In the ranking of modern affordable drugs with a pronounced effect of anesthesia, the Nise drug takes the leading position, which is why the use of this drug is so popular among dentist patients. Experts quite often recommend “Nise” for toothache, because after the first dose in most cases there is relief, regardless of the cause of the unpleasant symptoms.
In this case, doctors advise always to consider a large number of contraindications and side effects from the use of this drug.
Etiology of toothache
Of the main triggers that provoke the occurrence of various types of toothache in patients, experts distinguish: caries, softening the hard tissue of the teeth, as a result of which it is destroyed and holes form inside the cavity, which are popularly called "holes". These destructive elements are gradually filled with decomposed dental tissue residues, various microorganisms that come with food, further accelerating the process of tooth decay, increasing the “hollow” not only in diameter, but also in depth.
If a person postpones going to the dentist as much as possible, then the painful process in the bone tissue can expose the nerve and cause severe discomfort. “Nise” pills for toothache at the initial stage will help to alleviate the condition for several hours (from 4 to 12), but to cure the disease and restore the structure of tissues, you need to see a doctor. Otherwise, there is a risk of a complication of caries, called pulpitis.
It can also be triggered by dental trauma. This disease is characterized by the appearance of spontaneous, impulsive acute pain, intensifying at night. It can be given to other teeth, ears or temples. The next stage of neglect of dental health can be periodontitis - inflammation of the tissues surrounding the affected tooth. It can spread beyond its upper part, caused by pulpitis or trauma, as well as be a consequence of exposure to toxic substances. With this ailment, the pain takes on a permanent character, when it comes into contact with a tooth or pressure on it, it intensifies.
Despite purulent inflammation that extends beyond the tooth during acute periodontitis, it can be anesthetized with Nise tablets for several hours. However, you should not delay the trip to the doctor; you should visit it in the coming days, as there is a high risk of serious complications - abscess, osteomyelitis, or phlegmon.
The composition of the drug and release form
The main active ingredient in the Nise toothache tablets is called nimesulide. This substance blocks the synthesis of prostaglandins, eliminating pain and relieving inflammation. Nimesulide tablets for oral administration are supplemented with calcium hydrogen phosphate, corn starch, microcrystalline cellulose, magnesium stearate and sodium glycolate, colloidal silicon dioxide, aspartame, talc and flavoring.
The dispersible tablet form, which, when taken, dissolves in a small amount of water, includes 50 mg of nimesulide and additional components: microcrystalline cellulose and corn starch, talc and magnesium stearate, sodium carboxymethyl starch, calcium phosphate and silicon dioxide, aspartame and pineapple flavor. If in a normal pressed tablet “Nise” for toothache (the instruction confirms this) contains 100 mg of the active substance - nimesulide, then in a suspension, which is intended for children, its concentration is 50 mg per 5 ml of solution.
Of the auxiliary components of the liquid form of anesthetic medicine, the annotation names: sucrose and sorbitol; methyl- and propylparabens - natural food additives extracted from berries (cranberries, lingonberries, blueberries); pineapple flavor; yellow quinoline dye; xanthan gum; citric acid; polysorbate 80; glycerin and water.
The only form of Nise that is not used to relieve toothache is gel. It is intended for external use in inflammatory and degenerative processes in the musculoskeletal system, with exacerbations of rheumatism and gout, radiculitis, sciatica or lumbago, psoriatic arthritis and other ailments.
pharmachologic effect
Despite the fact that toothache is not included in the list of medical indications for the use of the Nise drug, its antipyretic, analgesic effect, as well as its ability to block the inflammatory process and prevent pain, come in handy when a person experiences dental problems.
In addition to the effect of analgesia, the described drug has an antioxidant and decongestant effect. The three main therapeutic effects (analgesic, antipyretic and anti-inflammatory) are due to the function of nimesulide, which blocks the work of cyclooxygenase, an enzyme that stimulates the synthesis of leukotrienes and prostaglandins. These highly active compounds with a wide range of biological effects provide the inclusion of a protective reaction and further support of painful symptoms (redness and swelling, pain and tissue damage). With a weak and moderate degree of manifestation of these signs, “Nise” helps well, with severe or advanced toothache, it can slightly muffle the severity of the symptom, giving it a dull character.
Indications
Most often, the described drug is prescribed to relieve symptoms of people suffering from osteoarthritis, osteoarthritis, bursitis, tendonitis, rheumatism, neuralgia or myalgia, fever, and also with ankylosing spondylitis. With its help, stopping muscle or vertebral pain, relieve post-traumatic syndrome, block the development of infectious foci and inflammations.
When asked about whether Nise helps with toothache, dentists respond positively, prescribing it before and after treatment (filling, nerve removal, canal cleaning, or other manipulations). This medicine is best for patients with mild or moderate toothache. In the case of severe and acute pain, “Nise” dulls it, leaving aching discomfort. In addition, in some patients it may lower the temperature, in others it may not have such an effect.
The benefits of using the drug "Nise" for toothache
Of the benefits of this medicine, dentists note its rapid action. It begins only 15-30 minutes after administration, and the peak of effectiveness occurs within three hours. The duration of exposure to Nise may be between 6 and 12 hours. This helps to forget about a bad tooth during the whole working day or to rest calmly at night before a visit to the dentist. In most pharmacies, Nise tablets are available over-the-counter. Most patients tolerate the drug well, even in cases of prolonged use. However, children and pregnant women are prescribed it with caution, strictly according to indications, given the ratio of benefits and possible side effects.
How to use
Pressed toothache tablets are prescribed for people whose weight exceeds 40 kg. These patients can take one pill (after meals) twice a day, drinking plenty of water. In severe cases, when the pain resumes more often than after three-hour intervals between seizures, the intervals between doses of the drug can be reduced. However, it should be remembered that the maximum daily dose should not exceed 400 mg (or 4 pills).
If after taking 2-3 tablets of “Nise” there is no improvement in toothache, then the problem is not its low efficiency, but the nature of the disease itself. In this case, abuse of the drug can lead to problems with the gastrointestinal tract, kidneys and liver, without having a therapeutic effect.
Dispersible tablets are dissolved in 5 ml of water (one teaspoon), then the solution is drunk. Suspension is prescribed for children under 12 years of age. The doctor calculates the dose of the Nise drug based on the weight of the child: 3-5 mg of active substance per 1 kg of body weight The total dose is divided in half, into morning and evening receptions. Dentists advise taking the suspension before meals, but if the child complains of discomfort, then it is better to drink the medicine after eating. An effective course of symptomatic treatment with Nise does not exceed 10 days, an increase in this period should take place under the strict supervision of the kidneys, which is carried out by the doctor.
Contraindications, side effects, possible overdose and other important indications
The instructions for the Nise drug say it has an anti-inflammatory effect, but you can’t rely on it for pulpitis. This acute inflammation, accompanied by throbbing pain, especially at night, must be treated by a dentist.
This rule also applies to periodontitis and other dental diseases. “Nose” from toothache only helps to alleviate the symptom, temporarily calm the pain, but it is not able to stop the progression of the disease. It is often used in a complex for local treatment, as it effectively relieves pain and fever, but does not affect the disease itself. This can lead to the development of complications and deterioration of the teeth. Doctors do not recommend taking Nise on their own for more than 3-4 days. For patients in adulthood who have cardiovascular problems, impaired renal and hepatic function, the drug should be prescribed by a doctor.
An overdose of the medicine may be accompanied by heartburn, diarrhea, nausea, dizziness, pain in the abdomen, drowsiness, headache. Sometimes Nyce can provoke blood in the urine, skin rash, thrombocytopenia, anemia, hepatitis, agranulocytosis, and even anaphylactic shock.
Of the contraindications to taking the drug, one can distinguish: children's age up to two years; heart, kidney and liver failure; pregnancy and lactation; gastrointestinal diseases; dermatoses; hypertension hepatitis; diseases of the blood systems and blood-forming organs. A large number of contraindications and side effects are the reason that prevents the appointment of nimesulide by dental surgeons to children (most often use the children's Panadol or Nurofen) or people sensitive to the components of a popular product.
Reviews of patients and doctors
Offering the drug “Nise” for toothache, reviews recommend it as the most effective and affordable tool that helps to quickly eliminate unpleasant sensations.
Some patients talk about how they had toothache within half an hour and were able to work calmly all day. Others characterize the drug as a medium-effective remedy, because in a neglected case it only helps to calm a sick tooth, and not completely eliminate unpleasant sensations. Doctors advise you to carefully read the instructions, which contain information about contraindications and side effects of the drug "Nise" to reduce the risk of negative consequences for the body. In addition, effective pain relief with this medicine is not a reason to avoid a visit to the doctor. With any discomfort in the gums and teeth, you must quickly visit the dentist.