In recent years, more and more women of reproductive age suffer from endometriosis. This is a very unpleasant hormonal disease that requires complex correction. Often, an antitumor drug is used to eliminate it. However, the greatest effect will be achieved with additional surgical intervention.
This article will tell you about the Buserelin Depot medication. Reviews with endometriosis about him are different. The opinions of some patients will be described later. You will also find out what doctors think about this medicine. It is worth saying that the user is informed about the composition of Buserelin Depot by the user.
In what form is the medicine made?
The instruction says about the medicine “Buserelin-depot” that the drug has two main types - a spray for nasal use and a lyophilisate for intramuscular administration. In this case, the second type of medication must be diluted before use. The method of use is always described in detail in the instructions attached to the medication.
The active substance of the drug is buserelin acetate. Depending on the form of release, the drug may also have additional components.
What is the price of Buserelin-Depot medicine? The cost of the medicine also varies depending on the type of drug. Nasal spray will cost you 800-900 rubles per bottle of 17 ml. If you need to buy an injection of Buserelin-Depot medicine, the price of one ampoule with a device for administration will be about 4000 rubles.
What is this medicine? Description of the action of the drug
The antitumor drug Buserelin Depot is a gonadotropin-releasing hormone. Abbreviated as GnRH. Also from doctors, you can hear the designation of gonadorelin and others. To clarify the situation a little, it is worth saying that this class of hormones is stimulating. Gonads are the testes. In other words, Buserelin Depot Spray or Injection acts on sex hormones.
The drug actively stimulates the anterior dose of the pituitary gland. Under its action, the production of two main substances is switched off - follicle-stimulating and luteinizing hormones. Without these components, ovulation is completely blocked in the body of a woman. In the treatment with the described agent, a decrease in plasma of estradiol to postmenopausal values ​​is observed.
Indications for use of the drug: as reported by the instructions
About the medicine “Buserelin-Depot”, the instructions for use say that this composition is prescribed if a woman has an excess of estrogen in the body. Often such a hormonal disorder leads to the development of endometriosis and the formation of uterine fibroids. Also, the drug is sometimes used among representatives of the stronger sex. The instructions for use about the Buserelin-Depot medicine say that it is strictly forbidden to use the medicine on your own. Prescribe the drug and choose an individual regimen should be a specialist. Otherwise, very unpleasant consequences of improper treatment may develop. The following conditions are indicated in the annotation when it is necessary to use the described medicine:
- benign ovarian tumors (follicular and luteal cysts) ;
- endometriosis and endometriomas;
- uterine fibroids of various sizes and types;
- endometrial hyperplastic transformations;
- preparation for surgery for fibroids and endometriosis;
- prostate cancer or suspected cancer;
- infertility treatment and so on.
The medication is often combined with other methods of treatment (laparoscopy, laparotomy, hysteroscopy, mobilization of arteries in the uterus, and so on).
What are the contraindications to the use of the drug?
Treatment with Buserelin Depot is possible only after a thorough examination and diagnosis of blood levels of hormones. Also, previously a woman is recommended to do an ultrasound examination of the pelvic organs. In some situations, additional research manipulations are indicated.
The composition is strictly forbidden to use during pregnancy and breastfeeding. It is known that this drug is able to pass into breast milk. Consequently, the medicine will affect not only the woman, but also her baby. The medication is contraindicated during the period of bearing a child due to the teratogenic effect on the fetus. Such a correction can lead to an abortion or a delay in the development of the embryo.
The medicine is prohibited for use in girls under puberty. The use of the medication may adversely affect their future hormonal background. It is also impractical to prescribe the composition to women during menopause. After all, these representatives of the weaker sex do not already produce the above hormones.
With increased sensitivity to the components, the drug is not used. The composition with extreme caution should be used during the period of depression, with diabetes. Arterial hypertension may worsen after such treatment.
Method of application of the nasal spray: dosage and scheme
What do the reviews say about Buserelin Depot? With endometriosis, the use of a spray is very convenient. Women who are afraid of injections and want to save money, choose this option. Consumers note that the described drug is several times cheaper than ampoules for intramuscular administration.
For the treatment of endometriosis, 900 mcg of medication is prescribed per day. The specified portion should be divided into three doses. One spray contains 150 micrograms of medication. Based on this, we can draw the following conclusion. The medicine is administered one spray into each nasal passage three times a day.
Consumers say that before using the medication, you need to clean your nose. To do this, you can use any means convenient for you (shower, spray, washing). The use of the described substance during rhinitis is allowed. The duration of therapy is up to 6 months.
The disadvantage of this form of release is that it must be taken after a certain time without any deviations from the rules. So, between each injection of the drug should take from 6 to 8 hours. When using the spray, doctors advise you to think in advance the mode of its use and adhere to it.
Injections: method of using the drug in ampoules
Buserelin Depot may be used as an injection. In this case, the injection is made exclusively intramuscularly. Other administration of the drug is unacceptable. Before use, the composition must be prepared. Detailed instructions are included with each vial. However, to get competent treatment, you should consult a doctor and, in a hospital, administer the medication.
Prepare the suspension with a special solvent. At the same time, it is inserted with a needle with a red or pink pavilion. After mixing the substances, you need to shake them well and wait a while to obtain a homogeneous liquid. Next, type the composition into the syringe. A feature of this manipulation is that you do not need to turn the ampoule over. After filling, the syringe is removed from the red needle and inserted into the green. Existing air bubbles are released and immediate injection is performed. It is preferable to use the gluteus muscle for injection. Wipe the skin with an alcohol wipe first. In an extreme case, it is allowed to inject the medicine into the muscle of the leg. However, there must be appropriate evidence.
The duration of therapy is from 3 to 6 months. If necessary, it can be longer. An injection is given once every 4 weeks. Women say that it is much more convenient than spraying the composition on the nasal mucosa three times a day. However, this correction will be more expensive.
Buserelin Depot: side effects of treatment. What do women feel?
The described drug is rarely well tolerated. In most cases, it always causes adverse reactions. The composition may have a different effect on each patient. That is why you should not look up to your friends who suffered such treatment and complained about certain reactions.
Most often after the "Buserelin Depot" a woman stops menstruating. At the same time, doctors point out that this is more likely not a side effect, but a favorable effect from treatment. Composition through its work blocks the production of major sex hormones. As a result of this, the endometrium simply does not grow, ovulation does not occur, the phases of the cycle do not change. Menstruation is usually absent just as long as the treatment lasts.
The action of Buserelin Depot is often accompanied by all the symptoms of menopause and menopause. A woman can feel hot flashes, frequent mood swings, decreased libido. Representatives of the weaker sex report an exacerbation of the depressive state, increased headaches. That is why during the treatment period the patient needs psychological help.
Less commonly, the drug can cause hearing and vision problems. Patients note a feeling of pressure on the eyes, tinnitus, discomfort. If previously there were problems with the heart and blood pressure, then they can worsen. Some consumers report an allergic reaction to the described product. It can be expressed by urticaria, itching, anaphylactic shock. In such situations, the drug must be replaced with any other analogue.
The composition can provoke weight gain, digestion, deterioration of the hair. Nasal administration of the solution sometimes leads to bleeding, dryness and itching in the nose.
Buserelin Depot: reviews for endometriosis
Women with this diagnosis often use the described medicine as prescribed by the doctor. They note that the cost of the drug is not so high as it seems at first glance. The composition of Buserelin-Depot has analogues that also treat endometriosis. For example, the drug "Zoladex." However, its cost is much higher. One ampoule will cost you the price of three ampoules of Buserelina Depot.
Many women with advanced stages of the disease suffer from infertility. They can not get pregnant because of the unstable hormonal background. Also, the absence of children is explained by the presence of a strong adhesive process in the small pelvis. Often miraculously, the onset of pregnancy begins to develop in the abdominal cavity or fallopian tube. Using the described medication allows for artificial insemination in childless couples. Moreover, the woman first takes “Buserelin” during the cycle, after which ovarian hyperstimulation is performed. Representatives of the weaker sex say that after pregnancy and prolonged lactation (provided there is no menstruation), the disease can recede completely.
Patients say that when using the Buserelin Depot medication, all symptoms of endometriosis quickly disappear . Pain stops, blood circulation. After all, a patient with such hormonal imbalances never knows what time to wait for another menstruation. Breakthrough "chocolate" bleeding greatly knocks down the usual rhythm of life. Patients also say that Buserelin helped them get rid of the constant pain that always accompanied sexual intercourse.
Of course, treatment often leads to adverse reactions. Women feel severe discomfort, hot flashes, they sometimes grow fat. During the correction period, a deterioration in well-being is observed. If the patient’s goal is the birth of a child, then depression about this can be greatly aggravated. A representative of the weaker sex during the correction period must definitely enjoy the support of her relatives and friends. Women who have had this kind of therapy say it's worth it. However, an integrated approach will be more effective. We learn what gynecologists think about this.
What do doctors say about the described treatment?
The drug "Buserelin-Depot" reviews of doctors has the following. Doctors say that the medicine is quite effective. During treatment, the frenzied foci of endometriosis fade away. However, once treatment is complete, the problem may return. That is why gynecologists advise a comprehensive treatment.
If drug therapy is combined with surgical intervention, very good results can be obtained. Most often, doctors prescribe the described medicine for two months. After this, an operation is performed (usually laparoscopy). By that time, the foci of endometriosis are becoming much smaller, which means that the treatment will be minimally traumatic. After the intervention, hormonal correction continues for another 4-8 months. The forecasts for this approach are very good. In most cases, the woman is no longer bothered by the usual symptoms, since the adhesions and foci of endometriosis are removed, and hormonal treatment does not allow them to form again.
A little summary
You learned about a sex hormone blocker under the trade name Buserelin Depot. Reviews with endometriosis, the drug has positive and negative. Those women who undergo correction may speak negatively about the drug. After all, their side effects manifest themselves in full force. Many representatives of the weaker sex do not withstand therapy and halfway through treatment. Positive opinions are expressed by those patients who were able to gain strength and complete such a difficult treatment. They began to feel much better, all the disturbing signs were gone.
Doctors say that the drug “Buserelin-depot” is one of the most effective drugs that help cope with endometriosis. The medicine works on the problem from the inside out. It blocks the production of estrogens, which provoke a large number of foci growth. Patience to you in treatment and good health!