The article discusses the medication "Buserelin" instructions for use and reviews of doctors. This drug is a synthetic analogue of the hormone, which is one of the antitumor. The drug has anti-estrogenic and antiandrogenic effects. Such medicines are currently widely used in the treatment of malignant neoplasms.
Reviews about "Buserelin" and patients, and doctors are available in large numbers.
Composition and release forms
The medicine is produced in the following forms:
- metered-dose nasal spray (dark glass vials of 17.5 milliliters with a metering pump-stopper);
- Buserelin-Depot solution for administration under the skin of 0.1 or 0.5 milligrams per milliliter (ampoules of one milliliter, packaged in 7, 5 or 1 piece).
The active substance of the spray is buserelin acetate. Auxiliary components of the spray: benzalkonium chloride, injection water. Auxiliary ingredients of the solution are sodium chloride and injection water. Reviews about Buserelin Depot are mostly positive.
The effect of the drug on the body
The drug "Buserelin" inhibits the production of its own gonadotropic hormones by the pituitary gland, reduces the degree of female and male hormones, and acts against tumors. This drug combines with cellular receptors on the anterior pituitary lobe and stimulates an increased amount of sex hormones in the human body. After two weeks of therapy, a marked decrease in the production of sex hormones is observed in patients.
For example, the concentration of estrogen in women is compared with indicators in the postmenopausal period, in men, the amount of testosterone is reduced by 90-95%. It was determined that continuous therapy of a man with this drug in two to three weeks causes a state of āpharmacological castrationā. Its highest concentration in the body is observed after 2-3 hours with intramuscular injection. The drug remains for four weeks at a concentration that is necessary for effective therapy.
The main active ingredient of this drug is buserelin acetate. Patient reviews about Buserelin are presented at the end of the article.
At the very beginning of the treatment course, gonadotropins are released in the patient, which leads to a short-term increase in the content of sex hormones. At the end of the second week of treatment, the gonadotropic pituitary function is blocked, due to this, the production of luteinizing and follicle-stimulating hormones stops. At the same time, the production of sex hormones is suppressed. It is depressed depending on the patientās gender or testosterone production, or estrogen synthesis. In women, as a result, āmedical pseudomenopauseā is achieved, in men, the effect of ācastrationā.
Every day, the use of Buserelin for a long time, for example, in the treatment of prostate cancer, causes a significant decrease in the concentration of testosterone in the male body. It was found that it is dihydrotestosterone and testosterone that affect the growth of prostate cells, including pathogenic ones. That is why the use of the drug in many situations is justified in the treatment of men with cancer. Reviews of patients who have undergone treatment with Buserelin should be read in advance.
The drug has a reversible effect. After completing the treatment course, the concentration of estrogen and testosterone gradually returns to normal. The drug can be prescribed for endometriosis in the period before surgery. In this case, it will reduce pathological foci and suppress their blood supply, reduce the intensity of manifestations of inflammatory phenomena in the affected area. The use of Buserelin, according to patients, reduces the number of relapses, as well as the severity of the formation of adhesions.
Indications for use
For the use of Buserelin, a common indication is the pathology of the reproductive system, dependent on hormones that were caused by relative or absolute hyperestrogenia. This condition is noted by an increased degree of estrogen, due to which there is a hormonal imbalance, the functioning of many organs is disrupted. These diseases are uterine fibroids, infertility during IVF, endometriosis in the pre- and postoperative period with the aim of reducing recurrence, breast cancer, hormone-dependent prostate cancer, endometrial hyperplasia.
The drug for endometriosis
The amount of estrogen in endometriosis depends on the severity of the symptoms of the disease. Buserelin is one of the drugs that suppress hypothalamic releasing factors, which creates the conditions for reducing estrogen synthesis. Specialists use the following varieties of this drug: the forms of "Depot" and "Long", "Goserelin." The use of each of them provides a stable therapeutic effect, however, the most positive reviews for endometriosis about Buserelin are original.
It has several advantages:
- does not cause disruption of the digestive organs, liver and kidneys;
- does not affect body weight;
- easy to use - injections are done monthly;
- does not increase hormones with androgenic effects, that is, seborrhea, hirsutism and acne will not appear;
- does not negatively affect metabolism.
From infertility
The drug can also be used in the treatment of infertility. It is administered before hyperstimulation on days 2 or 21-24 of a woman's cycle. After suppression of the pituitary function (this is evidenced by a low estrogen content (at least 50%)), the patient is prescribed a certain amount of gonadotropins to stimulate ovulation. This treatment technique increases the chances of pregnancy. She needs to monitor the degree of estradiol. The woman is periodically given ultrasound monitoring.
Fibroid therapy
Myoma is a benign tumor in the uterine muscle layer, that is, in the myometrium. This is one of the most common gynecological diseases. The effect of the drug in this case is to reduce the growth of the neoplasm, depending on the hormonal background. During the treatment of fibroids, the medication has several advantages:
- preservation of the function of childbearing and the main reproductive organ;
- accelerated therapeutic effect;
- to get a positive result, you need one injection.
Reviews about Buserelin Depot confirm this.
Dosage and route of administration
During the treatment of uterine fibroids, foci of endometriosis, as well as tissue hyperplastic processes, the drug must be sprayed into the nasal passages in an amount of 900 mcg per day. With a single press, 150 mcg of the drug is injected. āBuserelinā in the required dosage is sprayed into the nasal passage once every three times a day, it is necessary to take breaks for 6-8 hours. Treatment begins on the 1-2nd day of the menstrual cycle. The duration of the course is usually four to six months. During infertility therapy with IVF, the drug is used intranasally in each nostril in an amount of 150 mcg. The daily dose is from 900 to 1200 mcg. Therapy is prescribed on the 21-24th or 2nd day of a woman's cycle before IVF.
special instructions
With the use of this drug, first of all, you need to be careful for those who suffer from various types of depression. In this case, therapy necessarily requires careful monitoring by a specialist.
During treatment, the patient must take into account the possibility of the appearance of ovarian cysts. Caution should be exercised with the drug in patients who use contact lenses, since the appearance of symptoms of irritation is possible. When the first treatment course is completed, it is necessary to compare the intended benefit and the possible likelihood of osteoporosis, only after that, if necessary, take a second course.
If the drug is used in the form of a nasal spray, irritation may appear on the mucosa, less commonly bleeding.
There are no contraindications for rhinitis, however, before use, it is necessary to clean the nasal passages. When using Buserelin at the same time as surgery for endometriosis, the size of the affected lesion decreases, their blood supply decreases, inflammatory manifestations are suppressed, the time of surgical intervention is reduced, as well as the duration of postoperative treatment.
Before starting treatment, women need to exclude the presence of pregnancy. When using contraceptive hormonal drugs, they should be canceled. In the first two months of therapy with this drug, non-hormonal contraceptives should be used.
During treatment, caution should be exercised when performing various tasks that require increased concentration of attention and a quick reaction, as well as when driving vehicles. Such classes are not contraindicated, but you need to monitor your well-being.
With simultaneous use with other drugs that have sex hormones in their composition, ovarian hyperstimulation syndrome may appear. Reviews about the treatment with Buserelin are of interest to many.
Pregnancy Use
Pregnancy before treatment should be excluded, the use of hormonal contraceptives is suspended. During the bearing of the baby, this medication is contraindicated. When pregnancy occurs, the medicine is immediately canceled.
If there is a need for its use during breastfeeding, lactation should be discontinued. This is stated in the instructions for use. According to reviews, Buserelin is very effective.
In childhood
There is no reliable information on the use of the drug in pediatrics. This is explained by the fact that the diseases in which it is used are most often diagnosed in adult patients. In addition, hormonal drugs are strong, and therefore less aggressive medications are used in pediatrics. Although children's age is not indicated as a contraindication for use, the drug cannot be used to treat children.
Doctors' feedback on Buserelin will also be presented.
Buserelin and spirits
The manufacturer does not describe the likely consequences of taking alcohol on the background of Buserelin therapy, but doctors still advise eliminating alcohol. It can not be combined with any drugs. The reaction to such a combination can be the most unpredictable. Because of this, not only side effects will increase, but also memory, concentration of attention, vision and hearing will sharply worsen. Hormonal drugs are already distinguished by an extensive list of negative reactions, in combination with alcohol, they affect the body even more destructively.
According to reviews, āBuserelinā and alcohol in joint use cause a very large number of adverse reactions.
Drug interaction
With the use of other drugs, the effect of Buserelin may change. This mainly applies to the following medicines:
- with sex hormones containing in their composition - can cause ovarian hyperstimulation syndrome;
- hypoglycemic agents - a decrease in effectiveness is observed.
Side effects
According to the instructions and reviews for Buserelin, like most hormonal drugs, this medicine has an extensive list of side effects. It includes such undesirable reactions of various organ systems as urticaria, headache, mood swings, sleep disturbances, nosebleeds, skin hyperemia, angioedema, osteoporosis, depression.
Often, women experience symptoms similar to menstrual bleeding and dryness in the vagina. These signs appear in the first weeks of therapy. In rare cases, the following are noted: the occurrence of obstruction of the ureters, compression of the spinal cord, thromboembolism of the artery of the lung, dyspeptic disorders.
In the treatment of prostate cancer in men, the disease may worsen. The reason for it is to stimulate the synthesis of testosterone and gonadotropins. In some patients, the appearance of gynecomastia, a decrease in potency, severe sweating and hot flashes were observed. With such symptoms, the dosage should be reviewed, otherwise signs such as urinary retention, weakness in the legs, increased androgens in the blood, swelling of the legs, eyelids and face may develop.
According to patients, Buserelin Depot provides the maximum number of side effects.
Contraindications
The medicine has very few contraindications. It is used with caution in case of arterial hypertension, depression and diabetes. The absolute contraindications are: lactation, pregnancy and hypersensitivity to the components of the drug.
Analogs
The drug "Buserelin" has several analogues that differ in a similar principle of influence or composition. These include: Decaptil Depot, Vantas Implant, Suprefact Depot. They should be prescribed by a doctor.
Reviews about Buserelin
"Buserelin" in accordance with reviews is most often used in the form of a spray. The effectiveness of the drug is assessed ambiguously. Some patients really consider it effective, but many claim that after application certain undesirable reactions occurred, including cysts. "Buserelin", according to doctors, can only be used under the qualified supervision of a physician. However, it is often used in medical practice and helps in the treatment of uterine fibroids, hyperplastic endometrial processes and endometriosis, as well as tumor hormone-dependent processes of the genital area in women.