The drug "Cardiomagnyl" refers to a group of pharmacological agents with a pronounced antiplatelet effect. It contains acetylsalicylic acid as an active ingredient. This substance has been used in clinical practice for more than 130 years and has proven effective. Due to the increase in the number of pathologies of the heart and blood vessels in the overall morbidity and mortality, international cardiology organizations (the European Cardiology Community and the more conservative American Heart Association) recommend the use of acetylsalicylic acid cardioforms as effective preventive drugs.
The importance of their use is due to a significant decrease in the number of myocardial and cerebral infarction in the presence of atherosclerotic lesions of arterial vessels. Similarly, the use of Cardiomagnyl in cases of varicose leg disease is justified. This reduces the likelihood of thrombosis of the branches of the pulmonary artery and pelvis. Therefore, any of the cardioforms of aspirin has much more positive aspects of use than side effects.
System characteristic
The preparation “Cardiomagnyl” lists the instructions for the use of contraindications in the most detail. This is a modern and high-quality drug, really necessary in clinical practice. It is affordable and should be used continuously if the patient’s health condition allows.
Acetylsalicylic acid is used as the active substance. A strong antiplatelet effect that prevents platelet adhesion and the onset of thrombus formation is an important mechanism in preventing acute coronary events. Moreover, the “Cardiomagnyl” preparation has contraindications due to the use of enteric film membrane and cytoprotectant significantly decreased in comparison with earlier, gastro-soluble cardiac forms of ASA.
Indications for use
In the Cardiomagnyl preparation, contraindications due to the enteric form are less significant, although this does not affect the number of indications. It, like gastro-soluble cardioforms, is used in the following clinical situations:
- in acute myocardial infarction at the stage of elevation of the ST cardiographic segment and without it;
- with unstable angina for emergency care and long-term treatment;
- with ischemic stroke in acute and subsequent periods, as well as for long-term therapy;
- with transient ischemic attacks for long-term treatment;
- in the prevention of myocardial infarction, when the patient is concerned about progressive angina pectoris;
- in the prevention of ischemic stroke against the background of transient ischemic attacks;
- with venous varicose disease of the pelvis and lower limbs;
- in the prevention of shunt thrombosis after CABG (CABG), BPS;
- in the presence of arterial hypertension in patients with already high cardiovascular risk.
The last indication requires the use of the drug “Cardiomagnyl”, the contraindications of which are less important than therapeutic effects. Since in any of the clinical situations described above the medicine has more benefits than potential or actual harm, it is considered relatively safe and is recommended if there are risks of developing a heart attack, myocardium, or pulmonary thrombosis and bypass vessels.
Contraindications
Despite the presence of a progressive enteric form of the drug “Cardiomagnyl,” there are still contraindications to the drug. They cover conditions in which the use of acetylsalicylic acid is more harmful than practical benefit. In such clinical situations, Cardiomagnyl can be replaced by a class analogue, Clopidogrel. Contraindications are as follows:
- bleeding disorders (hemophilia, hemorrhagic diathesis, thrombopenia);
- organic diseases of the stomach (erosion, acute duodenal ulcers, acute gastric ulcers, any bleeding from the digestive tract);
- pregnancy in the first and third trimesters;
- lactation
- severe liver failure with creatinine clearance less than 30 ml / min .;
- renal failure (in this case, for the cardiomagnyl preparation, indications and contraindications are determined individually);
- allergic reactions to any salicillates;
- bronchial asthma in any clinical stage and degree of manifestation;
- methotrexate treatment;
- age to 18 years.
Side and most important combined effects
It is logical that virtually any drug has both therapeutic and side effects. The same characteristic applies to the Cardiomagnyl. Contraindications, side effects and features of its use should become determining criteria when prescribing a medicine to a patient. The most formidable negative effect is a violation of the reproduction of cells of the gastric and intestinal epithelium with an increased risk of erosion of the mucous membranes and ulcers, followed by bleeding from the upper gastrointestinal tract.
The likelihood of damage to the stomach and intestines increases with the simultaneous use of the drug Methotrexate and other cytostatics. All other NSAIDs enhance the effects of the medication in question and are not recommended for joint use with it.
The drug “Cardiomagnyl”, the use and contraindications of which are interrelated, can aggravate the violation of hepatic functions if the patient consumes alcohol during treatment. It is also possible to develop an allergy to salicylates. Common side effects are bronchospasm, increased bleeding, headache, and insomnia. A rare manifestation can be called tinnitus, dizziness, drowsiness. The likelihood of drug poisoning is only in the case of a single consumption of 60 or more tablets of 75 mg.
Dosage form
The drug “Cardiomagnyl” (contraindications and side effects discussed above) refers to modern conditionally safe drugs due to the presence of an enteric coating. It is also present in most other similar medicines, since this is a recognized pharmacological standard for a dosage form that is aggressive against the stomach. The drug is available in tablets made in the shape of a heart.
Composition and dosage
The drug is available in two standard dosages of 75 and 150 mg. They are prescribed depending on the tolerance of the dose and the clinical condition. The most commonly used dose is 75 mg. It is recommended for a single dose after dinner according to the indications described above.
The tablet contains 75 mg of acetylsalicylic acid, magnesium hydroxide - 15.2 mg. In addition, auxiliary substances are present in the composition: magnesium stearate - 150 μg, microcrystalline cellulose - 12.5 mg, corn starch - 9.5 mg, potato starch - 2.0 mg.
All important points regarding the administration of Cardiomagnyl (contraindications, duration of administration, identification of side effects and the fight against them) should be obtained from your doctor. The appointment of a dose and monitoring of therapy is carried out by a cardiologist or therapist.
Reviews of specialists about the drug
It is important to indicate the totality of statistics confirming the appropriateness of the drug. So, all cardioforms, including gastro-soluble ones, reduce mortality among patients with already high cardiovascular risk by 16%. Acetylsalicylic acid by a quarter reduces the likelihood of thromboembolism of the pulmonary arteries and ischemic stroke.
Cardiomagnyl will also reduce the risk of clinically significant pelvic and lower limb vein thrombosis by 29% in the presence of varicose veins. Moreover, the most important is a proven reduction in the likelihood of developing myocardial infarction in the presence of any form of chronic cardiac ischemia. All these effects make it possible to increase the life expectancy of any patient at risk of developing heart and brain infarction. Also, 40% cardioform of acetylsalicylic acid will reduce the likelihood of shunt thrombosis during any revascularization operation.
Overview of the opinions of patients
Patient reviews about the drug are often not indicative, because there is no quick way to determine the effectiveness of this drug. Therefore, the person to whom Cardiomagnyl is prescribed should rely on the advice of a doctor. This is a conditionally safe drug, with proper use of which side effects are minimized. However, a combined analysis of patient reviews proves that Cardiomagnyl is much better tolerated than any of the gastro-soluble cardioforms.
Application features
Considering the reviews, contraindications and the breadth of the therapeutic effect characterizing Cardiomagnyl, the doctor will recommend a dosage for treatment. More often, according to the recommendations of ESC 2014 and AHA 2014, a dose of 75 mg is used. 150 mg of acetylsalicylic acid is recommended for patients with high weight and wide (extended stenosis) coronary arteries.
The drug should be used continuously and, if required by the clinical situation, be withdrawn gradually due to the likelihood of acute thrombosis in the first ten days from refusal to take it. According to the results of numerous studies of the pharmacokinetics and pharmacodynamics of acid, the safest is considered to be taken after dinner about 1.5 hours before bedtime.