Is the drug "Nolitsin" an antibiotic or not? The answer to this difficult question we will give in the presented article. We will also tell you about which diseases the medication under consideration is prescribed for, whether it has side effects and contraindications, and also discuss how much it costs and what substances it includes in its composition.
Packaging, form, composition of the medicine
Nolitsin tablets (from which they help, we will tell further) contain such an active substance as norfloxacin. As for the auxiliary components, they use magnesium stearate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, purified water and povidone.
It should also be noted that the shells of the tablets in question include hypromezole, propylene glycol, talc, dispersed yellow dye (E 110) and titanium dioxide.
The drug "Nolitsin", the price of which is indicated below, is available in blisters for 20 or 10 tablets, which are placed in cardboard boxes.
Pharmacological properties of the drug
Medication "Nolitsin" - an antibiotic or not? Many patients ask this question to their doctors. As you know, the active substance of the drug in question is norfloxacin. It has an antimicrobial effect on strains of staphylococci, as well as neiseria, Klebsiella, enterobacteria, Escherichia coli, Legionella, Chlamydia, Salmonella, Shigella and other pathogens of infectious diseases.
The mechanism of action of the drug is based on the interaction of the active substance with DNA gyrase (i.e. an enzyme of microorganisms). Such an effect leads to the destabilization of the DNA chain, as well as the subsequent death of bacteria.
So is Nolitsin a antibiotic or not? From the foregoing, we can safely conclude that this medication is an antibiotic, since it has a negative effect on harmful microorganisms.
The antimicrobial effect of tablets can last about 12 hours. As a rule, such a drug is prescribed for diseases that were caused by enterococci and other mycobacteria.
Pharmacokinetics of the drug
Now you know what the drug "Nolitsin" is. An antibiotic or not this medication, we also found out. Now I want to tell you about whether the drug in question is absorbed into the systemic circulation.
According to pharmacists, the active component of this drug is absorbed quite quickly in the digestive system. Its peak concentrations are observed after 1-2 hours after taking the tablets. The bioavailability of the drug is 30-40%. Approximately 15% of the active substance binds to plasma proteins.
The medication in an unchanged form is excreted through the renal system. And only a small part of it passes through the digestive tract.
In people with renal pathology, the pharmacokinetic properties of the drug may appear differently.
Indications for use of the drug
In what cases are Nolitsin tablets prescribed? What do they help from? According to the attached instructions, the medication in question is prescribed for the treatment of diseases of the genitourinary system, which are infectious or inflammatory in nature:
- urethritis;
- chronic prostatitis of bacterial origin;
- endometritis;
- cystitis;
- cervicitis;
- uncomplicated form of gonorrhea;
- pyelonephritis.
For what other purposes is the medicine "Nolitsin" used? Indications for taking this drug may be as follows:
- shigellosis;
- bacterial gastroenteritis;
- prevention of diarrhea;
- salmonellosis;
- prevention of septic complications in patients with neutropenia.
Contraindications
Reception of "Nolitsin" should be prohibited under the following conditions:
- impaired cerebral blood supply;
- fluoroquinolone intolerance;
- epileptic syndrome;
- gestation;
- changes (atherosclerotic) in the vessels of the brain;
- congenital deficiency of the G6PD enzyme;
- allergic reactions to acetylsalicylic acid.
It should also be noted that the drug in question is prohibited for use in pediatric practice.
How to take "Nolitsin"?
Take tablets "Nolitsin" should be taken orally, washed down with plain water.
For infectious diseases of the genitourinary system, the drug is prescribed twice a day, 400 mg each. The duration of such therapy is 7-10 days.
Therapy of uncomplicated cystitis is carried out for 4-7 days.
Recurrent urinary tract infections (chronic) should be treated for 12 weeks. As for acute gastroenteritis of bacterial origin, with this diagnosis, the drug is prescribed twice a day at 400 mg for five days.
With proctitis, cervicitis, pharyngitis and urethritis, tablets are taken once in an amount of 400 mg.
Overdose Signs
After taking high doses of the drug, the patient displays the following symptoms: intense vomiting, dizziness, nausea, drowsiness, cold sweat. Therapy of such conditions includes gastric lavage and forced diuresis.
Side effects after taking the pills
Are there any adverse reactions after taking the Nolitsin medication? Instructions, reviews of doctors indicate the following adverse events:
- nausea;
- hypercreatininemia;
- vomiting
- glomerulonephritis;
- bitterness in the mouth;
- polyuria;
- epigastric pain;
- urethral bleeding;
- impaired appetite;
- crystalluria;
- diarrheal syndrome;
- dysuria;
- pseudomembranous enterocolitis;
- albuminuria;
- increased ALT and AST.
Also, patients may experience headaches, hallucinations, skin itching, arrhythmias, vasculitis, insomnia, tachycardia, swelling, fainting, exudative erythema and urticaria
Very rarely, people taking the drug "Nolitsin", recorded changes in blood counts, candidiasis, arthralgia, decreased hematocrit, fear of light and chemosis.
Drug interaction
The drug in question reduces the effectiveness of a drug such as Nitrofuran and increases the concentration of indirect anticoagulants and Cyclosporin. It should also be noted that norfloxacin reduces the total clearance (about ¼) of theophylline.
With the combined use of Nolitsin tablets with drugs that lower the epileptic threshold, epileptic seizures may increase in patients .
With the simultaneous administration of antihypertensive drugs, a sharp drop in pressure is observed.
Antacids reduce the absorption of Nolicin.
The use of medications intended for general anesthesia requires special control of heart rate, blood pressure and heart function.
Special instructions for using the medication
Before prescribing the antibiotic Nolicin, the sensitivity of the flora to the active substance of the drug should be determined.
With such a diagnosis as pyelonephritis, the medication in question must be prescribed along with herbal preparations (for example, together with Kanefron).
During treatment, patients should receive a large amount of water (under the control of diuresis).
During therapy with the drug "Nolitsin" it is advisable to avoid prolonged exposure to direct sunlight.
If the patient has tendon pain or signs of tendovaginitis have begun to be observed, then the drug should be discontinued immediately.
During treatment with norfloxacin, it is advisable to avoid intense physical exertion.
The drug "Nolitsin": price and analogues
The following drugs are analogues of the drug in question: Loxon-400, Norfacin, Norbactin, Sofazin, Norilet and Renor.
The price of Nolitsin tablets depends on their quantity in the package: 10 pieces - 150 rubles, 20 pieces - 305 rubles.
Drug Reviews
Reviews about the drug "Nolitsin" are more positive. It is especially effective for cystitis. According to patients, the drug taken quickly eliminates all the unpleasant signs of the aforementioned disease (pain, pain, frequent urination).
Thus, we can safely conclude that the drug "Nolitsin" is an effective and inexpensive antibiotic, designed to treat diseases of the genitourinary system. At the same time, one cannot fail to mention that some patients claim that this remedy can cause a fairly large number of adverse reactions. In this regard, the medicine should be taken only as prescribed by the doctor and after a detailed study of the instructions.