied that for a long time they could not pick up the drug for high blood pressure, and only after the appointment of "Lisinopril" it returned to normal.
Many patients note the absence of side effects even after a long course of therapy. Blood pressure remains within normal limits, even if you take the drug once a day.
Also, Lisinopril tablets receive reviews about the manifestation of side effects. Most often, patients note the appearance of a dry cough if the drug has to be taken for several months.
There is also a category of patients to whom the drug “Linsinopril” did not fit. But there are much fewer than those to whom this medicine helped to feel better.
It is worth noting that drugs to lower blood pressure must be taken strictly after consulting a doctor. It is not always possible to find an active drug the first time. But only by the selection method, together with the doctor, keeping under control your health and observing how your body reacts to the new drug, you can find the most effective medicine. It is in this case that you will be able to choose the optimal treatment regimen and drug that will not harm your body.
If you have been prescribed the drug "Lisinopril", why these pills and how to take them should be explained only to the doctor, and be sure to read the instructions before use. Self-medication with high blood pressure will not lead to anything good. Follow the recommendations of specialists and be healthy.