"Bicillin 5" is a complex antimicrobial agent that belongs to the category of antibiotics of a small spectrum of activity, the penicillin group. Representatives of this type of medicine are famous for their plant origin, as they are produced by certain varieties of mold. Benzylpenicillin, which is part of the drug, is one of the most stable natural penicillins.
Pharmacological properties
The main active substance "Bicillin 5" has an antibacterial effect in relation to:
- meningococcus
- streptococci;
- listeria;
- spirochetam;
- enterococcus;
- staphylococci;
- clostridia.
The antibiotic does not exhibit antibacterial activity and is not used to eliminate diseases provoked by:
- protozoa;
- fungi;
- viruses;
- rickettsiae.
The mechanism of influence of the drug is based on blocking a specific strain involved in the formation of the main active element of the cell walls. As a result, their strength is violated, and the pathogenic bacteria themselves are eliminated.
True, this ingredient also has some disadvantages:
- instability in relation to penicillins;
- slight digestion in the digestive system;
- the absence of a positive reaction to gram-negative sources of pathologies.
"Bicillin 5" injections are a combination of several poorly soluble salts. Due to prolonged resorption, a depot is formed at the injection site, which helps to reduce the number of antibiotic administration procedures and maintain the necessary level of medication in the blood.
Composition and form of release
"Bicillin 5" is produced in the form of a powder, which is intended for the preparation of a special solution for intramuscular administration. The medication has a cream color and a bitter taste. Available in transparent bottles of 10 ml. The drug is produced in Russia.
The composition of the tool includes:
- novocaine salt of benzylpenicillin ;
- benzathine benzylpenicillin.
This medicine is sold exclusively by prescription.
The shelf life of the drug is 3 years. Store the drug in a dry place that is not accessible to children. In this case, the temperature should not exceed 15 degrees. The use of the drug after the expiration date is strictly prohibited.
Indications for use
According to the instructions, "Bicillin 5" is advisable to use in case of detection of infections provoked by strains that are sensitive to penicillin. Often, this drug is prescribed if long-term treatment is necessary, for example, with:
- acute infection, accompanied by intoxication of the whole body and rashes on the body;
- erysipelatous disease;
- syphilis;
- Frambesia
- rheumatism;
- rheumatoid arthritis;
- rheumatic heart disease;
- rheumatoid pathologies;
- tonsillitis;
- purulent lesions;
- lacunar angina;
- burns;
- mechanical injuries of the skin and the penetration of infection into the tissue;
- catarrhal sore throat.
The use of "Bicillin 5" is characterized by a prolonged action, since the therapeutic result persists for 28 days after administration of the drug intramuscularly. The product is excreted from the body naturally, through the kidneys, and also partially with sweat, saliva and sputum.
Contraindications
Like any other medication, "Bicillin 5" has a number of restrictions on the use, in the presence of which it is necessary to abandon the use of funds. These include:
- bronchial asthma;
- hypersensitivity to the components of the drug;
- sensitivity to the ingredients of the drug and penicillin.
Instructions for use "Bicillin 5"
Adult patients and children over 8 years of age, the drug is administered once a month. The recommended dosage for the first age category is 1.5 million units. For the second group, 1.2 million units are suitable. As for children under the age of 8, they are recommended to administer the drug once every 21 days at a dosage of 600 thousand units.
How to chop "Bicillin 5"? The powder should be diluted immediately before administration. To prepare the solution, special injection water, chloride or novocaine is used. The product made must be shaken thoroughly to obtain a mixture with a uniform consistency, and then injected into the patient intramuscularly.
Storage of the prepared suspension and its further use is strictly prohibited.
For the introduction of the drug, experts recommend stopping the choice on the upper outer square of the gluteal muscle. Manipulation should be done immediately after preparation of the solution. Otherwise, you may encounter a change in the colloidal and physical characteristics of the product, which will make it difficult to pass through the needle.
Side effects
In case of improper use, treatment with Bicillin 5 may produce a negative result. As side effects may occur:
- thrombocytopenia;
- eosinophilia;
- leukopenia;
- fever;
- anemia;
- rashes on the body;
- migraine;
- deterioration of blood coagulation;
- angioedema;
- inflammation of the oral mucosa;
- joint pain;
- anaphylactic shock;
- skin damage of an inflammatory nature.
Recommendations for use
The drug has some features that should be considered when applying.
- The drug is not allowed to be administered intravenously.
- After the manipulation, the area into which the drug was injected cannot be rubbed, as after a simple injection - you need to press down a little and hold for a minute.
- In case of an allergic reaction of the body, the use of "Bicillin 5" should be discarded.
- If anaphylactic shock occurs, you should immediately seek help: use Norepinephrine and glucocorticosteroids.
In addition, before starting treatment with Bicillin 5, it is necessary to conduct microbiological examinations. The same procedures are recommended over the next four months in case of suspected syphilis.
As a preventive measure to prevent fungal diseases, you should use B vitamins and ascorbic acid. The use of too small doses of the drug or a complete rejection of therapy before the due date can provoke the emergence of resistant microorganisms.
In the case of parallel use of "Bicillin 5" with antibiotics that have a bactericidal effect, its properties are significantly enhanced, but the quality of other medicines, on the contrary, decreases. In addition, when taking the drug, the effectiveness of combined oral contraceptives decreases. And diuretic drugs, for example, "Phenylbutazone" or "Allopurinol," slow down the excretion of benzylpenicillin, due to which its content in the blood rises.
Identical drugs
"Bicillin 5" has analogues in the form of various salts of domestic production of benzylpenicillin. Other drugs based on penicillins are semi-synthetic drugs that are resistant to penicillinase and a wide range of antibacterial effects. These are drugs that are based on amoxicillin, ampicillin, produced in the form of capsules and tablets. Similar in composition to "Bicillin 5" are considered:
- Retarpen.
- "Benzicillin 1".
- Moldamine.
- Extensillin.
Substitutes in their exposure spectrum are:
- Augmentin is a complex preparation with a wide spectrum of antibacterial action based on clavulanic acid and amoxicillin.
- "Amoxiclav" - active against a huge number of different bacteria, is a semi-synthetic antibacterial drug, is produced in the form of tablets.
- "Ampioks" - produced in the form of tablets, refers to the penicillin series of medicines.
Reviews on "Bicillin 5"
Typically, the responses about this drug speak mainly of its high effectiveness at a fairly low cost. Users rank "Bicillin 5" as a minimally toxic means, separately noting its prolonged action. True, patients using this medicine warn about the powerful properties of this drug. That is why injections should be extremely careful.
However, in addition to positive reviews about the drug, there are negative opinions: many patients noticed a deterioration in the intestinal microflora after using the drug. As for children, they can negatively endure severe soreness of injections of "Bitsillin 5".