Instructions for the use of candles "Nurofen" for children should be studied every mother. This is due to the fact that such a medication has quite a few contraindications, and is also capable of causing side effects.
basic information
Candles for children "Nurofen", the instruction of which is enclosed in a cardboard box, are rectal suppositories that have a torpedo shape, smooth surface, and also white or practical white color.
The drug in question is a non-steroidal anti-inflammatory drug derived from propionic acid.
Composition and pharmacological action
According to the instructions for candles for children "Nurofen", their active active ingredient is ibuprofen. Also, the composition of the mentioned suppositories includes such auxiliary substances as Vitepsol H15 and Vitepsol W 45 (solid fat 1 and solid fat 2, respectively).
This medication has not only anti-inflammatory effect, but also has analgesic and antipyretic properties.
The principle of the drug
The instructions for candles “Nurofen” for children (60 mg) say that the mechanism of action of the main substance of this drug is due to a slowdown in the biological synthesis of mediators of inflammation and pain. Once inside the body, ibuprofen has an inhibitory effect on cyclooxygenase. It also reduces the synthesis of prostaglandins in the inflamed area and in the zone of thermoregulation of the hypothalamus. Due to this effect, the use of this drug in young children helps to eliminate heat, reduce the intensity of inflammation and eliminate pain. The latter effect is achieved by reducing the number of prostaglandins in the nervous system and slowing down the generation.
In the instructions for candles for children "Nurofen" there is information that the use of this drug can reduce platelet aggregation. This occurs due to inhibition of cyclooxygenase activity, which reduces the synthesis of thromboxane A.
Pharmacokinetic features of the drug
What pharmacokinetic features do Nurofen candles for children have (60)? The instructions attached to this medicine report that after using rectal suppositories, its active ingredient is quickly absorbed into the general systemic circulation. Thus, within 45 minutes, ibuprofen reaches its peak concentration in the blood.
The drug in question is able to easily penetrate the blood-brain barrier. Its main substance is metabolized in the liver, resulting in the formation of inactive metabolites. From the child's body, this medication is excreted mainly through the kidneys. The half-life of the drug is 120 minutes.
What is the duration of the therapeutic effect of suppositories for children under the age of Nurofen? The instruction of this drug says that suppositories can reduce fever, as well as eliminate pain for 8 hours.
In what cases is prescribed?
The drug "Nurofen" in the form of rectal suppositories is intended for children from three months to two years.
Most often, this medication is used as an effective antipyretic agent for various diseases (for example, with acute respiratory viral infections and other infectious or inflammatory conditions), which are accompanied by an increase in body temperature. In addition, the aforementioned medicine can be used when a post-vaccination reaction occurs.
According to the instructions for candles “Nurofen” for children from birth, this drug can be prescribed to the child not only in the heat, but also if he has uncomfortable sensations. As a painkiller, rectal suppositories are recommended for bruises, earaches, sprains, toothaches and headaches, neuralgia, as well as other similar moderate-intensity syndromes.
In what cases can not be used?
In the instructions for candles for children "Nurofen" the following contraindications are indicated:
- the presence of bronchial asthma;
- individual intolerance to the main and additional components of the drug;
- diagnosed hypokalemia;
- body weight of children less than 6 kg;
- any inflammation of the intestines;
- the presence of proctitis;
- hepatic as well as renal failure;
- ulcerative lesions of the digestive tract;
- various blood diseases, including leukopenia, hemophilia and hypocoagulation;
- the child's tendency to develop allergies, which is provoked by the intake of salicylates;
- hearing dysfunction;
- gastric or intestinal bleeding;
- autoimmune connective tissue diseases.
Cost, dose, instruction for candles "Nurofen" for children
The price of this drug is available to most parents. Usually it ranges from 115-145 rubles.
When using the Nurofen rectal suppository, the age as well as the body weight of the child should be taken into account. In case of post-immunization fever, children up to one year old are recommended to use 1/2 candle. After a year, the children are given a whole suppository, and, if necessary, after six hours - another one.
With severe pain and high temperature, a single dosage of the drug should be at least 5-10 mg per 1 kg of body weight of the child. In this case, the maximum daily dose should be divided into 3-4 applications, with an interval of six hours (no more than 30 mg).
Babies weighing 6-8 kg should be used 1 / 2-1 candle, no more than three times a day. If the child’s body weight is 8-12 kg, then he is prescribed 1 suppository, up to four times a day.
Children's "Nurofen" in the form of candles should be used no more than three days in a row. If the drug does not contribute to the improvement of the patient's condition, it must be canceled, and immediately consult a pediatrician.
With the simultaneous use of the rectal and oral form of this agent, its daily dosage and the intervals between use are calculated based on their total addition.
Side effects
In some cases, children's candles "Nurofen" contribute to the development of such negative effects as:
- nausea, rectal irritation, vomiting, flatulence, abdominal pain, stool disorders;
- blood pressure lability, the development of edema, heart failure;
- dizziness, sleep disturbances, headaches, tinnitus, fatigue;
- oliguria (with impaired renal function), cystitis, interstitial nephritis, nephrotic syndrome;
- anemia, thrombocytopenia, leukopenia and pancytopenia;
- urticaria, various allergic reactions, Quincke's edema, bronchospasm, Lyell syndrome, anaphylaxis, Stevens-Johnson syndrome.
Overdose Signs
Cases of overdose with the drug in question are a fairly common phenomenon. When using more than the prescribed amount of the drug, the patient may develop headaches and abdominal pains. Also, the use of high doses of children's “Nurofen” contributes to the appearance of nausea, tinnitus, vomiting, drowsiness, diarrhea, bradycardia, lowering blood pressure, metabolic acidosis, overexcitation, disorientation in space, acute renal failure, convulsions, coma.
There is no specific antidote for this medication. The patient is prescribed symptomatic therapy, which includes taking enterosorbents and drugs that stimulate urination.
Reviews
Parents who use Nurofen candles for their children respond mostly to them on the positive side. They note that this medication is able to quickly bring down the fever, as well as significantly improve the condition of a sick child, completely eliminating all the uncomfortable sensations in him.
Also, many users claim that such a form of the drug as rectal suppositories is very convenient to use (compared with oral baby syrup).
As for negative reviews, they sometimes mention the following side effects: diarrhea, allergic reactions, discomfort in the anus, digestive system problems.