What do you know about a medicine like Moditen Depot? Instructions for use, contraindications, reviews and side effects of this medication will be discussed later.
Packaging and form of the drug, its composition
In what form is a drug such as Moditen Depot produced? The instruction for use reports that it can be purchased in the form of an oil solution intended for intramuscular administration. The main active ingredient of this drug is fluphenazine decanoate. It goes on sale in dark glass ampoules, packaged in contour cells and paper bundles, respectively.
Pharmacology
What are the medicinal properties of the Moditen Depot medication? Instructions for use, reviews claim that this is a long-acting antipsychotic medicine. It belongs to the group of polyvalent antipsychotics and exhibits pronounced antipsychotic properties, which are combined with some activating and antiemetic effect. Also, this drug has a moderate sedative effect.
What determines the effectiveness of Moditen Depot? Instructions for use states that its antipsychotic effect is associated with blockade of dopamine D2 receptors of the mesocortical and mesolimbic systems.
Sedative properties of this medication are moderate and are observed only when using high doses of the solution. They are caused by blockade of adrenoreceptors of certain sections of the brain stem.
As for the antiemetic effect of this drug, it is associated with blockade of the dopamine D2 receptors of the trigger zones of the vomiting center. It should also be noted that the hypothermic effect of this drug is due to blockade of the dopamine receptors of the hypothalamus.
How long does the Moditen Depot medication take effect? Instructions for use (a photo of the injection solution is presented in this article) reports that the therapeutic effect of this drug usually manifests itself 25-72 hours after the injection. It should also be noted that the antipsychotic properties of the drug in question are most pronounced in the period from 49 to 97 hours after administration of the solution.
Kinetics of the drug
What pharmacokinetics is typical for Moditen Depot? Instructions for use states that fluphenazine in the form of high molecular weight ester, oil solution and fatty acid is able to accumulate in fat depots, as well as slowly released.
After intramuscular injection, the maximum plasma concentration of this element is reached after 25 hours. In this case, fluphenazine binds to blood proteins by 90%.
The drug in question easily penetrates the placental barrier and passes through the blood-brain-brain, and is also not excreted through hemodialysis.
Fluphenazine is completely and actively metabolized in the liver with the participation of enzymes of the cytochrome P450 system. It is excreted from the body along with bile and urine. The activity of the metabolites of this element has not been fully studied.
The half-life of flufenazine is 7-10 days.
Indications
In what cases is the patient prescribed injections of Moditen Depot? Instructions for use indicate indications such as:
- exacerbation of schizophrenia (for the purpose of prevention);
- long-term supportive treatment of chronic forms of schizophrenia.
Bans to use
The medication in question should not be used in the following cases:
- in severe SS diseases, including decompensated chronic circulatory failure and arterial hypotension;
- with increased sensitivity of the patient to fluphenazine, as well as to other elements of the drug;
- with depressed central nervous system and coma;
- during pregnancy;
- with trauma to the skull, as well as progressive systemic diseases of the spinal cord and brain;
- during feeding;
- with impaired liver and blood system;
- up to 12 years old.
Careful use of the drug
With caution, the drug "Moditen Depot" is prescribed for:
- alcoholism, as well as with an increased predisposition to hepatotoxic reactions;
- pathological changes in blood, as well as in violation of blood formation;
- allergies to phenothiazine derivatives, including a history of;
- angle-closure glaucoma;
- breast cancer
- liver and / or renal failure;
- an ulcer of the digestive tract, including during an exacerbation of the disease;
- prostatic hyperplasia with clinical manifestations;
- myxedema;
- ailments accompanied by thromboembolic complications;
- Parkinson's disease;
- chronic diseases with respiratory failure (including in children);
- Reye's syndrome;
- epilepsy, vomiting, convulsive seizures;
- cachexia;
- in old age.
Medicinal solution "Moditen Depot": instructions for use
In ampoules, this drug is intended for long-term courses of therapy (at least three months). Its initial dosage for most patients is 12.5-25 mg. Subsequent doses, as well as the interval between injections of the solution are determined depending on the therapeutic effect.
Treatment of patients with hypersensitivity to phenothiazine should be started with extreme caution.
Older people require lower doses than younger patients (approximately 1/4 to 1/3 of the dosage). Moreover, they need constant monitoring.
Side effects
The Moditen Depot drug solution can cause the following undesirable reactions:
- extrapyramidal syndrome, akathisia, tardive dyskinesia, dystopia, oculogyric crises, hyperreflexia, opistotonus;
- neuroleptic malignant syndrome with possible fatal outcome;
- orthostatic hypotension, sweating, fluctuations in blood pressure, nausea, hypotension, loss of appetite, glaucoma, salivation, atony of the bladder, polyuria, bowel obstruction, dry mouth, tachycardia, headache, impaired vision, constipation, nasal congestion;
- ventricular arrhythmia, sudden death, ventricular tachycardia, cardiac arrest;
- pathological lactation, peripheral edema, menstrual irregularities, hyponatremia, impotence in men, change in body weight, change in libido in women;
- pruritus, exfoliative dermatitis, erythema, seborrhea, urticaria, anaphylactic reactions, photosensitivity, angioedema, bronchospasm, laryngeal edema;
- agranulocytosis, leukopenia, cholestatic jaundice;
- convulsive seizures, fever, ECG changes, irreversible dyskinesia, vomiting, venous thromboembolism, lupus-like syndrome and others.
Patient Reviews
Now you know what injections of Moditen Depot are made of. Instructions for use, side effects and contraindications for the use of this solution were also discussed above.
According to patients who previously took various antipsychotics, the drug "Moditen Depot" is much more effective and relieves all the negative symptoms of schizophrenia. The introduction of this medication causes a stable and fairly long-term remission.
The only disadvantage of this tool is a huge number of side reactions. In the early days of therapy, some people had hyperthermia, hypertension, and autonomic disorders. Also, many patients observed hyperkinesis of the muscles of the mouth and face, smacking the movements of the tongue and lips. In addition, the use of this drug often caused depression of varying severity.