Duodenogastric reflux is a pathological condition in which bile enters from the duodenum into the stomach due to various pathologies of the gastrointestinal tract. As a result of the disease, the digestive process is disrupted, which patients feel for characteristic symptoms.
One of the drugs used in the casting of bile is Ganaton. Patient reviews about him are mostly positive. Consider the instructions for this drug, its advantages, disadvantages and analogues.
Bile in the stomach
According to experts, duodenogastric reflux (also called bile reflux) is observed in every second inhabitant of the planet. However, most people with this pathology do not notice any symptoms that bile from the duodenum enters the stomach. Many doctors even consider them completely healthy in terms of the digestive tract.
There are doctors who claim that duodenogastric reflux is observed in every person (sick and healthy), and bile is in the lower parts of the stomach for about 8-9 hours a day. Reflux is activated at night, and during the day its intensity decreases. However, people do not feel any discomfort. Of course, in this case, when throwing bile, “Ganaton” is not appointed.
Duodenogastric reflux becomes hazardous when the bile is in the stomach for a longer time, which leads to the development of chemical-toxic gastritis. It is this disease that makes itself felt by the characteristic symptoms, which we will discuss below. When they begin to bother the patient, doctors prescribe "Ganaton" when throwing bile.
The reasons why bile enters the stomach
Why does it happen that bile is in the stomach? The main reason is the weakening of the gatekeeper's closure function. Also, pathology can occur with chronic duodenitis and high pressure in the duodenum, often occurring in the organ, if there is inflammation of its membrane.
The above pathologies can be triggered by many reasons, among which the following can be distinguished:
- Unbalanced diet.
- Alcohol abuse.
- Excessive physical exertion associated with weight lifting.
- The abuse of coffee and strong black tea.
- Regular consumption of very spicy foods.
- Acceptance of pharmacological preparations.
- Regular overeating.
- Hereditary predisposition.
- Smoking
There are a number of diagnoses in which duodenogastric reflux becomes a concomitant pathology. It:
- Pyloric stenosis.
- Obesity and type 2 diabetes.
- Dyskinesia of the gallbladder and biliary tract.
- Ascites.
- Swelling of the internal organs.
- Diaphragmatic hernia.
- Neoplasms of various etiologies.
Normally, bile should enter the duodenum. Why is casting into the stomach? To get into it from the intestine, she needs to go through the pyloric sphincter, which is a kind of damper that separates the stomach and duodenum.
In some people, not only the pyloric, but also the cardiac sphincter is weakened. Its functions are to prevent the contents of the stomach from entering the esophagus. If the second “flap” does not work well, then the patient has gastroesophageal reflux (bile and acids enter the esophagus). Reviews of "Ganaton" when throwing bile report that regular use of the drug can save the patient from unpleasant symptoms in these painful conditions.
When bile becomes dangerous
Bile in relation to the mucous membranes of the lower stomach and esophagus is an aggressive environment. This feature of her helps to digest food. However, bile can disrupt the integrity of the internal membrane of the digestive tract, causing erosion and ulceration.
At the same time, patients note abdominal pains, a feeling of heaviness and overflow in the stomach (food is poorly and long digested), heartburn, belching, nausea, a characteristic yellow coating appears on the tongue. The injection of bile into the esophagus is especially dangerous, since its mucous membranes have practically no protection against contact with aggressive media, because its function is only to transport food from the oral cavity to the stomach.
General information about "Ganaton"
This drug belongs to the group of prokinetics. These are medicines that help improve the digestion process, improve the motility of the digestive tract (food moves faster, which makes it possible to avoid stagnation). They also affect the contractile function of the sphincters and to reduce or completely eliminate the vomiting reflex.
Ganaton is available in tablets. The main active ingredient is itoprid hydrochloride. One tablet contains 50 mg of this substance. The following substances are used as auxiliary components:
- Lactose.
- Carmellose.
- Silicic acid.
- Magnesium stearate.
- Hypromellose.
- Titanium dioxide.
- Carnauba wax.
The tablets are packaged in blisters. Each can have 7, 10 or 14 pills. Blisters are placed in cardboard packs, in which they can contain from 1 to 5 pieces.
Pharmacodynamics and pharmacokinetics
Once in the stomach, the shell of the Ganaton tablet dissolves very quickly. The active substance (itoprida hydrochloride) acts on dopamine receptors (is their antagonist) and inhibits acetylcholinesterase. This leads to the activation of motility and increased tone of the sphincter. As a result, the stomach empties faster, and gastroduodenal coordination improves. Therefore, all symptoms of the disease in patients quickly stop.
The active substance is absorbed very quickly. Its bioavailability is 60%. Food has no effect on this. The maximum plasma concentration is reached after 30-40 minutes after taking the pill.
In the liver of itopride, the hydrochloride undergoes a biological transformation with the formation of metabolites. They are excreted mainly in the urine.
Indications for use
Instructions for use with "Ganaton" reports that the tool is effective in treating symptoms caused by impaired motility in the digestive tract, such as:
- Bloating.
- Feeling of heaviness and fullness in the stomach.
- Fast saturation.
- Decreased appetite.
- Abdominal pains.
- Heartburn.
- Nausea.
It is indisputable that while taking the drug, appetite improves significantly. What helps Ganaton? Reviews of patients who took this medication report that they have had pain in their stomach, the feeling of heaviness, fullness, as well as nausea, belching, rumbling in the digestive tract have disappeared.
Dosage
Instructions for use "Ganaton" recommends taking this medicine by mouth at 50 mg (1 tablet) three times a day before meals. The optimal time interval between taking a pill and eating is about 20 minutes. Recommended daily dosage can be reduced. Such a decision should be made by the doctor based on the patient's condition. It can be reduced based on the age of the patient.
Possible side effects
Reviews of the Ganaton tablets report that patients on the background of treatment noted the presence of the following side effects:
- Drawing pains in the stomach.
- Nausea.
- Diarrhea.
- Gynecomastia (with a long course of treatment).
- Hormonal imbalance (more often in men).
- Dizziness.
- Rash, itch.
- Decreased white blood cell count.
- Thrombocytopenia.
- Leukopenia
- Patients with weakened liver may develop jaundice.
- Swelling of the tongue and palate.
If side effects are evident, then you should refuse to take this drug. Reviews of "Ganaton", when throwing bile prescribed by doctors, report that in some cases the manifestations of reflux do not soften, but side effects appear. In this case, it is also better to refuse to take these tablets.
Contraindications
The instruction for the drug reports that there are the following contraindications for use:
- The period of pregnancy and breastfeeding.
- Age is under 16 years.
- Mechanical obstruction.
- Internal bleeding;
- Exacerbation of chronic diseases of the gallbladder, liver (in this case, administration is possible only as directed by a doctor).
- Intolerance to the components that make up the Ganaton.
With caution, the drug can be taken in such categories of patients:
- The elderly.
- Suffering from renal and / or liver failure.
The drug can be purchased without a prescription. However, before starting treatment, you should carefully study the instructions and, if there are contraindications, abandon the medication.
Medicinal interaction of "Ganaton" with other medicines
While taking with Diazepam, Warfarin, Diclofenac, there are no disturbances in the interaction of Ganaton with blood proteins, but the patient should be monitored.
Since taking the medication in question helps to improve gastric motility, it affects the absorption of the drugs used simultaneously. Particular care must be taken when using drugs with a low therapeutic index, prolonged release of the active substance and enteric coating.
Analogs
Not always the patient can afford to take the described drug, since he has a number of contraindications and side effects. This is confirmed by the instruction. Reviews of Ganaton's analogues report that they often suit the patient better. The list of such drugs according to the principle of action:
- Passasics.
- "Aceclidine."
- Domrid
- Motilium.
- Itomed.
- Zirid.
Perhaps the most commonly used drug as an analogue of Ganaton is Motilium. This medication has an antiemetic property, and also activates the motility of the digestive tract.
Domrid is one of the cheapest analogues of Ganaton. Instructions for use and reviews of the drug report that it helps with stomach pain, nausea, bloating, heartburn, vomiting. An important advantage is that this drug can be given to children from the first days of life.
Reviews of "Ganaton" when throwing bile into the stomach or esophagus
With this pathology, patients often feel a bitter taste in the mouth, which creates a certain discomfort. Reviews about "Ganaton" when throwing bile indicate that the drug is effective only if you abandon bad habits and normalize food. It is important to understand that the medication helps only with complex treatment, which includes diet. Do not starve or significantly change the diet. It is enough to refuse fatty meat, fried foods, mayonnaise and similar high-calorie sauces.
There are also negative reviews about the Ganaton. When bile is thrown into the stomach, a number of processes occur that contribute to the development of gastritis, and later ulcers. To cure these ailments, the medicine must be used for a long time or repeat the course after a break. That is, at one time, the medication may not have the expected result.
In reviews of Ganaton, patients also report that the medication is too expensive. The price is from 330 rubles for 10 tablets. Therefore, its prolonged use may not all.
Reviews of doctors about "Ganaton" when throwing bile into the stomach
Many gastroenterologists believe that taking this drug when throwing bile into the stomach does not have a therapeutic effect, that is, it does not eliminate the cause of the development of reflux, but only reduces the symptoms. If the gastrointestinal sphincters have weakened, then a diagnosis should be made and the cause of this condition determined. After this, we can talk about the appointment of certain pharmacological drugs that will directly affect the cause of the pathology.
Doctors in reviews of "Ganaton" when throwing bile are skeptical. They believe that the medication can only be used as part of complex therapy to reduce discomfort in the stomach in patients.
It should be noted that the drug is often prescribed to people with poor appetite. Reviews about the "Ganaton", when throwing bile into the stomach prescribed by specialists, are ambiguous. What do doctors think about the effectiveness of its use in anorexia?
Doctors say that to get rid of this condition, the medication is quite suitable. Patients in their reviews write that their appetite has improved already in the first day after taking the pill. In this case, "Ganaton" does not cause psychological and pharmacological dependence.
Proper nutrition and reception "Ganaton"
In parallel with the use of pharmacological preparations, the patient must adhere to the principles of proper nutrition:
- Refuse the use of spicy and salty foods.
- Prefer stewed foods, exclude fried, smoked and fatty dishes.
- Completely abandon the use of alcoholic, sweet carbonated drinks.
- Reduce the use of coffee and black tea.
At the same time, bile production is restored. Reviews of "Ganaton" indicate that the medicine works better if you eat properly.