Antianginal drugs are medicines that increase blood flow to the heart, and also reduce its oxygen demand. Such medications are very often used to stop or prevent angina attacks.
Angina pectoris is a disease that is characterized by pain or discomfort behind the sternum. As a rule, pain with such a disease manifests itself suddenly with emotional stress or physical exertion, as well as after eating food. Usually it gives to the neck, left shoulder, between the shoulder blades, the lower jaw and the left subscapular region. Such discomfort disappears after ¼ hours. Also, the pain disappears after the cessation of physical activity or after taking an antianginal drug. As the last very often use the medicine "Cordinik". Instructions for use, a description of the drug and its properties are presented below.
Description of the medicinal product, its form, composition and packaging
What form is inherent in the medicine "Cordinik"? Instructions for use indicate that this drug can be purchased in the form of tablets. They have a flat-cylindrical shape, have a white or weak grayish-yellow color.
The drug in question includes nicorandil. As auxiliary components, potato starch, calcium stearate and microcrystalline cellulose are used.
The Cordinica medication, the instructions for use of which is packaged in a pack of cardboard, are available in contour cells.
Pharmacology of the drug
Why is the medicine “Cordinik” (tablets) more remarkable? Instructions for use indicate that nicorandil has an antianginal effect. It is based on a combination of nitrate-like properties, as well as the ability to open potassium channels. Due to the latter property, this drug causes hyperpolarization of the cell membrane.
The nitrate-like effect of this drug is to increase the content of cyclic guanyl monophosphate inside the cells. Such pharmacological effects contribute to the relaxation of smooth muscle, as well as the protection of the myocardium during ischemia.
As for hemodynamic effects, they are expressed in a balanced decrease in post- and preload. Given the vasodilation of the (selective) coronary arteries, the load on the ischemic myocardium is minimized.
Nicorandil does not affect myocardial contractility. In addition, this substance does not change heart rate. However, it reduces systemic blood pressure, and also has a beneficial effect on the blood circulation of the brain in people with ischemic stroke.
What other properties are inherent in the Cordinik preparation? Instructions for use (drug analogues are listed below) states that nicorandil has no effect on glucose metabolism and lipid metabolism. It stops an attack of angina pectoris, and also reduces pain within seven minutes after administration under the tongue. Complete elimination of discomfort is observed after ¼ hours.
Kinetics means
Where is the medicine “Cordinik” absorbed from? Instructions for use indicate that the absorption of the drug in question comes from the digestive tract. It reaches its peak plasma concentration after 35-60 minutes.
Nicorandil binds only slightly to plasma proteins. Its free fraction in the blood is 75%.
This medication is not subjected to intense metabolism in the liver. It is excreted by the kidneys within 50 minutes.
Indications for admission
When should I use Cordinic tablets? The instruction states that this tool works well with:
- prevention of angina attacks (stable) in combination with other antianginal drugs;
- relief of angina attacks;
- monotherapy with intolerance to BMCC and beta-blockers.
Contraindications
When should you not prescribe Cordinic tablets? Instructions for use (synonyms of the drug mentioned below) indicate contraindications such as:
- collapse, cardiogenic shock;
- AV blockade of the third and second degree;
- acute myocardial infarction, as well as within 90 days after it;
- angina is unstable ;
- chronic heart failure (third or fourth functional class according to NYHA classification);
- arterial hypotension;
- pregnancy period;
- severe bradycardia;
- lactation period;
- left ventricular failure with reduced filling pressure;
- minor age;
- the simultaneous use of phosphodiesterase-5 inhibitors (for example, "Sildenafil", "Vardenafil" or "Tadalafil");
- hypersensitivity to the drug.
With caution, such tablets are prescribed for impaired heart rhythm, Prinzmetal angina, first-degree AV block, arterial hypotension, impaired liver and kidney hypovolemia, pulmonary edema, hyperkalemia, angle-closure glaucoma and anemia.
The drug "Cordinick": method of administration and dose
Cordinic tablets should be taken orally, regardless of the meal.
The dosage of this drug is selected individually. As a rule, it depends on the duration and severity of the disease.
To stop an attack of angina pectoris, the medication should be used at the first signs of the disease. In this case, it is prescribed in a dosage of 20 mg. The tablet is placed under the tongue and held until it dissolves.
For the prevention of stable angina attacks (including with prolonged therapy), the drug is usually prescribed in a dosage of 10-20 mg three times a day.
The maximum dosage of this medicine per day is 80 mg. For headaches, the initial dose may be reduced.
Side effects
What you need to know before taking Cordinic tablets? The instruction for use states that this tool can cause undesirable reactions such as:
- weakness, palpitations, headache, decreased blood pressure, dizziness;
- tachycardia, tinnitus, flushing of blood to the face, insomnia;
- allergic reactions, peripheral edema, nausea;
- a feeling of fullness in the stomach, vomiting, increased activity of “liver” transaminases, discomfort in the abdomen, stomatitis.
Overdose of pills
When taking a large number of tablets, the patient has symptoms such as tachycardia and a marked decrease in blood pressure. In this case, the victim is washed the stomach and give activated charcoal. They also support the work of the cardiovascular system.
Interaction with other means
The antianginal effect of the drug in question is enhanced while taking antidepressants, vasodilators, phosphodiesterase-5 inhibitors, antihypertensive drugs and tricyclic antidepressants. The same goes for diuretics, MAO inhibitors, beta-blockers and ethanol.
Special recommendations
Cancel the drug should be gradual. During therapy, it is necessary to monitor the ECG and blood pressure, as well as the content of sodium and potassium ions in the blood. Also, while taking this medication, an increase in heart rhythm disturbances is possible.
Analogues and synonyms of the drug, its cost
Now you know how the Cordinique medication works. Instructions for use, photos and properties of this medication were presented above.
How much is the drug in question? As a rule, the price of this product for 60 tablets (10 mg) is 450 rubles. Although in some regions of our country this figure can be increased or, conversely, reduced.
In case of urgent need, this medication can be replaced by analogues such as Dilacid, Corvamin, Carbocromene, Corvaton, Sidnofarm, Oksikardin, Reasanz and others.
As for synonyms, only Coronel is referred to them.
Drug Reviews
There are many positive reviews about Cordinic. Consumers argue that such an antianginal drug completely copes with the task. Taking the pill in question effectively relieves angina attacks, and also eliminates pain and discomfort behind the sternum.
In addition, the advantages of this medication include its availability and the ability to replace with analogues, and the disadvantages are the high price and a large number of adverse reactions.