Spasms are called involuntary muscle contractions, which are often accompanied by aching and sharp pain. Specialists distinguish several types of such convulsions. These include spasms of skeletal or striated muscles (for example, with paralysis) and smooth muscles, that is, vascular walls (for example, with angina pectoris).
The first type of seizures impedes the movement of a person, and the second - violate the functions of internal organs.
To get rid of pain, as well as restore their condition, doctors recommend using a drug such as “Combispasm”. Instructions for use, indications, doses and contraindications for this medication are presented below.
The composition of the medication, its description, release form and packaging
In what form do “Combispasm" take? Instructions for use states that this product is available in the form of tablets without a shell. They are round in shape, white in color and at risk.
The medication in question includes paracetamol, magnesium stearate, dicycloverin hydrochloride (i.e. dicyclomine), corn starch, methyl paraben, talc, povidone, sodium starch glycolate, propyl paraben and colloidal silicon dioxide.
The medicine "Combispasm", the instructions for use of which are enclosed in a box of thick paper, are packaged in blisters for 10 tablets.
The effect of the drug (pharmacology)
What effect does the drug “Combispasm” have on a person? Instructions for use, the description reports that this is a combined medicine that has antispasmodic and analgesic effects. In addition, this medication has an antipyretic, myotropic and anticholinergic effect.
Paracetamol, which is part of the drug, is a classic non-steroidal anti-inflammatory drug. It has analgesic and antipyretic properties. This component inhibits the synthesis of prostaglandins, and also reduces the intensity of their effect on the thermoregulatory centers that are located in the hypothalamus (brain).
As for dicyclomine, it also eliminates spasms of smooth muscles and reduces the intensity of pain. Like paracetamol, this ingredient has a myotropic, antispasmodic and anticholinergic effect.
What role does dicyclomine play in Combispasm? Instructions for use (the composition of this medication was presented above) reports that this component acts according to 2 different principles:
- Atropine-like when it acts on acetylcholine or cholinergic receptors.
- Direct effect on smooth muscle. The ingredient in question blocks spasms induced by bradykinin and histamine, as well as relieves pain, relieves spasms of the digestive tract, and reduces the secretion of bronchial, salivary, gastric, and sweat glands.
It should also be noted that when combined with paracetamol, the activity of dicyclomine significantly increases.
Kinetic features of the drug
What kinetic indicators are inherent in the Combispasm drug? Instructions for use informs that after taking the medicine inside, its active ingredients are absorbed quite quickly in the digestive tract and penetrate into the systemic circulation.
The peak concentration of this medication in the blood is reached after 35-65 minutes. About 10% of the drug binds to plasma proteins.
In the liver tissue, paracetamol undergoes a metabolic reaction, and is also oxidized using the P450 cytochrome system.
The half-life of the substance in question is 120 minutes. It is excreted through the kidneys.
Dicyclomine reaches its maximum level in the blood 65-125 minutes after administration. Its half-life is 1.9 hours. Approximately 70% of this component will be excreted along with urine, and the rest - through the digestive tract.
Indications for taking the drug
In what cases is the medication “Combispasm” prescribed? Instructions for use (tablets are the only form of this drug) states that this remedy is prescribed for pain of various origins:
- with radiculitis, rheumatism and neuralgia;
- with muscle, headache, or toothache;
- for stopping menstrual pain and renal colic.
Contraindications
Does the medicine “Combispasm” have contraindications? Instructions for use (tablets for pain of various origins should be prescribed only by an experienced doctor) reports that this tool should not be used for:
- glaucoma, alcoholism, obstruction of the biliary tract;
- under the age of seven;
- anemia, myasthenia gravis, leukopenia and tachycardia;
- blood diseases, severe disorders in the liver and kidneys;
- pregnancy
- allergies to the components of the drug;
- hyperbilirubinemia (congenital);
- deficiency of the G6PD enzyme;
- breastfeeding;
- obstructive diseases of the gastrointestinal tract;
- an ulcer of the stomach and duodenum;
- urinary retention, which is observed with benign prostatic hypertrophy;
- intestinal obstruction.
The drug "Combispasm": instructions for use
Tablets, the price of which is indicated below, should be taken orally, washed down with plain water. The treatment regimen and dosage regimen should be determined by the doctor.
For children from 15 years of age and adults, this drug is prescribed one to two tablets one to four times a day.
Treatment begins with four tablets per day. This medicine can be taken no more than eight pieces per day (in the absence of adverse reactions).
For children 7-13 years of age, the medication in question is prescribed one tablet per day (divided into two doses), and at the age of 13-15 years, up to three tablets per day.
The duration of therapy with this tool is determined individually.
In the event that within two weeks after the start of treatment, improvements did not occur or undesirable side effects were manifested, the medication should be stopped.
Side effects
The drug "Combispasm", the instructions for use of which were described above, are well tolerated by patients. The development of undesirable side effects can only be associated with uncontrolled and prolonged use of the drug.
The patient may manifest:
- skin rashes, loss of appetite, hyperemia, vomiting, redness of the skin;
- increased gas formation, paresthesia, nausea, urticaria, nervousness, diarrhea;
- drowsiness, constipation, numbness of body parts, violation of sensitivity;
- dizziness, bradycardia, emotional and psychomotor agitation, arrhythmia, impaired speech functions, increased sweating, confusion;
- tachycardia, disorientation in space, increased heart rate;
- hypoglycemia, stomach pain, general weakness, toxic effects on the liver;
- muscle weakness, glomerulonephritis, renal colic;
- anorexia, dry skin and mucous membranes, asphyxia, violation of taste sensations, nasal congestion, apnea and hyperemia of the throat.
Also rarely occur:
- nephrotoxic effect, hemolytic anemia, pancytopenia, bronchial obstruction, neutropenia, urinary incontinence, aplastic anemia;
- thrombocytopenia, papillary necrosis, leukopenia;
- Stevens-Johnson syndrome, methemoglobinemia, toxic epidermal necrolysis, loss of consciousness, anaphylactic reactions, impotence, Quincke edema.
Due to the presence of dicycloverin in the patient, an increase in intraocular pressure, dilated pupils and an increase in sensitivity to light may occur. Paralysis of accommodation and mydriasis are also possible.
The price of the drug and its analogues
How much is the drug "Combispasm"? Instructions for use (the price of this medicine will be indicated right now) does not give an answer to this question. You will find it only in a pharmacy.
The cost of 10 tablets of the medication in question is about 100 rubles.
If necessary, it can be replaced with drugs such as Trigan-D, Diklo-p, Bol-run Neo, Cefekon, Sedalgin Neo, Solpalgin, Dolaren, Kaffetin , "Novalgin", "Spazgo", "Dollar", "Sigan-DBS", "Apap", "Solpadein", "Solpadein", "Unispaz", "Paracetamol".
Consumer Reviews
Now you know how the medicine “Combispasm” works. Instructions, applications, reviews about this tool are presented in this article.
Most consumers claim that the drug in question manifests itself as a highly effective antispasmodic and analgesic. It helps to cope with pain of various origins, including those manifested during menstruation in women. Also, this medicine quickly eliminates headaches.
In addition to high efficiency, the advantages of this medicine include its availability (sold in almost every pharmacy), as well as a relatively low cost.
As for the shortcomings, they also have a place. Some patients complain of excessive toxicity of the drug, a feeling of numbness of the tongue and problems with the digestive tract.