"Omeprazole" is an effective drug that is used in the treatment of erosion of the gastric walls, gastritis of certain varieties and ulcers that occur against a background of high acid content.
The active component of the solution, tablets and capsules of Omeprazole, the indications for use of which will be discussed below, effectively eliminates inflammatory foci in the gastrointestinal tract. The active component is released when it enters the aggressive acidic environment of the stomach. The medication helps to reduce the aggressiveness of the acid against the gastric walls, restores the alkali balance in the fluid, thereby reducing the severity of the manifestations of various gastrointestinal pathologies.
Structure
Before considering the indications for the use of Omeprazole, let's talk about its composition and properties.
The drug is presented in pharmacies in the form of tablets, capsules and a solution for intravenous administration. The active component in the drug is omeprazole, the content of which depends on the form of the drug:
1. Capsules that dissolve in the intestines - 10 or 20 mg of omeprazole. The number of capsules in one package depends on the manufacturer.
2. Tablets in a gastro-soluble coating - 10, 20 or 40 mg of omeprazole. Sold in 7, 14 or 28 pieces.
3. The powder for the preparation of the solution is 40 mg. omeprazole. One package contains five ampoules of powder.
The properties
Omeprazole reduces the production of hydrochloric acid due to the suppression of parietal gastric cells. He is from the group of prodrugs, the activation of which occurs in the acidic environment of the gastric mucosa.
Therefore, the main indications for the use of "Omeprazole" are gastrointestinal diseases.
The effectiveness of the drug is due to a decrease in stimulated and basal secretion production, regardless of the type of stimulus. The antisecretory effect of the drug appears one hour after taking 20 mg of omeprazole. The maximum inhibition of secretion occurs during the first day. With a single dose, there is a rapid inhibition of day and night gastric secretion, the maximum values of which are achieved on the fourth day of treatment and persisting for several days after drug withdrawal.
Indications for use of tablets "Omeprazole"
The medication is intended for conducting maintenance therapy of various pathological processes in the digestive tract. Indications for the use of "Omeprazole", according to the instructions, are the following diseases:
1. Zollinger-Ellison syndrome.
2. In combination with other drugs for the treatment of polyendocrine adenomatosis.
3. Eosophagitis of an erosive species identified by the endoscopic method.
4. Elimination of uncomplicated heartburn, the duration of which is two days a week. What other indications for the use of Omeprazole tablets are known?
5. Gastropathies resulting from taking drugs from the category of non-steroidal anti-inflammatory drugs.
6. Elimination of symptoms of gastroesophageal reflux, in which the contents of the stomach are thrown into the lower part of the esophagus.
7. In combination with other drugs during the treatment of stomach ulcers and duodenal ulcers, which are in the active stage, the appearance of which was provoked by infection with the Helicobacter pylori bacterium.
8. For prophylactic purposes to prevent a recurring episode of the disease with a duodenal ulcer in a chronic form of the course, as well as against a background of peptic ulcer caused by stress or regular intake of acetylsalicylic acid.
9. Correction of disorders in the upper digestive system caused by hypersecretion.
The list of indications for the use of "Omeprazole" is quite extensive.
Caution and contraindications
Caution must be exercised when taking the drug against a background of liver or kidney failure. Under the absolute prohibition is the reception of funds under the following conditions:
1. Women during pregnancy and breastfeeding.
2. To children.
3. With hypersensitivity to the components that make up the drug.
In these cases, you should choose another medication.
Instruction manual
According to the information provided by the instructions for use, the medication is taken in the morning on an empty stomach. You do not need to chew the drug, you can drink it with a small amount of water. The instruction provides for the following dosage regimens:
1. Prevention of repeated ulcerative pathology - 10 mg once a day.
2. Zollinger-Ellison syndrome - 60 mg once a day. It is possible to increase the dosage to 80-120 mg taken in the morning and evening.
3. Peptic ulcer in the acute stage, gastropathy while taking NSAIDs and reflux esophagitis - 40 mg. once a day.
Treatment of peptic ulcer located in the duodenum can last for 2-4 weeks with the possibility of prolongation up to 4-5 weeks. With stomach ulcers, as well as with reflux esophagitis and gastrointestinal lesions with erosive ulcers, the duration of Omeprazole therapy can reach two months.
Indications for the use of the drug "Omeprazole" should be strictly observed.
Treatment duration
A decrease in the severity of symptoms and the appearance of scars on the ulcer occurs, as a rule, after two weeks of regular use of the drug. If ulcer scarring does not occur after this period, the treatment is extended for a similar period. If the patient has resistance to other anti-ulcer drugs, Omeprazole is prescribed in a dosage of 40 mg. The duration of treatment in this case will be similar to the schemes described above.
If we are talking about the defeat of the body by the Helicobacter pylori bacterium, therapeutic regimens should be used in the treatment, involving the simultaneous administration of two or three drugs at once. Typically, this is omeprazole in combination with clarithromycin, metronidazole and amoxicillin. The dosage and duration of administration should be prescribed by the attending physician.
Against the background of liver failure, a dose of 10-20 mg is prescribed once a day. If severe liver damage is detected, the daily dosage should not be higher than 20 mg of omeprazole. Indications for use in this case can be any.
For elderly patients, especially against the background of renal failure, adjustment of standard dosages may be required.
Adverse reactions
In most cases, the drug is well tolerated by patients. However, against the background of prolonged regular intake for several months, the appearance of unwanted reactions from the body is possible. As a rule, doctors recognize one month of taking the drug as the optimal course duration. Further, the resumption of taking "Omeprazole" after a break is allowed.
Against the background of incorrect reception of Omeprazole, the following undesirable reactions are possible:
1. Musculoskeletal system - arthralgia, myasthenia gravis, myalgia.
2. The hematopoietic system - agranulocytosis, leukopenia, pancytopenia, thrombocytopenia, etc.
3. Allergic reactions in the form of rash and itching, multiforme exudative erythema, photosensitivity and alopecia.
4. Digestive organs - constipation or diarrhea, nausea and vomiting, flatulence. Significantly less, while taking the drug, increased activity of liver enzymes can be observed, accompanied by dry mouth, stomatitis and a violation of taste sensations. With severe liver damage, hepatitis can also occur.
5. Nervous system - dizziness, headache, state of depression and nervous excitement. Against the backdrop of severe liver damage, the development of encephalopathy is possible.
6. Others - visual disturbances, swelling of the legs and arms, general malaise, hyperhidrosis, gynecomastia, the formation of glandular cysts in the stomach of a benign nature.
Overdose symptoms
If the drug is taken incorrectly, namely, exceeding the prescribed dosages and not observing the indications for the use of Omeprazole 20 mg capsules, signs of an overdose may occur. They consist of symptoms such as drowsiness, nausea, and headache. Sometimes this condition is accompanied by visual impairment, confusion and tachycardia.
If the symptoms described are identified, seek medical attention. Symptomatic treatment is prescribed and consists in washing the stomach and taking enterosorbents. Dialysis is ineffective, since omeprazole is absorbed into the bloodstream almost immediately after administration.
Analogs
On the shelves of modern pharmacies you can find quite a lot of similar drugs, including those based on omeprazole. Among them are the following drugs:
1. Omitox.
2. “Omez”.
3. "Omekaps."
4. "Omeprazole-Acre."
5. Omeprazole Richter.
6. Omipix.
7. "Promez."
Indications for use of Omeprazole and Omitox, as well as other analogues, are completely identical.
All these drugs should be taken only after consulting a doctor, since each of them has its own characteristics of administration, form of release and dosage. The difference between Omeprazole and Omez is that the first is produced in Russia and is quite cheap, while the second is more expensive and manufactured in India.
It should be noted that Omez is a more common drug and many go to the doctor for a prescription for this drug. Omeprazole, however, is no different in terms of its effect and composition. Experts warn that the cost of Omez is justified by its additional components, which are not in Omeprazole.
However, almost one-component "Omeprazole" shows effectiveness in the treatment of various diseases of the gastrointestinal tract.
Reviews
Patients respond well to the drug, it quickly eliminates heartburn, helps to cope with manifestations of gastritis and peptic ulcer.
Patients call the disadvantages of the drug its side effects, which are often manifested in the form of nausea, heaviness in the abdomen and dry mouth. In addition, against the background of regular use of "Omeprazole" may worsen overall health, dizziness and insomnia. The list of side effects of Omeprazole and Omeza is the same, however, the second drug has similar symptoms much less often, which is explained by a higher degree of purification of the Indian drug.
We reviewed the indications for the use of Omeprazole.