Known to all, acetylsalicylic acid is widely used as a means of lowering the temperature. However, not everyone knows that this medication is often prescribed to patients in the treatment of diseases of the cardiovascular system. This article will focus on a drug such as Acecardol tablets. The instruction for use states that this medication includes acetylsalicylic acid. This medicine has been used in cardiological practice for more than a year and has proven itself in both doctors and patients. How Acecardol tablets help can be found in this article.
A full description of the drug, instructions for use, reviews, indications and side effects - all this information is given for information only and cannot serve as a basis for taking the drug on its own. Self-medication with such a medication can harm health, and therefore it should be taken only as directed by a doctor.
Pharmacological features
The drug "Acecardol" is acetylsalicylic acid, coated, which dissolves directly in the intestine. It is a non-steroidal drug with anti-inflammatory effect. The mechanism of action of the drug is that the active component has an irreversible inhibition of COX, resulting in suppression and blockade of the synthesis of thromboxane A2 and platelet aggregation. The effect of the active component lasts for a week, the maximum concentration of the drug is achieved in the blood 15 minutes after administration. During normal operation of the urinary system, a single dose of the drug is excreted in the urine from 24 to 72 hours.
In addition, high doses of the drug have the ability to anesthetize and relieve fever. Suppression of platelet synthesis allows the use of this medication in the treatment of various cardiovascular diseases.
Who is indicated for the drug "Acecardol"
Instructions for use describe the conditions in which it is recommended to take these tablets.
As a rule, the drug is prescribed for prophylactic purposes in case of a threat of acute primary and repeated myocardial infarction, if the patient has such risk factors as diabetes mellitus, obesity, hypertension, hyperlipidemia.
Indications are also considered unstable angina, the threat of ischemic stroke (including with transient disturbance of the blood circulation of the brain).
The drug “Acecardol” can be prescribed to patients for the prevention of thromboembolism after surgical and invasive intervention on vessels, such as coronary artery and aorto-venous bypass grafting, angioplasty of the carotid and coronary arteries.
Contraindications
Almost all medications have a list of conditions in which their reception is impossible. Acecardol tablets are not an exception. The use of this medication is not recommended for persons with disorders such as:
- gastrointestinal bleeding;
- erosion, gastrointestinal ulcers;
- bronchial asthma in the stage of exacerbation and remission;
- hemorrhagic diathesis;
- chronic heart failure;
- polyposis of the paranasal sinuses and nose.
It is strictly forbidden to take the medicine "Acekardol", analogues and similar preparations in the period of gestation and lactation of the baby. Also a contraindication can be considered individual sensitivity to acetylsalicylic acid and auxiliary components in the composition of the drug, in particular lactose.
With caution, a medication is prescribed in case of impaired liver function and during anticoagulant therapy. With the alleged surgical interventions, it is also undesirable to drink Acekardol tablets. The instructions for use contain information that with special care this medicine should be prescribed to people with kidney diseases, since it is excreted through the urine.
These tablets are intended for prolonged use. High doses of the drug can be prescribed as a last resort to reduce high fever.
Reception schedule
How to administer Acecardol? Instructions for use states that the drug is intended for oral use. Drink pills before eating and drink a glass of water.
In the prevention of acute myocardial infarction, 100 mg is prescribed daily or 300 mg once every 48 hours. To quickly assimilate and achieve a concentration of the active substance in the plasma, the tablets are chewed and then washed down with water.
If the medicine is prescribed for patients with unstable angina pectoris or to prevent re-infarction, ischemic stroke or to prevent thromboembolism in the postoperative period, 100 mg tablets are taken every 24 hours.
To prevent pulmonary embolism and its branching, as well as deep vein thrombosis, it is recommended to drink 100 mg tablets once a day or 300 mg every 48 hours.
Unwanted effects
Does the drug Acekardol (tablets) have a negative effect on the body? Instructions for use and reviews indicate the following possible side effects:
- hematopoietic system: anemia and increased likelihood of bleeding;
- Gastrointestinal tract: abdominal pain, nausea, vomiting, heartburn, perforated duodenal ulcers and stomach, increased activity of liver enzymes;
- immune system: allergic rashes in the form of spots, blisters, urticaria, Quincke's edema and anaphylactic shock;
- from the respiratory system spasm of the bronchi is possible;
- central nervous system: hearing loss, tinnitus and buzz in the ears, headache and dizziness.
These are the side effects that are described for the Acecardol drug by the instructions for use, however, reviews indicate that these manifestations are rare and, as a rule, the drug is well tolerated.
Pregnancy use
Why can not you use the drug "Acekardol during pregnancy and lactation? The answer to this question lies in a simple explanation. Acetylsalicylic acid is considered an undesirable substance in an immature child's body. Among the many contraindications to the drug “Acecardol”, the instruction also includes a clause regarding the prohibition of taking the medicine for people under 18 years of age.
The active substance, reaching a maximum concentration in the blood after ingestion, is able to penetrate the developing body of the fetus.
Especially dangerous is its effect in high dosages in the first and third trimesters. Taking this medicine increases the risk of developmental defects, in particular split palate and congenital heart defects.
Acecardol tablets, analogues of this drug containing the same active component, are prescribed only with an adequate assessment of the risk and benefit of therapy.
Acetylsalicylic acid in a dose of more than 300 mg in the last months of pregnancy negatively affects labor and causes premature closure of the ductus arteriosus in the fetus, and also increases the risk of bleeding during childbirth and cesarean sections in mother and baby.
What does the instruction for use say about the possibility of using Acecardol tablets before delivery? Analogs and the medicine itself immediately before childbirth can cause cerebral hemorrhage in the baby, in a particular risk group are premature babies. Therefore, it is better to refuse such therapy.
Lactation
During breastfeeding, the single use of Acecardol tablets, reviews of which say that they relieve temperature well, does not require the abolition of breastfeeding. But long-term therapy with this medication can harm the baby's body, so you need to choose between taking the medicine and breastfeeding, assessing the condition of the woman.
Reviews of doctors and patients
Basically, all responses about the drug are positive. Doctors say that the tablets are designed to prevent recurrent heart attacks, strokes, as well as thrombosis after surgery and do a good job of their task.
Patients who have undergone a course of therapy claim that if you do not chew the tablet, then there will be no discomfort in the stomach after taking it. The main thing is only to adhere to the dose recommended by your doctor. Also, the fact of positive dynamics in the prevention and treatment of blood clots was attested to by patients.
Among the reviews noted such a positive point as pricing. The tablets are inexpensive and belong to the drugs of the public group.
Interaction with other medicines
Taking the drug itself and Acecardol drug analogues, the indications for which are almost identical, you need to be extremely careful when combining it with other medicines, since acetylsalicylic acid is able to enhance the effect of certain substances that make up other drugs.
So, for example, due to the weakening of renal clearance and its displacement from communication with proteins, the effect of Methotrexate tablets is enhanced, which is undesirable during chemotherapy with this agent.
The main component of the drug “Acecardol” displaces valproic acid from its association with proteins and thereby increases its effect on the body. It is undesirable to simultaneously drink thrombolytic and antiplatelet drugs and Acecardol tablets. Reviews of doctors about such a combination indicate a negative effect on the human body.
Acetylsalicylic acid enhances the action of insulin and its derivatives, which must be taken into account by people who monitor the level of sugar in the body.
It is strictly forbidden to take Acekardol tablets in conjunction with preparations containing ibuprofen and its derivatives.
Special Instructions for Taking Acecardol Tablets
Instructions for use, the photo of which is presented in the article, is the original version of the description of the drug from its manufacturers, which is attached to each package. It contains all the data on the recommended doses, describes the pharmacological effect, indications and side effects. And although this medicine is dispensed in pharmacies without a doctor’s prescription, it is not recommended to resort to independent long-term treatment with this medicine. Also, special attention should be paid to a single dose to lower body temperature, especially for those patients who have problems with the hematopoietic system.
It is strictly forbidden to take the drug “Acecardol” with alcohol, since such a combination will adversely affect the gastric mucosa and can lead to serious diseases.
In patients with bronchial asthma, aspirin can cause bronchospasm and provoke an asthma attack, therefore, before drinking Acekardol tablets, the benefit and risk of the drug should be evaluated.
The drug does not affect the concentration of attention, does not cause inhibition and drowsiness, and therefore patients during the treatment period can drive vehicles and perform work of increased danger.
Overdose
Exceeding a single dosage can lead to bleeding in the stomach. Symptoms of an overdose include nausea, vomiting, buzzing in the ears, cardiovascular and respiratory failure, which can cause a patient's coma. If the dose is greatly exceeded, fever, respiratory alkalosis, ketoacidosis, and hyperventilation may develop. In such conditions, it is necessary to adjust the daily and single dose of the drug, and in some cases, its cancellation and symptomatic treatment. In order to quickly eliminate and neutralize the action of the active component, Acekardol preparation is undergoing emergency therapy: gastric lavage, hemodialysis, administration of absorbent substances and determination of acid-base balance for subsequent diuresis.
Storage conditions and release form
How to store the medicine "Acekardol"? Instructions for use, reviews of the drug indicate that no special conditions are required for the storage of tablets. It is enough to adhere to general recommendations and contain packs with tablets in a dark and dry place at a temperature of no higher than 25 degrees. In such conditions, the medicine will retain its healing properties for three years.
Acecardol tablets are available in different dosages of the active component: 50, 100 and 300 mg. Acetylsalicylic acid acts as the main active substance. Auxiliary components are corn starch, povidone, microcrystalline cellulose, talc, magnesium stearate, lactose, titanium dioxide and castor oil.
The tablets have a round biconvex shape and are provided with a membrane that dissolves only in the intestine, which prevents undesirable effects on the gastric mucosa.
Analogues of the drug
What does the instruction for use say about the replacement of the drug “Acecardol”? Analogs must contain the same active component and also affect the body. Substitutes may include drugs such as Aspirin, Acetylsalicylic Acid, Cardi ASA, Thrombo ACC, and Aspirin Cardio.
Each of these medicines has its own dosage regimen and recommended doses. Analogs, as well as the Acekardol preparation itself, which consist of acetylsalicylic acid, are not used in pediatrics, have a number of contraindications and prohibitions on combining with other medicines.
During therapy, it is necessary to systematically monitor the state of the blood, as well as monitor the presence of blood in the stool of the patient. For this, it is necessary to periodically conduct clinical tests, the results of which should determine the further treatment.
The drug "Aspirin": instruction
The healing properties of this medicine are its ability to relieve fever, inhibit inflammatory processes and reduce platelet adhesion. Indications for therapy are fever in acute respiratory viral infections and influenza, the prevention of heart attack and thrombosis, as well as rheumatic diseases.
Tablets are taken orally for an analgesic effect of 325, 400, 500 mg, for an antiplatelet effect of 50, 75, 100, 300 and 325 mg.
With fever and pain, adults are recommended to drink the drug in a dosage of 100 mg. Effervescent tablets are dissolved in water and consumed after meals. A single dose should not exceed 1 g of the active substance. If the medication is prescribed for the prevention of thrombosis, then its dosage should be 40–325 mg once every 24 hours.
This drug has the same contraindications and side effects as the drug "Acekardol."
The drug "Thrombo ACC": instruction
The drug with the name "Thrombo ACC" is identical in action and composition to the analogue of the drug "Acecardol". In appearance, these are round and convex tablets on both sides with a shiny and slightly rough surface. The active substance is acetylsalicylic acid in an amount of 100 mg per tablet. Auxiliary components are lactose, silicon dioxide, triacetin, talc, potato starch, anti-foaming silicone agent, methacrylic acid and ethacrylate copolymer.
The medicine is sold in packages of 3 blisters, each of which includes 10 tablets. The recommended dose of the drug is 50-100 mg at a time. However, the doctor may prescribe a large dosage, given the condition of the patient and the presence of contraindications.
Medication "Acetylsalicylic acid": features of use
The peculiarity of this drug is that it does not have an enteric membrane, and therefore these tablets strongly irritate the gastric mucosa. This fact makes it impossible to take medication for gastrointestinal ulcers in the acute stage. This medication is contraindicated in children under 15 years of age.
It is recommended to drink tablets for the prevention of thromboembolism, heart attacks and strokes, as well as for rheumatism, infectious and inflammatory diseases. Dosage is selected individually. The official instructions for use contain recommendations regarding the regimen. The dose of the drug can vary from 40 to 100 mg at a time, but not more than 8 g of the active substance per day.