The drug "Hydrocortisone" (suspension) has anti-shock, anti-inflammatory, desensitizing, anti-allergic, immunosuppressive, antitoxic and antimetabolic effects.
The drug promotes an increase in blood glucose concentration, deposition of glycogen in the liver, slows down the excretion of water and Na +, increases the excretion of K +, and lowers histamine synthesis. The medicine "Hydrocortisone" (suspension) reduces inflammatory cell infiltrates, the migration of lymphocytes and white blood cells to the site of inflammation. The use of large doses prevents the development of connective and lymphoid tissue, the increase in mast cells in which hyaluronic acid is formed , helps to suppress hyaluronidase and reduce capillary permeability. The drug "Hydrocortisone" accelerates the breakdown and delays protein synthesis.
With its use, the production of corticotropin is inhibited due to the effect on the pituitary gland. Prolonged administration can cause atrophy and inhibition of the adrenal cortex, the formation of thyroid-stimulating and gonadotropic hormones.
Hydrocortisone acetate has an effect that develops slowly, but lasts a long period, in contrast to water-soluble drugs. The medication is used when injected into damaged areas, soft tissues and joints. In these areas, the drug "Hydrocortisone" (suspension) has an anti-inflammatory effect locally. However, systemic hormonal effects are also likely. Intra-articular administration causes a therapeutic effect for six to twenty-four days, which lasts several days (or weeks).
Hydrocortisone phosphate injections can quickly suppress inflammation for a short period. This type of drug is used in acute conditions.
The drug "Hydrocortisone" (suspension) is indicated in case of ineffectiveness of therapy for shock of various origins (traumatic, burn, surgical, cardiogenic, toxic). The drug is used for severe bronchial asthma, thyrotoxic crisis, systemic diseases in the connective tissue (rheumatoid arthritis and others), acute adrenal insufficiency, hepatic coma, acute hepatitis. The medication is prescribed for allergic reactions in severe, acute forms, anaphylactic and blood transfusion shock, cerebral edema (including that associated with surgical intervention, against the background of a tumor, trauma or radiation therapy). To reduce inflammation and prevent cicatricial narrowing, the drug is used for poisoning with cauterizing fluids.
The hydrocortisone medication is contraindicated for articular administration in case of previous arthroplasty, with an intraarticular fracture, an infectious inflammatory process, and pathological bleeding. The drug is not used with severe periarticular osteoporosis, the absence of signs of inflammation, severe bone destruction and deformation, instability due to arthritis, aseptic necrosis in the pineal glands. Suspension is not prescribed in the post-vaccination period (before vaccination for eight weeks and after it for two), in immunodeficiency states (including AIDS), lymphadenitis after BCG. The drug is not used for ulcerative pathology in the stomach and duodenum, latent (latent) or acute peptic ulcer, gastritis, esophagitis, diverticulitis, ulcerative colitis with the risk of perforation or abscess formation, recently created intestinal anamostosis.
Before using the Hydrocortisone (emulsion), it is necessary to carefully study the instructions and consult a doctor.
In addition to the liquid form, there is also a drug in the form of an ointment. As practice shows with external use, the effect is equally high, regardless of the form in which the drug "Hydrocortisone" is used. Reviews of some experts in relation to the drug are positive. In particular, English doctors recommend a medication externally in the treatment of childhood atopic dermatitis.