Elevated body temperature indicates pathological processes in the patient’s body. If the fever is small and does not exceed subfebrile values, then it should not be eliminated by taking tablets. If the temperature is very high, then it should be immediately brought down. Otherwise, this can lead to serious consequences.
Modern pharmaceutical companies produce a huge number of drugs that can quickly eliminate any fever. However, the medication Pentaflucin is considered the most effective among them. The composition of this medicine, its analogues, method of application and form of release will be presented below.
Composition, description, form and packaging
What does Pentaflucin contain? Instructions for use (powder is the only form of this drug) reports that the active ingredients of the medication in question are ascorbic acid, paracetamol, calcium gluconate, rutin and diphenhydramine. As for the additional elements, then sugar, low molecular weight polyvinylpyrrolidone and essence are used as them.
The medicine "Pentaflucin" is a white granule that is designed to dissolve. They are contained in 5 g sachets (for single use).
Pharmacology
What is remarkable about Pentaflucin? Instructions for use (powder should be prescribed only by a doctor) reports that this is a combined medication that has an antipyretic effect.
This tool is used to alleviate the condition of the patient with colds and flu. It has antipyretic and anti-inflammatory properties.
Drug properties
The effectiveness of the drug for adults and adolescents is due to the ingredients that make up its composition.
Paracetamol is a non-narcotic analgesic that not only has an antipyretic effect, but also blocks COX-1 and COX-2 in the central nervous system.
Ascorbic acid is involved in blood coagulation and carbohydrate metabolism. It also increases resistance and promotes tissue regeneration.
Diphenhydramine, or diphenhydramine, has an antihistamine effect. It eliminates swelling of the mucosa and its inflammation, has a sedative and hypnotic effect.
Rutoside, or rutin, reduces capillary fragility, reduces blood coagulation and is an antioxidant.
Calcium gluconate regulates calcium metabolism, normalizes the concentration of phosphorus in the plasma.
Pharmacokinetic properties
What pharmacokinetic parameters are inherent in Pentaflucin granules? Instructions for use (the powder should be dissolved before use) states that paracetamol is rapidly absorbed from the digestive tract. Its maximum concentration is reached after approximately 30-55 minutes. It is instantly distributed in the tissues and has a low bond with proteins. The metabolism of paracetamol is carried out in the liver, and excreted by the kidneys.
The maximum concentration of rutoside is reached after 2-9 hours. Its half-life is 10-25 hours.
Ascorbic acid is also rapidly absorbed from the digestive tract. Its highest concentration is reached after 4 hours. It is metabolized in the liver.
Diphenhydramine, or diphenhydramine, is rapidly absorbed into the blood. Its bioavailability is 50%, and the highest concentration is observed after 20-40 minutes. A large amount of this component is found in the lungs, liver, brain and kidneys. It penetrates the BBB, and after a day it is completely excreted by the kidneys and together with breast milk, which often causes a sedative effect in children.
Indications for use of the drug
From what is the drug in question prescribed for adults and adolescents? This drug works well at elevated body temperature, with flu and colds.
Contraindications
On how to dissolve the powder "Pentaflucin", we will describe further.
The mentioned medication is contraindicated:
- with renal or hepatic insufficiency;
- with increased sensitivity;
- during breastfeeding and pregnancy;
- with a tendency to hemorrhage;
- under the age of 16 years.
Caution is indicated for congenital hyperbilirubinemia.
"Pentaflucin": instructions for use
A powder intended to lower body temperature is taken orally by one sachet. This procedure is carried out three times or four times a day, before meals. Therapy with this tool should last no more than 3-5 days.
How to dissolve granules for their intake? The contents of one packet are dissolved in 0.5 cups of hot water, and then immediately taken orally. When preparing the solution, a slight precipitate is allowed in it.
According to the instructions, the intake of the drug in question is not recommended to be combined with the intake of alcohol. It is also necessary to refrain from driving vehicles.
Side effects after taking the medication
Pentaflucin medicinal powder, analogues of which are listed below, can cause the following undesirable reactions:
- nausea;
- skin rash;
- vomiting
- headache;
- drowsiness;
- general weakness;
- dizziness;
- thrombocytopenia;
- leukopenia;
- agranulocytosis.
When taking the drug in high dosages, a nephrotoxic or hepatotoxic effect may also occur.
Drug interaction
The drug "Pentaflucin" is able to enhance the effect of drugs that reduce blood coagulation and reduce platelet aggregation. It also enhances adverse reactions of non-narcotic analgesics, glucocorticoids, NSAIDs, sulfonylureas and methotrexate derivatives.
You should avoid combining this drug with barbiturates, anticonvulsants, Diphenin, Rifampicin, Carbamazepine, alcohol, and Zidovudine.
Cost and drug analogues
The price of Pentaflucin powder is 150-170 rubles. If required, it can be replaced with drugs such as Coldrex, Max Flu, Antigrippin and Coldflu.
Drug Reviews
According to experts, this drug should be prescribed only for symptomatic treatment of patients with respiratory diseases. All those who have repeatedly taken this medication note its high effectiveness, reasonable cost and availability in pharmacies. Taking one sachet of medicine almost immediately eases the patient's condition.
Of the shortcomings of the powder, such a side effect as drowsiness is noted. Doctors explain this reaction by the fact that diphenhydramine is part of the medication. By the way, Pentaflucin Daytime does not include this ingredient, therefore it is deprived of such an effect.