How to make a diprospan allergy injection? The answer to this question is presented in the article. It also contains information about what patients say about the medicine, whether it has side effects, contraindications, etc.
Composition, description and packaging
Diprospan allergy injection can be purchased at any pharmacy. The drug is available in the form of a slightly viscous, transparent and colorless suspension (can be slightly colored yellow), which is used for injection.
The medication contains easily suspendable elements of white or almost white color. It is free from impurities, and when agitated forms a stable homogeneous liquid.
What is the diprospan allergy injection? The active substances of the drug are betamethasone sodium phosphate and betamethasone dipropionate. It also includes distilled water, sodium hydrogen phosphate dihydrate, hydrochloric acid, sodium chloride, macrogol, disodium edetate, sodium carmellose, polysorbate 80, propyl parahydroxybenzoate, benzyl alcohol and methyl parahydroxybenzoate.
In what packaging can I get a diprospan allergy injection? Reviews of patients say that such a drug goes on sale in glass ampoules, which are placed in packs of cardboard. Also, the medication can be purchased in disposable syringes made of colorless glass (2 sterile needles are included). Syringes are placed in plastic containers, which are in cardboard packaging.
Pharmacological properties
What are the properties of Diprospan allergy injections? The instructions attached to the tool say that this drug is a glucocorticoid. It has insignificant mineralocorticoid and high glucocorticoid activity. The medication has an immunosuppressive, anti-allergic and anti-inflammatory effect. It also has a pronounced effect on all types of metabolism.
Pharmacokinetic properties
How does the diprospan allergy injection affect the human body? Experts say that betamethasone sodium phosphate is very soluble. After intramuscular injection, the drug undergoes hydrolysis rather quickly and is immediately absorbed. This absorption rate provides a good therapeutic effect.
The drug is completely excreted within one day.
As for betamethasone dipropionate, it is absorbed slowly (from the depot). The substance is metabolized gradually. This fact determines the long-term effects of the drug. This item is displayed for 10 days.
The relationship between betamatesone and plasma proteins is approximately 62%. Its metabolism in the liver is carried out with the formation of inactive metabolites. The drug is excreted mainly by the kidneys.
Indications for use
What is Diprospan intended for? Joint injections (reviews will be presented later) and other parts of the body are used to treat diseases and conditions in which glucocorticoids can achieve the maximum therapeutic effect. We must not forget that with some deviations, therapy with this tool is additional, and not basic.
So what is the Diprospan allergy shot for? Such a drug is used for:
- diseases of soft tissues, bone and muscle systems;
- allergic reactions;
- dermatological diseases;
- systemic diseases of the connective tissue;
- hemoblastosis;
- secondary or primary adrenal insufficiency;
- other diseases and pathological conditions that require therapy with systemic corticosteroids.
Contraindications
Before you make an injection "Diprospana", you should carefully study the instructions. It indicates that this drug cannot be used in the following cases:
- with systemic mycoses;
- for subcutaneous and intravenous administration;
- for administration to infected surfaces;
- for insertion into the intervertebral space;
- for intraarticular administration (with an unstable joint or infectious arthritis);
- in children under three years of age (due to the presence of alcohol in the composition of the drug);
- with increased sensitivity to the substances of the drug;
- with increased sensitivity to other glucocorticoids.
Cautious use of the drug
In what cases is Diprospan prescribed with extreme caution? Joint injections (reviews about this drug are ambiguous) and other parts of the body should be carried out under the strict supervision of a doctor with:
- parasitic and infectious diseases of a bacterial, fungal or viral nature;
- immunodeficiency conditions;
- diseases of the digestive tract;
- pathologies of the heart and blood vessels;
- endocrine diseases;
- severe renal or hepatic (chronic) failure;
- thrombocytopenic purpura;
- hypoalbuminemia and conditions that predispose to its occurrence;
- obesity, systemic osteoporosis, eye diseases caused by herpes, lactation, myasthenia gravis, polio, acute psychosis, open-angle and angle-closure glaucoma, pregnancy;
- in the post-vaccination period.
It should also be noted that for intra-articular administration, this drug is prescribed carefully with the general serious condition of the patient and the ineffectiveness of the previous two injections.
The drug "Diprospan": instructions
The injections, reviews of which can be seen in this article, are used for intramuscular, periarticular, intraarticular, intradermal, intra-bursal, intracranial and interstitial administration.
The insignificant dimensions of the active substances of the drug allow the use of needles of minimal diameter. It should be noted immediately that the medication is not intended for intravenous and subcutaneous administration.
Injections must be carried out with strict observance of all asepsis rules.
The method of administration of the drug and its dosage regimen is established individually, depending on the severity of the disease, indications and reaction of the patient.
As a rule, the initial dosage of the drug is 1-2 ml. Repeated administration is carried out as necessary.
Intramuscular injection is done deeply, choosing large muscles and avoiding other tissues.
Let's say a prick in the heel. "Diprospan" in this case, as well as with intra-articular administration, is used in a dose of 0.5-2 ml. This amount is enough to relieve pain and remove the limited mobility of the joints.
With dermatological diseases, intradermal administration of the drug helps quite effectively.
After the therapeutic effect is achieved, the doctor must select a maintenance dosage by gradually lowering the initial dose.
If there is a threat of a stressful situation that is not associated with the disease, an increase in the volume of the drug may be required.
At the end of long-term treatment or the use of the drug in high doses, the patient should be monitored for at least a year.
The drug "Diprospan" (injections): side effects
The drug in question causes a fairly large number of side effects:
- Hypernatremia, fluid retention in tissues, lipomatosis, increased excretion of potassium, increased excretion of calcium, weight gain, hypokalemic alkalosis.
- Increased blood pressure, heart failure (chronic).
- Muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, joint instability, compression fracture of the spine, tendon ruptures.
- Erosive or ulcerative lesions of the digestive tract with possible bleeding or perforation, flatulence, pancreatitis, hiccups.
- Violation of wound healing, petechiae, thinning of the skin and atrophy, ecchymosis, dermatitis, excessive sweating, striae, steroid acne, a tendency to develop candidiasis and pyoderma.
- Convulsions, personality disorders, increased intracranial pressure, dizziness, increased irritability, headache, depression, euphoria, insomnia and mood changes.
- Disorders in the menstrual cycle, diabetes mellitus, delayed sexual development and growth in children.
- Subcapsular cataract posterior, blindness, increased intraocular pressure, exophthalmos and glaucoma.
- Anaphylactic reactions, angioedema, shock, arterial hypotension.
- Rush of blood to the face, neurogenic arthropathy.
- Skin and subcutaneous atrophy, hyper- or hypopigmentation, aseptic abscesses.
Patient Reviews
Many patients note that the drug "Diprospan" is highly effective in the treatment of joint, dermatological and allergic diseases. However, most people complain that injections with the said remedy are extremely painful. Moreover, after several injections, adverse reactions often occur. This fact makes subsequent treatment impossible, which forces patients to consult a doctor again and acquire new medications. Given that one ampoule of the drug “Diprospan” costs about 200 rubles, such a refusal to continue therapy noticeably hits the wallet.