In the article, we consider the instructions for use and reviews of "Rezoklastin".
The medication is classified as a drug that slows down the absorption of bone tissue. This process is called resorption, it is normal under the condition of the constant formation of new, and at the same time healthy, bone cells. In the event of a pathological change in the body, bone decomposition can accelerate, and the formation of new tissue slows down or stops completely. The result of such changes is the weakening of the supporting and motor apparatus in certain areas or completely.
So, we will consider the instruction and the description of "Rezoklastina".
Drug features
The main active ingredient in the drug is zoledronic acid, which can significantly slow down or stop the destruction of the skeleton. The following properties of the agent are also observed:
- Osteoclast (cells that destroy bones) is inhibited by the medicine.
- In addition, this medication has an antitumor orientation.
- The components of this medication block the vessels that supply blood to the tumor, preventing the growth of bone metastases.
- The drug lowers the concentration of calcium in the blood and, in addition, reduces the side effects that occur during the destruction of skeletal tissue.
Composition and format of the issue
Zoledronic acid is a synthesized bisphosphonate. The substances of this group are similar in structure to human bone tissue. Due to this, the binding process of the ingredients of the drug occurs only with fragments of the skeleton. In addition to the main zoledronic acid, the composition of this medication includes substances in the form of mannitol, sodium citrate and water for injection. It is worth emphasizing that absolutely all components are very well balanced, and, in addition, they enhance and stabilize each other's effects.
The resorption inhibitor presented is typically marketed in cardboard boxes. Directly inside these boxes are laid contour plastic pallets.
The concentrate for the preparation of the solution (4 and 5 milligrams of the active component) is poured into a glass bottle, in which the capacity is 5 or 6 milliliters.
Instructions are also put in the box. "Resoclastin" 5 mg and 4 mg should be stored only in a cool, and, in addition, in a dark place. It is advisable to exclude access to it from the side of mentally unstable patients, children, and at the same time pets. The shelf life of this concentrate is four years after release. After this, this medicine must be disposed of without fail, like regular garbage.
The instruction to "Rezoklastin" should be strictly observed.
Cost and analogues
Depending on the packaging format, the location of the settlement, and, in addition, the pharmacy’s affiliation, the cost of this drug, as a rule, ranges from twelve to seventeen thousand rubles. The analogues of “Rezoklastin” in the event that they do not belong to domestic production have an even higher cost, and they are not in all pharmacies. We are talking about the following drugs: Aklast along with Veroclast, Zoladex, Blaster, Zoledronate-Teva, Resorbix and Zometa.
If the patient has a cancerous tumor, some medications (as part of a regional or state program) can be given free of charge.
Indications for use
The manufacturer of this drug is a company called F-Synthesis. This brand recommends the use of this medicine for the treatment of a wide range of diseases that are associated with bone damage of various origins.
According to the instructions for use with "Rezoklastin", prescribe therapy with this drug in case of the following diseases:
- In the presence of hypercalcemia caused by cancerous tumors. Injection is carried out if the blood concentration of calcium reaches critical values.
- With osteoporosis caused by prolonged use of steroids. As a rule, this ailment is diagnosed in athletes and people who abuse the nutritional supplements needed to gain muscle mass.
- Against the background of osteoporosis after menopause. This medicine is prescribed for therapeutic and prophylactic purposes to prevent bone fragility.
- With Paget's disease. This drug helps stabilize the replacement of old and new bone tissue.
- For the treatment of severe fractures that occur in the hip joint, and, in addition, in the spine. Treatment is carried out in order to prevent a repeated fracture.
In some cases, this drug is prescribed for the treatment of breast cancer in women. Reviews of doctors and patients indicate that the use of "Rezoklastin" helps to avoid surgical intervention, and, in addition, reduces the amount of chemical treatment.
Contraindications
This medicine is sold only by prescription in pharmacies and online stores. As the instructions to “Rezoklastin” indicate, the contraindications to its use are as follows:
- The presence of allergy to zoledronic acid. Or the presence of an allergy to the ingredients that make up this medicine.
- Impaired function or renal failure.
- The period of pregnancy, and, in addition, feeding a newborn baby.
- Children under sixteen years of age (it is also worth noting that this drug was not tested in adolescents).
- In the presence of bronchial asthma in patients.
- Against the background of chronic diseases of the cardiac and vascular system at the stage of exacerbation.
- Against the background of deviations in mental development or instability of the psyche.
Side effects
Zoledronic acid is a toxic substance that affects almost the entire human body. In a particularly acute undesirable manifestations occur in the first few days after injection.
According to the instructions and reviews for "Rezoklastin", adverse reactions during therapy with this medication may be as follows:
- The nervous system can respond with headaches, loss of consciousness, and insomnia. Sometimes there may be a violation of taste, tremor and increased anxiety.
- The digestive system can respond to nausea and vomiting, constipation and diarrhea. Rarely, gastritis and pancreatitis can occur.
- The organs of vision sometimes respond to the use of this drug with a violation of sharpness and rupture of blood vessels. Rarely, conjunctivitis is also possible in patients.
- Respiratory organs respond with a dry cough, shortness of breath and a feeling of lack of air. Rarely may cramps with asthma attacks.
- On the part of the skin, severe sweating occurs along with rashes and mild itching.
- On the part of the functioning of the supporting and motor apparatus, patients sometimes experience aches in the joints, bones, and pain with muscle cramps.
- The cardiovascular system responds to the use of this drug by tachycardia, a decrease or increase in pressure, and, in addition, damage to the aorta.
Common negative symptoms
Common symptoms include fever with intense fever. It may also cause malaise and weakness. The injection site may swell, redden, and, in addition, hurt for several days. It is worth noting that this is considered a normal reaction to a potent component.
In the instructions for use "Rezoklastina" customer reviews are not indicated. We will consider them at the end of the article.
Therapeutic effect
The pharmacological effect of this drug is based on the selective effect of synthetic bisphosphonates exclusively on the damaged area of the skeleton. Penetrating into bone tissue, the components of the solution inhibit the activity of pathological cells and formations. Against this background, zoledronic acid does not affect the process of mineralization, strengthening and regeneration of bone tissue. Acting on the elements of calcium in the blood serum, this medicine helps to remove them from the body without the appearance of sand and stones.
As the instruction to “Rezoklastin” tells us, in the case of metastasis on the skeleton, the neoplasm is blocked by the medication. The medicine does not allow nutrients to enter the tumor. This leads to a reduction in the number and the gradual destruction of pathological cells. The effect on the nerve endings leads to a decrease in pain syndrome while maintaining sensitivity.
In the treatment and prevention of osteoporosis, regardless of the origin of the pathology, an increase in bone density and strength was noted. After the first injection, the risks of compression fractures of the clavicle, spine and femoral neck are significantly reduced. Diagnosis shows an improvement in skeletal mineralization and bone metabolism.
This is confirmed by the instructions for use with "Rezoklastin".
Zoledronic acid, as a rule, is characterized by the preservation of a prolonged therapeutic effect. Positive changes in the supporting and motor apparatus are observed years after the end of the treatment course.
How do droppers with "Rezoklastin" do according to the instructions?
Dosage and route of administration
Regardless of the identified pathology, this drug is administered intravenously for at least fifteen minutes. To do this, use a dropper, which is placed only in a clinic.
In accordance with the instructions "Resoklastin" 5 mg / 6, 25 ml must be diluted immediately before use. This is due to the fact that after opening the bottle, it can be stored only for a day at a temperature of two to eight degrees. Before use, this solution must be heated to the temperature of the human body in order to exclude cramping with convulsions. Dosage is determined based on the patient’s diagnosis.
As part of the treatment of hypercalcemia, which is provoked by malignant tumors, patients are prescribed a single injection of Rezoklastin in the amount of 4 milligrams. For effective treatment of bone cancer, a patient is given 4 milligrams of the drug every month. The course of therapy lasts until it is possible to achieve positive results. Additionally, patients are prescribed vitamin D with calcium.
In accordance with the instructions for “Rezoklastin”, in the presence of postmenopausal and secondary forms of osteoporosis, the treatment course is only three years.
A single dosage of the drug is 5 milligrams, the drug is administered once a year. To enhance the therapeutic effect, the patient is prescribed a diet high in calcium in foods along with a course of vitamins.
The treatment of Paget's disease involves the use of a single intravenous injection in an amount of 5 mg "Resoclastin" according to the instructions for use.
Since this disease is directly related to the pathological level of the bone metabolism, vitamin D supplementation with calcium is additionally prescribed for ten to fifteen days after the solution is administered.
In case of an overdose, the patient is placed on a hospital bed, where he needs to be under the regular supervision of medical personnel who can provide emergency assistance if necessary. In order to prevent complications due to the high level of calcium in the blood, additional injections are performed. So it says in the instructions.
Reviews of patients about "Rezoklastin"
As a rule, the use of Rezoklastin medication is carried out in cases when patients are in a condition that is very close to critical health. In the event that oncological pathology therapy is carried out at the last stage, it is extremely problematic to guarantee successful therapy with zoledronic acid. However, when using this medication at an early stage of the disease, absolute or partial recovery usually occurs in most patients. In that case, if you carefully study the description of the drug in question, you can find out that it is very effective for the treatment of local lesions.
People who are diagnosed with Paget's bone disease write in their reviews that they transferred the dropper with this drug relatively easily. True, it is also reported that for some, a fever rises after a dropper, the head begins to hurt very much, begins to shake and feel sick. In the bones of many, after such droppers, a terrible ache occurs. As people say in their comments, a similar condition after injecting Rezoklastin lasts three days, after which the person begins to release a little. According to the stories, people finally come to their senses only in ten days.
On the positive side, after repeated examination, the results of the patients are generally encouraging, since the general state of bone metabolism is significantly improved. Thus, many write about Rezoklastin that this medicine is quite good, despite the presence of severe side effects.
In the primary form of osteoporosis, doctors also prescribe such droppers to their patient. Doctors, in fact, very often prescribed Rezoklastin droppers to patients, since today this drug is considered the best medicine. But, unfortunately, very many during the injections, judging by the reviews, become ill. And after such a dropper, as noted earlier, for a week the patient is tormented by vomiting along with diarrhea and severe joint pain.
In general, people note that such suffering is worth it, because after three months the doctors tell patients that the disease is stopped, and the general condition itself is normalized. It is worth noting that many people who have undergone treatment with this drug say they recommend it to absolutely everyone who needs appropriate treatment.
We reviewed the drug "Rezoklastin" instructions and reviews.