In the article, we will consider the instructions for use of Nimesil, and also describe how to dilute the powder.
"Nimesil" is an anti-inflammatory drug, which also has a pronounced analgesic effect. It is prescribed to patients with the goal of stopping any type of pain, including headache and toothache. It is not suitable for long-term therapy, as it can provoke a wide range of negative reactions that lead to dangerous complications.
Pharmacological form
According to the instructions, "Nimesil" is an anti-inflammatory drug, is able to actively fight the symptoms of inflammatory processes, has the qualities of an antipyretic and analgesic. The analgesic property of the drug should be noted separately, since pain significantly affects the quality of human life.
The manufacturer produces the medication in the form of a powder consisting of small granules. The powder is packaged in individual sachets, used to make a suspension, which is then taken orally. The medicine has a pleasant orange aroma. Each sachet contains 2 grams of the drug, which is equivalent to 100 mg of nimesulide - the active substance.
Composition, description of the drug
As the instruction indicates, Nimesil so quickly and effectively eliminates pain that often patients mistakenly take it for an analgesic. In addition to efficiency, the characteristics of the active component should be noted. The properties of the nimesulide molecule prevent its penetration into the mucous membranes of the upper gastrointestinal tract, which radically reduces the likelihood of mucosal inflammation and contact irritation.
Together with this, the drug has a high degree of bioavailability. Half an hour after applying the suspension, the concentration of nimesulide in the blood plasma reaches 80%. The drug easily penetrates into areas affected by inflammation. Thanks to such qualities, he successfully and quickly brings relief.
In accordance with the instructions for use with the Nimesil powder, in addition to nimesulide, the preparation contains such auxiliary substances as ketomacrogol-1000, sucrose, anhydrous citric acid, and orange flavoring.
These substances give the drug the ability to maintain the shape of the powder and, at the same time, can provoke an allergic reaction in patients.
Nimesil is pharmacologically an anti-inflammatory selective inhibitor of COX type 2 sulfolamide groups.
Indications for use
What else can you learn from the instructions? "Nimesil" is a symptomatic agent that acts at the time of admission on the symptoms of the inflammatory process. Adult patients are indicated for admission with:
- Painful menstruation.
- Acute pain accompanying periods of exacerbation of osteochondrosis.
- Dislocations, subluxations, sprains, bruises and other lesions of the ligaments and joints.
- Acute toothache.
The price of Nimesil is not indicated in the instructions.
The advisability of admission should be determined by the doctor individually, taking into account the likely benefits and possible risks.
The drug is allowed for use in the treatment of children from 12 years old; indications for its use by patients of this age group are similar to those in adults.
The use of the drug in the lactation period and pregnant women is strictly contraindicated. This is confirmed by the instructions for use with the Nimesil powder.
Contraindications
Do not use the medication if the patient has an individual hypersensitivity to the active or any additional component. It is strictly forbidden to use the medication by persons who have (also in history) hypersensitivity to salicylates and other NSAIDs, manifested by the development of bronchospasm, urticaria or rhinitis.
According to the instructions, Nimesil should not be taken:
- In parallel with drugs that can potentially have toxic effects on the liver (other NSAIDs and analgesics).
- In the presence of serious ulcerative inflammatory lesions of the gastrointestinal mucosa, especially during periods of exacerbation.
- In the presence of pathologies of the blood system, accompanied by an increase in bleeding.
- With circulatory disorders in the brain, accompanied by bleeding in the body (in history).
- With pathological changes in internal organs that have a severe degree (insufficiency of hepatic, renal, cardiac activity).
- With active hepatic pathologies.
- If the patient is under 12 years old.
- In the lactation period.
- During pregnancy.
How to breed Nimesil powder is described in detail in the instructions.
It is contraindicated to use the medication for the purpose of symptomatic therapy for patients suffering from drug addiction, from alcoholism.
It is important to exercise caution when prescribing the drug to people:
- With severe arterial hypertension.
- Gastrointestinal lesions provoked by Helicobacter pylori.
- Long smoking.
- Having pathological changes in the peripheral vessels.
It is recommended to refrain from using the medication for patients taking sertraline, fluoxetine (and other SSRIs), warfarin (and other anticoagulants), aspirin, clopidogrel (and other antiplatelet agents). Parallel administration of other NSAIDs and oral hormonal agents (for example, prednisone) is not allowed. This is stated in the instructions for use of the Nimesil powder. How to breed it, consider below.
Use of medication
Before use, it is necessary to open the sachet with medicinal powder, pour its contents into a container and dilute with water in an amount of 100 ml. The resulting suspension is thoroughly mixed and taken orally.
It is recommended to take twice a day, preferably after eating. The suspension should be prepared immediately before taking it.
It is important to remember that only persons over 12 years old can take the drug, and the duration of therapy should be no more than 15 days.
Dose adjustment in the treatment of elderly patients is not required if other medications are not used. Otherwise, the attending physician must adjust the dose.
Patients suffering from a moderate degree of kidney damage, dose adjustment is also not required. The risk of developing adverse reactions will be reduced by taking the drug in minimum effective doses over a short period of time.
For the treatment of children under 12 years of age, the drug is not used. Children from 12 years of age are shown to use the same dosages as for the treatment of adult patients. In the absence of specific treatment, dose adjustment is not necessary. This is also confirmed by the instructions for use with Nimesil. The price of the drug is of interest to many. This will be described below.
Negative impact
In accordance with the instructions and reviews to Nimesil, against the background of the systematic use of the drug, various undesirable effects may develop. The drug has a particularly strong effect on the hepatobiliary system and irritates the digestive tract. Most often, such negative effects are manifested as:
- The development of gastritis, up to the appearance of a perforating ulcer.
- The development of hepatitis, fulminant jaundice, cholestasis.
Quite often, patients note the appearance of nausea, dyspeptic symptoms, stomatitis, diarrhea, diarrhea, the appearance of tar-like stool, which is a sign of bleeding in the digestive tract. This is indicated in the instructions for Nimesil powder.
Bleeding occurs not only as a result of exposure to the mucous membranes of the gastrointestinal tract of nimesulide, but also as a result of disturbances in the activity of the blood system (purpura, thrombocytopenia, anemia and other pathologies). Such violations are characteristic of those patients who take the drug for a long time.
Nimesil, like any other drug of the NSAID group, is capable of provoking intolerance and allergic manifestations.
In rare cases, patients note the development of such adverse reactions as:
- Impaired urination.
- Increased levels of potassium in the blood plasma.
- Hyperthermia, asthenia.
- Bronchospasm, shortness of breath.
- Raynaud's syndrome, nightmares, dizziness.
- Hot flashes, blood pressure and heart rate lability, increased heart rate.
If you experience any negative manifestations during the use of Nimesil, you should consult your doctor.
Interaction with other medicines
Nimesulide is able to pharmacologically interact with drugs of the following groups:
- Antihypertensive drugs.
- Steroid hormonal drugs.
- Antiplatelet agents and anticoagulants.
- Other NSAIDs.
- SSRIs, diuretic agents.
- Cephalosporins.
You should not take "Nimesil" in parallel with lithium preparations and methotrexate.
Special instructions for use
Information on how nimesulide affects psychomotor reactions is not available, since such studies have not been conducted.
The active component of Nimesil adversely affects a woman’s ability to bear children. In this regard, it is recommended to abandon the use of the drug during pregnancy planning.
Nimesulide negatively affects gestation and development of the embryo.
Overdose
With an overdose of nimesulide, the severity of side symptoms increases. The patient develops gastropathy, gastralgia, apathy, drowsiness, anaphylaxis, bleeding, coma, respiratory depression. As a rule, the symptomatology is reversible. Therapy for overdose is prescribed symptomatic.
How to breed "Nimesil" according to the instructions, we explained.
Analogs
If necessary, "Nimesil" can be replaced by one of the following drugs:
- Ketanov. Clinical and pharmacological analogue of Nimesil. The manufacturer is available in injection and tablet form. It is not allowed to be used in the treatment of patients under 16 years of age, in the lactation period and during pregnancy.
- Nimulide. It is a complete analogue of Nimesil. It is available in several therapeutic forms - soluble tablets, suspensions, and gel intended for external use. It is allowed to use infants weighing from 7 kg.
- Nise. It is a complete analogue of Nimesil. May have such pharmacological forms as suspension, gel, tablets. It can be prescribed to small children, whose weight is from 7 kg. Often used as an anti-inflammatory, analgesic, antipyretic.
- Movalis. It is an original drug, the active ingredient in its composition is meloxicam. The drug is able to act as an analgesic, antipyretic, anti-inflammatory agent. The drug is prescribed to patients from 12 years of age, however, it is allowed to use the suspension form from 2 years of age, if children suffering from rheumatoid juvenile arthritis are treated. In the lactation period and during pregnancy, the drug is prohibited. In addition to the suspension form, the drug is available in the form of rectal suppositories, injection solution, tablets. This will confirm the instruction.
Price of Nimesil
The average cost of packaging a drug in Russian pharmacies is about 690 rubles. It depends on the region and the pharmacy network.
Reviews
Patients who have experienced using Nimesil to combat toothache or pain accompanying trauma or algodismenorea report it is highly effective. It is noteworthy that with proper and short-term use, Nimesil practically does not cause negative reactions.
The negative sides of the drug is its rather high cost and high hepatotoxicity. It is the last quality of the drug that makes it impossible to use it for a long time.
It is important to remember that the doctor should prescribe the drug, as well as the fact that Nimesil is a symptomatic remedy and does not eliminate the cause of the pain.
We examined the Nimesil preparation instructions for use, how to dilute the powder, its analogues and reviews about the medicine.