"Gentamicin" is considered an antibacterial agent of the aminoglycoside group. Available in several forms - injection, ointment, tablets.
In addition, there is Dex-Gentamicin, which is also available as an ointment. This drug is widely used in ophthalmology. Both drugs include gentamicin sulfate, and Dex-Gentimycin still contains dexamethasone.
Pharmacological actions
"Gentamicin" is an antimicrobial agent that belongs to the aminoglycoside aminocyclitols therapeutic group. It has a bactericidal effect, which leads to disruption of the intracellular production of proteins and the elimination of bacterial cells. Gram-negative bacteria are considered the most sensitive to Gentamicin. The medication practically does not show activity against streptococci and anaerobes.
After use, the drug quickly reaches a pharmacological concentration in the blood and spreads evenly throughout all body tissues. It passes through the placenta into the structures of the nervous system. During pregnancy, the drug can penetrate the body of the unborn baby. When breastfeeding, an antimicrobial drug passes into breast milk. The active component is exchanged in the liver, metabolic products are excreted from the body by the kidneys with urine.
Indications
"Gentamicin" is considered a second-line antibiotic, it is used for severe systemic infectious diseases:
- Superficial folliculitis (infection of the middle and deep parts of the hair follicle, leading to its purulent inflammation).
- Pyoderma (a purulent disease of the skin that occurs as a result of the penetration of pyogenic cocci into it).
- Furunculosis (purulent-necrotic disease of the hair follicle and near the follicular connective tissue).
- Paronychia (dermatological lesion of the periungual roller, which is caused by trauma, the influence of chemicals or elevated temperatures, followed by infection).
- Sycosis (a chronic recurrent inflammation of the hair follicles that occurs when staphylococci penetrate them).
- Infected acne
- Infected dermatitis (destruction of epithelial tissues as a result of a strong inflammatory process, the development of which was an infection of the skin).
- Cuts.
- Burns.
- Ulcers (a disease that manifests itself in the formation of chronic ulcerative defects in the gastroduodenal zone).
- Insect bites.
- Infected skin abscesses.
- Cyst (pathological cavity in tissues or organs that has a wall and contents).
- Abscess (purulent inflammation, accompanied by fusion of tissues and the formation of a cavity filled with pus).
In addition, "Gentamicin" is used for any infection provoked by gram-negative bacterial sources with weakened immunity.
"Dex-Gentamicin" is used for the following diseases:
- Allergic processes of the anterior segment of the eye.
- Barley (acute purulent inflammatory process of the eyelash hair sac, which is located near the eyelashes).
- Keratitis (inflammation of the cornea of the eye, manifested mainly by its clouding, ulceration, pain and redness of the eye).
- Conjunctivitis (a polyetiological inflammatory lesion of the conjunctiva - the mucous cavity covering the inner surface of the eyelids and sclera).
- Blepharitis (bilateral recurrent inflammation of the ciliary edge of the eyelids).
Contraindications
According to the instructions for use, the drug is known to be prohibited in certain diseases and conditions, which include:
- Individual intolerance or increased sensitivity to the active substance and other representatives of the antibiotic aminoglycoside group.
- Azotemia (elevated levels of nitrogenous metabolic products in the blood of a person, mainly of protein origin, which leads to impaired renal excretory function).
- Auditory nerve neuritis (an inflammatory disease of the peripheral nerves).
- Myasthenia gravis (an autoimmune neuromuscular disease characterized by pathologically rapid fatigability of striated muscles).
Analogs of "Gentamicin"
The following medicines are substitute drugs:
- Synthomycin.
- "Supirocin".
- "Fusiderm".
- "Baneocin."
- "Tyrosur".
- "Microcid".
- Fusicutan.
- Bonderm.
Dex-Gentamicin Ophthalmic Ointment: analogues
Ophthalmic preparation also has a number of substitutes:
- Tetracycline.
- Tobrex.
- Medetrom.
- "Betagenot".
- Dexapolus.
- Neladex.
- Alox Duo.
- Oftipipro.
Before replacing the original product with a generic drug, consult a medical professional. Next, the most effective and inexpensive substitutes will be considered.
"Baneocin"
This is a complex antibacterial agent that is used only externally and consists of two active ingredients - neomycin and bacitracin.
Thanks to neomycin, the drug is capable of slowing down the production of proteins that are inside bacterial cells. Neomycin can have a negative effect on gram-negative and gram-positive microorganisms.
And bacitracin is considered a polypeptide component, which helps it inhibit the synthesis of cell walls of bacteria. It acts on certain types of gram-negative pathogens and gram-positive microorganisms, for example:
- staphylococcus;
- streptococcus;
- beta hemolytic.
It is also important to note that the immunity of the human body to bacitracin is extremely rare.
According to the instructions for use with the Gentamicin analogue, it is known that due to the presence of two active substances in the preparation, the drug has an extensive spectrum of action.
"Syntomycin"
The drug belongs to the group of antimicrobials, which are intended to eliminate diseases of the skin. The main component is chloramphenicol.
According to reviews and instructions, the analogue of "Gentamicin" is used externally, the main indications for prescribing medication are:
- purulent diseases of the skin;
- non-healing wounds;
- boils;
- carbuncles;
- trophic ulcers;
- burns of the second and third degree;
- deep cracks.
"Supirocin"
The structure of the medication includes one active substance - mupirocin. "Supirocin" is an antibacterial agent that has a bactericidal effect.
Ointment is not recommended to be applied to mucous membranes. Do not allow the product to reach the mucous membranes of the eye. If this happens, it is recommended to rinse the eyes well with water. After applying the medicine to the skin, wash your hands well.
In rare situations, severe irritation of the skin or allergies may occur, as a result of which it is necessary to stop using Supirocin, rinse the affected area with water and consult a medical specialist for an alternative antimicrobial treatment.
With prolonged use of mupirocin, as well as other antibacterial agents, increased growth of insensitive microorganisms is possible.
Tobrex
A broad-acting antimicrobial drug that belongs to the group of aminoglycosides. It has a bactericidal and bacteriostatic effect. Active against most viruses that provoke bacterial inflammation of the anterior segment of the eye.
According to the instructions, the continued use of this analogue of the ointment "Gentamicin" leads to increased growth of insensitive microorganisms, including fungi. Therefore, with poor results of therapy, sowing should be done. During treatment with eye ointment, wearing contact lenses is prohibited.
The use of "Tobrex" in childhood is possible only if absolutely necessary under the strict supervision of a specialist.
In case of temporary visual clarity impairment as a result of the use of the medication, driving and potentially dangerous machinery is not recommended.
Oftocipro
Ointment is a medicine for eliminating bacterial eye infections, the main active component of which is ciprofloxacin, an antimicrobial agent from the group of fluoroquinolones.
According to the instructions for the Dex-Gentamicin analogue, ophthalmic ointment refers to antimicrobials from the group of fluoroquinolones, which, unlike traditional antibacterial medicines, are of only synthetic origin. But this did not stop them from becoming one of the main groups among antimicrobials today. This position is ensured by a number of unique properties of fluoroquinolones:
- High degree of bactericidal activity.
- A wide range of actions.
In particular, the active substance is active against gram-positive organisms. In addition, Oftocipro is effective in influencing certain intracellular pathogens and enterococci.
Good hit in body tissues, with the accumulation of high content. Long half-life and the formation of post-antibacterial action.
Tetracycline ointment
The drug is an antibacterial drug for topical use. The main component of the drug is tetracycline hydrochloride.
During treatment with the drug for external use, patients should avoid being in direct sunlight, since the sensitivity of the skin to light increases and pigmentation can be increased. All these phenomena are reversible and pass immediately after the abolition of the course of therapy.
Reviews
Opinions about Dex-Gentamicin generics are generally positive. In the reviews about medicines, there is practically no information about the occurrence of adverse reactions, but patients praise the instant effect and a good result. In this case, often people use the same medication for eye and skin diseases. For example, many people supplement the reviews with messages about the successful elimination of barley.
Reviews about the analogues of "Gentamicin" are usually positive. Those people who have already used this drug on themselves note that it helps to eliminate problems with the skin and various inflammatory processes literally in a matter of days.
Acne drugs, according to reviews, are used quite often. Many patients claim that this is perhaps the best medicine for people with problematic skin surfaces.