One of the most popular and sought-after medicines that are effective in combating the symptoms of coronary heart disease is Preductal tablets. Reviews about the use of this drug are controversial. This is due to the fact that, along with extreme effectiveness, this medication does not heal the disease, but only relieves its symptoms. About how appropriate the use of the drug "Preductal" will be discussed in our article.
general characteristics
There are drugs whose use has earned numerous positive reviews. "Preducted" is one of them. This drug has the ability to neutralize the effects of oxygen starvation of nerve cells of the brain and heart muscle due to increased metabolism. The drug "Preductal" improves energy metabolism in cells that are deficient in oxygen, so it is prescribed to patients suffering from coronary heart disease to prevent the occurrence of angina pectoris, as well as in case of retinal (visual impairment) and cochleovestibular (hearing loss, dizziness, tinnitus) disorders .
Varieties
Currently, two types of the same medicine are produced - this is Preductal and Preductal MV. They have the same therapeutic effect, because they contain in their composition one active substance - trimetazidine. So which of these drugs has earned the most praise? “Preductal MV” is considered by some to be more effective, since it was created using special technology, due to which its main active substance is released more slowly, which means that it has a longer effect on the body. There are no other differences between the two drugs. Everyone can choose the one that, for subjective reasons, seems better to him.
Dosage form
The dosage form of the above preparations is almost identical. They are both available in pill form. There are sixty of them in the package with Preductal medicine, and Preductal MV is sold at 300, 180, 90, 60 units per pack. Both those and other tablets have a biconvex shape and are painted white on the fault. However, there are still some differences. The Preductal MV tablets are pink, and the Preductal tablets are red-orange.
Structure
The drug "Preductal MV", reviews of which will be presented below, contains in one tablet 35 mg of trimetazidine. In a weaker Preductal, this substance is present in a much lower concentration - only 20 mg. But the auxiliary components in these medicines are different. “Preductal MV” consists of calcium hydrogen phosphate dihydrate, hypromellose, red iron oxide, colloidal silicon oxide. "Preductal" - from corn starch, aluminum yellow varnish, cochineal aluminum varnish, talc mannitol. These drugs also have common components - glycerol, povidone, titanium dioxide, hypromellose, macrogol 6000, magnesium stearate.
Therapeutic effect
Trimetazidine maintains a stable level of ATP in the tissues and, due to this, ensures normal cell activity under conditions of oxygen deficiency. In addition, this substance inhibits the oxidation of fatty acids and stimulates the utilization of glucose, which is necessary for energy production and requires less oxygen. It is this process that underlies the therapeutic effect of the preparations Preductal and Preductal MV.
Patient reviews indicate that these drugs have the following properties:
- Slow down the development of a heart attack caused by physical activity (from the fifteenth day of therapy).
- Reduce blood pressure fluctuations associated with excessive fatigue.
- Reduce the frequency and intensity of angina attacks.
- Level the need for nitroglycerin.
- Stimulate blood circulation.
- They improve hearing with deafness caused by coronary heart disease.
- Increase visual acuity associated with oxygen starvation.
Indications for use
- For coronary heart disease, Preductal MV and Preductal tablets are used. Reviews of cardiologists indicate that they are effective in long-term therapy with the goal of preventing angina attacks.
- To eliminate cochleovestibular disorders (dizziness, hearing impairment, tinnitus) in the ENT practice, the preparations described by us are also used.
- In ophthalmology, the medicines Preductal MV and Preductal are no less in demand: they eliminate dystrophy and atrophy of the retina caused by oxygen deficiency.
Instructions for use
Preductal tablets must be swallowed whole with food, washed down with a small amount of water. Usually they are prescribed one at a time two to three times a day. Therapy, as a rule, lasts several months, its duration depends on the appointment of the attending physician. The daily concentration of the drug in the blood should not exceed 60 mg, which corresponds to three tablets. The use of a larger amount of the drug is fraught with negative consequences, as evidenced by reviews. "Preductal" in a strong concentration provokes pronounced side effects.
Preductal MV tablets should be taken one at a time twice a day - in the morning and in the evening. They need to be absorbed without chewing, while eating, washed down with water. The daily maximum dosage of the drug in the blood is 70 mg (two tablets). To avoid side effects, it should not be exceeded. The duration of the use of Preductal MV is also several months (under close supervision of a treating specialist).
Side effects
The drugs "Preductal" and "Preductal MV" can cause the same side effects. Through clinical trials and prolonged monitoring of patients, it was found that they can provoke some disturbances in the functioning of organs and systems.
- From the gastrointestinal tract, nausea, abdominal pain, diarrhea, constipation, vomiting, dyspepsia (bloating, belching, gas exhaustion, heartburn, etc.) can be observed.
- From the side of the central nervous system: dizziness, asthenia, akinesia (inability to make arbitrary desired movements), headaches, tremors, instability in the Romberg position, increased muscle tone, restless legs syndrome, specific parkinsonian gait, gait, drowsiness, and insomnia.
- The skin and subcutaneous fatty tissue can suffer from rashes, itching, urticaria, acute generalized exanthematous pustulosis and Quincke's edema.
- From the cardiovascular system: extrasystole, palpitations, a strong decrease in blood pressure, tachycardia (fast pulse), flushing of the face, orthostatic hypotension (pressure drop when moving to a standing position).
- The following disorders may appear in the blood and lymph after the use of the drug: agranulocytosis (a decrease in basophils, neutrophils and eosinophils), thrombocytopenic purpura, thrombocytopenia.
- In addition, in some cases, the use of the medication described by us can cause hepatitis.
The fact that the above side effects disappear immediately after discontinuation of the drug is confirmed by numerous reviews. "Preductal", however, should be taken with caution, under the supervision of a physician.
Patient Reviews
The use of the drug described by us causes numerous disputes. Most patients are satisfied with the therapeutic effect that causes the use of the drug Preductal MR. Reviews of its use suggest that it is very effective in eliminating pain, a feeling of compression and pinching in the heart. The disappearance of the above sensations significantly improves people's lives and allows them to forget about the existing chronic serious disease for a long time. In addition, many patients note that shortness of breath and endurance increase during medication. Some people noticed that while taking Preductal, their need for nitroglycerin decreased.
Negative opinions about the drug are due to subjective factors. So, some people think that the imported Preductal has cheaper domestic generics. Analogs (reviews about them are very diverse) are widely represented on the pharmaceutical market, and it is difficult to judge which one is more effective. But many prefer the proven Preductal to other medicines.
Cardiologist reviews
The drug "Preductal" is actively used in medical practice. Reviews of doctors pay attention to the fact that the observed patients sharply increase the quality of life, increase endurance, and the severity and frequency of angina attacks decreases. Experts confirm that the use of symptomatic drugs is advisable, as it allows people to temporarily forget about the serious diseases that plague them.
However, there are other opinions. Some doctors believe that the drug "Preductal" does not produce any positive effect. Reviews of cardiologists who literally believe in evidence-based medicine are based on the fact that this medication does not cure, but only eliminates the symptoms of serious diseases. From this position, some experts call the “Preductal” tablets a placebo absolutely unnecessary. Whether it is this way or not is decided by patients who have experienced the effectiveness of this drug on their own experience.
Analogs
Many generics have the drug "Preductal". Analogues, reviews of which are very contradictory, can be found in any pharmacy. The most popular of them are: “Angiosil”, “Antisten”, “Vero-Trimetazidine”, “Deprenorm MV”, “Carditrim”, “Medarum”, “Metagard”, “Predizin”, “Precard”, “Rimekor”, “Tridukard” "," Trimectal "," Trimet "," Trimetazide "," Trimetazidine "and many others. The question of the appropriateness of their use can only be decided by the attending physician.
Now you know what the product "Preductal" is. Instructions, reviews, analogues of this drug are now no secret to you either. Remember that these "magic" pills do not treat, but only eliminate the symptoms. However, for many people suffering from severe diseases of the cardiovascular system, they are a real salvation and a pass into an interesting and active life.