In the article, we consider the analogues of Sindopa and the instruction.
The presented medicine is a combined tablet medicine intended for the treatment of parkinsonian conditions of various origins (with the exception of those caused by the use of antipsychotic drugs), Parkinson's disease.
The main active ingredients in Sindopa are carbidopa in an amount of 25 mg and levodopa in an amount of 250 mg. The auxiliary substances are: dye, colloidal silicon dioxide, povidone, cellulose, magnesium stearate, corn starch, sodium starch glycolate, butyl hydroxyanisole, lactose, and purified talc.
What else does the application instruction for Sindope tell us?
Pharmacological forms
The manufacturer produces the drug exclusively in tablet form. The tablets have a flat-cylindrical shape, light pink with a splash. Crossing risks are located on one side of the tablet, and the name of the drug is engraved on the other.
Tablets are packaged in contour packs, each cardboard pack contains 5 contour packs.
Sindopa is part of the group of dopaminergic and antiparkinsonian drugs.
Indications for use
What does Sindopa help from? The medication is indicated for use with the purpose of therapy:
- Parkinson's disease.
- Parkinsonism syndrome, which may be a consequence of cerebrovascular disorder, intoxication, encephalitis.
It is important to understand that only a doctor should prescribe the drug. Self-medication is unacceptable.
Contraindications
As the instructions for use for Sindope indicate, the list of contraindications to the drug is quite extensive. It should not be used if the patient has such physiological or pathological conditions as:
- Melanoma or suspected presence.
- Angle-closure glaucoma.
- Age less than 18 years.
- The lactation period.
- Essential tremor.
- Susceptibility to any of the components of the drug.
- Huntington's disease.
- Severe forms of neurosis.
- Pregnancy.
- Secondary parkinsonism resulting from the use of antipsychotics.
- Skin pathologies, the etiology of which is not clear.
- Severe forms of psychosis.
Among the relative contraindications are the following:
- Pathology of the endocrine system.
- Bronchial asthma.
- Mental disorders.
- Myocardial infarction.
- Ulcerative, erosive lesions of the stomach, duodenum.
- Diabetes.
- Severe forms of liver, kidney dysfunction.
- Heart rhythm disturbances.
- Heart failure.
- Epileptic seizures.
Negative effects of the drug
The use of the drug “Sindopa” can cause the development of undesirable symptoms:
- Diplopia, blepharospasm, weight gain, mydriasis.
- Hemolytic type anemia, moderate leukopenia, thrombocytopenia.
- Cardiac arrhythmia, orthostatic hypotension, collapse, tachycardia.
- Epigastric pain, ulcerogenic effect, nausea, dysphagia, vomiting, constipation.
- Paranoid conditions, drowsiness, dizziness, psychotic reactions, on-off syndrome, sedation, increased irritability, convulsions, choreoathetosis, hypomania, hallucinations, focal dystonia, insomnia, increased libido, dyskinesia, euphoria, nightmare dreams, anxiety, ataxia, nerves depression, anorexia, dementia.
The use of the drug can affect laboratory parameters: a positive Coombs reaction, deviations in alkaline phosphatase, glutamate oxalate transaminase, bilirubin, lactate dehydrogenase, iodine, urea nitrogen.
The severity of negative symptoms depends on the patient's sensitivity to the components of the drug and dose. To eliminate side effects, you should temporarily reduce the amount of the drug used, while continuing the therapy. In the absence of a regression of undesirable symptoms, a gradual cessation of therapy is recommended.
Drug use
The product should be taken orally, after eating, avoiding chewing and grinding, washed down with water. During therapy, it is recommended to reduce the amount of protein consumed. The average daily dose of the drug is 70-100 mg. When using high doses, an increase in the therapeutic drug is not observed. The maximum amount allowed for intake during the day is 2 grams.
The therapy should be started with twice the use of 0.5 tablets per day. If necessary, increase the daily dose by 0.5 tablets. At the initial stages of treatment of severe forms of parkinsonism, it is recommended to use no more than three tablets per day (the use of this is three times).
Overdose and price of medication
As a result of drug intoxication, the patient may develop the following symptoms: anorexia, insomnia, orthostatic hypotension, confusion, agitation, anxiety, sinus tachycardia, and jumps in blood pressure.
Intoxication therapy involves gastric lavage and intake of enterosorbents. In a hospital setting, symptomatic therapy is prescribed.
The average cost of packaging a drug is 140 rubles, depending on the region and the pharmacy chain.
Analogs of Sindopa
If necessary, the doctor may recommend the use of substitutes. These include: “Madopar”, “Nakom”, “Tidomet forte”, “Tremonorm”.
They can be purchased at any pharmacy. Consider each medication in more detail.
The drug "Nakom"
It is an antiparkinsonian drug.
The manufacturer of the analogue of Sindopa Nakom is available in tablet form. The tablets have a biconvex oval shape, blue with dark blue and white blotches. Tablets are packaged in blisters of 10 pieces, each cardboard package holds 10 blisters.
The price of Nakoma is of interest to many.
The main active ingredients in the composition are carbidopa and levodopa in the amount of 25 and 250 mg, respectively. As auxiliary components are used: dye, microcrystalline cellulose, gelatinized starch, corn starch, magnesium stearate.
Among the indications for using the drug are Parkinson's disease, Parkinson's syndrome.
Absolute contraindications to the use of "Nakoma" are:
- Increased susceptibility to the components of the drug.
- Concurrent use of non-selective monoamine oxidase inhibitors.
- Age less than 18 years.
- The lactation period.
- Pregnancy (an exception is a vital necessity).
- Angle-closure glaucoma.
- Skin pathologies, the etiology of which is not clear.
- Melanoma, suspicion of her presence.
The drug is relatively contraindicated in the following cases:
- Severe forms of renal, liver failure.
- Open angle glaucoma.
- Ulcerative, erosive lesions of the digestive tract.
- Diabetes mellitus, other decompensated pathologies of the endocrine system.
- Epileptic, other convulsive seizures.
- The presence in the history of information about myocardial infarction, heart failure, severe pathological disorders of CVS.
- Bronchial asthma, other severe forms of pathology of the respiratory system.
It is recommended to take Nakom in a daily dosage of carbidop 70-100 mg. The exact dosage, frequency of use, treatment regimen is established by a specialist on the basis of examination data and the general condition of the patient.
A medication can provoke the development of a wide range of undesirable phenomena, including fainting, dyspnea, anorexia, arrhythmia, phlebitis, anemia, convulsions, bradykinesia, depression, suicidal tendencies, confusion, psychotic conditions, and many others. Before taking the drug, it is important to carefully read the manufacturer's annotation.
The price of Nakoma is an average of 1,460 rubles.
Madopar
Madopar is an antiparkinsonian drug, a precursor to dopamine.
The manufacturer produces in capsule form and in the form of dispersible tablets.
The main active ingredients in the composition of Madopar capsules are benserazide and levodopa hydrochloride. As additional components are used: gelatin, titanium dioxide, dye, magnesium stearate, povidone, talc, microcrystalline cellulose.
Capsules are packed in dark glass bottles of 30 and 100 pieces, in addition, the bottles are packed in cardboard boxes.
An analogue of “Sindopa” “Madopar” is recommended for use for the treatment of Parkinson's disease, restless legs syndrome.
Among the contraindications, the following conditions are distinguished:
- Increased hypersensitivity to the components of the drug.
- The lactation period.
- Pregnancy.
- Age less than 25 years.
- Simultaneous therapy with MAO inhibitors of a non-selective type.
- Angle-closure glaucoma.
- Mental illness having a psychotic component.
- Decompensated pathologies of CVS.
- Decompensated impaired renal function (except for patients suffering from restless legs syndrome and receiving dialysis).
- Decompensated impaired liver function.
- Decompensated dysfunctions of the endocrine system.
The therapy should be started with the use of the minimum doses of the drug determined by the doctor (as a rule, 62.5 mg three times a day). With normal tolerance, the dosage is gradually increased.
Using Madopar can cause many negative effects, including anorexia, thrombocytopenia, bronchitis, arrhythmia, hypertension, severe drowsiness, depression, temporary disorientation, delirium, hallucinations and many others.
The average cost of a Madopar package depends on the dosage of capsules (tablets). So, 100 capsules with a dosage of 125 mg will cost about 720 rubles.
Tidomet forte - what is this drug?
It is a combination therapy for Parkinson's syndrome, Parkinson's disease.
The manufacturer produces the drug in tablet form. The tablets have a round, flat shape, white color. The medicine is packaged in aluminum strips of 10 tablets. Each cardboard pack can contain 5 or 10 aluminum strips.
The active components of Tidomet Forte are carbidopa, levodopa. Additionally, talc, microcrystalline cellulose, starch, colloidal silicon dioxide, magnesium stearate, povidone are used in the manufacture of the preparation.
Which is better - "Tidomet" or "Sindopa" is rather difficult to solve, since these medicines are completely identical in composition and action. Consider the indications for use and contraindications of the first drug, an analogue of the drug described by us.
The use of the drug is recommended for Parkinson's disease, Parkinson's syndrome, which arose against the background of intoxication with carbon monoxide, manganese, after encephalitis.
Among the absolute contraindications to the use of the drug:
- Hypersensitivity to the components of the drug.
- Age to 18 years.
- The lactation period.
- The parallel use of MAO inhibitors is not a selective type.
- Skin pathologies, the etiology of which is not clear.
- Huntington's disease.
- Melanoma, suspicion of its presence.
- Severe forms of neurosis, psychosis.
- Angle-closure glaucoma.
- Essential tremor.
- Secondary parkinsonism that occurs with the use of antipsychotics.
In addition, the drug has a number of relative contraindications, which are also worth familiarizing yourself with before starting therapy.
The use of the drug should begin with the initial doses - twice a day for half a tablet. The average daily dose of the drug is 70-100 mg of carbidopa. A more accurate dosage, frequency of applications, treatment regimen is determined by the doctor.
The use of “Tidometa forte” can cause the development of many undesirable phenomena, including arrhythmia, phlebitis, darkening of the saliva, depression, fainting, drowsiness, bradykinesia, agitation, psychotic reactions, and many others.
The cost of packaging, containing 100 tablets, is an average of 615 rubles.
"Levodopa Benserazide": description and instructions
Levodopa Benserazide Teva is an anti-Parkinsonian medicine.
The manufacturer produces in the form of tablets with a marble-pink color, round, convex on both sides, shape.
The main components in the composition of the drug are bonserazide hydrochloride, levodopa. The following substances are used as additional substances: magnesium stearate, dye, colloidal silicon dioxide, crospovidone, povidone, anhydrous calcium hydrogen phosphate, gelatinized corn starch, microcrystalline cellulose, mannitol.
Tablets are packaged in bottles of polyethylene of 20, 30, 50, 60, 100 pieces. Each bottle is additionally placed in a pack of cardboard.
The main indication for the use of the drug is Parkinson's disease.
Take "Levodopa Benserazid" is necessary before eating, at least half an hour. The initial dosage is 50 + 12.5 mg, should be taken twice or four times a day. If the patient is well tolerated, the dose is gradually increased until the desired effect appears.
Contraindications to the use of the medication are similar to those of Sindopa. In addition, before starting a therapeutic course, you should carefully study the likely negative manifestations - there are a lot of them.
On average, the cost of the package "Levodopa Benserazide" depends on the number of tablets inside the bottle and is 550-1250 rubles.
We reviewed the brief instructions, synonyms "Sindopy" and analogues.