Modern people are increasingly suffering from various diseases of the digestive tract. This is due not only to poor nutrition, but also to the quality of food consumed, a sedentary lifestyle, as well as poor ecology and the use of all kinds of medications.
A stomach ulcer or gastritis today will not surprise anyone. Moreover, such diseases occur not only in adults and the elderly, but also in young children. That is why many pharmaceutical companies produce various drugs that contribute to the restoration of the gastric mucosa and normalization of the digestive tract as a whole.
Very often, to treat such conditions, patients are prescribed the drug “Barol”. Instructions, composition, use of this medication will be described later.
Composition, packaging, description and release form
In what form is a drug such as Barol made? Abstract, reviews report that the drug in question goes on sale in the form of blue and white capsules, which are packaged in blisters and packs of thick paper, respectively.
The active substance of this medication is rabeprazole sodium. As additional components, NPS, talc, hypromellose, sodium hydroxide, magnesium carbonate, macrogol, titanium dioxide, copolymer methacrylic acid, as well as red and black iron oxides and purified water are used.
Pharmacological characteristics
How does the drug "Barol 20" (capsules) work? Instructions, a description of the drug indicate that this drug has antisecretory and antiulcer effects.
According to experts, the medication in question is a class antisecretory drug that does not exhibit anticholinergic action. In addition, he does not have the properties of histamine H2 receptor antagonists. It should be noted that Barol (price, consumer reviews will be presented below) inhibits gastric secretion. As a result, gastric H + and K + adenosine triphosphotases located on the secretory surface of parietal cells are suppressed.
Among other things, the drug in question is a proton pump inhibitor of the stomach.
The action of this agent leads to blocking the final stage of acid secretion. After taking the capsules, they accumulate and protonate, as well as transform to active sulfenamide.
The antisecretory effect of the drug occurs after 60 minutes from the moment of its oral administration. It should also be noted that taking the first dose of the drug leads to a moderate inhibitory effect.
Kinetics of medication
What kinetic properties are inherent in Barol capsules? Instructions, a description of the drug report that this drug is characterized by a bioavailability of 50%.
The use of food, especially oily, delays the absorption of the active ingredient by an average of four hours. However, this fact does not have a significant effect on its therapeutic effect.
The relationship of the drug with plasma proteins is 96%. During metabolism, components such as sulfone and thioether are formed. They have significant antisecretory effect.
Withdrawal of the drug occurs mainly through the kidneys.
Indications
What diseases are effectively treated with Barol 20? Instructions for use (the price of this medication is not very high) indicates that this drug works well with:
- reflux gastroesophageal disease;
- ulcer of the duodenum and stomach;
- Zollinger-Ellison syndrome.
It should be noted that this medication is often prescribed for eradication Helicobacter Pilori in combination with antibacterial agents.
Contraindications
Are there any contraindications to the medicine "Barol 20"? The instruction for use reports that such capsules should in no case be used for:
- pregnancy
- hypersensitivity to the drug;
- under the age of 15 years;
- breastfeeding.
The drug "Barol 20": instructions for use
Analogs of this tool will be presented at the end of the article.
According to the instructions, the capsules in question are intended for oral administration. For various violations, they are taken one at a time. The duration of treatment is set only by the doctor.
In the presence of gastroesophageal reflux disease, this drug is used one capsule for 4-8 weeks. If improvements do not occur, then the appointment of re-treatment is possible.
As a supportive treatment, the daily dose of this medication is 10-20 mg.
In symptomatic therapy, the medication is prescribed in an amount of 10 mg once a day for 4 weeks.
For the treatment of Zollinger-Ellison syndrome, “Barol 20” is recommended to be taken in a dose equal to 60 mg (initial daily dosage). At the discretion of the doctor, the indicated amount of the drug can be divided into two doses.
The daily dose of the drug in the treatment of duodenal ulcer is 20 mg. In this case, the drug should be taken for a month.
Often, treatment with this tool is carried out throughout the year. In this case, the maximum single dose of the medication should not exceed 60-120 mg per day.
Side effects
What side effects does Barol 20 cause? Instructions for use indicate that this drug often causes undesirable effects such as abdominal pain, nausea, constipation, vomiting, diarrhea, flatulence, dyspepsia and a feeling of dry mouth.
Sometimes, while taking the medication, the patient has headaches, asthenia, dizziness, chills, sleep problems, respiratory depression, changes in body temperature, skin rashes, etc.
Overdose Signs
What are the symptoms of an overdose of Barol 20? The instructions for use states that no such cases have occurred. However, experts do not exclude the possibility of increasing adverse reactions.
In this case, treatment is carried out in the form of gastric lavage.
Interaction with other medicines
What drugs are forbidden to combine Barol 20 capsules with? Instructions for use reports that rabeprozole is able to significantly reduce the secretion of hydrochloric acid. This affects the kinetic parameters of drugs, the absorption of which directly depends on the acidity of the juice of the stomach.
It was also found that the medication in question reduces the concentration of Ketoconazole in the blood and increases the content of Digoxin. In this regard, the simultaneous administration of the mentioned drugs requires special monitoring by the attending physician (if necessary, a dose adjustment is carried out).
In general, the medication in question is characterized by a rather low interaction with other drugs.
Special recommendations
Before prescribing the drug “Barol” for the treatment of various diseases of the gastrointestinal tract, a medical examination of the patient must be carried out in order to exclude the presence of cancer. This is due to the fact that taking this drug can hide the symptoms of a serious pathology.
The medication in question is not prescribed during breastfeeding, since there is no information about the penetration of its active substance into breast milk.
In severe violations of the kidneys and liver, careful medication is required.
The drug "Barol" does not adversely affect the patient's ability to drive vehicles or work with other dangerous mechanisms.
If changes in the skin appear, the medication must be stopped.
Storage, shelf life and leave in pharmacies
The drug "Barol" is available in pharmacies without a doctor's prescription. However, using it without consulting a doctor is highly discouraged. Otherwise, this may aggravate the patient’s difficult situation.
It is desirable to contain the medication in a dark, inaccessible to children and dry place, where the air temperature does not exceed 26 degrees. The shelf life of the capsules is two years from the date of manufacture. At the end of this period, the use of medication is prohibited.
Cost and similar drugs
The price of antiulcer medicine is about 215 rubles. If required, it can be replaced with one of such drugs as Veloz, Rabimak, Pariet, Rabelok, Rabeprazole, Rabizol. Only an experienced doctor should prescribe the funds listed, based on the data of tests and a medical examination.
Reviews of consumers and doctors
Now you know the properties and characteristics of the drug "Barol 20". Instructions and analogues of the drug were also presented above.
Reviews about this tool can be found completely different. Most patients confirm its high effectiveness.
Experts have found that for many drugs that were created on the basis of rabeprazole, an instantaneous action is characteristic. In this case, there is no need to use high doses of the drug or increase the frequency of its use.
It should also be noted that the drug "Barol" has a fairly good tolerance. It successfully inhibits the secretion of hydrochloric acid.
The medication in question can be prescribed for almost any violations that are indications for its use. For example, it helps quite well during the treatment of reflux. However, some patients claim that other drugs of a similar action did not always help them.
In combination with antibiotic agents, such capsules are very often prescribed in the treatment of peptic ulcer. This gives highly positive results.
Very many people, with the sensation of "increased acidity", begin to independently choose for themselves various drugs for its treatment. Quite often, Barol capsules are used for these purposes. Some consumers claim that this tool has significantly improved their condition. Although it did not help other patients. Experts say that the reason for the ineffectiveness of this drug lies in the fact that the above-mentioned discomfort is associated with completely different disorders in the digestive tract, which require appropriate therapy. Therefore, it is very important to consult a doctor in a timely manner, who, after a medical examination, will give you an accurate diagnosis and prescribe the right treatment.