The problems of the functioning of the heart and blood vessels thoroughly occupy one of the main places in the list of diseases of the modern world that can lead to death. Ischemic diseases, various forms of heart failure, damage to the muscle middle layer of the heart - all this can develop in every second resident of a large metropolis.
If the problem is left and not solved, the patient’s condition will only worsen, which may result in acute cerebrovascular accident or other serious illnesses.
Mildronate is a synthetic preparation that improves metabolism and energy supply of tissues. The main purpose of treatment for patients with heart diseases is to reduce myocardial oxygen demand, as well as increase tolerance to mental and physical stress. What is the effect of Mildronate? Angioprotective, antihypoxic and cardioprotective effect.
Release form
The medication is available in the form of milky gelatin tablets, which contain a hygroscopic white powder with a faint aroma, are packaged in blisters, and then placed in a cardboard box. The drug is also available in the form of a clear liquid (ampoules of 5 milliliters). One milliliter of medicine contains 100 milligrams of active substance.
Structure
The main active trace element that is part of Mildronate is meldonium dihydrate in two dosages - 250 and 500 milligrams. Additional substances are:
- calcium stearate;
- colloidal silicon dioxide;
- potato starch;
- titanium dioxide;
- gelatin.
pharmachologic effect
Meldonium dihydrate helps to improve metabolism, enhancing the elimination of accumulated toxins from tissues, providing a tonic effect and protecting tissues from damage.
After taking "Mildronate" increases the susceptibility to physical and mental stress and the ability to instantly recover from them. Due to this, the medication is used to improve blood supply to the brain and the treatment of various disorders in the functioning of the heart and blood vessels, as well as to increase efficiency.
In the presence of heart failure, according to the instructions for use, "Mildronate" increases contractility of the heart muscle, reduces the frequency of angina attacks, while increasing susceptibility to physical activity.
With cerebral ischemia, the drug is recommended to be used to normalize blood microcirculation in the source of the disease, which contributes to its correct distribution.
Based on the reviews on the drug, we can conclude that the drug works effectively with lesions of the central nervous system, withdrawal symptoms, as well as pathology of the fundus. Does Mildronate have contraindications and side effects? Naturally, like every drug.
Mildronate: contraindications and indications
The drug is used in complex therapy for:
- A pathological disease that is characterized by complete or partial damage to the microcirculation to the myocardium.
- Myocardial infarction (one of the clinical forms of ischemia, proceeding with the development of ischemic necrosis of the myocardial site, due to the absolute or relative insufficiency of its blood supply).
- Angina pectoris (a clinical syndrome characterized by sensation or discomfort behind the sternum).
- An inflammatory disease that develops as a result of a sharply formed or having a prolonged decrease in contractile activity of the myocardium, which has congestion in the circles of blood circulation.
- Myocardial inflammation, which is formed as a result of a lack of sex hormones in the body.
- Strokes (a sharp decrease in the movement of blood to the brain, which leads to a constant focal inflammation.
- Cerebrovascular insufficiency (a disease that provokes pathological changes in the vessels of the brain).
- Reduced performance.
- Retinopathies (damage to the retina of the eyeball of any origin).
- Hemophthalmia (penetration of blood into the vitreous body or into one of the spaces formed around it).
- Retinal hemorrhages (bleeding into the retinal tissue resulting from damage to the walls of the eye vessels).
- Vascular diseases, which are manifested by ischemia, expansion and tortuosity of the veins of this area of the eye, mainly intraretinal hemorrhage and edema of the macula.
- Chronic alcoholism (a mental illness caused by prolonged intoxication of the body with alcohol).
In addition, the drug is used to restore performance and reduce signs of mental and physical fatigue.
Ban
According to the instructions to "Mildronate", the drug still has contraindications for use:
- children under 18 years old;
- with hypersensitivity to the drug;
- with increased intracranial pressure;
- intracranial tumors;
- discirculation (violation of venous outflow).
It is not recommended to take the drug during pregnancy and during breastfeeding, since there is no information about the studies conducted in these conditions.
Instructions for use
With coronary heart disease or with prolonged heart failure, the drug should be used as part of complex therapy 1 or 2 times a day for 6 weeks. The maximum daily dosage varies from 0.5 to 1 gram.
To persons who suffer from menopause of the myocardium, the drug is prescribed as a medicine in conjunction with complex treatment. For 12 days, you need to take 500 milligrams per day.
With a sharp lesion of cerebral circulation, "Mildronate" is prescribed 1 gram 1 or 2 times a day for six weeks.
In case of chronic damage to the microcirculation of the brain, the drug is used two or three times a year as part of a comprehensive treatment (0.5 milligrams for six weeks).
For mental and physical overloads and reduced performance, it is recommended to use two tablets (500 milligrams) daily for fourteen days. If necessary, the course can be repeated after three weeks.
Before training, athletes are prescribed Mildronate twice a day from 0.5 to 1 gram for three weeks before the competition.
In the presence of delirium tremens, it is recommended for people suffering from alcoholism to take 0.5 grams four times a day for two weeks.
According to contraindications for use, Mildronate must be taken in the morning. This condition must be observed, since the drug has an exciting effect (it is advisable to take the medicine until about 12 hours).
Mildronate: side effects
Contraindications to use indicate that an incorrectly calculated dose of the drug can cause some negative reactions:
- Hyperemia (excessive overflow of blood vessels of an organ or part of the body with blood).
- Rashes.
- Utricaria (skin disease, dermatitis of mainly allergic origin, characterized by the rapid onset of severely itchy blisters).
- Itchy skin.
- Angioneurotic edema (a sharp disease, which is characterized by the instantaneous occurrence of edema of the mucous membrane).
- Dyspepsia (a violation of the normal activity of the stomach, difficult and painful digestion. Dyspepsia syndrome is defined as a feeling of pain or discomfort).
- Low or high blood pressure.
- Tachycardia (rapid heart contraction from ninety beats per minute).
- Increased nervous irritability.
- General weakness.
- Eosinophilia (a condition in which a relative or absolute increase in the number of eosinophils in the blood is diagnosed).
Interaction
Mildronate enhances the therapeutic effects of cardiac glycosides, antihypertensive drugs, and coronary-expanding drugs. The drug can be combined with prolonged forms of nitrates and anticoagulants, bronchodilators and arrhythmic drugs.
The use of Mildronate in combination with nitroglycerin and drugs that help lower blood pressure can contribute to the development of arterial hypotension and tachycardia.
Overdose
Acceptance of excessively high dosages can lead to the appearance of undesirable reactions:
- lowering blood pressure;
- increased heart rate;
- dizziness
- migraine;
- general weakness.
Features
As already mentioned, during pregnancy during the period of breastfeeding, you should not take the drug, since clinical studies have not been conducted and there is no information about the safety of the drug.
"Mildronate" is contraindicated for persons suffering from renal and hepatic insufficiency.
In the reviews, people who were treated with this medicine note increased performance, improved emotional state, normalized functioning of the heart muscle.
Storage
Keep "Mildronate" should be in a dark place, at a temperature of no more than twenty-five degrees. Shelf life is four years. The cost of the drug varies from 230 to 750 rubles.
Analogs
Like any other medication, Mildronate has substitute drugs:
- Melfort.
- "Meldonium."
- Idrinol.
- "Cardionate".
- "Angiocardyl."
- "Flowerpot".
- "Metazidine."
- "Presidin".
"Meldonium" is available in the form of a suspension, capsules, solution for injection. The drug has anti-ischemic and cardioprotective effects. Effective in the pathology of the vessels of the fundus. Relieves of disorders of the central nervous system. "Meldonium" is contraindicated for people under the age of eighteen. The cost of the drug is 150-250 rubles.
"Idrinol" refers to drugs that improve metabolism and energy conservation. It is dispensed in pharmacies in the form of a solution for injection. One milliliter of Idrinol contains 100 milligrams of meldonium dihydrate (active ingredient). The medicine should be taken at the beginning of the day, as it has an exciting effect. In the treatment of withdrawal symptoms, as a rule, intravenous injections of 500 milligrams are prescribed twice a day. The duration of treatment is fourteen days. Idrinol should not be taken by anyone under the age of eighteen. The cost of the drug varies from 240 to 310 rubles.
“Cardionate” improves energy processes in the body, prevents the formation of long chain fatty acids in the body and reduces the production of levocarnitine, and helps to increase immunity. With constant intake, it enhances the transport of oxygen to the myocardium. "Cardionate" is most effective for metabolic disorders in the tissues. The drug is available in the form of a solution for injection and capsules.
Reception "Cardionate" increases the pharmacological effect of cardiac glycosides, antihypertensive drugs. The drug is not recommended to be taken during pregnancy and during breastfeeding. The cost of the medicine is 180–250 rubles.
The review described the drug Mildronate in detail: actions, contraindications and indications for its use. Analogues of the drug are also mentioned in the article.