Is Nicergoline effective? Reviews, analogues and features of this tool will be considered in the article. You will also learn about the dosage in which it is prescribed to patients.
Description, composition, form of the drug
In what form do the Nicergoline medication take? The instructions say that this tool can be purchased in two forms:
- Lyophilisate in glass ampoules (i.e., odorless white powder), packaged in PVC contour cells and cardboard boxes, respectively, together with a solvent (0.9% sodium chloride), intended for the preparation of an injection solution.
What is included in this product? It contains nicergoline, as well as milk sugar and tartaric acid.
- Biconvex tablets with a white film coating, packaged in blisters.
What are the components of the form of Nicergoline in question? In addition to the active ingredient of the same name, the composition of the tablets includes the following substances: potato starch, basic magnesium carbonate, milk sugar, povidone, stearic acid and magnesium stearate.
As for the white shell, it consists of basic magnesium carbonate, sucrose, colloidal silicon dioxide, beeswax, povidone, titanium dioxide, medical gelatin and talc.
Pharmacodynamic features of the drug: characteristic
The drug in question has a vasodilating effect (that is, it affects the arteries of the brain), and also belongs to the group of alpha-blockers.
The drug "Nicergoline-LF", reviews of which are presented below, is a synthetic derivative of alpha-blocker and ergot alkaloids. The chemical formula of this product contains residues of bromosubstituted nicotinic acid.
The active component of the drug, as well as the ergoline derivative, contribute to a positive effect on the hemodynamic and metabolic processes that occur in the human brain.
Due to the fact that the drug in question has an alpha1-adrenergic blocking effect, its administration increases the blood flow velocity in the lungs, brain and extremities, as well as reduces platelet aggregation in the blood and improves its hemorheological parameters. Also, this drug compound exhibits antispasmodic properties and at the same time exerts a myotropic effect on the vascular muscles, increases glucose permeability and equalizes the effect of the ergoline ring.
The main properties of the drug
What is noteworthy for such a tool as "Nicergoline"? Reviews of experts claim that this medication reduces vascular tone, saturates the arterial blood flow with oxygen and glucose. It also has a beneficial effect on blood pressure, which with hypertension can gradually normalize.
It should be noted that the drug in question contributes to the improvement of hemorheological parameters, as well as to a decrease in platelet aggregation and increased blood circulation during arteriopathy.
Pharmacokinetics of the drug
The drug "Nicergoline", reviews of which are mostly positive, reaches its maximum concentration in the blood after 90 minutes after the first application. The bioavailability of this tool is about 60%.
From the patient's body, 80% of the drug is excreted through the kidneys (with urine), and 20% - along with feces.
Indications for use
When are patients prescribed Nicergoline? Reviews (pills and injections with the same name are sold in all pharmacies) state that the following conditions are the main indications for using this medication:
- migraine;
- disturbances in the work of metabolic cerebral vessels of a chronic or acute nature caused by atherosclerosis, hypertension, ischemic attack, embolism, vasospasm, thrombosis or vascular dementia;
- Raynaud's disease;
- vertigo;
- diabetic angiopathy ;
- circulatory disturbance (peripheral);
- diabetic retinopathy;
- endarteritis;
- optic neuropathy;
- limb arteriopathy;
- corneal diseases.
Contraindications
What conditions of the patient are forbidden to use the Nicergoline medication? Reviews (injections and tablets have the same contraindications) indicate the following prohibitions:
- hypersensitivity;
- galactose intolerance;
- heart attack;
- hypotension;
- pregnancy;
- bradycardia;
- minor age;
- breast-feeding;
- glucose-galactose malabsorption;
- lack of lactose.
With caution, this medicine should be used by people with gout, hyperuricemia, as well as in combination with drugs that affect the metabolism and excretion of uric acid from the body.
Medication "Nicergoline": instructions for use
Reviews of doctors claim that this tool must be taken in strictly recommended dosages. As a rule, Nicergoline tablets are prescribed three times a day before eating or during meals at a dose of 5-10 mg.
The duration of treatment with this medicine is usually 3 weeks. But if necessary, this period can be extended to several months.
Before use, the lycerol "Nicergoline" should be diluted with a solvent (with sodium chloride), and then administered intramuscularly (2-4 mg twice a day). The duration of therapy and the dosage of this agent depend on the severity and nature of the disease, as well as on the condition of the patient.
For people with impaired renal function, the drug in question is recommended to be used in the smallest possible amounts.
Side effects after applying the medicine
Side effects are prescribed in the instructions for the drug "Nicergoline". Customer reviews report that during the use of the drug in question, they often had such adverse reactions as:
- nausea, decreased blood pressure, drowsiness;
- abdominal pain, allergic reaction, dizziness;
- fever, diarrhea, increased uric acid levels, insomnia.
Overdose, drug interaction
What symptoms occur when using large doses of the drug in question? Signs that indicate an overdose are conditions such as orthostatic collapse, hypotension, and also allergic reactions. In addition, when the dosage of the drug recommended by the doctor is exceeded in patients, the severity of side effects increases significantly.
According to the instructions, the drug "Nicergoline" is able to enhance the effectiveness of antipsychotic and antihypertensive drugs, as well as anxiolytics. It should be noted that antacids and colestyramines reduce the absorption of this medication.
With the parallel use of the drug with adrenostimulants, idiosyncrasy may occur in patients.
The drug "Nicergoline": reviews of patients and doctors, analogues
Analogues of this tool are drugs such as Nilogrin, Sermion, and Nicergoline-Fereig.
The medication in question is strictly forbidden to be used in conjunction with narcotic drugs and alcoholic beverages.
To avoid the development of hypotension, including at the very beginning of therapy, after intramuscular injection of the drug solution, patients need to remain in a horizontal position for some time.
It should also be noted that most doctors during treatment with the Nicergoline medicine forbid their patients to drive cars and engage in activities that require instant psychomotor reactions and increased concentration of attention.
As for consumers, their main part leaves negative feedback about Nicergoline. This is primarily due to the fact that patients very often encounter its side effects, and also for a long time they have not noticed any improvement or drug effect.