The drug "Suprax Cefixime" with a dosage of 400 milligrams is a semisynthetic cephalosporin antibiotic with a wide spectrum of effects and belongs to the third generation. Intended for oral administration. This medication is bactericidal. Next, consider the instructions for its use.
The composition of this drug
One capsule of 400 mg suprax cefixime contains an active ingredient called cefixime in the form of a trihydrate. Excipients are silicon dioxide along with magnesium stearate and calcium carmellose. The composition of the capsule shell is represented by titanium dioxide, dyes azorubine, indigo carmine and gelatin. Food grade inks are made from shellac, ethanol, isopropanol, butanol, propylene glycol, sodium hydroxide, povidone and titanium dioxide.
The pharmacological effect of this drug
The mechanism of action of Suprax Cefixime is due to inhibition of the synthesis of cell membranes of pathogens. The antibiotic is resistant to the effects of lactamases, which are produced by most bacteria. This drug differs in bactericidal effect and is related to the third generation of antibiotics.
Pharmacokinetics of the drug
As part of the description of the drug, it is worthwhile to focus on absorption and distribution. When used internally, the bioavailability of the drug is fifty percent, regardless of food intake, but the maximum concentration in serum is achieved faster when the drug is combined with food.
When using capsules, its high values in blood serum are observed after four hours and amount to 3 micrograms per milliliter. When receiving a suspension in an amount of 200 milligrams, Cmax is reached after four hours and is 2 micrograms per milliliter.
Binding to plasma proteins predominantly with albumin is sixty-five percent. About half the dose is excreted unchanged in the urine during the day, the rest is removed with bile.
Indications for the use of this medication
Suprax Cefixime must be used in a number of the following cases:
- Against the background of infectious and inflammatory diseases that are caused by microscopic organisms sensitive to the drug.
- It is advisable to use the medication in question with pharyngitis, tonsillitis, sinusitis.
- Against the background of acute and chronic bronchitis.
- In the case of otitis media.
- With uncomplicated urinary tract infections.
- In the presence of uncomplicated gonorrhea.
Contraindications to the use of the drug
According to the instructions to Suprax Cefixime, the use of this pharmaceutical product in a number of the following cases is prohibited:
- In case of impaired renal function with CC less than 60 milliliters per minute.
- In childhood, up to twelve years.
- In case of hypersensitivity to cephalosporins and penicillins.
With caution, it is recommended to prescribe medication for patients in old age, with chronic kidney failure, and, in addition, with pseudomembranous colitis.
During pregnancy
The use of Suprax Cefixime (400 milligrams) during pregnancy is possible only in cases where the benefits to the woman outweigh the potential risks to the fetus. If there is a need for use during lactation, be sure to stop breastfeeding.
Dosage and administration
Adults and children over twelve years of age with a body weight of more than fifty kilograms are prescribed Suprax Cefixime at a dose of 400 milligrams once. With an uncomplicated form of gonorrhea, the same dosage is prescribed once. The average duration of treatment is from seven to ten days. In case of infection caused by Streptococcus pyogenes, the course of therapy should be at least ten days. Patients with impaired renal function who are on hemodialysis, the medication should be prescribed in suspension format.
Side effects
The drug in question may have the following undesirable effects:
- Allergic reactions in the form of urticaria, flushing of the skin, itching, eosinophilia, fever, erythema multiforme, toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock, and symptoms resembling serum sickness.
- The activity of the nervous system is sometimes noted by headache, dizziness, tinnitus, and convulsions.
- The digestive system responds with dry mouth, anorexia, nausea, vomiting, diarrhea, constipation, flatulence, abdominal pain, dysbiosis. Organs can also respond with impaired liver function, cholestasis, cholestatic jaundice, candidiasis, stomatitis, glossitis, pseudomembranous enterocolitis.
- The hematopoietic system responds with pancytopenia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, hemolytic anemia.
- The organs of the urinary system react with interstitial nephritis, impaired renal function and acute insufficiency of this organ.
- The reproductive system responds with vaginitis, itching in the reproductive system.
- Laboratory indicators reflect an increase in hepatic transaminase activity, hyperbilirubinemia, an increase in urea, hypercreatininemia, and, in addition, an increase in prothrombin time.
- Other side effects include candidomycosis and shortness of breath.
Overdose
As indicated by the instructions for use with Suprax Cefixime, an overdose symptom is an increase in the manifestations of the adverse reactions described above, especially from the digestive system, excluding allergic symptoms. As a treatment, gastric lavage, symptomatic and supportive therapy is required, which, if necessary, includes the use of antihistamines. Epinephrine is mainly used along with Norepinephrine, Dopamine, oxygen therapy with transfusion of infusion solutions is carried out. Suprax Cefixime is not excreted in large quantities from circulating blood through peritoneal dialysis.
Interaction
Tubular secretion blockers (Allopurinolum and diuretics) delay the excretion of Suprax Cefixime 400 mg by the kidneys, which can lead to an increase in the concentration of the drug in the blood plasma. With simultaneous use with "Carbamazepine", the concentration of this drug in the blood increases, the prothrombin index decreases and the effect of indirect anticoagulants increases. Antacids that contain magnesium or aluminum hydroxide can slow the absorption of the drug, so it should be used two hours before or four after taking the above medicines.
special instructions
With prolonged use of this drug, a violation of normal intestinal microflora is possible, which can lead to the growth of Clostridium difficile, causing severe diarrhea and pseudomembranous colitis in patients. People who have a history of allergic penicillins may experience hypersensitivity to cephalosporin antibiotics.
During therapy, a false positive reaction of urine to glucose is possible. Patients with diabetes should be aware that sucrose is part of the suspensions. Those who take this medication should be careful when driving and when doing other dangerous activities that require concentration and quick reactions.
Analogs
The “Pantsef” along with “Cemidixor”, “Iksim”, “Lupine”, “Cephoral Solutab” refers to substitutes of the antibiotic in question. Before using cheap analogues, you should make sure that the main active ingredient in it is cefixime, and its amount will not be less than in the package of the original drug. If you want to buy more packs, then the total cost may be higher than the original. Unfortunately, no Russian manufacturer offers analogues of Suprax Cefixime. Further we learn that people talk about this medication.
Reviews on "Suprax Cefixime"
Consumers respond positively about this antibiotic and report that it is quite effective in the case of treatment of the diseases stated in the instructions. But very often there are complaints of side effects, and mainly it concerns the appearance of problems in the digestive system. There are also complaints of headaches and the occurrence of allergic reactions.