For the drug "Nazonex" indications for use are polyps in the nasal cavity, as well as a runny nose, provoked by various factors. This drug belongs to the class of hormonal. The drug is intended for use under the supervision of a doctor. This is a fairly powerful tool, known for numerous positive feedback about its effectiveness. Consider the features of its effectiveness and application rules.
Technical information
To find out what the indications for the use of "Nazonex" are, you must refer to the instructions that accompany this drug. It must be enclosed by the manufacturer in a package containing a bottle of medication. It also describes the composition. Nasonex is a metered-dose aerosol intended for use in the nose. Each dose contains 50 mcg of active ingredient. The drug is sprayed through a bottle, looks like a white or close to this color suspension.
The main ingredient that ensures the effectiveness of the drug is mometasone furoate. For the manufacture of the medicine, it is used in micronized form. As additional ingredients used cellulose, glycerol, polysorbate, specially prepared water. The composition of the medication has citric acid, sodium and benzalkonium compounds.
Pharmacology
The use of "Nazonex" is recommended if there is a need for a steroidal local treatment of the common cold, polyps. This drug belongs to the class of glucocorticosteroids, designed specifically for local use. It has a pronounced anti-inflammatory effect. The medication is one of the effective against an allergic reaction. At the same time, it is important to observe reasonable dosages so that the use of the drug does not cause a systemic effect.
The active ingredient slows the release of pro-inflammatory mediators. Under the influence of the agent, the generation of lipomodulin, which inhibits type A phospholipase, is activated, which causes less active release of arachidonic acid into the circulatory system. As a result, the generation of prostaglandins, endoperoxides slows down. The active ingredient of the drug prevents certain types of neutrophil accumulation. Under its influence, the volume of exudate becomes smaller, lymphokines are not so aggressively produced, macrophages are less actively moved. This affects granulation, infiltration, weakening under the influence of the drug. The generation of chemotaxis is becoming weaker, the activity of an immediate allergic response is inhibited, since the generation of products of the processing of arachidonic acid will slow down while reducing the release of inflammatory mediators by cells.
Nuances and their verification
As you can learn from the instructions for the use of Nazonex, which tells about the rules for treating children and adults, the manufacturer organized special studies involving provocative tests. During the event, antigens were applied to the nasal mucosa of the subjects. It was possible to fix the increased anti-inflammatory activity of the main ingredient of the pharmaceutical product. This is characteristic of both an early allergic response and a late reaction.
Confirmation of the results can be seen from screenings showing a decrease in histamine compared to the placebo group. A decrease in the activity of eosinophils was found. In addition, decreased volumes of neutrophils, adhesive epithelial proteins in comparison with the initial indicators.
Kinetics
Using in accordance with the indications for use, Nazonex, a person faces minimal health risks. Systemic bioavailability of the active ingredient is less than one percent. If the drug appears in the digestive tract, although absorption processes are initiated, their level of effectiveness is extremely low. A small amount of the drug that can penetrate the gastrointestinal tract when using a means for treating the nasal cavity is actively metabolized during the initial treatment with liver cells. Elimination is carried out by bile, urine.
When will it help?
The main indication for the use of Nazonex is a seasonal runny nose or a worrying year-round, if this is due to an allergic reaction. With this diagnosis, it is allowed to use aerosol to treat people over two years of age. You can also use the drug to treat adolescents and adulthood. You can use the drug for acute sinusitis, including in chronic form. In this case, the pharmaceutical product is used to treat persons over the age of twelve. "Nazonex" acts as an additional element of a comprehensive therapeutic course while taking antibiotics.
You can prescribe a drug if rhinosinusitis is established, the disease proceeds in an acute form, the symptoms are moderate or easy, there are no manifestations of infection by bacteria in a severe form. With this diagnosis, aerosol is used to treat persons over the age of twelve. You can use the remedy for polyps in the nose, if this has caused respiratory failure through the nose. The drug is prescribed if, due to polyps, the ability to distinguish odors has worsened. With this diagnosis, the medication is used only when reaching adulthood.
It is allowed to prescribe "Nazonex" as a preventive measure. The tool prevents seasonal exacerbations of the common cold on the background of allergies, if the course is severe or moderate in severity. In such conditions, the drug is used by people over the age of twelve. It is recommended to start prevention a couple of weeks before the dangerous season.
Application rules
Following the instructions, "Nazonex" in the nose is used in case of allergy-related runny nose during the season or all year round (for persons over the age of twelve). To prevent an acute period and facilitate its course, it is shown daily to perform a pair of inhalations in each nostril. Each serving contains 50 mcg of the active ingredient. In total, the patient receives 200 mcg of the drug per day. In order to provide a pronounced therapeutic effect in case supportive treatment is needed, volumes can be reduced to one injection into the nostril. The procedure is also carried out daily, that is, for 24 hours the needy receives 100 micrograms of the steroid.
If the use in the indicated volume does not allow to achieve a significant improvement in the patient's condition, the daily volume can be increased. In each half of the nose, the medicine is administered four times. In total, the needy receives 400 mcg daily. As soon as the symptoms subside, they reduce the volume obtained to standard.
In most cases, clinical improvement is observed 12 hours after the initial administration of the steroid.
Introduction to children
For children, Nasonex in the nose is permitted if the child is over two years old. The optimal volume to achieve a sufficient therapeutic effect is one injection into each nostril. The drug is used daily. In total, a patient receives 100 mcg of active ingredient per day.
If you need to use the drug to treat a minor patient, you will need the help of seniors.
Optional course
For this format, the introduction of "Nazonex" in the nose for children with instructions is allowed only after reaching the age of twelve. You can also use the drug for middle-aged, elderly people. The best use is twice daily for two injections in each half of the nose. A total of 400 micrograms of mometasone is administered to the needy per day.
If the use of the drug is not accompanied by a decrease in the manifestations of the disease, the drug volumes received by the needy should be increased. Four injections are made in each half of the nose, the event is shown twice a day. In total, 800 μg of the drug enters the human body per day. As soon as the symptoms subside, return to the standard program.
Diagnoses and Doses
The instructions for the use of "Nazonex" in the nose for children and adults recommended the appointment of a drug in case of rhinosinusitis, which developed in acute form. First you need to make sure that there is no severe bacterial infection. The optimal format for use in patients over the age of twelve is a pair of injections into each nostril twice daily. In just a day, the patient receives 400 mcg of the active ingredient. There is a risk of worsening the symptoms of the disease. If this is observed, you must use qualified medical help.
Instruction for use "Nazonex" in the nose for adults is recommended for polyposis. With this diagnosis, the pharmaceutical product is prescribed strictly to adults. You can use the medication if the patient is an elderly person. The optimal dosage is a pair of injections into each nostril. The event is shown twice daily. In the 24-hour period, the needy receives 400 μg of the active compound. When the symptoms of the disease subside, volumes can be reduced. The one-time procedure is left the same, but the frequency is reduced to one administration per day, that is, the patient receives only 200 μg of mometasone per day.
Application rules
Instructions for use in the nose "Nazonex" for adults and children are allowed only if the rules specified in this accompanying document are followed. A vial containing a pharmaceutical product is filled with a suspension. To introduce this product into the body, you must use the dispenser provided by the manufacturer. This is attached to the bottle. It is necessary to use only the original product, measuring the necessary volumes of funds. Before initial use, the nozzle must be calibrated. To do this, press the dispenser ten times in a row until they see stable spray. This indicates the readiness of the product for use.
Using the product, they tilt their heads, only after that they distribute the product with the help of a sprayer into the nostrils. It is necessary to introduce a medicinal composition, following the doctor's recommendations regarding the scheme and features of use. If the drug has not been used for two consecutive weeks or longer, you must first double-click on the dispenser, fixing the moment the spray appears. Only after this, the product is considered ready for further use. Before each new administration, the vial is vigorously shaken.
Cleansing Rules
Describing the features of the introduction, indications for the use of "Nazonex" for children and adults, the instruction also contains rules for cleaning the nozzle intended for dosing the drug. Cleaning should be regular, otherwise the product will start to work incorrectly. First, remove the cap, designed to protect the object from dust, then carefully remove the tip, with which the contents are sprayed. It is washed under running water. Clean the dust cap at least thoroughly. Use warm liquid. Be sure to rinse the subject under running water.
Do not open the applicator with a needle or any other sharp objects, as this will damage the structure of the product. The result may be improper dosing.
The tip, cap is dried in a warm place. Then the tip is fixed in its original place, put on the cap in order to protect the product from dust. At the next application, the product is recalibrated first, pressing the nozzle a couple of times to highlight the desired dose.
Unwanted effects
The instructions for the use of "Nazonex", which tells about the rules for introducing into the nose, indicate the possibility of undesirable effects on the background of polyps, runny nose due to allergies. It is known that nosebleeds in most people suffering from them were mild. This phenomenon took place on its own. The frequency of occurrence in the general case was only slightly higher than that observed in the placebo group, while it was the same or less than that characteristic of other steroid drugs for nasal administration.
As can be seen from the “Nazonex” instructions describing the application of the nose to the nose, pharyngitis, increased pressure in the eye, and glaucoma are possible while taking the drug. Some had a headache, others were allergic. The use of the product is accompanied by the danger of nosebleeds, pharyngeal irritation, improper perception of smells, tastes.
Some children, while using the Nazonex drug, had a headache, sneezing, mucous membranes, nosebleeds. The frequency of such events coincided with the inherent placebo group.
Sometimes you can’t
For adults, for children, the instructions for the use of "Nazonex" identified some restrictions. In particular, it is strictly forbidden to use the drug if the human body is excessively susceptible to the active ingredient or any other substance used by the manufacturer of the drug. You can not use a steroid drug if a person has recently undergone surgery or became a victim of an injury, which damaged the mucous membrane. After complete healing of the wound, you can again use the Nazonex aerosol. This limitation is due to the ability of the steroid compound to slow down regenerative local processes.
As indicated above, the instructions for use "Nazonex" for children is allowed only with a strictly limited list of diagnoses. For most cases of use, a contraindication is an age younger than twelve, with the exception of a runny nose due to allergies during the season or year round. In case of polyps in the nose, Nazonex is allowed to be used only from the age of 18. Such restrictions are due to a lack of official information on the effectiveness of the tool, its safety and possible risks.
Possible but neat
For adults and children, “Nazonex” is prescribed very carefully, if tuberculosis infection is established, the respiratory tract is affected. This applies equally to the latent course, and to the active form of the disease. Caution must be exercised if there is infection with fungi, bacteria, viruses, it has developed in a systemic form, a person does not receive treatment. Caution requires the appointment of a remedy against a background of herpetic invasion, the target of which is the eyes. For all these conditions, “Nazonex” is used only in the case when the treating doctor has stopped on this tool due to the lack of more reliable and effective products. Maximum caution is required in the case of local infection that engulfs the nasal mucosa.
Mother and child
As indicated above, age is a contraindication for prescribing Nazonex to children, since specialized studies have not been conducted to determine official information on the effectiveness and safety of a pharmaceutical product. For a similar reason, there is no reliable data on the effect of the drug on the body of a pregnant woman. In general, any steroid medication intended for local use is used if the apparent benefit of use significantly exceeds the possible dangers associated with the treatment program. This also applies to the use of the product by expectant women and nursing mothers. If a newborn was born in a woman who used steroid drugs during gestation, her condition should be carefully analyzed. Particularly high risk of insufficient adrenal gland activity.
Will it help me?
As you can conclude from the reviews, "Nazonex" shows a pronounced effect in allergic rhinitis. The persons who used it noted the reliability of the tool. Almost no one complained about unwanted effects. Others noted that the basic dosage was not enough, but the maximum stipulated by the instructions turned out to be a sufficient dose for people to improve the general condition.
Reviews containing opinions on the instructions for use of "Nazonex" indicate the comprehensibility of this document. It is noted that it simply, in an accessible language, explains the scheme for using the tool. - , . .
Is there an alternative?
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Studies were conducted involving the placebo control group. Children participating in the experiment were given 100 μg of mometasone. The duration of the research was a year. Failed to detect growth retardation.
It was not possible to notice cases of oppression of the adrenal glands, hypothalamus, pituitary gland against the background of prolonged use of the Nazonex aerosol. Sometimes the spray is used by people who have previously received steroid drugs with a systemic effect for a long time. Such cases require particularly careful attention. The cancellation of drugs with a systemic effect can provoke weak adrenal glands. Recovery processes sometimes last for months.