Instructions for use, composition and analogue "Akkuzida"

In the article, we consider the analogues of Akkuzid.

It is a combined drug with diuretic and hypotensive effects. The main active ingredients in the composition are hydrochlorothiazide and quinapril hydrochloride.

The auxiliary components in Akkuzid tablets are: wax, macrogol, titanium dioxide, magnesium stearate, iron oxide, povidone, crospovidone, magnesium carbonate, lactose monohydrate.

Pharmacological forms of this drug

The manufacturer of the medicine "Akkuzid" is available in tablet form. Tablets have a convex rounded triangular shape on both sides, pink. Packed in blister packs and placed in cardboard packs of 30 pieces. "Akkuzid" refers to the group of diuretic, antihypertensive drugs.

Indications for the use of a medication

As indicated by the instructions for Accuid, the main indication for the use of the medication is the combination therapy of arterial hypertension in patients with indications for the use of hydrochlorothiazide and quinapril.

Find out below in which cases the drug is not prescribed.

Contraindications to the use of the drug

The main contraindications to the use of "Akkuzid" are the following pathological and physiological conditions:

1. Lactase deficiency.
2. Severe forms of hepatic, renal failure.
3. Lactation period, pregnancy.
4. Diabetes.
5. Age less than 18 years.
6. Anuria
7. Addison's Syndrome.
8. The presence of a history of information about the occurrence of angioedema against the background of the use of ACE inhibitors.
9. A high degree of sensitivity to the components of the drug.

This must be considered before the appointment of funds.

Negative effects of the use of a medication

According to the instructions for use with Accuid, the combined use of quinapril and hydrochlorothiazide often provokes such negative symptoms as:

1. Alopecia.
2. Peripheral puffiness.
3. Arthralgia.
4. Skin rash, itching.
5. Hepatitis.
6. Flatulence.
7. Pancreatitis
8. Diarrhea, constipation.
9. Dry throat.
10. Nausea.
11. Anaphylactic reactions.
12. Fainting, hypotension.
13. Heartbeat
14. Tachycardia.
15. Hyperactivity.
16. Asthenia.
17. Unproductive cough.
18. Headache.
19. Dizziness.

If adverse reactions occur, stop taking and consult a doctor.

Use of this drug

Photo "Akkuzida" presented in the article. It is recommended to take the drug once a day, regardless of meals. It is recommended for patients who do not receive diuretic therapy to start using the drug with small doses - with one tablet. If necessary, the dose can be doubled.

Elderly patients do not need dose adjustment. If there are severe impaired renal function, it is not recommended to use the Akkuzid preparation as a means of initial therapy.

Overdose with this drug

With the onset of drug intoxication as a result of prolonged use or use in excessive doses, a persistent decrease in blood pressure levels, disturbances in the water-electrolytic balance, which are manifested by hypokalemia, hyponatremia, hypochloremia, can be observed.

Reviews about Akkuzid will be presented at the end of the article.

Interaction with other medicines

The simultaneous use of the drug with tetracycline antibiotics causes a decrease in the absorption of tetracycline by a third. The parallel use of diuretics and lithium preparations is not recommended, since diuretics are able to reduce lithium clearance, as a result of which the likelihood of intoxication increases sharply.

The simultaneous use of drugs with general anesthesia, barbiturates, opioid analgesics, ethanol increases the likelihood of orthostatic hypotension. The instruction for the medicine "Accuid" confirms this.

Combination with hypoglycemic drugs, insulin requires dose adjustment of a hypoglycemic medication.

The hydrochlorothiazide contained in Accuid is able to enhance the effect of antihypertensive drugs.

Concurrent use with corticosteroid drugs can cause increased loss of potassium or other electrolytes. The use of NSAIDs can cause weakening of the natriuretic, diuretic, antihypertensive effects of diuretics. Combination with muscle relaxants causes an increase in the effect of the latter.

In the instructions for tablets "Akkuzid" price is not indicated.

Cost

The average cost of a drug package containing 30 tablets with a dosage of 12.5 + 20 mg is approximately 450 rubles. It depends on the region and the pharmacy network.

Analogues of Akkuzid

The drug has no structural analogues.

If necessary, it can be replaced by one of its therapeutic analogues. The most popular products are: Quinard, Quinapril, Enap N, Iruzid, Ko-Diroton, Enalozid, Enap NL, Enapril-N, Capozid, Tritace Plus ”,“ Enzix ”,“ Liprazid ”,“ Ko-Renitek ”,“ Khartil N ”,“ Noliprel ”,“ Ko-Perineva ”,“ Kaptopres ”.

It is important to remember that any of the listed analogues is capable of provoking negative symptoms and has a number of contraindications, therefore, replacement of the drug is possible only after consultation with the doctor.

Iruzid

The main active substance in the composition of the Akkuzid analog is lisinopril dihydrate. As auxiliary materials are used: magnesium stearate, indigo carmine, gelatinized starch, corn starch, mannitol, calcium phosphate dihydrate, hydrochlorothiazide.

"Iruzide" refers to a group of diuretic, antihypertensive drugs.

The main indication for the use of the Akkuzid drug analogue is arterial hypertension.

The drug is contraindicated if the patient has sensitivity to its components, anuria, severe renal failure, severe forms of diabetes, lactation, pregnancy, hepatic coma, hyponatremia, angioedema, under the age of 18 years.

It is also important to exercise caution when prescribing "Iruzide" to elderly patients suffering from coronary heart disease, impaired bone marrow circulation, gout, arterial hypotension, aortic stenosis, renal failure, and liver activity.

The use of “Iruzide” can cause the development of such negative symptoms as arthralgia, arthritis, myalgia, fever, decreased potency, impaired renal function, allergic responses, increased sweating, photosensitivity, hair loss, bronchospasm, dyspnea, muscle cramps, paresthesia, drowsiness , mood lability, impaired concentration, increased fatigue. In addition, pancreatitis, hepatitis, taste change, dyspepsia, anorexia, abdominal pain, vomiting, dry mouth, nausea, heart failure, tachycardia, bradycardia, decreased blood pressure, dizziness, chest pain, headache can occur.

Take "Iruzid" should be once a day for 1 tablet. If necessary, a specialist can recommend an increase in the dosage of the drug.

Currently, it is impossible to purchase “Iruzid” in Russian pharmacies. Its full structural analogue is Lysinoton, which costs about 350 rubles.

What other analogues of Akkuzid are available for sale?

Enalozide

The active substances in Enaloside are enalapril maleate and hydrochlorothiazide. The auxiliary components are: povidone, calcium stearate, lactose monohydrate, potato starch.

In addition, there are variations of the drug: “Enaloside Forte”, “Enaloside Mono”. The first contains hydrochlorothiazide, enalapril maleate, lactose monohydrate, iron oxide, sodium bicarbonate, corn starch, gelatinized starch, magnesium stearate; the second contains enalapril maleate, calcium stearate, lactose monohydrate, low molecular weight polyvinylpyrrolidone.

“Enaloside” is a combined medicine and can be used in cardiological and therapeutic practice for the treatment of symptomatic and essential arterial hypertension. Also, "Enaloside" can be used to treat chronic forms of heart failure (as part of complex therapy).

The use of the Akkuzid drug analogue in patients with individual susceptibility to thiazide diuretics, with lactose deficiency, galactosemia, galactose-glucose malabsorption, porphyria, after kidney transplantation, with primary hyperaldosteronism, gout, diabetes, anuria, and liver failure is prohibited.

Also, the drug is contraindicated in the age of 14 years, in the lactation period, during pregnancy.

Caution should be exercised during treatment with "Elanoside" in conditions provoking dehydration, subaortic muscle stenosis, disturbances in the blood supply to the brain of the head, atherosclerotic vascular lesions, and chronic alcoholism.

Using a medication can provoke many negative manifestations: vomiting, pancreatitis, indigestion, hepatitis, nausea, stool, abdominal pain, hyperbilirubinemia, anemia, neutropenia, facial skin hyperemia, angina pectoris, thrombocytopenia, arterial hypotension, orthostatic hypotension. Also, Enaloside therapy can cause dry cough, the development of acute renal failure, hypercreatinemia, changes in the structure of the nail plate, Raynaud's syndrome, impotence, dyspnea, proteinuria, psoriasis-like changes, urticaria, rash, Quincke's edema, pruritus, photosensitivity. Often there are violations of the activity of the National Assembly: visual perception, vertigo, dizziness, headaches, asthenia, convulsive syndrome.

It is recommended to start therapy with "Enaloside" from the minimum dosages, constantly monitoring blood pressure. Take a daily dosage should be 1 time. The initial dose is 10 + 12.5 mg, after which, if the body's reaction is normal, it can be doubled.

It is important to pay attention that “Enaloside” can negatively affect the body if combined with other drugs. Before use, it is imperative to familiarize yourself with the manufacturer's annotation and consult a specialist.

The average cost of an Enaloside package is 100 rubles.

Co-Diroton

Active components in the composition of "Co-Diroton" are hydrochlorothiazide and lazinoprin. The auxiliary substances are: yellow iron oxide, indigotine, aluminum varnish, calcium hydrogen phosphate dihydrate, magnesium stearate, corn, pregelatinized starch, mannitol.

"Co-Diroton" refers to a group of diuretic, antihypertensive drugs.

The main indication for its use is arterial hypertension.

Do not use the medication if the patient has the following physiological or pathological conditions:

1. Age to 14 years.
2. The lactation period.
3. Pregnancy.
4. Severe forms of diabetes.
5. Hepatic coma, precoma condition.
6. Hyponatremia.
7. Hypercalcemia.
8. Porphyria.
9. Hemodialysis.
10. Anuria
11. Severe forms of urinary failure.
12. The presence of a history of information about angioedema.
13. Increased susceptibility to ACE inhibitors, hydrochlorothiazide, lisinopril, excipients as part of the drug.

Caution should be exercised during drug therapy in the following situations:

1. Elderly age.
2. Severe forms of liver, heart failure.
3. Cerebrovascular pathology.
4. Ischemic heart disease.
5. Violations of bone marrow hematopoiesis.
6. Hyperkalemia
7. Hyperuricemia
8. Diabetes.
9. Gout.
10. Scleroderma, lupus, other pathologies of connective tissues.
11. Hypovolemic condition.
12. Hyponatremia.
13. Bone marrow hypoplasia.
14. Primary hyperaldosteronism.
15. Arterial hypotension.
16. Hypertrophic cardiomyopathy.
17. The period after kidney transplantation.
18. Aortic stenosis, renal artery stenosis (unilateral, bilateral).

The use of the drug often becomes the cause of the development of side symptoms. "Co-Diroton" can cause: exacerbation of gout, arthritis, myalgia, arthralgia, metabolic disorders (hyperuricemia, hypokalemia, hyponatremia and other manifestations), the development of renal failure, decreased potency, oliguria, uremia, anuria, eosinophilia, fever, fever, skin rashes, vasculitis, angioedema, anemia, agranulocytosis, thrombocytopenia, leukopenia, neutropenia, dry cough, dyspnea, apnea, bronchospasm. Also, during therapy, confusion, twitching of the lips, limbs, drowsiness, asthenia, paresthesia, concentration disorders, mood lability, alopecia, itching, photosensitivity, increased sweating, urticaria, jaundice, hepatitis, pancreatitis, abdominal pain, dyspepsia, and others can occur. violations of the digestive tract. In addition, the occurrence of myocardial infarction, disturbances in atrioventricular conduction, tachycardia, bradycardia, orthostatic hypotension, chest pain, a significant decrease in blood pressure are not ruled out.

Take the drug, as a rule, once a day, 1 tablet. In the absence of the desired effect within two weeks, a specialist may recommend a double increase in dosage. Patients with renal failure require dose adjustment.

It is important to consider the possible interactions of Co-Diroton with other medicines, so you should first familiarize yourself with the manufacturer's annotation and consult a doctor.

The average cost of "Co-Diroton" is about 480 rubles per package.

Enap N

The main active components of Enap N are hydrochlorothiazide and enalapril maleate. As auxiliary substances are used: magnesium stearate, corn starch, anhydrous calcium hydrogen phosphate, talc, quinoline dye, lactose monohydrate, sodium bicarbonate.

According to the instructions for use with the Akkuzid analogue, the main indication for the use of the drug is arterial hypertension.

Enap N should not be used if the patient has such contraindications as:

1. High sensitivity to the substances in the composition of the drug.
2. Age less than 18 years.
3. Lactase deficiency, glucose-galactose malabsorption, lactose intolerance.
4. Lactation period, pregnancy.
5. The only kidney, renal artery stenosis.
6. Hereditary, idiopathic angioedema.
7. Anuria
8. Severe renal failure.

In addition, there are conditions the presence of which is a reason to exercise caution during medication therapy. Among them: hyperkalemia, chronic heart failure, stroke, aortic stenosis and others.

On the background of the use of the drug, a variety of negative manifestations can develop:

1. Eosinophilia.
2. Leukocytosis.
3. Skin rash.
4. An increase in ESR.
5. Vasculitis.
6. Myalgia.
7. Arthralgia.
8. Fever.
9. Increased hepatic transaminases, bilirubin.
10. Hyponatremia.
11. Hypokalemia.
12. Hyperglycemia.
13. Arthralgia, muscle cramps.
14. Impotence.
15. Decreased libido.
16. Acute renal failure.
17. Skin necrosis.
18. Alopecia.
19. Increased sweating.
20. Rash, itch.
21. Cholestatic jaundice.
22. Dry mouth.
23. Angioneurotic edema.
24. Shortness of breath, coughing.
25. Asthenia.
26. Insomnia.
27. Tachycardia.
28. Hypotension.
29. Gout.
30. Thrombocytopenia.

The listed side symptoms are far from all the manifestations that can occur as a result of using Enapa N, therefore it is important to coordinate the use of the medicine with the doctor and follow all the instructions of a specialist.

Take "Enap N" should be once a day, 1 tablet. If necessary, a specialist can recommend a double dosage increase. It should be noted that the medicine should be taken daily, at the same time. The duration of therapy is determined by the doctor individually.

“Enap N” in combination with other drugs can have various effects (including negative) on the body. Therefore, before using the medicine, you should notify the doctor of all the drugs used, as well as familiarize yourself with the manufacturer's annotation.

The average cost of an Enap N package containing 20 tablets is an average of 200 rubles.

Reviews about "Akkuzid" and analogues

It is difficult to judge which drug is most effective for a particular patient. When choosing a drug, you should rely on the recommendations of a specialist and the individual characteristics of the body.

According to reviews, analogues of Akkuzid are quite effective.

Most comments are always positive. The only negative quality that combines Akkuzid and all its analogues is a large number of contraindications and negative manifestations. To minimize the risk of side symptoms, all medical recommendations should be fully observed.

We reviewed the instructions for use and analogues of "Akkuzida".