Of course, to maintain the process of life, each person must receive the substances he needs. To do this, we eat food and with it proteins, fats, carbohydrates, minerals and vitamins. However, there are conditions when a person simply can not eat. In this case, it is transferred to intravenous nutrition. The drug "Kabiven Central" is designed specifically for this.
In the article we will talk about what this remedy is, and also find out what the indications and contraindications for its use are, and get acquainted with the features of its use. Carefully read the information provided and you can find answers to all your questions.
A few words about the composition and form of release
āKabiven Centralā is a medicine placed in three-chamber bags. The drug is available in various volumes, and it is on this that its calorie content will depend. The smallest bag has a volume of 1026 ml, and at the same time its energy value is 900 kcal. As we have already said, the package consists of three bags, each of which has such components as:
- glucose;
- Vamin 18 Novum;
- intralipid.
When used, the contents of the three bags will be mixed, and the result will be a white liquid emulsion. The composition of the "Kabivena Central" includes all the necessary substances to maintain the correct process of human life. For this reason, the tool is a real salvation for those who can not eat on their own.
There are such volumes of "Kabivena Central": 1540 ml, 1026 ml, 2053 ml and 2566 ml.
Pharmacological features of the drug
The described tool is intended for parenteral nutrition, that is, for intravenous administration. Glucose, which is part of the composition, is a very important source of released energy, which is so necessary for the body. Also takes an active part in the metabolic processes of amino acids. Vamin 18 Novum is a source of protein that does not completely enter the human body or comes in very small quantities. Intralipids are a valuable source of energy and essential fatty acids.
In what cases is it worth using the product?
According to the instructions, āCabiven Centralā is prescribed to those patients for whom it is impossible to administer enteral or oral nutrition, or it is contraindicated. Also, the tool can be used if, for any reason, natural nutrition is not enough. The drug can be used by adults, as well as children who have reached the age of two.
Are there any contraindications for use?
āCentral Cabivenā, despite its effectiveness, can still not be used in all cases. So, patients who have hypersensitivity to soy or egg proteins, as well as to any component that is part of this drug, will have to abandon its use.
Consider under what other circumstances the use of the drug will have to be abandoned:
- The presence of severe liver failure, as well as problems with blood coagulation.
- Violation of the metabolic processes of amino acids. This is especially true in cases where violations are congenital in nature.
- You should also not use the drug in the presence of acute liver failure.
- It is also very important to pay attention to the concentration in the blood of the elements that make up the medication. If they are pathologically enlarged, then when using the solution, the patient's condition will be even worse.
- Also, do not use the product in the presence of general contraindications to the implementation of infusion therapy. These include pulmonary edema, heart failure, and many other conditions.
- The drug can not be administered to the patient in the presence of unstable conditions, such as the acute stage of diabetes mellitus, severe sepsis, and so on.
When should you be especially careful?
It is very careful to use the āCabiven Centralā application instruction in the presence of lipid metabolism disorders in the body that have arisen against the background of diabetes mellitus, liver or kidney failure, as well as sepsis. In the presence of such contraindications, the agent must be administered very carefully, carefully observing the patient's condition.
Is it possible to develop unwanted reactions?
Despite the fact that the described drug is very necessary and effective, nevertheless its use can lead to side effects. Consider what exactly can happen:
- If the patient has allergic reactions to the constituent components, then they can make themselves felt in the form of a skin rash, urticaria, fever or chills.
- The drug can also have a negative effect on blood pressure, lowering or increasing it. Changes in respiratory function are also possible.
- Patients may be concerned about abdominal pain.
- It is possible that an increase in the efficiency of liver enzymes.
- When conducting infusions, local reactions such as thrombophlebitis may occur.
If the drug is administered correctly, taking into account the instructions for use, then the likelihood that side effects can be detected is extremely small.
"Kabiven Central": instructions for use
Note that the presented drug can only be entered into the central veins. For this, the infusion method is used. Many patients are interested in the question: āCentral Cabivenā or āPeripheralā - what is the difference? These medicines are injected into different types of veins. It is because of this that the drug has a different name. There is no general data on how long and how long to inject. It depends on the condition of the patient, as well as on the needs of his body for nutrients. The dosage, as well as the rate of administration of the drug should depend on how quickly the body can remove lipids, as well as metabolize glucose.
As mentioned above, the drug is available in special bags, which can have four volumes. When choosing one of them, you need to consider how much a person needs nutrients. In order to carry out a full infusion diet with the help of the drug, it is also recommended to additionally introduce a vitamin-mineral complex to the patient.
The dosage of the drug is selected purely individually, taking into account the patient's need for nutrients, as well as his body weight and general condition of the patient. If a person is obese, then in this case, the dosage should be calculated as if the patient has his ideal weight at the moment.
If a person suffers from severe or moderate catabolic stress, then the daily dosage of the drug should be 27-40 ml per kilogram of weight. Without the presence of catabolic stress - 19-38 ml of the drug per kilogram of body weight.
Please note that the maximum dosage of the drug should be no more than forty milliliters of active substance per kilogram of body weight. Therefore, a large bag is ideal for the average adult. However, the dosage must be monitored daily and, if necessary, changed, depending on the clinical condition of the patient at the moment.
In order to correctly calculate the dose for a child, it is very important to consider the ability of his body to metabolize certain substances. Children under the age of ten are recommended to increase the dosage gradually, starting from 14-28 ml per kilogram of weight per day. The next day, you can already add about 10 milliliters to this. In children, as in adults, the maximum daily dosage should not exceed forty milliliters of the active substance. For patients over ten years of age, the dosage is set in the same way as for adults.
The rate of infusion should also be determined individually. It is necessary to introduce the drug into the central veins drip, very slowly. The duration of one procedure should be about twelve to twenty-four hours.
How to use the bag?
What is the difference between āCabiven Centralā and āPeripheralā? It is very important to find the answer to this question. Please note that if the first remedy can be administered only in the central veins, then the second - both in the central and peripheral. Only a doctor, depending on the condition of the patient, will be able to determine which remedy is most suitable.
So, before you drive the tool, you need to understand how, in fact, to use a three-chamber bag. Consider how this is done:
- First you need to remove the outdoor bag. To do this, tear it in a special place with an incision and gently pull along the bag itself.
- Now pull the walls of the bag so that the latches open and turn the bag over several times so that its contents mix thoroughly.
- After you have done this, lay the bag on a table or other smooth surface and insert the needle through the center of the membrane. Thus, you can add the necessary vitamins and other components to the medication. However, it should be borne in mind that they must be compatible with Central Cabiven and Peripheral.
- Now remove the cap that is on the needle designed for the infusion, while holding the ring that you want to pull up. Please note that when you use the infusion system, you need to do this without access to air. In order to secure the needle, insert it fully. If this is necessary, it must be turned and pushed.
- Now hang the bag on a rack and perform all the steps that you need to take to inject the medicine into the central vein.
What will happen in case of an overdose?
āCabiven Centralā OKPD2 has 21.20.10.134. According to these numbers, you can find the code of the all-Russian classification of products.
If the dosage of the medicine has not been observed correctly, then the patient may experience a condition such as fat overload syndrome. If the body is not able to excrete such a large amount of fat entering it, then this can lead to this syndrome. This phenomenon can occur not only as a result of an overdose, but also with the occurrence of hepatic and renal acute failure.
Typically, this syndrome makes itself felt in the form of fever, thrombocytosis, hyperlipidemia and coagulopathy. In order to get rid of this condition, you need to stop the introduction of lipids, as well as conduct symptomatic therapy.
Are there any analogues?
The differences between the āCentral Cabivenā and āPeripheralā are insignificant, therefore both means can be considered analogues. There are also other substitutes for the drug, namely:
- Nutriflex
- "Oliklinomel";
- "Aminoven";
- Nefrotect and many others.
However, only an experienced specialist will be able to determine with what particular remedy the Caviben Central preparation can be replaced. The composition of these medicines, of course, is not much different, but nevertheless, the same remedy cannot be suitable for all people at the same time.
About drug interactions
The simultaneous use of the described drug with Heparin can cause the release of lipoprotein lipase into the blood, which will lead to a significant increase in lipolysis.
Insulin can also affect lipase activity. However, there is no evidence that it will reduce the therapeutic effectiveness of the drug "Kabiven Central" (1400 kcal contained in a package that has 1540 ml of solution).
If the patient is forced to take vitamin K1 in addition, then he needs to regularly monitor the blood coagulation process.
Please note that āCabiven Centralā can be mixed with some solutions, but not with all of them. It is worth using only those drugs whose compatibility has been scientifically proven.
conclusions
The described drug can significantly improve the patient's condition, as well as provide his body with nutrients in those cases when a person cannot take food on his own and needs infusion nutrition. One bag with three components is enough for daily use. If the entire contents of the bag were not used in one day, you cannot continue to use it again.
It is very important to correctly calculate the dosage for the maximum therapeutic effect, as well as to minimize the risk of adverse events. During the use of the medication in question, it is necessary to regularly check blood counts and, if necessary, reduce or, conversely, increase the dosage.
According to doctors, the tool is really very effective and perfectly absorbed by the human body. If the drug was administered correctly, then usually negative reactions do not occur at all. If the dosage was incorrectly calculated or the agent was administered very quickly, this can lead to a phenomenon such as fat overload syndrome.