Sinaflan ointment belongs to the group of topical glucocorticosteroids. The main active ingredient in this drug is fluocinolone acetonide. This substance is obtained synthetically, it has a pharmacological activity that is similar to glucocorticosteroids. Sinaflan ointment, or rather each of its molecules, in its composition has an additional two fluorine atoms, due to this there is a decrease in local absorption and its anti-inflammatory effect is enhanced. The main active substance of this drug has a high glucocorticoid activity and almost no mineralocorticoid effect. When applied topically, Sinaflan ointment has anti-allergic, antipruritic and anti-inflammatory effects, in addition, this drug activates local vasodilation.
The action of this drug is based on the process of inhibition of phospholipase A2. The inhibition of the activity of this enzyme occurs, and thus, the conversion of arachidonic acid to its pharmacologically active form is prevented. Due to this effect, the number of leukotrienes and prostaglandins, which are the main mediators of inflammation, is reduced.
Due to the fact that the release of histamine is reduced, Sinaflan ointment causes inhibition of the development of a hypersensitivity reaction. After applying Sinaflan, the risk of the occurrence and development of exudative reactions is significantly reduced, because there is a narrowing of the lumen of the vessels. Also, this drug reduces the synthesis of protein and collagen deposits.
The ointment is applied topically, it penetrates well through the stratum corneum of the epidermis and accumulates in the dermis. The specified drug is not biotransformed in the skin. It should be noted that systemic absorption in adolescents and children is significantly higher than in adults.
Sinaflana ointment - instructions for use
The use of the drug is recommended for various skin ailments, when it is necessary to carry out therapy with glucocorticosteroids. These are such diseases:
- discoid lupus erythematosus and lichen planus;
- psoriasis and seborrhea of the skin;
- the presence of varying degrees of eczematous lesions;
- neurodermatitis and allergic skin reactions, as well as skin itching;
- the occurrence of first-degree burns, including sunburn;
- bites of various insects.
Sinaflan ointment (the instructions for using this drug are quite simple) is applied to the affected areas up to 3 times a day. It should be remembered that after applying the ointment, it should be rubbed a little in a sore spot. Treatment with this drug is carried out for 5-10 days, but if necessary, it can be continued up to 25 days. Applying ointment to sensitive and large areas of the skin is not recommended.
Possible side effects
If the ointment is used for a long time, then patients may experience skin atrophy and even develop its necrosis. If applied to large or sensitive areas of the skin, then adrenal hypofunction may occur.
Contraindications to the use of the drug:
- the patient has an increased individual sensitivity to the components of the drug;
- with infectious skin diseases of various etiologies;
- ointment is not used in areas of the skin where there are ulcerative lesions, and ointment should not be applied to open wounds;
- the use of this drug during pregnancy and with skin tuberculosis is prohibited .
Since the specified drug is applied topically, its overdose is impossible.
Keep Sinaflan ointment away from direct sunlight, in a dry room and the ambient temperature should not exceed 30 degrees.
Remember that the use of this drug should be preceded by a consultation with a doctor.