The article provides instructions for use for the Trental 400 medication. Vascular constriction, including cerebral, peripheral and coronary, and changes in blood properties can not only harm human well-being, but also cause irreversible effects, including tissue death.
To avoid this process, doctors advise taking medications with myotropic and vasodilating relaxing effects. This type of drug includes Trental 400.
Release form and composition
The drug is made in the form of rounded biconvex coated tablets. Its color is white, there are no visible inclusions and inclusions.
There are also no chamfers and notches on the tablets, however, on one half there is embossing in the form of a combination of letters “ATA”.
The tablets contain the active substance pentoxifylline - 400 milligrams per piece. Auxiliary components of their inner part are represented by hydroxyethyl cellulose, talc, povidone and magnesium stearate.
The composition of the shell has some differences from the inside. In addition to the substances listed above, benzyl alcohol and macrogol 600 are included.
The tablets are packed in contour cells of ten pieces each, then two pieces are placed in cardboard boxes.
Pharmacological effect
Trental 400 reduces blood viscosity, contributing to an improvement in its rheological properties due to restoration of red blood cell deformability disorders, decreased aggregation of red blood cells and platelets, fibrinogen concentration, decreased white blood cell activity and white blood cell adhesion to vascular endothelium.
The active component of the drug - pentoxifylline - is a xanthine derivative. Its mechanism of action is due to the inhibition of phosphodiesterase and the accumulation in the cells of vascular smooth muscle and cAMP shaped blood elements.
Producing a small vasodilating myotropic effect, pentoxifylline to some extent reduces OPSS and contributes to a small expansion of the coronary vessels.
Pentoxifylline has a slight positive inotropic effect on the heart.
In the area of impaired circulation, microcirculation improves.
Treatment with this drug leads to an improvement in blood circulation disorders of the brain.
In case of peripheral arterial occlusion diseases, the use of Trental 400 causes an increase in the distance of walking, the disappearance of pain at rest and the elimination of cramps at night in the calf muscles.
Indications for use
The Trental 400 medicine is used when there is a change (decrease) in cerebral and peripheral blood circulation, which occurs due to changes in blood properties or due to narrowing of blood vessels.
The drug is prescribed for the following diagnoses:
- intermittent claudication;
- hearing loss due to the influence of vascular pathologies of the inner ear;
- diabetic origin angiopathy;
- otosclerosis, that is, insufficient circulation of blood in the retina;
- gangrene;
- condition after a stroke;
- trophic leg ulcers;
- ischemic conditions;
- cerebral atherosclerosis;
- defects of memory and attention.
Method of use and dosage
The drug "Trental 400" in accordance with its dosage form is used orally. The dosage that is suitable for a particular patient is determined by the doctor.
The average amount is two to three tablets per day. The maximum permissible dose during the day is 1200 milligrams, that is, three tablets.
If the creatinine clearance decreases, which accompanies defects in renal activity, the maximum dose per day is 800 milligrams. The dosage is also reduced with liver diseases. This is confirmed by the instructions for use with Trental 400. We consider the price and analogues below.
Therapy of poor circulation with arterial hypotension also needs to reduce the amount of the drug, with poor tolerance, severe type of coronary heart disease and impressive cerebral stenosis.
The medicine must be taken with a sufficient amount of liquid to pass it through the alimentary canal. At the same time, ordinary clean water is recommended.
Drug Interactions
According to the instructions for use with Trental 400, the active ingredient can interact with many drugs. For example, it enhances the action of the following medicines:
- ACE inhibitors;
- theophylline;
- nitrates;
- hypoglycemic drugs and insulin preparations;
- indirect anticoagulants;
- cephalosporins and other antibiotics;
- thrombolytics.
With simultaneous use with "Cimetidine", the concentration of pentoxifylline in the blood may increase, which is dangerous because of the possibility of exacerbation of side symptoms.
The use of Trental 400 along with medicines containing xanthan can cause excessive excitation of the nervous system.
Side effects
During the administration of the drug, various symptomatic phenomena may appear - side symptoms. These include:
- defects in the functioning of the nervous system: dizziness and headaches; falling asleep; feeling of anxiety; convulsive muscle contractions;
- allergic skin reactions and changes in fatty tissue under the skin: edema, urticaria, hot flashes and hyperemia (most often on the skin of the face);
- changes in the gastrointestinal tract: intestinal atony, a feeling of fullness of the intestines and stomach, thinning of the stool, vomiting and bloating;
- changes in cardiac function: arrhythmia, abrupt progress of angina pectoris, cardialgia, decreased blood pressure;
- a change in the hematopoietic process: pan-, cyto-, leuko- and thrombocytopenia;
- changes in the state of the vessels: bleeding from the vessels of the intestines, stomach and skin is possible;
- changes in the sensory perception: another perception of color, stingray.
This is confirmed by the instructions for use and reviews of "Trental 400".
Symptoms and signs of aseptic meningitis and intracranial cholestasis are very rare. If any of the listed phenomena occurs, you should stop taking the tablets and consult a specialist.
Contraindications
Tablets can not be used for certain physiological and other disorders, which include:
- hypersensitivity or intolerance to the compounds that make up the drug;
- predisposition of the body to bleeding;
- massive massive bleeding;
- CHF;
- an outflow of blood into the retina of the eye;
- gastric ulcer;
- cerebral stroke;
- severe liver and kidney disease;
- acute form of myocardial infarction;
- lactation and pregnancy;
- adolescence and childhood.
If there are vital indications, in extreme cases, the medicine is prescribed for:
- arterial hypotension;
- severe form of arrhythmia.
If any, the use of the drug should be constantly accompanied by medical supervision.
Use of the drug during pregnancy
As the instructions indicate, Trental 400 cannot be used to treat pregnant women and mothers who breastfeed their babies.
If there are indications for the use of this particular drug, it is recommended to choose another medication that will be less dangerous for the course of pregnancy and the fetus.
In the event that the tablets are supposed to be used to treat a nursing mother, it is advisable to temporarily stop feeding.
Analogs of Trental 400
In the pharmaceutical industry, other drugs are produced with the same active ingredients in the composition. Structural analogues of this drug are: “Arbiflex”, “Vasonit”, “Pentilin”, “Pentamon”; Pentohexal, Trenpental, etc.
Despite the fact that their influence is similar, the listed medications can cause other side effects and may differ from Trental in contraindications and indications for use.
Before deciding to replace the tablets with analogues, you need to consult your doctor.
Price
The cost of this medication is 580-600 rubles per package. It depends on the region and the pharmacy network.
Reviews about the drug
In 80% of cases, patients speak about tablets exclusively positively, assessing the tolerability of this drug and its properties.
Only a small number of people surveyed had severe side effects or acute intolerance to the active ingredient.
If the medicine is not suitable, it makes sense to tell the doctor about it and replace it with another, which will be well tolerated by the body of a particular patient.
We reviewed the Trental 400 preparation instructions for use and price.